ライフサイエンスコーパス: syn-

1 ous population, with nucleotide diversity pi syn = 0.00017, tenfold lower than the autosomal region (

2 tenfold lower than the autosomal region (pi syn = 0.0017) and 12-fold lower than the Y-linked region

3 d 12-fold lower than the Y-linked region (pi syn = 0.0021).

4 Three isomeric forms with hydrides in syn (2), anti (3), and cis (4) conformations have been c

5 DH4 did not dehydrate syn-(2S,3R)-2b-ACP, syn-(2R,3S)-2c-ACP, or anti-(2S,3S)-2d-ACP generated in

6 yl 2-chloroacetoacetate to the corresponding syn-(2R,3S)-alcohol on a multigram scale using whole cel

7 de-SNAC 14, and a 40-fold advantage over the syn-(2R,3S)-diketide-SNAC 13.

8 sence of the N-acetylcysteamine thioester of syn-(2S,3R)-2-methyl-3-hydroxypentanoate (6), methylmalo

9 DH4 did not dehydrate syn-(2S,3R)-2b-ACP, syn-(2R,3S)-2c-ACP, or anti-(2S,3S)-

10 Initial data in humans suggest that syn-(99m)Tc-D-MAEC has a higher clearance than that of (

11 anged from 45% (anti-(99m)Tc-L-MAEC) to 74% (syn-(99m)Tc-D-MAEC) with the 180-min urine excretion equ

12 ude mice also showed higher tumor uptake for syn [(99m)TcO]depreotide (6.58% ID/g) than for the anti

13 ng) expressing a mutated form of human alpha-Syn (A53T) in dopaminergic (DA) neurons were video-taped

14 PD rhesus monkeys that express mutant alpha-syn (A53T).

15 , triplication or genetic mutations in alpha-syn (A53T, A30P and E46K) are linked to autosomal domina

16 nulated perylene bisanhydrides (ab-PBA 6 and syn-(ab)2-PBA 19) were explored as universal starting ma

17 onene-type molecules like anti-(ab)2-PBI 15, syn-(ab)2-PBI 16, and syn-(ab)2-PTE 18.

18 ike anti-(ab)2-PBI 15, syn-(ab)2-PBI 16, and syn-(ab)2-PTE 18.

19 mice were immunized with GP-alone, GP-alpha-syn (active humoral immunization), GP+RAP, or GP+RAP/alp

20 This suggests that the syn [AF]dG opposite dA junctional alignment can be readi

21 ture of the AF-intercalated conformer with a syn-[AF]dG adduct defines for the first time the capacit

22 potentials of the Cu(2+) complex with alpha-syn (alpha-syn-Cu(2+)) and alpha-syn(1-19) were determin

23 emonstrate that C-terminally truncated alpha-Syn (alpha-SynDeltaC), enriched in the pathological alph

24 by the splice isoforms and full-length alpha-syn (alpha-synFL).

25 rmined the tumor-initiating activity of (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-di

26 ene (DB[a, l]P) is activated in cells to (+)-syn- and (-)-anti-DB[a,l]P-11, 12-diol-13,14-epoxide (DB

27 Slow adduct removal occurred for both (+)-syn- and (-)-anti-DB[a,l]PDE adducts over a time period

28 tudy, we analyzed mutagenesis induced by (+)-syn- and (-)-anti-DB[a,l]PDE at the cII transgene in Big

29 The mutational spectra of (+)-syn- and (-)-anti-DB[a,l]PDE were quite similar except f

30 E)-alkenyl neopentyl boronic esters gave (E)-syn- and (E)-anti-homoallylic alcohols, respectively, in

31 ctivity differences between the triazole 1,5-syn- and 1,4-anti-isomers showed a preference for the 1,

32 ignificantly, at frequencies of 18.5% by (+)-syn- and 18.1% by (-)-anti-DB[a,l]PDE.

33 to T transversions, which were 43.9% for (+)-syn- and 38.8% for (-)-anti-DB[a,l]PDE.

34 An efficient four-step synthesis of N-BOC-5-syn- and 5-anti-carboxymethanopyrrolidines (12 and 13) a

35 were performed on Sprague-Dawley rats using syn- and anti-(99m)Tc-L- and -D-MAEC coinjected with (13

36 The clearances of syn- and anti-(99m)Tc-L-MAEC in the rats were higher tha

37 probed the two distinct CH3CHOO conformers, syn- and anti-, both of which react readily with SO2 and

38 The regio- and stereospecific conversion of syn- and anti-1,2-amino alcohols to their respective syn

39 ric allylic boronation (AAB) gives access to syn- and anti-1,2-diols.

40 anti-1,2-amino alcohols to their respective syn- and anti-1,2-imidazolylpropylamines via treatment w

41 2 with catecholborane and LiBHEt(3) provides syn- and anti-1,3-amino alcohols with very high diastere

42 s described for asymmetric synthesis of both syn- and anti-1,3-amino alcohols.

43 syn- and anti-1-amino-3-[18F]fluoromethyl-cyclobutane-1-

44 s to form major DNA adducts through both the syn- and anti-11,12-dihydrodiol 13,14-epoxide metabolite

45 oxide, syn- and anti-4-hydroxy-2-norcarene, syn- and anti-2-hydroxy-3-norcarene, 2-oxo-3-norcarene,

46 this work are 2-norcaranone, 3-norcaranone, syn- and anti-2-norcarene oxide, syn- and anti-3-norcare

47 orcaranone, syn- and anti-2-norcarene oxide, syn- and anti-3-norcarene oxide, syn- and anti-4-hydroxy

48 rene oxide, syn- and anti-3-norcarene oxide, syn- and anti-4-hydroxy-2-norcarene, syn- and anti-2-hyd

49 lished as a viable and economical entry into syn- and anti-aldol products.

50 ree-step procedure for the synthesis of both syn- and anti-alpha,beta-disubstituted beta-amino acids

51 ptanone to sulfinimines resulted in only the syn- and anti-alpha-substituted beta-amino ketones.

52 E olefins without isolation or separation of syn- and anti-beta-silyl alkoxides.

53 e to an aryl aldehyde generated a mixture of syn- and anti-beta-silyl alkoxides.

54 ucts obtained by the reaction of the racemic syn- and anti-BgCDEs with calf thymus DNA and with purin

55 e larger Criegee intermediates, (CH3 )2 COO, syn- and anti-CH2 C(CH3 )C(H)OO on the water droplet sur

56 simulations examine the dynamic behavior of syn- and anti-CH3 CHOO at the air-water interface.

57 simplest Criegee intermediate (CH2 OO), both syn- and anti-CH3 CHOO remain inert towards reaction wit

58 The direct infrared detection of syn- and anti-CH3CHOO should prove useful for field meas

59 we report the transient infrared spectrum of syn- and anti-CH3CHOO, produced from CH3CHI + O2 in a fl

60 ure variation reveals that 1 reacts from its syn- and anti-conformations in competition with trapping

61 The structure reveals both the syn- and anti-conformations of template 8-oxoG in the co

62 RNAP II, the modeling studies show that both syn- and anti-conformations of the 1,N(2)-epsilon G are

63 ymidine upon 350 nm irradiation forming both syn- and anti-cyclobutane adducts (17 and 18), which are

64 The syn- and anti-diastereoisomeric forms of the reported st

65 ive cyclization to give 2,3,6-trisubstituted syn- and anti-dihydropyranones in good yields.

66 nesis in mouse skin, we have found that both syn- and anti-DMBADE are active tumor initiators, and th

67 Previously, we showed that both the syn- and anti-DMBADE bind to the adenine (A182) at codon

68 Topical application of syn- and anti-DMBADE produced stable adducts in mouse ep

69 ethylbenz[a]anthracene-3,4-diol-1,2-epoxide (syn- and anti-DMBADE), the two metabolically formed bay-

70 of the data showed that levels of the major syn- and anti-DMBADE-deoxyadenosine adducts formed after

71 orinated products were observed for both the syn- and anti-DP which were continued throughout the dur

72 .48 +/- 0.09 and 0.79 +/- 0.12 pmols/day for syn- and anti-DP, respectively.

73 ther eliminative pathways, such as concerted syn- and anti-E2 as well as gamma-deprotonation, are exc

74 yl rings in the outmost BDT units are in the syn- and anti-fashion, are designed.

75 n satisfactory yields to provide mixtures of syn- and anti-isomers 6-9 with moderate to good diastere

76 While the syn- and anti-isomers of 1,8-dipyridylnaphthalenes inter

77 ces in the absorption characteristics of the syn- and anti-isomers of CbDI, on one hand, and CbDI vs

78 The syn- and anti-isomers of CbDIs were unambiguously charac

79 with acenaphthenequinone leads to the trans-syn- and anti-porphodimethenes, which in turn can be con

80 A boron-mediated syn- and anti-stereoselective aldol reaction giving rise

81 The meso syn- and C(2)-symmetric anti-isomers of 1,8-bis(4,4'-dim

82 Dechlorane Plus (anti- and syn-) and alpha- and beta-tetrabromoethylcyclohexane wer

83 -shifted) conformer of both molecules to the syn (anti) conformer.

84 for the conversion of the anti (syn) to the syn (anti) isomer at 66.2 degrees C.

85 for the conversion of the anti (syn) to the syn (anti) isomer at 71.0 degrees C.

86 of the samples, and SigmaDP concentrations (syn-+anti-DP concentrations) ranged from 0.05 to 5 pg/m3

87 st buffelgrass (Pennisetum ciliare (L.) Link syn = Cenchrus ciliaris L.) genotypes reproduce by oblig

88 3-fold rotor to a 2-fold rotor with a strong syn (CH-2-C-2-O-2-CPg) preference once the donor was ion

89 moral immunization), GP+RAP, or GP+RAP/alpha-syn (combined active humoral and Treg) and analyzed usin

90 biscalix[5]arene from anti (uncomplexed) to syn (complexed).

91 d sequence (amino acids 121 to 123) of alpha-syn (CT alpha-syn) and performed immunocytochemical and

92 duced the accumulation of CT-truncated alpha-syn (CT-alpha-syn) in axons, rescued the loss of tyrosin

93 tion of alpha-syn in vitro by using an alpha-syn -fragment complementation assay.

94 ypass all the photoproducts in the order cis-syn > Dewar > (6-4) > trans-syn-II.

95 was able to bypass them all in the order cis-syn > Dewar > trans-syn-II > (6-4).

96 ive stabilities: syn-anti > anti-anti > anti-syn > syn-syn.

97 This is followed by a thermal syn-->anti C14-C15 conformational relaxation to form Pfr

98 nterconversion is an indication of a C14-C15 syn-->anti conformational change.

99 mediated by the caspase, according to alpha-syn-->caspase-->ROS-->apoptosis.

100 ith mice selectively expressing human mutant SYN (hSYN(A53T)) in neurons.

101 However, the incorporation of FN(syn-) into fibrils and the deoxycholate-insoluble matrix

102 ter prolonged incubation, indicating that FN(syn-) is defective in progression of the assembly proces

103 e expressing pathogenic Ala53Thr human alpha-syn (M83 mice) that develop extensive alpha-syn patholog

104 exhibited a marked ability to reduce mBBr to syn-(methyl,methyl)bimane, an ability that was quenched

105 Here, we show that alpha-Syn-/- mice are viable and fertile, exhibit intact brain

106 oncurrent with the altered DA release, alpha-Syn-/- mice display a reduction in striatal DA and an at

107 Nigrostriatal terminals of alpha-Syn-/- mice display a standard pattern of dopamine (DA)

108 oluble p-Tau in striatum of WT but not alpha-Syn-/- mice.

109 d cells not expressing alpha-Syn or in alpha-Syn-/- mice.

110 f detection in DNA treated directly with (+)-syn- or (-)-anti-DB[a,l]PDE or in DNA from Chinese hamst

111 ts provides straightforward access to either syn- or anti-1,2-amino alcohols.

112 dergo highly diastereoselective reduction to syn- or anti-1,3-amino alcohols.

113 rganise both reactants, affording either the syn- or anti-adduct with high diastereo- and enantiosele

114 ried stereoselectively to produce either the syn- or anti-amino alcohol diastereomer.

115 Either syn- or anti-amino alcohol products can be obtained by t

116 isomers of the retinal cofactor with either syn- or anti-configuration, each comprising six consecut

117 that insertion is accommodated in either the syn- or anti-conformation, respectively.

118 - or (Z)-beta-trifluoromethyl enones forming syn- or anti-dihydropyranone products, respectively.

119 on of diastereomeric pairs carrying either a syn- or anti-oriented hydroxyl at C-5'.

120 With the development of substrate-controlled syn- or anti-selective reductions of alpha-fluoro ketone

121 CSF NFL (p<0.001), sAPPalpha (p<0.001) and a-syn (p=0.003) independently predicted diagnosis of PD ve

122 -alpha-syn (P=0.221), or oligo-phospho-alpha-syn (P=0.181).

123 e for total alpha-syn (P=0.244), oligo-alpha-syn (P=0.221), or oligo-phospho-alpha-syn (P=0.181).

124 hereas this was not the case for total alpha-syn (P=0.244), oligo-alpha-syn (P=0.221), or oligo-phosp

125 The monodeuterated aziridine syn-(p-CH(3)C(6)H(4)SO(2))NCHDCH-n-Bu (1e) reacts with e

126 neuroprotection in proteolipid protein alpha-syn (PLP-SYN) mice, a transgenic mouse model of MSA.

127 g di- or trisubstituted alkenes and anti- or syn- relative stereochemistry at the allylic and homoall

128 identification of dominantly inherited alpha-syn (SNCA) gene mutations in rare cases of familial PD.

129 kJ/mol and 115.2 (109.0) kJ/mol for the anti/syn- (syn/anti)-isomerization of 8 and 9, respectively.

130 like combination of Li and B carbenoids and syn (thermal) elimination whereas the E isomer was obtai

131 wo internal cationic ferric hemes drives the syn- to anti-switch, as demonstrated in two ways.

132 n array of UV-induced DNA photoproducts (cis-syn-, trans-syn I- and trans-syn II CPDs, 6-4PP and Dewa

133 The stereodivergent behavior of 2,3-syn- vs 2,3-anti-alpha-methyl-beta-hydroxy aldehydes is

134 mbinant FN containing a synergy mutation, FN(syn-), was tested for its ability to form fibrils.

135 The interaction of wild type alpha-Syn (WTS) and alpha-Syn variants (E57K, A30P, and aSyn(3