ライフサイエンスコーパス: switching to

1 One hour after switching to 40 degrees C, the amount of DMADP fell but

2 Switching to 8-week to 12-week IFN-free DAAs in prisons

3 story of glaucoma or ocular hypertension and switching to a 'PRN' injection protocol in patients suff

4 The highest-cost option of switching to a 3-dose IPV schedule only marginally decre

5 is associated with poor renal response when switching to a calcineurin inhibitor (CNI)-lowered or CN

6 This problem can be solved upon switching to a catalyst comprising a [Ru-Cl] bond, provi

7 ng of a system ranging from controlled state switching to a catastrophic break-down; signals that pre

8 nt lymphocytic and IFN-gamma response before switching to a chronic eosinophilic inflammation of the

9 he same location in Experiments 3 and 4) and switching to a constant number of pecks.

10 we examined their transfer of learning when switching to a contralateral hand, the second identical

11 lapse, either by restoring cooperation or by switching to a defector strategy.

12 cognitive therapy was better tolerated than switching to a different antidepressant.

13 ver consecutive trials in one context before switching to a different context.

14 m that require either stopping altogether or switching to a different response, we examined the brain

15 Importantly, switching to a fish oil-supplemented diet induced a reco

16 C) tracks the relative advantage in favor of switching to a foregone alternative when choices are mad

17 improvement of their variety of symptoms on switching to a GFD.

18 and inflammation that was irreversible upon switching to a healthy diet.

19 Remarkably, upon switching to a high fat diet, the mice begin to die with

20 were lean on a standard chow diet, but, upon switching to a high-fat diet, wild-type mice became obes

21 otility at high calcium is due to calmodulin switching to a higher affinity binding site, which leave

22 and to a neutral thiol, instead of by ligand switching to a histidine, as prior studies have suggeste

23 lternating pattern under control conditions, switching to a hopping activity at any frequency after r

24 -type alpha2-3-linked sialosides rather than switching to a human-like receptor specificity and highl

25 ns on' both reactivity and luminescence upon switching to a hydrated state.

26 s this splicing event and similarly mediates switching to a ligand-independent, constitutively active

27 e deficiencies caused by HFD were rescued by switching to a low fat diet for one month, suggesting a

28 Switching to a low temperature triggers the folding of t

29 r 2 d of high-fat feeding, but reduces after switching to a low-fat diet for 1 d.

30 hypocalciuria and displayed salt wasting on switching to a low-Na diet.

31 at least 80%, down-titration was defined by switching to a low/moderate-intensity statin with a prop

32 inent myotonia at rest and muscle fiber-type switching to a more oxidative phenotype compared with co

33 lusion, increasing auxiliary gas pressure or switching to a more volatile spray solvent also increase

34 is important to compare the risk in patients switching to a new product with that in a parallel contr

35 less is known about the regions that support switching to a new, appropriate, response.

36 r omitting postoperative chemotherapy and/or switching to a noncross-resistant regimen in patients wi

37 ) management recommend heparin cessation and switching to a nonheparin anticoagulant (ie, argatroban,

38 spective why mental fatigue diminishes after switching to a novel task and explains action selection

39 Cytokines direct IgH class-switching to a particular isotype by initiation of germl

40 stion the goal of eradication and to suggest switching to a policy of control.

41 lation, while reducing to a smaller size and switching to a positive surface charge for efficient pen

42 ted of cell-associated hyaluronan respond by switching to a pro-catabolic metabolism that includes en

43 al that LH2 complexes undergo photoactivated switching to a quenched state, likely by a conformationa

44 Therefore, we propose that, in switching to a resistive state, the nanotube oxidizes by

45 Switching to a running gait at 2.0 m.s(-1) caused fascic

46 also show the clinical benefit and safety of switching to a second TNF inhibitor without a washout pe

47 d viral load to promote adherence and timely switching to a second-line regimen.

48 Cold progressively promotes cell-autonomous switching to a silenced state.

49 ed the efficacy, safety, and tolerability of switching to a single-tablet regimen containing rilpivir

50 We investigated the efficacy and safety of switching to a single-tablet regimen of darunavir, cobic

51 We show that pro-B cells undergo robust switching to a subset of immunoglobulin H (IgH) isotypes

52 onventional quantitative confirmation) after switching to a TD-ESI source from a conventional ESI sou

53 Switching to a tenofovir alafenamide-containing regimen

54 icacy of switching to mirtazapine to that of switching to a tricyclic antidepressant (nortriptyline)

55 Switching to a wP-priming vaccination strategy could red

56 Solutions include switching to ablative laser prostatectomy (which may car

57 Here we report the biological event switching to activate necrosis over apoptosis.

58 rtolizumab pegol and 40 (62%) of 65 patients switching to adalimumab responded 12 weeks later by achi

59 ab seem to exhibit retinal dehydration after switching to aflibercept, whereas there was no demonstra

60 Switching to agalsidase-alfa is safe, but microalbuminur

61 ors must be rapidly removed upon mating-type switching to allow the master regulators of the alternat

62 eward, and monitoring the potential value of switching to alternative courses of action.

63 ineffective drugs taken and facilitate early switching to alternative medication when available.

64 g any medication, under tamoxifen, and after switching to an AI.

65 er 21 days of first-line chemotherapy, early switching to an alternate cytotoxic therapy was not effe

66 Thus, conformational switching to an alternative monomeric fold of comparable

67 cular dynamics simulations display transient switching to an alternative open conformer.

68 se reward to promote choice repetition after switching to an alternative option due to a diminished i

69 studies have established that a strategy of switching to an aromatase inhibitor after 2 to 3 years o

70 ffered the choice of continuing tamoxifen or switching to an aromatase inhibitor for 10 years total a

71 The program includes PERK-dependent switching to an eIF3-dependent translation initiation me

72 conversion, no association was found between switching to an employment model and improvement in any

73 performance up to 2 years after evidence of switching to an employment model; however, beneficial ef

74 Switching to an extremely clumped distribution is advant

75 ing a sequential IPV/OPV schedule instead of switching to an IPV-only schedule in 2005 would have kep

76 atellite cells lose reversible quiescence by switching to an irreversible pre-senescence state, cause

77 e conventional bar-shaped geometry) leads to switching to an off state while retaining the ultrahigh

78 ients who received L-T4 in tablet form after switching to an oral liquid formulation with the same L-

79 Thus, hepatic down-regulation of Ctr1 allows switching to an SCC-mediated removal of copper via kidne

80 id chromatography with positive/negative ion switching to analyze 258 metabolites (289 Q1/Q3 transiti

81 r patients had a remission of symptoms after switching to another antidepressant.

82 authors compared switching to clozapine with switching to another atypical antipsychotic in patients

83 ing phacoemulsification with PCT rather than switching to another backup IOL demanding wound enlargem

84 proved or changed within their channel or by switching to another channel.

85 may benefit from continued treatment without switching to another drug.

86 greater treatment persistence compared with switching to another injectable preparation following on

87 Commonly, doubling the PPI dose or switching to another PPI will be offered to patients who

88 dian of 3.3 years, with a number of patients switching to anti-interleukin-1beta receptor therapy or

89 hK1 inhibitor or in SphK1(-/-) mice, isotype switching to antigen-specific IgE was decreased in vivo

90 Switching to aripiprazole led to improvement of non-HDL

91 acy failure were similar between groups, but switching to aripiprazole was associated with a higher r

92 n ePET is positive after two cycles of ABVD, switching to BEACOPPesc + INRT significantly improved 5-

93 es for monopolar growth initiation and later switching to bipolar growth.

94 We investigated the outcomes of switching to bivalirudin after initial administration of

95 tients who receive early treatment with UFH, switching to bivalirudin before primary percutaneous cor

96 telaprevir skin rash and anal discomfort by switching to boceprevir.

97 Switching to Bt cotton producing two or more toxins and

98 n during 12 weeks of treatment compared with switching to bupropion monotherapy.

99 uggests a potential mechanism for polymerase switching to bypass lesions.

100 pletely antagonized by a SOCE antagonist, by switching to Ca(2+)-free medium, and by overexpression o

101 s were transplanted either directly or after switching to central bilateral centrifugal pump, ventric

102 certolizumab pegol; 33 (58%) of 57 patients switching to certolizumab pegol and 40 (62%) of 65 patie

103 membrane potential resulted in neuron delays switching to change in an anti-phase-maintaining manner.

104 Switching to cheaper asthma drugs, using less medication

105 dication use or that it is contributed to by switching to clozapine treatment.

106 In this study, the authors compared switching to clozapine with switching to another atypica

107 enitor were meiotically unstable, frequently switching to co-dominance.

108 therapy augmentation of citalopram, whereas switching to cognitive therapy was better tolerated than

109 Possible capsular switching to create novel ST associations with NVA/NVTs

110 environment was adequate to support isotype switching to cytophilic IgGs, the isotypes that are prot

111 interquartile range, 1.1-2.3 days]) prior to switching to daptomycin.

112 We exploit this switching to demonstrate energy-efficient control of a s

113 In contrast, switching to depsipeptide substrates effectively renders

114 In this work we studied var gene switching to determine if transcriptional switches favou

115 o address this issue, we asked whether class switching to different Ig isotypes could occur in a line

116 throcytic cycles and also achieve successive switching to different loci in order to evade the host i

117 Moreover, upon switching to divalent free external solutions, Orai3 cur

118 Data suggest that switching to dormancy not only represents a mechanism of

119 Switching to dual therapy was associated with a signific

120 reviously demonstrated the noninferiority of switching to efavirenz (EFV) versus remaining on ritonav

121 h ritonavir-boosted lopinavir-based therapy, switching to efavirenz-based therapy compared with conti

122 udies have directly compared the outcomes of switching to either of these agents.

123 Switching to Erwinia asparaginase leads to effective asp

124 ment showed that the on-treatment benefit of switching to exemestane (HR, 0.60; 95% CI, 0.48 to 0.75;

125 The protective effect of switching to exemestane compared with continuing on tamo

126 Within 6 months of switching to exemestane, BMD was lowered by 0.051 g/cm(3

127 all area intensively ('local search') before switching to explore a much larger area ('global search'

128 hila photoreceptor organ breaks this rule by switching to expressing a different type of Rhodopsin as

129 Impaired switching to fat oxidation in response to a high-fat die

130 After switching to fingolimod (M0-12 vs M13-EOS), patients ini

131 ived interferon beta-1a, ARR was lower after switching to fingolimod compared with the previous 12 mo

132 tching to natalizumab is more effective than switching to fingolimod in reducing relapse rate and sho

133 by approximately 50% in the first year after switching to fingolimod treatment (44.3% to 66.0%).

134 After switching to fingolimod, numbers of new or newly enlargi

135 es including laser and anti-VEGF injections, switching to fluocinolone achieved treatment benefit.

136 re low in 10 (26%) of 39 at some time before switching to foscarnet.

137 After switching to FP/FM-pMDI, asthmatic symptoms and plural v

138 ibitor (PI) + 3TC/ABC regimen, the merits of switching to FTC/TDF as the NRTI backbone are unknown.

139 Switching to FTC/TDF from 3TC/ABC maintained virologic s

140 Switching to FTC/TDF showed improved NCEP thresholds for

141 By TLOVR through week 48, switching to FTC/TDF was noninferior compared to continu

142 eek study to evaluate efficacy and safety of switching to FTC/TDF.

143 at VDCC trafficking is mediated by G protein switching to G(i) of the beta-AR, which plays a prominen

144 Compared with persons switching to generic latanoprost, patients who continued

145 d that these variations can be suppressed by switching to growth conditions with a low V/III ratio.

146 ubjects attempted to maximize their gains by switching to habitats that possessed low competition den

147 This finding links genotoxin induced switching to Hst3 regulation.

148 IL-6, also provided a milieu for both B cell switching to IgA and IgA synthesis.

149 GARP/latent TGF-beta1 complexes with isotype switching to IgA production.

150 esponse to interleukin 4 (IL-4), hence class switching to IgE and IgG1, is not fully understood.

151 e that early Iepsilon transcription leads to switching to IgE and occurs at lower activation levels t

152 s determines their capacity to undergo class switching to IgE ex vivo, with the GC-derived B cells yi

153 an IgE member, are consistent with indirect switching to IgE from IgG- or IgA-expressing lineage mem

154 esponses in T cells and immunoglobulin class-switching to IgE in B cells.

155 We evaluate models for isotype switching to IgE in human subjects using immunoglobulin

156 ated with IL-4 and anti-CD40 to induce class switching to IgE in vitro, mCD23 is upregulated, and sCD

157 falling close to the threshold required for switching to IgE production.

158 aling, cell proliferation, and de novo class switching to IgE were analyzed by RT-PCR and FACS.

159 vidence of local receptor revision and class switching to IgE, and B-cell differentiation into IgE-se

160 line transcript, reflecting antibody isotype switching to IgE, measured at 6 years of age.

161 n activation of the Cepsilon locus and class switching to IgE.

162 of CD4(+) T cell responses and B cell class switching to IgE.

163 by cytokines that regulate Ig H chain class switching to IgE.

164 synthesis in human B cells after heavy chain switching to IgE.

165 defective proliferation during activation of switching to IgG1 and IgE.

166 We found that class-switching to IgG1 biased the fate choice made by B cells

167 to the transgenic T cells and undergo class switching to IgG1 in the presence of the transgenic T ce

168 ntly to Ag specific IgG2a and IgG2b, whereas switching to IgG1 is not affected.

169 lls alone induce T helper 2-associated class switching to IgG1, but few AFC or GC B cells express CXC

170 ody response with preferential isotype class switching to IgG1, IgG2a, IgG2b, and IgG3, as well as th

171 Frequencies of isotype switching to IgG1, IgG2b, IgG2c, and IgG3 were the same

172 rophage activation, and immunoglobulin class switching to IgG1, were enhanced in Batf3(-/-) mice resp

173 IgG4 mAb to IgG1 decreased activity, whereas switching to IgG2 markedly increased activity.

174 gD(+)CD27(+) B cells into PCs, induced class switching to IgG2, and was reproducible in cocultures wi

175 cells to undergo preferential isotype class switching to IgG2a and IgG3 subtypes.

176 to express high levels of CXCR3, and diverse switching to IgG2a, IgG2b, with some IgG1.

177 ermines the generation of high-affinity IgG, switching to IgG2c, early memory B cells, and recall ant

178 The extrafollicular Ab response with switching to IgG2c, the IgG2a equivalent in C57BL/6 mice

179 a higher turnover rate during activation of switching to IgG3 and IgG2b, as well as delays in CSR ki

180 n regulate autoantigen selection and isotype switching to IgG3 but have minimal effect on end-organ d

181 Switching to IgG3 was significantly reduced in IkappaBNS

182 crosstalk impeded induction of IFN-gamma and switching to IL-10.

183 w, we use a phenomenon referred to as patchy switching to illustrate the interplay of nonlinearities,

184 isk, as was slower achievement of UMRD after switching to imatinib.

185 hat in the controls, including rapid isotype switching to immunoglobulin G antibody.

186 their characteristic quantum yield of photo-switching to imprint spatio-temporal modulations onto th

187 is an opportunistic forager capable of diet switching to include a greater proportion of alternative

188 Induced receptor switching to insulin-like growth factor-1 receptor and i

189 Switching to intravitreal aflibercept appears to be an e

190 h life-history evolved through older females switching to invest in their existing (grand)offspring,

191 research is needed to evaluate the effect of switching to ISCS from the physician and surgical facili

192 Thus lowering body weight by switching to LF diet in obese mice with heart failure is

193 oxide (CO2) emissions from fossil fuels make switching to low-carbon fuels a high priority.

194 sponses including cost-coping behaviors (eg, switching to lower-cost medications), reduced adherence

195 ntains stable lysogeny, yet allows efficient switching to lysis.

196 ysogeny and simultaneously ensures efficient switching to lysis.

197 to environmental changes, which may require switching to lytic conditions.

198 dose resulted in better disease control than switching to methotrexate alone or placebo, but no signi

199 This study compared the efficacy of switching to mirtazapine to that of switching to a tricy

200 associated cooling degree days by greening, switching to modern nonsolid cooking fuels, and anticipa

201 differ with respect to symptom control, and switching to monotherapy resulted in weight loss.

202 of staying on antipsychotic polypharmacy or switching to monotherapy.

203 strategies to counteract this and show that switching to monovalent vaccine may finally interrupt vi

204 usly showed that IgW VDJ can perform isotype switching to mu C regions; in this study, we found that

205 with injectable disease-modifying therapies, switching to natalizumab is more effective than switchin

206 filament within a bundle while occasionally switching to neighboring filaments.

207 no previous interactions, and elaborated by switching to new signals more with the unfamiliar than t

208 whether the clinical benefits observed with switching to nilotinib are associated with improved long

209 In summary, switching to nilotinib enabled more patients with chroni

210 ved cytogenetic and molecular responses with switching to nilotinib than with imatinib dose escalatio

211 ed to investigate the safety and efficacy of switching to nilotinib vs imatinib dose escalation for p

212 matinib-based approach with selective, early switching to nilotinib.

213 tity of liquid consumed; by current drinkers switching to no alcohol alternatives for part of the tim

214 le of transformation in facilitating capsule switching to non-vaccine serotypes and the emergence of

215 247 genomes, we demonstrate that regulatory "switching" to nonhomologous alternatives is ubiquitous,

216 ervention herds for the first 3 months after switching to nonmedicated milk replacer but declined in

217 ently insufficient data to warrant wholesale switching to novel lipid emulsions or the global use of

218 -induced inhibition of DNP dCTP synthesis by switching to NSP-mediated dCTP production.

219 Upon switching to open circuit, Co-Pi undergoes a continuous

220 ic and demographic characteristics predicted switching to or from active commuting, whether switching

221 able on such treatment would remain so after switching to oral eliglustat, a selective inhibitor of g

222 enefits and risks for patients in ceasing or switching to other medicines.

223 y IgW VDJ can take place at the DNA level by switching to other omega or mu C regions, as well as by

224 Switching to PBO bednets could avert up to 0.5 clinical

225 Compared with continuing alendronate, switching to placebo for 5 years resulted in declines in

226 ontinued to receive vedolizumab (rather than switching to placebo) were more likely to be in remissio

227 rits from the <10 nm into the 1 mum range or switching to polymeric frits with pores in the 1 to 10 m

228 s significantly greater at 24 and 48 h after switching to prasugrel versus continued therapy with tic

229 t represents task-reward associations, later switching to process tasks and rewards directly.

230 Although switching to raltegravir was associated with greater red

231 Recent reports suggest that switching to rapamycin from calcineurin antagonists redu

232 -scaffold complex undergoes stochastic state switching to reach an active state.

233 INTERPRETATION: Switching to rilpivirine, emtricitabine, and tenofovir a

234 INTERPRETATION: Switching to rilpivirine, emtricitabine, and tenofovir a

235 In RTR already receiving fluvastatin, switching to rosuvastatin further decreased LDL choleste

236 Switching to second-line antiretroviral therapy after 2

237 s to assess monitoring of first-line ART and switching to second-line ART in sub-Saharan Africa.

238 ociation with resistance and nonadherence on switching to second-line ART requires clarification.

239 frequencies and with different criteria for switching to second-line therapies.

240 nce of confirming virological failure before switching to second-line therapy.

241 ce to clearance could be enhanced by capsule switching to serotype 4, but it was enhanced to levels l

242 During extended wake, the rapid switching to sleep-like states with short timescales can

243 tic methods of quitting which do not include switching to smokeless tobacco.

244 atients when PPI is necessary for treatment, switching to structurally different alternatives should

245 documented, but the contribution of capsular switching to such changes is unknown.

246 ised resources are lower than the benefit of switching to super-abundant resources.

247 ved for carbon incorporation with antagonism switching to synergism at higher doses, while the CA mod

248 effects of anastrozole are intolerable, then switching to tamoxifen is a good alternative.

249 ally released into toothpaste slurries after switching to TCS-free alternatives.

250 ypes stimulated moderate levels of phenotype switching to Th1 or Th17 but a massive switching to Th2;

251 otype switching to Th1 or Th17 but a massive switching to Th2; 4) Th9 cells induced moderate inflamma

252 s and 9 admissions per month were avoided by switching to the acellular vaccine, which is a 38-fold h

253 n with MinD, suggesting it has difficulty in switching to the active form.

254 Sequential switching to the alternative HMA, clinical trials of nov

255 over, firing rate on any one trial predicted switching to the alternative option on the next trial.

256 f a perceptual representation and suppresses switching to the alternative.

257 After column switching to the analytical column Ascentis Express C-18

258 Switching to the cheapest generic AED may offer drug-bud

259 The rate of switching to the dark state depends on the concentration

260 Thus, antigenic variation is achieved by switching to the expression of a different VSG gene.

261 allowing improved matching of the stochastic switching to the frequency of environmental changes.

262 We found large alterations associated with switching to the high-fat diet, including a decrease in

263 to lead to [Fe(bpp)(H2L)](ClO4)2.C3H6O (2), switching to the high-spin state while experiencing a pr

264 BK1 as a pivotal negative regulator of class switching to the immunoglobulin A (IgA) isotype.

265 ne transcripts and inhibited efficient class switching to the immunoglobulin G1 isotype.

266 biogenesis displays an adaptive response by switching to the incorporation of mt-tRNA(Phe) to genera

267 e by the motors with high fidelity by either switching to the intersecting microtubule or eventually

268 We found that the intrinsic rate of switching to the lytic pathway, measured in a host lacki

269 ity, because restoring the zero frame causes switching to the MATalpha genotype.

270 this synergic sedation, herein we show that switching to the more reactive sodium-magnesium or sodiu

271 under continued low flow, there was further switching to the MYPT1 leucine zipper(+) isoform.

272 Whereas never switching to the new drug always minimizes Resistance an

273 the economic and epidemiological impacts of switching to the nonavalent vaccine both for individual

274 We propose that these factors increase switching to the opaque phase via a common mechanism-inh

275 ng biofilms, although the advantages of this switching to the organism are not well understood.

276 ors and to assess the efficacy and safety of switching to the other TNF inhibitor without a washout p

277 In case of treatment failure, switching to the other treatment arm was possible.

278 n went through a 4-wk washout period, before switching to the other treatment for the final 10 wk.

279 ption of staying with their initial guess or switching to the other unopened door.

280 ement of intersystem crossing and subsequent switching to the phosphorescent emission of blue light.

281 sed B cell death, low impairs antibody class switching to the pro-inflammatory IgG2c antibody isotype

282 e visual information to the same extent when switching to the second context as sensorimotor memory b

283 a high Psoriasis Area and Severity Index at switching to the second-line biologic therapy were predi

284 ounters with antigen, how they favor isotype switching to the secretory IgA isotype, and how their GC

285 the observed polarity of the voltage-biased switching to the sequence of the active and inert electr

286 Switching to the simplified regimen was associated with

287 oblematic, and synthesis was accomplished by switching to the trityl protecting group.

288 te the efficacy, safety, and tolerability of switching to this regimen compared with remaining on cof

289 l organization of the Igh locus may restrict switching to this subset of isotypes.

290 for a mean (SD) of 30.9 (15.9) months after switching to tocilizumab.

291 state is required for absence seizures, and switching to tonic firing rapidly halts absences.

292 ation to intubation is deemed inappropriate, switching to total face mask can be proposed as a last r

293 Switching to total face mask, which covers the entire fa

294 imming in regions of pure splay and bend but switching to unipolar swimming in mixed splay-bend regio

295 ion of the replication fork, primer-terminus switching to use the other daughter strand as an undamag

296 Switching to varenicline produced less robust effects, b

297 time the bladder is locked in storage mode, switching to voiding only when it is judged safe and/or

298 Before switching to weekly dosing, eGFR was 53.7 +/- 6.3 ml/min

299 During the 24-mo follow-up period after switching to weekly dosing, the mean rate of change in e

300 After switching to weekly dosing, three patients demonstrated