ライフサイエンスコーパス: synaptic function

1 ch has pleiotropic effects, in particular on synaptic function.

2 dwell time of many TM proteins important for synaptic function.

3 0 BDNF-coexpressed genes are associated with synaptic function.

4 e to long-term differences in CNS wiring and synaptic function.

5 The absence of both Cplxs perturbs ribbon synaptic function.

6 cesses to maintain neuronal excitability and synaptic function.

7 ceptors present in the hippocampus regulates synaptic function.

8 ion of SV size and consequent enhancement of synaptic function.

9 nly on synapse formation but also on ongoing synaptic function.

10 d CaMKII peptides and is essential for Arc's synaptic function.

11 he short-term dynamics of mossy fibre to CA3 synaptic function.

12 tters such as acetylcholine (ACh) are key to synaptic function.

13 dendritic spines is a critical indicator of synaptic function.

14 ent in nervous system development and proper synaptic function.

15 ng is a critical player in the modulation of synaptic function.

16 of genes linked to ion channel activity and synaptic function.

17 al for actin dynamics, which is critical for synaptic function.

18 zygous NRXN1 mutations alone directly impair synaptic function.

19 duction of segmental flexibility compromised synaptic function.

20 o regulate glutamate receptor clustering and synaptic function.

21 wnt signaling during development; and (iii) synaptic function.

22 waveform serves as an important regulator of synaptic function.

23 anges in the brain that may adversely affect synaptic function.

24 by releasing gliotransmitters that regulate synaptic function.

25 e an important role in regulating/modulating synaptic function.

26 functional insight into how CaMKII supports synaptic function.

27 ATP levels and how ATP availability controls synaptic function.

28 l new insights into the principles governing synaptic function.

29 acking EphA7, indicating that EphA7 enhances synaptic function.

30 oid precursor protein (APP) has an essential synaptic function.

31 anslation of proteins that are important for synaptic function.

32 homeostasis likely go along with altered APP synaptic function.

33 l of protein abundance that is essential for synaptic function.

34 etween neurons and astrocytes is crucial for synaptic function.

35 ional role for TRPV1 in modulating GABAergic synaptic function.

36 ecycling is essential for maintaining normal synaptic function.

37 n receptors, suggesting that they may have a synaptic function.

38 with associated alterations in cognitive and synaptic function.

39 e of Abeta on the regulation of cellular and synaptic function.

40 s, we still lack a detailed understanding of synaptic function.

41 function is essential for the maintenance of synaptic function.

42 these actin-rich structures correlates with synaptic function.

43 a, and is essential for normal photoreceptor synaptic function.

44 rties consistent with possible photoreceptor synaptic function.

45 ation and of dendritic spines independent of synaptic function.

46 his phenomenon has been linked to changes in synaptic function.

47 s in the hippocampal CA1 region and impaired synaptic function.

48 other times, through more subtle changes in synaptic function.

49 ulation, brain development and regulation of synaptic function.

50 of optogenetics to the molecular control of synaptic function.

51 f adolescent SHR and restored AMPAR-mediated synaptic function.

52 e encephalopathy, is required for inhibitory synaptic function.

53 a the endolysosomal pathway is essential for synaptic function.

54 es not impair axonal growth or signaling and synaptic function.

55 ering of cortical inputs as well as abnormal synaptic function.

56 of fueling presynaptic function to maintain synaptic function.

57 ne Phosphatase) is an important regulator of synaptic function.

58 hile Np65 is implicated in the regulation of synaptic function.

59 dendritic spines correlates with the loss of synaptic function.

60 ll excitability, two mechanisms required for synaptic function.

61 ociated with ligand receptor interaction and synaptic function.

62 oregulation of a subset of genes relevant to synaptic functions.

63 was "domesticated" in higher vertebrates for synaptic functions.

64 in genes that regulate dendritic growth and synaptic functions.

65 neurons in limbic cortical networks to alter synaptic functioning.

66 ers associated with abnormal development and synaptic functioning.

67 How do microglia regulate synaptic function?

68 ptic strength bidirectionally, with enhanced synaptic function accompanying loss of PI(3,5)P2 and red

69 sory modality leads to widespread changes in synaptic function across sensory cortices, which are tho

70 and supports a multi-level reorganization of synaptic function across the estrous cycle.

71 f Shank3 were equally effective in restoring synaptic function after knockdown of endogenous Shank3.

72 grammed cell death, microtubule disassembly, synaptic function, aging, and insulin resistance, all pr

73 ssential not only in development but also in synaptic function and as key regulators of synapse forma

74 This work identifies clear alterations in synaptic function and behavior in a novel, genetically a

75 ssembly of a glycolytic metabolon to sustain synaptic function and behavior.

76 ice has revealed benefits of young plasma on synaptic function and behavior.

77 estigate the mechanism by which PS regulates synaptic function and calcium homeostasis using acute hi

78 hat have emerged including the importance of synaptic function and calcium signaling.

79 iments suggest that an age-dependent loss in synaptic function and Cdk5/p39 activity in the NAc may b

80 tial to long-term depression, rescued normal synaptic function and cognition in cellular and animal m

81 that bioenergetic systems, important in both synaptic function and cognition, are abnormal in psychia

82 LRP6-mediated Wnt signaling is critical for synaptic function and cognition.

83 apse loss and rescue of impaired hippocampal synaptic function and cognitive deficits.

84 he increase in STEP activity likely disrupts synaptic function and contributes to the cognitive defic

85 pus results in increased baseline excitatory synaptic function and deficits in LTP and spatial learni

86 studied brain metabolism, a direct index of synaptic function and density, and neural connectivity t

87 e essential genes would significantly impair synaptic function and functional brain connectivity.

88 se RNAs have key roles in the maintenance of synaptic function and growth.

89 Developmental maturation of synaptic function and hearing were characterized in the

90 s study demonstrates a dual role of BRAG1 in synaptic function and highlights the functional relevanc

91 strated that Dab1 is a critical regulator of synaptic function and hippocampal-dependent associative

92 compartmentalization profoundly shapes both synaptic function and how that function can be assessed

93 energy metabolism is critical for supporting synaptic function and information processing.

94 ative phosphorylation can fuel low-frequency synaptic function and inhibiting both underlies loss of

95 NAcylation dynamically modulates hippocampal synaptic function and learning and memory, and suggest t

96 r, this work reveals a novel role of HSF1 in synaptic function and memory, which likely occurs throug

97 bility to regulate transcriptional activity, synaptic function and memory.

98 , TAR DNA Binding Protein Homolog (TBPH), in synaptic function and morphology, motor control, and age

99 A receptors (CP-AMPARs) is crucial in normal synaptic function and neurological disease states.

100 cycling endosome function in AMPAR-dependent synaptic function and neuronal connectivity in vivo, and

101 regulation and those related to disorders of synaptic function and neuronal connectivity.

102 ctor (BDNF) is a neurotrophin that regulates synaptic function and plasticity and plays important rol

103 vide evidence that PLCgamma1 is critical for synaptic function and plasticity and that the loss of PL

104 strocytic calcineurin/NFATs helps to protect synaptic function and plasticity in an animal model in w

105 propose that the overall lack of changes in synaptic function and plasticity in DBN deficient mice m

106 aged-related and region-specific changes in synaptic function and plasticity in the aging brain.

107 LIS1 supports synaptic function and plasticity of mature CA1 neurons.

108 Synaptic function and plasticity were measured using ele

109 emical processes, including those underlying synaptic function and plasticity, are pH sensitive.

110 genes, from neural development and wiring to synaptic function and plasticity, energy balance, social

111 PRMT8 reveal multiple defects in excitatory synaptic function and plasticity.

112 molecular details of how fasting influences synaptic function and plasticity.

113 able for understanding mechanisms underlying synaptic function and plasticity.

114 understanding of the role of microtubules in synaptic function and plasticity.

115 tion, and deficiencies lead to reductions in synaptic function and plasticity.

116 sk gene for major mood disorders involved in synaptic function and related intermediate phenotypes.

117 erall treatment strategy for re-establishing synaptic function and restoring memory in patients with

118 ocampal slices to investigate adaptations in synaptic function and synaptic plasticity arising from a

119 Mimicking changes in inhibitory synaptic function and transmembrane chloride regulation

120 a novel role for CDKL5 in the regulation of synaptic function and uncover an intriguing microcircuit

121 are targeted to specific synapses, but their synaptic functions and mechanistic redundancy are not co

122 tructural dynamics of dendritic spines while synaptic functions and plasticity were measured via elec

123 lopment of dendritic spines is important for synaptic function, and alteration in spine morphogenesis

124 axonal mitochondrial abnormalities, improves synaptic function, and attenuates loss of synapse, sugge

125 cal processes, including nerve regeneration, synaptic function, and behavior.

126 euronal d-serine is important in maintaining synaptic function, and deficiencies lead to reductions i

127 for selective regulation of AMPAR synthesis, synaptic function, and long-term plasticity, important f

128 chondrial motility influences neuron growth, synaptic function, and mitophagy.

129 nt and the processes of chromatin structure, synaptic function, and neuron-glial signaling.

130 ns play essential roles in memory formation, synaptic function, and neuronal survival.

131 sion molecules regulate signal transduction, synaptic function, and plasticity.

132 AD, and propose a novel strategy to preserve synaptic function, and thereby cognitive function, in ea

133 bition of BACE1 on dendritic spine dynamics, synaptic functions, and cognitive performance of adult m

134 rresponding baseline increases in excitatory synaptic function are responsible for the LTP impairment

135 ations of such higher-order conformations to synaptic function are unknown.

136 anner and whether HDAC2 regulates inhibitory synaptic functions are not well understood.

137 regulate NPY release, and its effects on CA1 synaptic function, are not fully understood.

138 Collectively, our results implicate synaptic function as a central target in p53-dependent p

139 fies changes in neurotransmitter release and synaptic function as a converging mechanism in the patho

140 tly, it has emerged that tau participates in synaptic function as part of the molecular pathway leadi

141 supplementation led to important changes in synaptic function as shown by increased input/output (I/

142 investigated wild-type PrP(C) signalling in synaptic function as well as the effects of a disease-re

143 s complementarity extends to these proteins' synaptic function as well.

144 s have implications in both the evolution of synaptic function, as well as the role of iGluRs in heal

145 Changes in the neuronal and synaptic functions associated with neuroinflammation may

146 hat Gbetagamma/SNAP-25 interactions regulate synaptic function at a ribbon-type synapse, contributing

147 JAK-STAT signaling also regulates excitatory synaptic function at the anatomically distinct temporoam

148 rough which group II mGlu receptors modulate synaptic function at the Schaffer collateral input to CA

149 s we study the DLG contribution to the basal synaptic-function at the Drosophila larval neuromuscular

150 l volumes of muscimol, which disrupts normal synaptic functions, before acute and repeated loud noise

151 that soluble Abeta oligomers interfere with synaptic functions by depleting NMDA-type glutamate rece

152 ic deficits, further restoration of striatal synaptic function can be achieved by reduction of mHTT e

153 beneficial effects on memory and hippocampal synaptic function can be reinstated by enhancing the exp

154 Dysfunction of the proteins regulating synaptic function can cause synaptic plasticity imbalanc

155 mbined application of both hormones provoked synaptic function collapse and spine disruption.

156 ce, brain glucose uptake and metabolism, and synaptic function, could be preserved by the insulin-lik

157 es related to presynaptic neurotransmission, synaptic function, cytoskeletal rearrangements, energy m

158 Abeta42-induced impairment of glutamatergic synaptic function depends on its internalization and int

159 ulation of neuronal and spine morphology and synaptic function during non-pathological aging which co

160 le hypotheses of ASD pathogenesis, including synaptic function (e.g., NRXN1, NRXN3), chromatin modifi

161 These data suggest that changes in synaptic function early in development caused by mutatio

162 d gene expression, indicating that restoring synaptic function early in the disease progression may r

163 Our identification of the role of SNX27 in synaptic function establishes a new molecular mechanism

164 e role of each of these genes in neuronal or synaptic function, evaluating the response of neuronal a

165 defects in endosomal trafficking that impair synaptic function, even in the absence of motor neuron c

166 ribute to ASD susceptibility, many linked to synaptic functioning, excitation-inhibition balance, and

167 y excitatory synapses in the brain, changing synaptic function for several weeks after exposure.

168 nes and pathways, including those related to synaptic function, glutamate signalling, insulin secreti

169 Whereas its synaptic function has been examined, it is not clear why

170 wever, discrete effects of SNARE proteins on synaptic function have been difficult to assess using co

171 he action and the role of Abeta42 buildup on synaptic function have been poorly investigated.

172 of both Cplxs perturbs photoreceptor ribbon synaptic function; however, Cplx3/4 function in photorec

173 are documented players in the regulation of synaptic function; however, the mechanisms underlying th

174 remains unknown whether presenilin regulates synaptic function in a gamma-secretase-dependent or gamm

175 ent of in vitro methods that can investigate synaptic function in a high-throughput format could be h

176 nd tau interdependently cause impairments in synaptic function in AD.

177 I)-mediated regulation of spine dynamics and synaptic function in adult brain, much less is know abou

178 w loss of PS activity inhibits glutamatergic synaptic function in Alzheimer's disease patients.

179 roteins, which may contribute to the loss of synaptic function in Alzheimer's disease.

180 Here we tested the effect of 7,8-DHF on synaptic function in an AD model both in vitro and in vi

181 avage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauop

182 The importance of genes related to synaptic function in brain disease has been implied in s

183 ses to meet local energy demands and support synaptic function in Caenorhabditis elegans neurons.

184 islocating glutamate receptors and impairing synaptic function in cultured neurons, and it prevented

185 r whether this innate property helps restore synaptic function in disease once the primary cause of d

186 augment neurotrophins in the CNS and improve synaptic function in disease states such as AD.

187 aling cascade offers new avenues to modulate synaptic function in disease.

188 he presynaptic compartment but do not impair synaptic function in fly neurons.

189 rate that CDKL5 is an important regulator of synaptic function in glutamatergic neurons and serves a

190 tic response gone awry and underlie impaired synaptic function in HAND.

191 r juvenile mice only modestly impaired basal synaptic function in hippocampus and caused no alteratio

192 ygous inactivation of NRXN1 directly impairs synaptic function in human neurons, and they illustrate

193 Vision loss also strengthened inhibitory synaptic function in L4 and L2/3 of A1, but via laminar

194 cted by the emergence of enhanced excitatory synaptic function in mature superficial cortical pyramid

195 caused by drugs of abuse, yet its effects on synaptic function in NAc MSNs are unknown.

196 rugs and stress trigger divergent changes in synaptic function in NAc.

197 gulates food intake by modulating excitatory synaptic function in neurons in the hypothalamus.

198 Exploring alpha-syn conformations and synaptic function in neurons, we found that alpha-syn pr

199 Changes of excitatory and inhibitory synaptic function in Np(-/-) neurons were confirmed eval

200 ophysiology and anatomical methods to assess synaptic function in Ptchd1-deficient dentate granule ce

201 ctrum disorders as well as in alterations in synaptic function in regions involved in social activity

202 tin state of subjects and restore memory and synaptic function in the aging brain.

203 he impact of lifelong deletion of CNTNAP2 on synaptic function in the brain remains unknown.

204 regulation whereby TRPV1 channels can modify synaptic function in the brain.

205 are critical to the regulation of excitatory synaptic function in the CNS.

206 re associated with inflammation and impaired synaptic function in the hippocampal CA1 region as the r

207 AR translation efficiency and therefore also synaptic function in the hippocampus.

208 ol-dependent D1R/mTORC1-mediated increase in synaptic function in the NAc may reflect a neural imprin

209 nd link this signaling pathway to changes in synaptic function in the neuromuscular junction.

210 The range of synaptic function in the presence of inhibitory and exci

211 tin cytoskeleton, an organelle necessary for synaptic function in the presynaptic and postsynaptic co

212 What remains unknown is how EAAC1 shapes synaptic function in the striatum.

213 ritical regulator of axonal excitability and synaptic function in unmyelinated axons.SIGNIFICANCE STA

214 (PAT) family, produces marked alterations in synaptic function in varied brain regions and significan

215 expression improves learning and memory and synaptic function in vivo AD mice, and alleviates Abeta-

216 e that redox changes contribute to senescent synaptic function in vulnerable brain regions involved i

217 CA1 synapse ultrastructural morphology, and synaptic functioning in adult C57BL/6J and DBA mice.

218 erentially impaired excitatory or inhibitory synaptic functions in an isoform-specific manner.

219 n-3 was differentially required for distinct synaptic functions in different brain regions.

220 ce of drug abuse by influencing neuronal and synaptic functions in multifaceted ways.

221 abinoid degradation normalized behaviors and synaptic functions in n-3 PUFA-deficient adult mice.

222 key factors in development, neurogenesis and synaptic functions in the central nervous system.

223 ts suggest that WRB plays a critical role in synaptic functions in these two sensory cells, and that

224 nteraction is essential for normal brain and synaptic functions in vivo.

225 We genetically validate a specific pathway, synaptic function, in p53-mediated neuroprotection.

226 module consists of 24 genes associated with synaptic function, including long-term potentiation and

227 s of age, levels of proteins associated with synaptic function, including SNAP-25, Rab3A and PSD-95,

228 , OPHN1 has been reported to control several synaptic functions, including synaptic plasticity, synap

229 ncreased synaptic spine density, and altered synaptic function (increased frequency of miniature exci

230 nt to many aspects of disrupted neuronal and synaptic function, increased permeability to inflammator

231 sma lipid levels can influence cognition and synaptic function independent of ApoE expression in the

232 ical and neurophysiological modifications in synaptic functions independently from age of disease ons

233 are available on the effects that 5LO has on synaptic function, integrity and cognition.

234 Synaptic function is a main target of A-to-I editing, wh

235 Synaptic function is central to brain function.

236 synapses are diminished, whereas inhibitory synaptic function is enhanced.

237 In AD mouse models, evidence of abnormal synaptic function is present before the onset of cogniti

238 that nonpathogenic huntingtin (HTT) plays in synaptic function is relatively unexplored.

239 ion, but the relevance of their mobility for synaptic function is unknown.

240 sly normal neuroanatomy, we found defects in synaptic function, learning and memory and a reduction i

241 Moreover, the FAD mutation impairs synaptic function, learning and memory, and age-dependen

242 and control vesicle acidification and hence synaptic function, likely through regulation of the asse

243 g a connection between cochlear activity and synaptic function maintenance.

244 n brain and that genes encoding for neuronal synaptic function may be particularly sensitive to the a

245 ingual central nervous tissue that underpins synaptic function, memory acquisition, and social behavi

246 (Abeta) are signaling molecules involved in synaptic function, memory formation and cognition, such

247 Disturbances of synaptic function might underlie abnormalities of neuron

248 DR) proteins are causally linked to abnormal synaptic function, neuronal growth and survival are unkn

249 rodents, changes in intrinsic properties and synaptic function of auditory neurons in developing prim

250 Excitatory synaptic function of CA1 neurons with recent in vivo Arc

251 normalized glutamate receptor expression and synaptic function of gamma2(+/-) mice to wild-type level

252 nslational target, which is required for the synaptic function of LRRK2.

253 To explore the synaptic function of Rab11Fip5, a neuronal Rab11 effecto

254 JIP1 mediates the synaptic function of Wnd via p38, which is not required

255 Several of these genes are associated with a synaptic function or are involved in oxidative stress.

256 focused on 3,087 candidate genes with known synaptic functions or prior evidence from genome-wide as

257 urden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 x 10(-11)) and neu

258 ndamental role in ensuring normal and stable synaptic function, our findings suggest that aberrant fu

259 changes in the trajectory of microglial and synaptic function over the first two decades, and sugges

260 athways for glutamatergic neurotransmission, synaptic function, pain sensing, metalloproteinases, and

261 Indeed, synaptic function relies on EphA7; the electrophysiologi

262 he mechanisms underlying DISC1 regulation of synaptic functions remain elusive.

263 ose to autism, but how such mutations affect synaptic function remains incompletely understood.

264 Proper synaptic function requires the spatial and temporal comp

265 d with neurotrophins, programmed cell death, synaptic function, sirtuins and aging, and insulin resis

266 Evidence from research on both autophagy and synaptic function suggests that there are links between

267 atal day 0 (P0) or day 21 (P21) and measured synaptic function, synaptic plasticity and spine numbers

268 amics of a synapse and may reveal aspects of synaptic function that can be inferred from anatomical s

269 ed with early alterations in corticostriatal synaptic function that precede cell death, and it is pos

270 l changes and levels of proteins involved in synaptic function, the cytoskeleton and axonal transport

271 these zones is believed to be essential for synaptic function, the mechanisms controlling their mutu

272 iven the large number of proteins needed for synaptic function, the proliferation of defective protei

273 established, but despite data linking tau to synaptic function, the role of tau in synapse loss remai

274 Here we report that USP14 regulates synaptic function through a novel, deubiquitination-inde

275 Somatodendritically released peptides alter synaptic function through a variety of mechanisms, inclu

276 ll adhesion molecules that are important for synaptic function through their trans-synaptic interacti

277 n 2 (SV2) family of proteins are involved in synaptic function throughout the brain.

278 of key elements of AD pathology and enhance synaptic functions to counteract oAbeta-induced synaptic

279 research has shown that long-term changes in synaptic function ultimately require changes in gene exp

280 We posit that the resulting alteration in synaptic function underlies cognitive dysfunction in RAB

281 To establish which synaptic functions unequivocally require neuroligins, we

282 nd night, and their network connectivity and synaptic function up through the evoked synaptic conduct

283 oreover, while Abeta1-42 oligomers impact on synaptic function, vAbeta1-42 does not.

284 ignificantly contributed in the retention of synaptic functions (VGLUT1 and GAD65) in cerebellar neur

285 s a critical regulator of actin dynamics and synaptic function via modulation of PICK1.

286 ow that PS regulates calcium homeostasis and synaptic function via RyR and suggest that disruption of

287 -associated spine loss was not affected, and synaptic function was not altered.

288 o the role of presenilins (PS) in excitatory synaptic function, we address the relevance of the prote

289 n/BLOC-1 participate in a pathway-regulating synaptic function, we examined the role for NSF in dysbi

290 ical findings are correlated with changes in synaptic functions, we used adult OVX rats to evaluate t

291 AARs at synapses, GABAergic innervation, and synaptic function were reduced in GODZ KO and DKO neuron

292 vels, expression of presynaptic proteins and synaptic function were restored.

293 Finally, synaptic functions were characterized using electrophysi

294 biological processes, including neuronal and synaptic functions, were consistently associated with ge

295 y the morphological correlates of defects in synaptic function which may underlie motor impairments a

296 is is well matched to the energetic needs of synaptic function, which, at steady state, results in ap

297 to postsynaptic cell outputs and to maintain synaptic function within a dynamic range.

298 moter-specific effects can drastically alter synaptic function within a specific region, without para

299 We hypothesized that NMJ synaptic functions would be altered precociously in an M

300 It has been shown to disrupt cellular and synaptic functions, yet its effects on the function of t