ライフサイエンスコーパス: switch off

1 s aggregate and the catalysis is effectively switched "off".

2 annels, recovering the electronic barrier to switch OFF.

3 I(1) and nifI(2) genes are both required for switch-off.

4 hese structures fall apart once the field is switched off.

5 ch different energy terms are systematically switched off.

6 rized, little is known about how formins are switched off.

7 cur for a similar period when the device was switched off.

8 a way that the downstream expression unit is switched off.

9 r mechanisms of this signaling and how it is switched off.

10 tomization was reached as soon as oxygen was switched off.

11 resulting motion responses seem to be simply switched off.

12 diately arrested if the excitation source is switched off.

13 , which is reversible, when ectopic Fra-1 is switched off.

14 d interactions, explaining why head activity switches off.

15 , but what mechanisms moderate the extent of switch-off?

16 gon response (peak change within 7 min after switch off = 31 +/- 1 pg/ml, n = 3, P < 0.01) was observ

17 as observed (peak change within 10 min after switch off = 61 +/- 15 pg/ml [mean +/- SE], n = 6, P < 0

18 was observed (peak change within 7 min after switch off = 71 +/- 11 pg/ml, n = 4, P < 0.01).

19 appears to mediate the action of steroids to switch off activated inflammatory genes, but in patients

20 occurs because corticosteroids use HDAC2 to switch off activated inflammatory genes.

21 together, our findings demonstrated that DA switches off activated NK cells, thus representing a che

22 we have tested whether a similar interaction switches off activity in myosin filaments regulated by C

23 lts provide insight into the mechanisms that switch off acute inflammation and prevent complications

24 tivators need to be modulated and eventually switched off after the initial event that triggers their

25 ficant perturbations, e.g., forced temporary switching off aimed at utilizing the flexibility of the

26 to be absent in humans, that can be used to switch off an essential pathway in S. pneumoniae, the me

27 mmediately after the external magnon flow is switched off and initially decreases if it is switched o

28 The rotor dynamics could be switched off and on by I2 absorption/desorption, showing

29 raquat/cryptand-based pseudorotaxanes can be switched off and on in a controllable manner on the basi

30 Remarkably, PrP(Sc) infectivity could be switched off and on in a reversible manner by first remo

31 m the action as the illuminated cylinder was switched off and the other illuminated simultaneously wi

32 g lactide polymerization, catalysis could be switched off and turned back on upon oxidation and reduc

33 fold higher in nitrogen-fixing cells than in switched-off and ammonium-grown cells.

34 alpha-methylisoserine-derived sulfamidates, switching off and on the nucleophilic ring-opening in a

35 ole azo dye allows the SERRS response to be "switched off" and subsequent exposure to protease restor

36 me cases, targeted groups of neurons can be 'switched off' and back 'on' at will in living, behaving

37 at we term facet-selective epitaxy: we first switch off, and then switch on, shell growth on the (000

38 rols a TGFbeta-dependent signaling node that switches off antimigratory miR-198 by suppressing the ex

39 n both its "switched on" (ligand-bound) and "switched off" (apo) states.

40 By contrast, if the phase string signs are "switched off" artificially, the pairing strength diminis

41 ell cycle and amplify their centrioles, then switches off as MCCs mature.

42 hesis of a cytoplasmic protein of 20 kDa was switched off at 37 degrees C, whereas synthesis of a 66-

43 miRNAs are likely to play a dominant role in switching off Atf3 expression post-induction.

44 Once activated, the enzyme switches off ATP-consuming anabolic pathways and switche

45 onse to cellular fuel depletion and leads to switching off ATP-consuming pathways and switching on AT

46 catabolic pathways that generate ATP, while switching off ATP-consuming processes such as biosynthes

47 ty acids and mitochondrial biogenesis) while switching off ATP-consuming, anabolic pathways (eg, the

48 ulate that Parp-1 activation plays a role in switching off Bcl-6 transcription and subsequent B-cell

49 %) had their device explanted or permanently switched off before 5 years.

50 Here, we use optogenetic manipulation to switch off Bicoid-dependent transcription in the early D

51 vated bile acids activate FXR, which in turn switches off bile acid synthesis by reducing the mRNA le

52 Depletion of NANOG content in cells switching off both gene alleles was slower than the accu

53 insulin and 16.7 mmol/l glucose, followed by switching off both the insulin and glucose perifusate, a

54 omain dynamics with the ability of myosin to switch off but not to switch on the ATPase and the actin

55 l-responsive factors, including enhanceosome switch-off by Notch.

56 demonstrate the physiological importance of switch-off by showing that it allows growth to accelerat

57 e Ag...H(3)C interactions in solution may be switched off by addition of a stronger Lewis base than [

58 The biofuel cell was also switched OFF by another biochemical signal which resets

59 s, fluorescence in the unhybridised probe is switched off by collisional quenching between adjacent i

60 How these kinases are switched off by dephosphorylation is not well understood

61 When neural stimulation was switched off by either light exposure or L-propranolol-i

62 sional dielectric layers that can be rapidly switched off by electric field through a topological pha

63 generates an active protein, which cannot be switched off by endogenous protein kinases.

64 rsibility was observed: the fluorescence was switched OFF by immersing the solid substrate in copper

65 show that the acute photocytotoxicity can be switched off by low doses (500 muM) of the amino acid l-

66 antly, plasmon excitation can be dynamically switched off by lowering the chemical potential and movi

67 Plasmon excitations can be dynamically switched off by lowering the chemical potential of graph

68 738 muM), the kinase activity was completely switched off by O(2) at concentrations well below the K(

69 depletion of cellular dNTPs but is naturally switched off by phosphorylation in a subpopulation of MD

70 ting parasitemia, these responses need to be switched off by regulatory mechanisms in a timely manner

71 ic essential yeast genes whose expression is switched off by the addition of doxycycline to the cultu

72 The H-function can be turned on/switched off by the concentration of complexes within co

73 cord development progresses, Gli activity is switched off by unknown mechanisms.

74 suggest that CSR and SHM are differentially switched off by varying the expression of splicing produ

75 e transit-time to late endosomes where it is switched-off by high PTP1B activity.

76 t with bone-lining cells or osteoblasts, and switched 'off' by osteoclasts remodelling the endosteal

77 ASE) inhibitor KIP-RELATED PROTEIN2 known to switch off CDKA;1 kinase activity.

78 The cleavage of GTP to GDP and P(i) in Ras switches off cellular signaling.

79 thesis that the ability of many organisms to switch off ChoP expression rapidly represents an importa

80 short time after ammonia was removed from a switched-off culture, suggesting that whatever the mecha

81 ransfer (FRET, switch-on) or superquenching (switch-off) depending on the type of signaling probe use

82 Furthermore, switch-off did not affect nif gene transcription, nifH m

83 imaging to monitor the effect of deleting or switching off different combinations of antagonistic for

84 tal muscle gene expression program, which is switched off during maturation, but is intriguingly reta

85 geminal motoneurons and masseter muscles are switched off during REM sleep in rats.

86 ut in contrast to AGR2, their expression was switched off during TC and PanIN formation.

87 bsent in mammals or whether it exists and is switched off early after birth has been unclear.

88 e cellular responses to low energy levels by switching off energy-consuming pathways and switching on

89 is present in the inner core LPS and lgtG is switched "off." Escape from the bactericidal activity of

90 Switching off expression of the cTnT-Q92 reversed functi

91 lifetime can be greatly extended by rapidly switching off fast triplet RP recombination.

92 n, Tm would sterically block myosin binding, switching off filament activity.

93 L acts as a sensor for Hg(2+) by switch-off fluorescence and exhibits a lowest detectable

94 gnition ensemble toward Cys, Asp, and Glu by switch-off fluorescence.

95 lators, in particular in their mechanisms of switching off gene transcription after activation.

96 or mechanisms, suggesting that MDV infection switches off genes involved in antitumor regulation seve

97 Switching off GSK-3beta promotes disease pathogenesis.

98 Conversely, both switching off GTP cyclohydrolase I expression as well as

99 imulations techniques, which allow to easily switch off HB interactions.

100 ty to atherosclerosis could be eliminated by switching off hepatic lipoprotein production.

101 s revealed for the time period of 30 s after switching off high frequency stimulation.

102 hted the critical role of TGFbeta pathway in switching off hiPSC-brown adipogenesis and revealed nove

103 ausative agent of human bacillary dysentery, switches off host sumoylation during epithelial cell inf

104 These results fully support the beta-cell switch-off hypothesis as a key mechanism for the alpha-c

105 de direct in vivo support for the beta-cell "switch-off" hypothesis and indicate that the alpha-cell

106 The beta-cell "switch-off" hypothesis proposes that a sudden cessation

107 The "switch-off" hypothesis to explain beta-cell regulation o

108 oxygen with the heme, the kinase is rapidly switched off; (ii) after dissociation of oxygen, the kin

109 Steroid removal switches off import thus allowing direct visualization o

110 When overexpression of pmp22 is switched off in adult mice, correction begins within 1 w

111 ow level in haematopoietic stem cells and is switched off in all non-macrophage cell types.

112 s of embryonic cardiovascular development is switched off in late stage heart tissue and replaced by

113 In the absence of telomerase--an enzyme switched off in normal diploid fibro-blasts-cells lose t

114 lQ promoter, even though tylQ could still be switched off in S. fradiae strains specifically disrupte

115 ss I MHC genes Q8 and Q9 (Qa-2 Ags) has been switched off in the entire panel of melanoma lines, sugg

116 n which the NMDA receptor can be temporarily switched off in the forebrain specifically during the st

117 The other, pMET3 (which is switched off in the presence of methionine), is employed

118 d by the solvent polarity: It is deactivated/switched-off in apolar toluene, while in polar benzonitr

119 to the anagen stage of the hair cycle, being switched-off in catagen to remain absent through telogen

120 However, when the radio emission ceases, it switches off in less than 10 seconds and remains undetec

121 ttranslational regulation of nitrogenase, or switch-off, in the methanogenic archaeon Methanococcus m

122 lational regulation of nitrogen fixation, or switch-off, in the methanogenic archaeon Methanococcus m

123 se was halted after transgene expression was switched off; in rats with limited loss of motor neurons

124 k persists even after the transgene has been switched off, indicating that it results not from contin

125 ly little is known about the mechanisms that switch off inflammation and resolve the inflammatory res

126 The failure to switch off inflammation in IL-10-null mice was accompani

127 ribing gene, which reverses this process and switches off inflammatory gene transcription.

128 e alpha,beta-unsaturated ketone resulting in switching off, intramolecular charge transfer (ICT) from

129 duced diabetic Wistar rats, we observed that switching off intrapancreatic artery insulin infusions i

130 Ligand-mediated activation of EGFR switches off IRF3-dependent transcription, activates can

131 Ammonia switch-off is the immediate inactivation of nitrogen fix

132 how that once COUP-TFII expression in LC has switched off, it is re-induced by DBP exposure, coincide

133 Comparison of switch-off kinetics with myofibril force relaxation kine

134 nding pocket is a central target site to (i) switch off LSD1 amino oxidase activity, thus H3-tail dem

135 ssembled upon fluoride ion addition, thereby switching off luminescence and offering a new tool for f

136 confirms a regulatory network whereby DUSP1 switches off MAPKs to maintain IRF1 expression.

137 amination of individuals with failed splenic switch-off may significantly improve test sensitivity.

138 The switching off mechanism has been mapped to the algT/U lo

139 luate the effectiveness of chitosanase as a "switch off" mechanism for this drug delivery system when

140 -level understanding of how phosphorylation 'switches off' microtubule nucleation complexes during th

141 easily resettable to the original position (switch OFF mode; INHIBIT logic gate) by applying reset c

142 ize with coinhibitory checkpoint blockade to switch off molecular programs for quiescence in exhauste

143 and glycine drive triggers REM paralysis by switching off motoneuron activity.

144 t effective anti-inflammatory treatments and switch off multiple activated inflammatory genes through

145 this interaction is a general mechanism for switching off myosin II-based motile activity in both mu

146 both for inducing muscle relaxation and for switching off myosin II-based motile activity in nonmusc

147 are treated with doxycycline in adulthood to switch off nAChR expression, baseline PA is maintained e

148 The fluorescence recovery of this switched-off nanoprobe was made possible by using Sudan

149 gression of the murine SCC Pam 212 and after switching off NF-kappaB by a dominant negative inhibitor

150 In addition, ammonia completely switches off nitrogenase enzyme activity.

151 g enzyme, some of these are able to rapidly "switch-off" nitrogenase, by shifting the enzyme into an

152 y providing a negative feedback mechanism to switch off Nrf2 activation and restore normal cellular h

153 Visually, splenic switch-off occurred in 90% of adenosine studies, but nev

154 In certain bacteria switch-off occurs by reversible covalent ADP-ribosylatio

155 Ammonia switch-off occurs in diazotrophic species of the methano

156 cts were associated with delayed capacity to switch off Oct4, Nanog and Fgf5 expression, decreased be

157 o bypass and extend the damaged DNA and then switch off of the DNA substrate to allow continued repli

158 Finally, odorant series affected by the switch-off of alcoholic fermentation with ethanol 96% (v

159 The switch-off of cytochrome b6f complex biogenesis in matur

160 32)P]NAD labeling experiments showed that no switch-off of nitrogenase activity occurred in any of th

161 These results suggest a model for switch-off of nitrogenase activity, where direct interac

162 fixing (diazotrophic) culture caused partial switch-off of nitrogenase.

163 During the logarithmic increase, the rapid switch-off of the initial dominant transcript p44-18 occ

164 kdown of alpha-catenin in hESCs prevents the switch-off of Wnt/beta-catenin transcription and promote

165 stone deacetylase-2 activation, resulting in switching off of activated inflammatory genes.

166 tures suggest that Mg(2+) contributes to the switching off of calmodulin activity and possibly other

167 a constant duty ratio of 0.05 and a parallel switching OFF of motors, explaining the very low rate of

168 only release-independent, stimulus-dependent switching off of release sites resulted in HSD that was

169 inks are seen to transiently form, including switching off of the E45-R209 link, within a network of

170 raction of aptamer with malathion results in switching off of the fluorescence signal of the probe du

171 uminescence would be better interpreted as a switching off of the promoter, or where an increase in b

172 n motor of approximately 0.05 and a parallel switching OFF of the thick filament, providing an explan

173 ggest that the truncated troponin T prevents switching off of the thin filament at low Ca(2+).

174 These findings suggest that "switching off" of the Hippo-YAP pathway could help to pr

175 ion of pancreas-specific factors but is then switched off once PAX4 protein reaches sufficient levels

176 activation domains, genes can be selectively switched off or on.

177 e changes in gene expression are required to switch off oxidative glucose disposal.

178 Switching off pancreatic artery infusions of zinc chlori

179 line instead of insulin was infused and then switched off (peak change within 5-10 min = -44 +/- 108

180 Pulse implementation or switching-off (PISO) of electrical currents has become a

181 During S phase, cdc18 transcription is then switched off, preventing the re-initiation of DNA synthe

182 Because switching off prion protein expression has been shown to

183 the differentiation of endocrine cells, but switching off prior to final differentiation.

184 ctively switch on antiatherogenic genes, and switch off proatherogenic genes.

185 Though poorly understood, this "switching off" process has provided a key experimental t

186 ne in DNA templates, base excision repair is switched off, protecting the complex from a repair pathw

187 ity and promotes and maintains LEC identity; switching off Prox1 activity is sufficient to initiate a

188 rthermore, a ventilator device with a simple switch-off pushbutton to eliminate insufflations during

189 Rap1GAP functions by switching off Rap1, the Ras-like protein that has been a

190 No difference in the switch-off rate of glucose-stimulated insulin secretion

191 previously that in Methanococcus maripaludis switch-off requires at least one of two novel homologues

192 Nitrogenase switch-off requires the nitrogen sensor homologs NifI(1)

193 ractants, but upon crossing the midline they switch off responsiveness to attractants and switch on r

194 t of normal thiol levels, sigmaR activity is switched off, resulting in down-regulation of trxBA and

195 the gamma-phosphate sensor of ATP site C is switched off, resulting in low affinity of RFC for DNA a

196 t ICDH-Coumarin is able to chelate Fe(3+) to switch off RssAB signaling, triggering swarming initiati

197 hyperthermia, when sympathetic activity is 'switched off', severe hypoxia initiates respiratory-rela

198 arted to regress within 3 days when VEGF was switched off, showing stasis and luminal occlusion, infl

199 isappearance of contiguous Pd ensembles also switches off side reactions catalyzed by these sites.

200 However, this glucagon response to the zinc switch-off signal during glucose deprivation was not see

201 d glucagon response to an endogenous insulin switch-off signal during glucose deprivation was observe

202 not the insulin molecule itself, provide the switch-off signal from the beta-cell to the alpha-cell t

203 nels is the mechanism through which the zinc switch-off signal triggers glucagon secretion during glu

204 nel) is the mechanism through which the zinc switch-off signal triggers glucagon secretion during glu

205 ts, a glucagon response to an exogenous zinc switch-off signal was observed during glucose deprivatio

206 l understood, less is known about how a cell switches off signaling by the activated receptor.

207 al inflammatory pathways may be dampened or "switched off." Significant regional heterogeneity, with

208 Additional drugs aimed at switching off silenced genes include histone deacetylase

209 SPDa insulin infusion was switched off simultaneously when blood glucose fell to <

210 amagnetic ions [e.g., Ge(IV)] allows one to "switch off" specific spin sites in order to examine the

211 ible region and hence switch ON-specific and switch OFF-specific mRNA contain different sequences.

212 fimE and the fim switch, indicating that the switch OFF-specific mRNA is inactivated by 3' to 5' degr

213 the myosin tail, which may contribute to the switched-off state.

214 QDs nanocomposites was efficiently quenched (switch "off" state).

215 The resting (switched 'OFF') structure of the thick filament is chara

216 Insight into the relaxed (switched OFF) structure of myosin has come from electron

217 dification of dinitrogenase reductase during switch-off, suggesting that the mechanism differs from t

218 represses the expression of p63: it fails to switch off suprabasally when either Dicer1 or miR-203 is

219 l signal generation based on an ion barrier "switch-off" system.

220 ic nonsteroidal compounds that switch on and switch off target sites throughout the body.

221 We can finely tune and even switch off the attractions between particles, rendering

222 bilis and also suggested that the ability to switch off the expression of MR/P fimbria might be impor

223 We can switch off the high conducting sulfur-to-silacycle pathw

224 ovir diphosphate provides a simple method to switch off the Pi mop as it is a tight inhibitor (Kd 12

225 It is unknown, however, how cells switch off the signals or protect themselves from the SN

226 as great doping affinity with polymer PEI to switch-off the fluorescence of P-CNDs, leading to the pr

227 n support for gold-palladium alloy catalysts switches off the decomposition of H2O2.

228 reduction of the [4Fe-4S] cluster reversibly switches off the DinG helicase activity.

229 boring oncogenic BRAF, the inhibitor PLX4720 switches off the ERK pathway and inhibits the expression

230 eriphery of the phosphine ligand (complex 4) switches off the majority of these interactions, leaving

231 ent Ras GTPase-activating protein (GAP) that switches off the Ras-MAPK pathway following a stimulus t

232 led with an appropriate heat treatment cycle switches off the sequential hydrogenation and decomposit

233 This could provide a mechanism for switching off the active SpoIVB intermediate(s) and sugg

234 giogenic mechanism of LPA may in part be via switching off the antiangiogenic switch mediated by TSR

235 l-insulator transition in the bulk (allowing switching off the bulk conduction).

236 nd this induction was rapidly reversed after switching off the CAIKK2 expression.

237 epolymerase KLP10A at spindle poles, thereby switching off the depolymerization of the minus ends of

238 closing quantum yield increased 10-fold upon switching off the donor by protonation.

239 ntirely new antibacterial class that work by switching off the DSB virulence assembly machinery.

240 d (2) switching on the expression of PYY and switching off the expression of certain other hormones i

241 ophore and quencher in close proximity, thus switching off the fluorescence.

242 or initiation, growth, and metastasis, while switching off the metabolic reprogramming of tumor cells

243 ponse to light intensity and plays a role in switching off the OCP's photoprotective response through

244 Notably, switching off the oncogene in advanced carcinomas reveal

245 r destruction might add important control in switching off the p53 pathway, we now test this notion f

246 DH) enzymes and it is currently thought that switching off the RA signal involves the CYP26 enzymes w

247 suggested by echocardiography and a delay in switching off the slow skeletal troponin I.

248 On switching off the stimulation, the headache recurred ins

249 as sufficient to cause this deficit, because switching off the transgene in adulthood did not rescue

250 Normalizing striatal D2R activity by switching off the transgene in adulthood recovered the r

251 otivation and D1R expression were rescued by switching off the transgene in adulthood.

252 T cells was observed for long periods after switching off the transgene.

253 transduction cascade is regulated by quickly switching off the visual pigment that acts as the recept

254 3,4)P3 in vivo is an efficient mechanism to "switch-off" the cellular regulation of Ins(3,4,5,6)P4 le

255 known about the mechanisms that diminish or "switch-off" the neuronal chronotropic action of Ang II.

256 -loxP-mediated DNA recombination efficiently switches "off" the loxP-flanked GFP expression unit in c

257 when the films are exposed to water, which "switches off" the noncovalent CNC interactions, a signif

258 When the PRE is switched off, the domain is in a state permissive for ge

259 When the UV irradiation was switched off, the MC reverted to the SP form, and the vi

260 By contrast, when the repump is switched off, the PL decreases first within 100-200 mus,

261 When the stimulator was switched off, the target probability affected the reacti

262 hat glnB-like genes are involved in "ammonia switch-off," the post-transcriptional inhibition of nitr

263 red fibroblast behaviour in which failure to switch off their inflammatory programme leads to the ina

264 e of finite duration ( approximately 1.5 h), switching off thereafter despite sustained amino acid av

265 centrations, a second dimer bound adjacently switches off these genes.

266 ing--share a common structural mechanism for switching off thick-filament activity in relaxed muscle.

267 Furthermore, many physiological stimuli switch off this flux gating mode to convert K2P channels

268 Tryptophan restoration switches off this signaling pathway when activated by ID

269 rading phosphodiesterase (PDE) necessary for switching off this cAMP signal has not yet been identifi

270 mooth muscle myosin suggest that activity is switched off through an intramolecular interaction betwe

271 tic relaxation in the Fe(II)2 complex can be switched off through one-electron oxidation to the mixed

272 s nearly normal when pmp22 overexpression is switched off throughout life by feeding the mice tetracy

273 e feedback reduces both the switching on and switching off times of a gene.

274 's mode of action can be varied from >5-fold switch-OFF to >30-fold switch-ON solely by changing the

275 llow the growth-promoting latent genes to be switched off to create a site of persistent infection th

276 , we used a cell line where LD synthesis was switched off to evaluate whether LD deficiency affects C

277 N-mediated inhibitory inputs can momentarily switch off tonic firing of action potentials in dorsal t

278 conclude that sgRNA2 is a riboregulator that switches off translation of replication genes from gRNA

279 ing a molecular mechanism that enables us to switch off type I collagen may prove beneficial in treat

280 Cyclohexene oxide polymerization could be "switched off" upon in situ reduction of the iron(III) ca

281 vity, appears to be a critical mechanism for switching off vertebrate smooth-muscle myosin molecules,

282 In neurons, almost all key NSC genes are switched off via HP1-mediated repression.

283 bias points the photon-qubit coupling can be switched off via quantum interference, and in other poin

284 Splenic switch-off was assessed in perfusion cardiac MR examinat

285 r agreement in the visual grading of splenic switch-off was excellent (kappa = 0.92).

286 Failed splenic switch-off was significantly more common in CE-MARC pati

287 To further understand the mechanism of switch-off, we assayed nitrogenase activity in cell extr

288 her explore the role of the NifI proteins in switch-off, we found proteins that interact with NifI(1)

289 transgene encoding the R992C collagen II was switched off were characterized by normal growth, and th

290 Genes that switched off were rich in transcription factors and neur

291 t observed if the insulin perifusion was not switched off when the islets were deprived of glucose or

292 Schwann cells of the peripheral nerve and is switched off when the mice are fed tetracycline.

293 We propose a model for switch-off where the NifI proteins have an inhibitory ef

294 emia trait exhibit a delay in the normal HbF switch-off, which might partially explain the protection

295 Failed splenic switch-off with adenosine is a new, simple observation t

296 in Ca concentration, the effect of recoverin switched off with little lag.

297 vessels occurred as soon as the lights were switched off, with the majority of vessels becoming refi

298 erate level during vegetative growth, but is switched off within the first 2 h of sporulation.

299 were deprived of glucose or when insulin was switched off without glucose deprivation.

300 However, switching off zinc-free insulin infusions had no effect.