ライフサイエンスコーパス: synaptic activity

1 avioral preference is encoded by altered AWC synaptic activity.

2 ate neural plasticity and glutamate-mediated synaptic activity.

3 , nourish and maintain neuronal fidelity and synaptic activity.

4 Group I mGluRs as well as their influence on synaptic activity.

5 inergic and neuropeptide signalling modulate synaptic activity.

6 MKII) subunits form a complex that modulates synaptic activity.

7 hich depends on the history of probabilistic synaptic activity.

8 nto these neurons maintains normal levels of synaptic activity.

9 nse to prolonged perturbation of network and synaptic activity.

10 ion of intrinsic conductances with preceding synaptic activity.

11 n gating RA signaling pathway in response to synaptic activity.

12 curs through different pathways regulated by synaptic activity.

13 ion can be regulated locally in dendrites by synaptic activity.

14 unction in mouse rod photoreceptors and thus synaptic activity.

15 ASD-like behaviors and increased excitatory synaptic activity.

16 vation of CB2 receptors has little effect on synaptic activity.

17 fewer synaptic vesicles and lack spontaneous synaptic activity.

18 ein homeostasis at the synapse by regulating synaptic activity.

19 gressive loss of action potential output and synaptic activity.

20 , and surprisingly, CPX mobility depended on synaptic activity.

21 ter spike fidelity even during high rates of synaptic activity.

22 sory-evoked responses and reduced background synaptic activity.

23 at ultimately affects its fine-tuning during synaptic activity.

24 kinase whose functions include regulation of synaptic activity.

25 tic capacity, to adapt to conditions of high synaptic activity.

26 pid bouton formation in response to elevated synaptic activity.

27 urrent sources mediated by network GABAergic synaptic activity.

28 king, which depends on factors active during synaptic activity.

29 in vivo leads to increased spine density and synaptic activity.

30 dynamin 1/3 and that operates during intense synaptic activity.

31 HT1A autoreceptor response, and lack of GABA synaptic activity.

32 temporal patterns of electrical and chemical synaptic activity.

33 non-FS, interneurons and exhibit synchronous synaptic activity.

34 a calcium barrier and sink during low-level synaptic activity.

35 neurons, and, in turn, this modulates NMDAR synaptic activity.

36 egulates alpha-synuclein dissociation during synaptic activity.

37 erate nested gamma frequency oscillations in synaptic activity.

38 ends on the proper detection and decoding of synaptic activity.

39 t could be triggered acutely with repetitive synaptic activity.

40 glutamate receptor (iGluR) channels control synaptic activity.

41 insic excitability in the context of network synaptic activity.

42 initiate hemodynamic responses or influence synaptic activity.

43 ynaptic M(1) muscarinic receptors normalized synaptic activity.

44 ependent (BOLD) response related to regional synaptic activity.

45 tegrate in circuits with high and correlated synaptic activity.

46 and complete inhibition of changes in basal synaptic activity.

47 uses loss of dendritic spines and changes to synaptic activity.

48 chronic disturbances in SPN excitability and synaptic activity.

49 hed pool of G-actin that can be regulated by synaptic activity.

50 of the postsynaptic membrane is sculpted by synaptic activity.

51 reby limiting inactivation during repetitive synaptic activity.

52 SK channels are not efficiently activated by synaptic activity.

53 eptor regulates a wide range of cellular and synaptic activities.

54 voked-fMRI cortical responses (189%), evoked synaptic activity (46%), evoked neuronal firing (200%) a

55 at binding of GluN3A to GIT1 is regulated by synaptic activity, a response that might restrict the ne

56 report the use of a genetic method to block synaptic activity acutely in the brain and subesophageal

57 Ts21 neurons displayed reduced synaptic activity, affecting excitatory and inhibitory s

58 tion which could help the recovery of normal synaptic activity after injury responses.

59 is strongly upregulated by pathophysiologic synaptic activity after kainic acid (KA) exposure and it

60 ewer action potentials in response to evoked synaptic activity after occlusion, likely because of inc

61 We found that synaptic activity altered approximately 2% of the PSD pr

62 Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodeg

63 min-1 cKO, and this change depends on strong synaptic activity and actin polymerization.

64 Synaptic activity and action potentials can independentl

65 plish these, we analyzed laminar profiles of synaptic activity and action potentials recorded in A1 o

66 ouse ZI GABAergic neurons at birth decreased synaptic activity and apical dendritic complexity of cor

67 At the molecular level, we find that synaptic activity and BDNF up-regulate Satb2, which itse

68 derived neurotrophic factor (BDNF) regulates synaptic activity and behavioral flexibility, and reduct

69 ) regulation in neurons during physiological synaptic activity and disease.

70 Hibernation causes reduced synaptic activity and experiments with mammals reveal th

71 Thus, in addition to attenuating cell death, synaptic activity and expression of ATF3 render hippocam

72 owth that leads to functional alterations in synaptic activity and formation.

73 induced in neurons in response to excitatory synaptic activity and in glial cells in response to infl

74 t evidence for a signalling pathway by which synaptic activity and its consequent Ca(2+) influx activ

75 Ongoing synaptic activity and MAPK signaling is required for fin

76 sensitivity directly onto multiple inputs on synaptic activity and might begin to provide a molecular

77 In turn, and to fine-tune synaptic activity and neuronal communication, numerous n

78 ed posterior parietal and occipital cortical synaptic activity and nigrostriatal function than PD non

79 activity was caused in part by increases of synaptic activity and NMDA-receptor-dependent calcium sp

80 teract dynamically with neurons by modifying synaptic activity and plasticity.

81 dent mechanisms results in the modulation of synaptic activity and plasticity.SIGNIFICANCE STATEMENT

82 rnative promoter usage that are regulated by synaptic activity and postnatal age.

83 whether glial cells are capable of decoding synaptic activity and properties during early postdevelo

84 ntial and action potential firing, decreased synaptic activity and reduced synaptic plasticity.

85 agmentation, enhances fusion, biogenesis and synaptic activity and reduces Abeta42 levels and protect

86 1 levels normalizes the increased excitatory synaptic activity and reverses mechanical hypersensitivi

87 Interestingly, synaptic activity and spatial memory induces Crtc1 depho

88 ation, resulting in persistent alteration of synaptic activity and stabilization of memory.

89 hat Mint overexpression increased excitatory synaptic activity and that APP was internalized predomin

90 govern translational control in response to synaptic activity and the mRNA populations that are spec

91 RRK2 mutation dramatically alters excitatory synaptic activity and the shape of postsynaptic structur

92 that liprin-alpha2 levels were regulated by synaptic activity and the ubiquitin-proteasome system.

93 te the position of lysosomes is regulated by synaptic activity and thus plays an instructive role in

94 t the interaction between glutamate-mediated synaptic activity and TrkB signaling is imperative to BD

95 -docking interplay was induced by Ca(2+) and synaptic activity and was necessary to establish an appr

96 ded on spontaneous but not evoked excitatory synaptic activity and was shown to be N-methyl-d-asparta

97 e interval evoking synchronous pre- and post-synaptic activity and which strengthens interregional co

98 naptic drive, elevated levels of spontaneous synaptic activity, and decreased neuronal intrinsic exci

99 tructural and functional brain connectivity, synaptic activity, and information processing require hi

100 ngent upon neuronal activity, NMDAR-mediated synaptic activity, and L-type Ca(2+) channel activity.

101 such as ARC, include long-term potentiation, synaptic activity, and memory.

102 hannel that regulates neuronal excitability, synaptic activity, and retinal homeostasis.

103 fasting-induced spinogenesis and excitatory synaptic activity, and that the AMPK phosphorylation tar

104 s the buildup of acquired neuroprotection, a synaptic activity- and gene transcription-mediated incre

105 0 pathway in the neuronal response to strong synaptic activity as a consequence of excitotoxic insult

106 ariances, and decrease the autocovariance of synaptic activity as a consequence of single node and la

107 gonist functions are driven by the levels of synaptic activity as inferred by recording long-term pot

108 urons, and (2) glutamate-mediated excitatory synaptic activity as well as AMPA-activated current resp

109 id concentration increases, as occurs during synaptic activity, ascorbic acid transporter 2 (SVCT2) t

110 sent the brain's response to the increase in synaptic activity associated with prolonged wake, cleari

111 Using slice recordings and modeling of synaptic activity at cerebellar granule cell to Purkinje

112 Furthermore, synaptic activity at cornu ammonis 3-cornu ammonis 1 syn

113 g two-electrode dynamic clamp and found that synaptic activity at physiologically relevant rates elic

114 CaMKII in triggering long-lasting changes in synaptic activity at some synapses has been established,

115 ustering behavior through the measurement of synaptic activity at the single-cell level, thus providi

116 ferent inputs by diffuse stimulation changes synaptic activity at the target brain region.

117 psyn-EGFP (WT and mutants) is independent of synaptic activity because they were inserted at denervat

118 s in terms of the efficacy of the reciprocal synaptic activities between the cortex and the thalamus

119 ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons

120 We found that synaptic activity bi-directionally regulates neuronal Te

121 heir cell bodies have altered electrical and synaptic activities, but whether such changes play a rol

122 both neurons and astrocytes correlated with synaptic activity, but only the astrocytic responses cor

123 py methods, we studied (i) mitochondrial and synaptic activities by measuring mRNA and the protein le

124 We studied mitochondrial and synaptic activities by measuring mRNA and the protein le

125 Importantly, modulation of synaptic activity by glial cells depends on the proper d

126 novo spinogenesis, but instead may increase synaptic activity by inducing morphological and function

127 role of Asc-1 in regulating NMDAR-dependent synaptic activity by mediating concurrent non-vesicular

128 in the control of the efficacy of GABAergic synaptic activity by regulating the trafficking and synt

129 eated dTg-211 cortices overrepresentation of synaptic activity, Ca(2+) transmembrane transport, TGFBR

130 This work demonstrates that synaptic activity can induce mRNA localization and local

131 Finally, increased synaptic activity caused an increase in the ratio of l-l

132 mouse and rat primary hippocampal cultures, synaptic activity caused an up-regulation of glycolytic

133 lating gene expression in response to global synaptic activity changes.

134 ntly, inner retinal neurons develop aberrant synaptic activity, compounding visual impairment.

135 Because increased MRI signal reflects synaptic activity, concomitantly increased signals in th

136 Healthy control levels of synaptic activity could be restored by treatment of ChAc

137 Our data indicate that synaptic activity counteracts the negative effects of Ta

138 ecreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and i

139 Prolonged blockade of synaptic activity decreases resting Ca(2+) levels in neu

140 rong correlations between action potentials, synaptic activity, dendritic complexity and gene express

141 is a new modulator, operating at the NE, of synaptic activity-dependent neuronal functions.

142 e we show that in mouse hippocampal neurons, synaptic activity-dependent nucleo-cytoplasmic shuttling

143 Stimulating sympathetic neurons with virtual synaptic activity, designed to replicate in vivo recordi

144 The local synaptic activity differs between hemispheres in prepube

145 ase (AMPK) is also an important regulator of synaptic activity-driven eEF2K dynamics in neurons.

146 Synaptic activity drives changes in gene expression to p

147 Together, these results suggest that intense synaptic activity drives tau to the postsynaptic density

148 gs reveal a signaling pathway that regulates synaptic activity during central nervous system developm

149 The role of synaptic activity during early formation of neural circu

150 at in the presence of spontaneous background synaptic activity, electrically coupled cerebellar Golgi

151 iving downstream molecular events related to synaptic activity embedded in these systems.

152 onal spikes in concert with local population synaptic activity, enhancing comprehension of neural pro

153 conductance had major negative consequences: synaptic activity evoked action potentials with lower fi

154 DCS applied during synaptic activity facilitates cumulative neuromodulation

155 ng increases dendritic spines and excitatory synaptic activity; feeding does the opposite.

156 SD) is a transient propagating excitation of synaptic activity followed by depression, which is impli

157 with GluN2B/alphaCaMKII interaction prevents synaptic activity from inducing ERK-dependent increases

158 Hence, because of their ability to decode synaptic activity, glial cells should be able to integra

159 e of glutamate triggered by pathophysiologic synaptic activity has been put forward as key mechanism

160 Stimulation of synaptic activity has been shown to be protective in mod

161 hypothesis is that increased random afferent synaptic activity (i.e. synaptic noise) within the epile

162 recordings demonstrated that increased GABA synaptic activity impinges principally on indirect pathw

163 otoxic dendritic damage following a burst of synaptic activity in a manner dependent on platelet-acti

164 amics, enhances mitochondrial biogenesis and synaptic activity in APP mice.

165 cs and enhances mitochondrial biogenesis and synaptic activity in APP mice; and that SS31 may confer

166 x suppresses spontaneous and stimulus-evoked synaptic activity in auditory cortical neurons and that

167 e-projecting vCA1 neurons induces excitatory synaptic activity in both the mPFC and amygdala.

168 Thus, CALHM1 controls synaptic activity in cerebral neurons and is required fo

169 analysis revealed a pathologically elevated synaptic activity in ChAc MSNs.

170 ology, we detected a pathologically enhanced synaptic activity in ChAc neurons.

171 on NL-1 and is phosphorylated in response to synaptic activity in cultured rodent neurons and sensory

172 ent manner, leading to reduced GlyR-mediated synaptic activity in cultured spinal cord neurons and th

173 Excitatory synaptic activity in D2017A SPNs was similar to wild typ

174 ade implicated in behavioral plasticity, and synaptic activity in different subpopulations of striata

175 othesis that global reductions of background synaptic activity in DOCs will associate with changes in

176 f GABA, ACh, and glutamate receptor-mediated synaptic activity in DSGCs evoked by motion.

177 and calcium currents, voltage responses and synaptic activity in hair cells from the lateral line an

178 ium transients in the cell nucleus evoked by synaptic activity in hippocampal neurons function as a s

179 population activity, but its relationship to synaptic activity in individual neurons is not fully est

180 This work highlights the importance of synaptic activity in initiating signalling cascades that

181 plore eEF2K dynamics in depth, we stimulated synaptic activity in mouse primary cortical neurons.

182 for increased frequency of spontaneous GABA synaptic activity in MSNs.

183 lace preference (CPP), focusing on GABAergic synaptic activity in neurons of the central nucleus of t

184 ents a novel mechanism for the modulation of synaptic activity in normal or pathological conditions.

185 How the TSCs sense the synaptic activity in physiological conditions remains un

186 amics, enhances mitochondrial biogenesis and synaptic activity in Tau mice.

187 investigated how PPARgamma agonism affected synaptic activity in Tg2576 DG.

188 The afferent synaptic activity in the hippocampus was modulated by fo

189 spatial organization of direction-selective synaptic activity in the optic tectum.

190 ized in this brain region, leading to higher synaptic activity in the right than in the left hemisphe

191 The model allows computing the statistics of synaptic activity in the spontaneous condition and in pu

192 GluN2D NMDA receptor subunits contribute to synaptic activity in the STN and may represent potential

193 Notably, synaptic activity in these neurons can be restored by co

194 uN2D-containing NMDA receptors contribute to synaptic activity in these regions.

195 Subsequent silencing of VGluT1(+) synaptic activity in VGluT1 KO mice significantly reduce

196 required for synapse unsilencing induced by synaptic activity in vitro as well as a brief exposure t

197 urine Arc nuclear expression is regulated by synaptic activity in vivo and in vitro.

198 ble membrane tubules in vitro and to promote synaptic activity in vivo.

199 Conversely, enhancing synaptic activity in WT, by feeding of picrotoxin is suf

200 n of excitation and inhibition of excitatory synaptic activity induced by exogenous application of ca

201 reas steady-state Abeta levels were similar, synaptic activity-induced endogenous Abeta production wa

202 neurons, nuclear calcium signaling controls synaptic activity-induced phosphorylation of MeCP2 on se

203 Here we show that following synaptic activity-induced SCOP degradation, SCOP is rapi

204 Here, we report that synaptic activity induces acute proteolytic cleavage of

205 Synaptic activity induces rapid Ca(2+) signals mediated

206 ce salience, through alterations in afferent synaptic activity, induces rapid changes in endocannabin

207 Chronic changes in synaptic activity influence the plastic growth of this m

208 t synapses to which it has bound and whether synaptic activity influences Abeta synaptic binding and

209 resynaptic glutamate pool was turned over by synaptic activity, inhibiting the presynaptic glutamine

210 rritory is the source of travelling waves of synaptic activity into adjacent cortical areas.

211 eptors (mGluRs) are also suitable to convert synaptic activity into intracellular signals for synapti

212 resence of voltage fluctuations arising from synaptic activity is a critical component in models of g

213 architecture and modulate it in response to synaptic activity is a crucial component of the cellular

214 Loss of synapses or alteration of synaptic activity is associated with cognitive impairmen

215 Here we show that synaptic activity is coupled, via the NMDA receptor (NMD

216 ed in Munc18-1(-/-) mice, demonstrating that synaptic activity is dispensable for early nervous syste

217 se (HD) mouse models, spontaneous inhibitory synaptic activity is enhanced in a subpopulation of medi

218 "fatigue" accrued during wake, when overall synaptic activity is higher than in sleep.

219 but the impact of RAB39B loss of function on synaptic activity is largely unexplained.

220 A presynaptic role for CaMKII in regulating synaptic activity is less clear with evidence for CaMKII

221 Aberrant synaptic activity is observed in many neurological disor

222 napsin, perturbed reclustering of SVs during synaptic activity is observed.

223 to corticostriatal synapses, thalamostriatal synaptic activity is unaffected by Sapap3 deletion.

224 The reduced synaptic activity is unlikely due to changes in motoneur

225 trans-synaptic spread of tau pathology with synaptic activity itself.

226 One proposed model suggests that synaptic activity leads to increased Abeta deposition.

227 egments in the dark, modulates photoreceptor synaptic activity; light exposure stimulates a reduction

228 that changes in action potential firing and synaptic activity may be secondary to altered resting me

229 on these data we suggest the existence of a synaptic activity-mediated neuronal Warburg effect that

230 Core-glycosylation is regulated by synaptic activity, modulates synaptic signaling and acce

231 induced action potential activity, enhanced synaptic activity, more complete development of a mature

232 In response to pathophysiologic synaptic activity, multiple signaling cascades are activ

233 alter the frequency or temporal precision of synaptic activity observed.

234 rence electrode, they often reflect those of synaptic activity occurring in distant sites as well.

235 Here, we show the underlying synaptic activity of a neuronal vocal corollary discharg

236 The synaptic activity of both wild-type and knock-out neuron

237 In addition, basal synaptic activity of GluA2-lacking AMPARs is increased i

238 rather than action potential shape, involves synaptic activity of glutamate or GABA signalling circui

239 Spontaneous and evoked synaptic activity of glutamate synapse in saline- and co

240 d that DAF failed to perturb singing-related synaptic activity of HVCX cells, although many of these

241 otentially be sources for the increased GABA synaptic activity of indirect pathway MSNs.

242 cytes selectively promote neurite growth and synaptic activity of neurons only from the same region i

243 The synaptic activity of V1 neurons is given as input to the

244 to enhance excitatory synapses dependent on synaptic activity or Ca(2+)/calmodulin kinase II (CaMKII

245 tentials (APs) in response to high-frequency synaptic activity or sustained depolarization.

246 ion of entropy, meaning that the spontaneous synaptic activity outlines a larger multidimensional act

247 ayed reward, which poses the question of how synaptic activity patterns associate with a delayed rewa

248 plasticity depends not only on pre- and post-synaptic activity patterns, but also on the strength of

249 and as key regulators of synapse formation, synaptic activity, plasticity, and synaptic vesicle recy

250 se findings suggest that central glycinergic synaptic activity plays a vital role in regulating MN mo

251 Here, we show that increased synaptic activity prior to excitotoxic injury protects,

252 rn of gene expression changes suggested that synaptic activity promotes a shift of neuronal energy me

253 re re-examined previously identified sets of synaptic activity-regulated genes to identify genes that

254 data suggest that spontaneous glutamatergic synaptic activity regulates constitutive neuronal COX-2

255 in the midst of ongoing protein turnover and synaptic activity, remain elusive.

256 , when, and how much zinc is released during synaptic activity remains highly controversial.

257 ended practice results in a reduction in the synaptic activity required to produce internally generat

258 Remodelling neuronal connections by synaptic activity requires membrane trafficking.

259 Synaptic activity reshapes the morphology of dendritic s

260 These three proteins bind to the synaptic activity response element (SARE), an enhancer s

261 Chronic inhibition of synaptic activity resulted in opposite outcomes, with bu

262 We find that synaptic activity results in a rapid, but transient, inc

263 ndritic spine loss, patch-clamp recording of synaptic activity revealed an increase in miniature EPSC

264 ALS (120 d), but PSC detection of endogenous synaptic activity revealed by intracellular Ca(2+) chang

265 hich morphogens, transcription programs, and synaptic activity sculpt neuronal form.

266 Thus, Tet3 serves as a synaptic activity sensor to epigenetically regulate fund

267 A accumulates at activated synapses and that synaptic activity simultaneously triggers mRNA decay tha

268 ng Ca(2+)-permeable forms and thereby alters synaptic activity, specifically in hippocampal neurons.

269 ynapses capable of capturing both neural and synaptic activity statistics relevant to BBCI conditioni

270 In this model, synaptic activity stimulates miR-134 expression, which t

271 nds to short pulses of correlated background synaptic activity synchronizing the output of cortical n

272 ERK1/2 activation, and long term changes in synaptic activity that are implicated in learning, memor

273 h steady-state LFPs could reflect underlying synaptic activity that does not necessarily lead to cort

274 The synaptic activity that is evoked by visual stimulation d

275 thology likely arises from poorly controlled synaptic activity that leads to excitotoxicity and neuro

276 Although UP states are maintained by synaptic activity, the mechanisms that underlie the init

277 ese oscillations arise from local inhibitory synaptic activity, these findings point to excitation-in

278 ediate early gene product Arc/Arg3.1 couples synaptic activity to postsynaptic endocytosis of AMPA-ty

279 leased opioids as neuromodulators engaged by synaptic activity to regulate moment-to-moment neuronal

280 edium to high expression, possibly by tuning synaptic activity to the stimulus features and hence a m

281 orded local field potentials as a measure of synaptic activity together with spiking activity and low

282 excitatory-inhibitory balance of prefrontal synaptic activity toward a state of disinhibition.

283 Specifically, synaptic activity transcriptionally represses Mcu, via a

284 s increased because of the decreased rate of synaptic activity under deep anesthesia, we blocked cort

285 col presented here enables the monitoring of synaptic activity using whole-cell current-clamp recordi

286 iously identified as a protein that enhances synaptic activity via interaction with PSD-95, mitigates

287 of astrocytic genes are acutely regulated by synaptic activity via mechanisms involving cAMP/PKA-depe

288 nome-wide the chromatin state in response to synaptic activity via nuclear CaMKII-MeCP2 signaling.

289 consequence of dopamine release, D2-receptor synaptic activity was assessed via virally overexpressed

290 Across tested frequencies, sustained synaptic activity was modulated by DCS with polarity-spe

291 ubset of sustained ON bipolar cells in which synaptic activity was suppressed by fluctuations at freq

292 left is highly dynamic and depends on recent synaptic activity, we explored the kinetics of ASIC1a an

293 dentified proteins whose levels changed with synaptic activity were RNABPs and included the heterogen

294 xpress elevated levels of Arc in response to synaptic activity, which coincides with severely impaire

295 ation, we discovered new maps for excitatory synaptic activity, which were organized similarly to tho

296 activity and has the potential to coordinate synaptic activity with a BMP retrograde signal required

297 n synaptic plasticity and the integration of synaptic activity with neuronal activity.

298 partially reversed by overnight silencing of synaptic activity with tetrodotoxin, a treatment that al

299 assess neuronal excitability and the derived synaptic activity within a controlled microenvironment w

300 tected synapses, while chronic inhibition of synaptic activity worsened Tau pathology and caused detr