ライフサイエンスコーパス: synaptic connection

1 ions to the prediction of the longevity of a synaptic connection.

2 two forms of plasticity interact at the same synaptic connection.

3 circuit is determined by the details of its synaptic connections.

4 te balance between excitatory and inhibitory synaptic connections.

5 rgic synaptic vesicles and involved in local synaptic connections.

6 Nervous system function relies on precise synaptic connections.

7 spinal neurons and testing of 3489 potential synaptic connections.

8 cycles and by comprehensively mapping their synaptic connections.

9 etwork because of pervasive and facilitating synaptic connections.

10 logous neurons with different layer-specific synaptic connections.

11 ce to assess the morphology and lifetimes of synaptic connections.

12 a period of refinement to eliminate aberrant synaptic connections.

13 ely control the development and longevity of synaptic connections.

14 ured to reveal the patterns and strengths of synaptic connections.

15 that they involve strengthening or weakening synaptic connections.

16 GABAergic neurons, which communicate through synaptic connections.

17 eved to be stored in the brain as changes in synaptic connections.

18 t each other to form a network of inhibitory synaptic connections.

19 nt on the activity that emerges from nascent synaptic connections.

20 ty-dependent signals to establish functional synaptic connections.

21 when starting from naive or already trained synaptic connections.

22 tworks through a redistribution of recurrent synaptic connections.

23 heir normal territory and establish aberrant synaptic connections.

24 ritical during development and plasticity of synaptic connections.

25 ophrenia, possibly due to loss of excitatory synaptic connections.

26 on not restricted to morphologically defined synaptic connections.

27 ere they elaborate specific morphologies and synaptic connections.

28 t depend on the precise arrangement of local synaptic connections.

29 ress that cause neuronal atrophy and loss of synaptic connections.

30 onal roles for the functional development of synaptic connections.

31 zatin does not compromise the maintenance of synaptic connections.

32 th changes in individual neurons or specific synaptic connections.

33 n of neurons and subsequent formation of new synaptic connections.

34 al and synaptic markers, and form functional synaptic connections.

35 can also be used to map multiple individual synaptic connections.

36 ndritic spines, the sites of most excitatory synaptic connections.

37 of neurons, each of which makes thousands of synaptic connections.

38 tion of synaptic plasticity at both of these synaptic connections.

39 orebrain neurons that are capable of forming synaptic connections.

40 function in activity-dependent modulation of synaptic connections.

41 a retrograde signal during the refinement of synaptic connections.

42 ion can be shaped by varying the strength of synaptic connections.

43 about activity-dependent plasticity of their synaptic connections.

44 in ways that are not easily predicted by its synaptic connections.

45 plays an important role in the formation of synaptic connections.

46 ced loss of Inner Hair Cell - Auditory Nerve synaptic connections.

47 ith loss of Inner Hair Cell - Auditory Nerve synaptic connections.

48 sed of local, subcortical, and intercortical synaptic connections.

49 f orthogonal laminar and vertical excitatory synaptic connections.

50 onal membrane properties and formed abundant synaptic connections.

51 l activity that promote the establishment of synaptic connections.

52 sms to downregulate DLK as they form stable, synaptic connections.

53 neurons and PV interneurons formed frequent synaptic connections.

54 in the control circuits and mapping of their synaptic connections.

55 s are thought to reflect those of excitatory synaptic connections.

56 nes that allow predicting future turnover of synaptic connections.

57 Mapping such networks at the level of synaptic connections, a field called connectomics, began

58 ize wiring length for a functional number of synaptic connections, a phenomenon called wiring optimiz

59 is refined via selection and elimination of synaptic connections, a process that is prolonged in hum

60 m short-term in recruiting the growth of new synaptic connections, a process that requires the partic

61 VIP+ cell morphologies, receptive fields and synaptic connections advances our understanding of their

62 We found that unitary synaptic connections among claustrocortical (ClaC) neuro

63 vertebrate retina, establishment of precise synaptic connections among distinct retinal neuron cell

64 Synaptic connections among FS cells are critical for reg

65 However, it is unclear whether synaptic connections among FS interneurons also play a c

66 nough to quantify the strength of individual synaptic connections and also scalable enough to simulta

67 ccompanied by a reduction in the strength of synaptic connections and altered functional connectivity

68 of the strength of excitatory and inhibitory synaptic connections and are associated with modulation

69 e that enabled us to selectively examine the synaptic connections and behavioural role of the CA2 reg

70 induced neuroplastic effects at the level of synaptic connections and circuits.

71 An offset in the weighting of synaptic connections and differential use of fast and sl

72 of Spastin function results in reduction of synaptic connections and disabling motor defects.

73 postsynaptic actions in dlPFC, strengthening synaptic connections and improving cognitive function.

74 Our findings indicate that RIN1 destabilizes synaptic connections and is a key player in postsynaptic

75 activity is critical for the development of synaptic connections and maintenance of synaptic homeost

76 , a process requiring functional analysis of synaptic connections and morphological identification of

77 Mapping synaptic connections and projections is crucial for unde

78 denervated after brain injury remodel their synaptic connections and show biphasic changes in their

79 en inflammation does occur, microglia modify synaptic connections and synaptic plasticity required fo

80 d analytical method was used to quantify the synaptic connections and to assess the kinetics of synap

81 nge networks, local circuits, and individual synaptic connections) and highlights opportunities for f

82 ortened outer segments, loss of bipolar cell synaptic connections, and a diminished flicker ERG, hall

83 erm changes in cell specification, growth of synaptic connections, and adaptation that occur througho

84 ugh the network size, strength and number of synaptic connections, and connection architecture may va

85 of neurons, creation of dendritic arbors and synaptic connections, and eventually dendritic pruning a

86 ntributes to behavioral deficits by altering synaptic connections, and RhoA-ROCK inhibition enhances

87 e types and numbers of neurons that form new synaptic connections, and the effect of sensory experien

88 ulation activities, the fixed parameters are synaptic connections, and the latent variables are multi

89 The formation and refinement of synaptic connections are dependent on the activity that

90 These synaptic connections are detected by trans-synaptic Neur

91 Neuronal synaptic connections are either chemical or electrical,

92 In the developing nervous system, synaptic connections are formed in excess and must remod

93 ctivity-dependent changes in the strength of synaptic connections are fundamental to the formation an

94 ment, as this is when central and peripheral synaptic connections are made onto and from MNs.

95 Surprisingly, reciprocal inhibitory synaptic connections are major players in choosing, sequ

96 Furthermore, emerging evidence suggests that synaptic connections are not only formed among specific

97 It has been proposed that synaptic connections are refined by neural activity to f

98 that action potential-dependent cholinergic synaptic connections are required for rhythmic lLN(v) ac

99 The laminar synaptic connections are symmetric sparse, random, and d

100 s (JL) matrices implemented by sparse random synaptic connections are thought to be a prime candidate

101 ablishment, specification, and validation of synaptic connections are thought to be mediated by inter

102 ems that different circuits, indeed specific synaptic connections, are differentially sensitive to th

103 a constant increase in the number of links (synaptic connections) as a function of the number of nod

104 ExM further resolved putative synaptic connections, as well as molecular differences b

105 Using a modified GRASP method to probe synaptic connections at the single-cell level, we reveal

106 rons and trace their axonal trajectories and synaptic connections at various stages of chick embryos.

107 x2-1-derived interneurons possess functional synaptic connections before emerging pyramidal cell netw

108 neurons interacting with each other through synaptic connection between axons and dendrites, therefo

109 ned anatomically at a cellular scale as 2287 synaptic connections between 279 neurons.

110 Here we interrogate synaptic connections between afferent pathways, PV-INs,

111 Such noise exposure destroys synaptic connections between cochlear hair cells and aud

112 e or aging, there can be massive loss of the synaptic connections between cochlear sensory cells and

113 cortex and that adult experience alters only synaptic connections between cortical neurons.

114 The generation of precise synaptic connections between developing neurons is criti

115 The strength and variability of electrical synaptic connections between GABAergic interneurons are

116 In the present study, we analyzed unitary synaptic connections between GCs and basket cells in acu

117 g techniques, we examined the effects of the synaptic connections between glycinergic interplexiform

118 cified during development, (2) revealing the synaptic connections between identified cell types ("con

119 Here, we investigated patterns of synaptic connections between identified motoneurons with

120 have been closely linked to strengthening of synaptic connections between neurons (i.e., synaptic pla

121 circuitry requires the formation of precise synaptic connections between neurons in the retina and b

122 reveals the existence of sexually dimorphic synaptic connections between neurons present in both sex

123 Stereotypic patterns of synaptic connections between neurons underlie the abilit

124 and stability is constrained by the sign of synaptic connections between neurons within the network.

125 in damage involve changes in the strength of synaptic connections between neurons.

126 and development of excitatory and inhibitory synaptic connections between neurons.

127 onse to experience, in part by remodeling of synaptic connections between neurons.

128 In rodent visual cortex, synaptic connections between orientation-selective neuro

129 of the central nervous system (CNS), precise synaptic connections between pre- and postsynaptic neuro

130 pment of the central nervous system, precise synaptic connections between presynaptic and postsynapti

131 acilitate future physiological assessment of synaptic connections between pRS neurons and spinal neur

132 effects of Tat on inhibitory and excitatory synaptic connections between rat hippocampal neurons usi

133 mmunoelectron microscopy revealed excitatory synaptic connections between regenerating host axons and

134 l adhesion proteins required for appropriate synaptic connections between specific subtypes of retina

135 orporates trace learning in the feed-forward synaptic connections between successive neuronal layers.

136 and withdrawal networks, we found no direct synaptic connections between the interneuronal and moton

137 nervous system, it is necessary to know the synaptic connections between the neurons, yet to date, o

138 However, it remains unclear when synaptic connections between these structures emerge or

139 We found rapid, strong excitatory synaptic connections between uPNs and LNs.

140 ansactivator of transcription (Tat) disrupts synaptic connections both in vitro and in vivo and has b

141 The synaptic connections, both chemical and gap junctional,

142 ited ability to extend neurites and make new synaptic connections, but the mechanisms that inhibit su

143 role for astrocytes as organizers of active synaptic connections by coordinating both pre and post s

144 Strengthening of synaptic connections by NMDA (N-methyl-d-aspartate) rece

145 We showed that direct synaptic connection can exist between AgRP1 and AgRP2 ne

146 sponses must exist before specific recurrent synaptic connections can be established.

147 Synaptic connections can be stably maintained for prolon

148 presynaptic expression of En strengthens the synaptic connection, consistent with there being more sy

149 c development, thalamic axons must establish synaptic connections despite the presence of the more ab

150 Divergent synaptic connections did not contribute directly to the

151 Moreover, these synaptic connections display the same interlaminar direc

152 onment and play essential roles in sculpting synaptic connections during brain development.

153 The assembly of specific synaptic connections during development of the nervous s

154 lly, we identified sidekick-1--important for synaptic connections during development--as a critical P

155 -sensitive primary afferent nerve fibers via synaptic connections, enabling them to detect and transd

156 Precise coordination of synaptic connections ensures proper information flow wit

157 elimb area of mouse M1 have multiple L4-like synaptic connections: excitatory input from thalamus, la

158 tes that changes in neuronal activity of one synaptic connection following early-life pheromone expos

159 neurons suppressed development of excitatory synaptic connections from all local input pathways teste

160 Thalamocortical neurons have thousands of synaptic connections from layer VI corticothalamic neuro

161 mice with cell-type-specific labelling, the synaptic connections from SACs to DSGCs were of equal st

162 The strength of synaptic connections fundamentally determines how neuron

163 et of hub-like neurons have large numbers of synaptic connections (>40).

164 eural development such as axon targeting and synaptic connection in the chicken embryo.

165 s and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartments in th

166 ction potentials, thus potentially sculpting synaptic connections in an activity-dependent manner in

167 on of auditory neurons and the refinement of synaptic connections in auditory nuclei; however, the me

168 ity, and abnormally reduced local excitatory synaptic connections in CA1 neurons.

169 relationships between sensory physiology and synaptic connections in cortical and retinal circuits.

170 ophila visual system, different neurons form synaptic connections in different layers.

171 ifferent neuronal populations, Npas4 affects synaptic connections in excitatory and inhibitory neuron

172 d optogenetic approaches to re-examine these synaptic connections in mice.

173 sed connectomics aims to comprehensively map synaptic connections in neural tissue.

174 rs regulate neuronal response properties and synaptic connections in order to adjust circuit function

175 During the process of skill learning, synaptic connections in our brains are modified to form

176 Long-term memory relies on modulation of synaptic connections in response to experience.

177 patterning of the olfactory sensory neurons' synaptic connections in the brain.

178 e spatial distribution and strength of local synaptic connections in the central nucleus of the infer

179 beta) triggers the elimination of excitatory synaptic connections in the CNS, an early manifestation

180 e development, maintenance and remodeling of synaptic connections in the CNS.

181 to the specification and differentiation of synaptic connections in the developing brain.

182 receptor, Frazzled, dictate the strength of synaptic connections in the giant fiber system (GFS) of

183 for efficient information transfer at DG-CA3 synaptic connections in the intact circuit.

184 muscular junctions and emerging parallels at synaptic connections in the mammalian central nervous sy

185 Synaptic connections in the nervous system are rearrange

186 Establishment of synaptic connections in the neuropils of the developing

187 In addition, the synaptic connections in the outer plexiform layer are de

188 Plasticity of synaptic connections in the primary motor cortex (M1) is

189 ct of inflammation and cytokine elevation on synaptic connections in the primary somatosensory cortex

190 e investigated functional AII amacrine-->RGC synaptic connections in the retina of the guinea pig (Ca

191 s; conversely, SPARC-null mice had increased synaptic connections in the superior colliculus.

192 he degree of functional specificity of local synaptic connections in the visual cortex, and point to

193 processes that normally establish and modify synaptic connections in visual cortex.

194 onnectivity of all four types of hippocampal synaptic connections, including two forms of increased i

195 aracterized by a change in the strength of a synaptic connection induced by repetitive and properly p

196 Long-lasting changes in synaptic connections induced by relevant experiences are

197 we investigated their effects on changes in synaptic connections induced by the HIV-1 envelope glyco

198 Unitary GPe-STN synaptic connections initially generated large conductan

199 The elaboration of nascent synaptic connections into highly ordered neural circuits

200 Optimal mPFC functioning relies on synaptic connections involving dendritic spines in pyram

201 Loss of synaptic connections is a hallmark of many neurocognitiv

202 Formation of appropriate synaptic connections is critical for proper functioning

203 Establishing precise synaptic connections is crucial to the development of fu

204 The visual-deprivation-induced decrease in synaptic connections is specific to asymmetric non-GABAe

205 articularly in the regulation of established synaptic connections, is not known.

206 EMENT The ability of neurons to modify their synaptic connections, known as synaptic plasticity, is a

207 ng to characterize the long-range excitatory synaptic connections made by multiple cortical and thala

208 hat there is some loss of specificity in the synaptic connections made in the SCG during reinnervatio

209 has been frustrated by the lack of detailed synaptic connection maps, or connectomes.

210 o investigate how structural variation among synaptic connections might affect neural computation, we

211 nd users should be cognizant that functional synaptic connections might exist despite the absence of

212 s, considerable prenatal development of rNST synaptic connections occurs and this will ensure postnat

213 the biophysical properties of a well-defined synaptic connection of the cortical microcircuit of huma

214 We reconstructed the morphologies and synaptic connections of all 983 neurons within the three

215 o track changes in the afferent and efferent synaptic connections of developing neocortical interneur

216 arily coded by dopamine, which modulates the synaptic connections of medium spiny neurons in the stri

217 Establishing synaptic connections often involves the activity-depende

218 al part in the maintenance and refinement of synaptic connections, often via competitive mechanisms,

219 rtex (AON) revealed functional glutamatergic synaptic connections on several types of bulbar interneu

220 Boc leads to a reduction in the strength of synaptic connections onto layer Vb, but not layer II/III

221 c circuit, with an enhancement of excitatory synaptic connections onto MSNs.

222 the songbird basal ganglia that makes strong synaptic connections onto output pallidal neurons, often

223 CNS and regulates the density of excitatory synaptic connections onto pyramidal neurons in a genetic

224 both SPNs and cholinergic interneurons, and synaptic connections onto SPNs are made exclusively over

225 We have characterized the afferent synaptic connections onto these neurons in the rat subst

226 leads, through an increase in the number of synaptic connections per GPe-STN axon terminal, to subst

227 Networks with few synaptic connections per neuron and network-activity-dep

228 of 0.25 or 0.1, and with the same number of synaptic connections per neuron for the recurrent collat

229 is set by the number of recurrent collateral synaptic connections per neuron, on which there is a bio

230 The multifaceted synaptic connections provide spinal networks with a rema

231 LN-LN synaptic connections putatively implement a bistable gai

232 ses (functional synaptic connectivity) in 90 synaptic connections reconstructed from cortical slice p

233 maller on average but are still able to make synaptic connections regardless of their size, as assess

234 The formation of synaptic connections requires a dialogue between pre and

235 asticity in response to the loss of critical synaptic connections; reversal of synaptic action in the

236 can cooperate to mediate release at a given synaptic connection.SIGNIFICANCE STATEMENT During synapt

237 neurons form highly stereotypic patterns of synaptic connections that are designed to serve specific

238 Immature neural circuits form excessive synaptic connections that are later refined through prun

239 are interconnected with recurrent excitatory synaptic connections that are thought to amplify signals

240 expression leads to a profound overgrowth of synaptic connections that correlates directly with the l

241 Wnt signalling increases axon plasticity and synaptic connections that drive greater functional recov

242 ly interconnected by thousands of excitatory synaptic connections that extend, largely undiminished,

243 stnatal life are prerequisites for selective synaptic connections that mediate meaningful neurotransm

244 uencies did not deviate between autaptic and synaptic connections, the frequency of mEPSCs in mixed p

245 tudy tested the hypothesis that the types of synaptic connections these boutons form are altered with

246 e expressed by strengthening or weakening of synaptic connections through morphological changes.

247 asome in neurons to facilitate remodeling of synaptic connections through protein degradation.

248 an rapidly and reversibly silence excitatory synaptic connections through the regulation of presynapt

249 We describe synaptic connections through which information essential

250 We describe the synaptic connections through which information required

251 MDA receptor activity is involved in shaping synaptic connections throughout development and adulthoo

252 ay a central role in shaping the strength of synaptic connections throughout development and in media

253 over substantially, potentially forming new synaptic connections to adopt the function lost in the d

254 ngs in neonatal CA1, MGE interneurons formed synaptic connections to and from neighboring pyramidal c

255 a, with orexin immunohistochemistry revealed synaptic connections to BAT from orexin neurons in PeF-L

256 ind that robustness to output noise requires synaptic connections to be in a balanced regime in which

257 Glutamate neurotransmission refines synaptic connections to establish the precise neural cir

258 unclear how local excitatory and inhibitory synaptic connections to excitatory neurons are spatially

259 nformation with rod/cone signals relayed via synaptic connections to influence light-dependent behavi

260 ired to control formation and maintenance of synaptic connections to maintain the general level of ne

261 central nervous system ranging from removing synaptic connections, to maintaining brain homeostasis b

262 Synaptic connections undergo activity-dependent plastici

263 Synaptic connections underlie learning and memory in the

264 The strength of synaptic connections varies significantly and is a key d

265 replay', the active potentiation of relevant synaptic connections via reactivation of patterns of net

266 In addition, the number of synaptic connections was increased and astroglial synapt

267 , combined with paired recordings of minimal synaptic connections, we have shown that AMPA receptor s

268 ites and allowing probabilistic formation of synaptic connections, we reconstruct network connectivit

269 ay provide a mechanism that ensures that the synaptic connection weights in the sparse population of

270 Bidirectional synaptic connections were found more frequently between

271 We found that human synaptic connections were purely depressing and that the

272 s based mainly on changes in the strength of synaptic connections whereas the other two motifs are ba

273 s is thought to regulate the strength of the synaptic connection, which depends vitally on the number

274 inted via alteration of activity of a single synaptic connection, which in turn shapes experience-dep

275 ain contains more than 100 trillion (10(14)) synaptic connections, which form all of its neural circu

276 ion is a reflection of the strength of these synaptic connections, which in turn can be altered by th

277 ys provide the physical substrate to the new synaptic connection, while cell-cell signaling may provi

278 dly and flexibly alter the efficacy of these synaptic connections, while leaving the synaptic archite

279 show that postnatal-born granule cells form synaptic connections with centrifugal inputs and mitral/

280 he prefrontal cortex (PFC) exhibit extensive synaptic connections with deep layer neurons, implying t

281 n of AgRP fibers revealed direct, inhibitory synaptic connections with Kiss1(ARH) and Kiss1(AVPV) neu

282 es of NPY(+) (NPY(+) NGF) interneurones form synaptic connections with MSNs, although the strength of

283 nce that tank-expressing neurons form likely synaptic connections with neurons expressing the neural

284 tions and optogenetic interrogation of their synaptic connections with neurons in the basolateral amy

285 r cell have a greater probability of forming synaptic connections with one another and are biased to

286 tical (ClaC) projection neurons, rarely form synaptic connections with one another and are unlikely t

287 6s, and determine the presence or absence of synaptic connections with patch-clamp electrophysiologic

288 ansplanted rod precursors form classic triad synaptic connections with second-order bipolar and horiz

289 nique that enables the systematic mapping of synaptic connections with single-cell resolution.

290 may be unidirectional, the establishment of synaptic connections with specific properties can involv

291 d in the extrastriate cortex where they form synaptic connections with spines and small-diameter dend

292 articularly diverse intrinsic properties and synaptic connections with the local network, suggesting

293 entral processes of primary nociceptors form synaptic connections with the second-order nociceptive n

294 icated in the response to hypoglycemia, make synaptic connections with the specific subset of glucore

295 Neurons establish specific synaptic connections with their targets, a process that

296 pses towards weakening, while preserving the synaptic connections within active neuronal assemblies.S

297 euronal connectomes, annotated graphs of all synaptic connections within defined brain areas.

298 how that neurons can undergo injury at their synaptic connections within the gray matter, independent

299 y of novel mechanisms that establish precise synaptic connections within the nervous system.

300 ystem (UPS) plays a central role in building synaptic connections, yet little is known about either w