ライフサイエンスコーパス: synaptic input

1 ents (e.g., NMDAR-mediated Ca(2+) influx) by synaptic input.

2 ent-evoked EPSC, which serves to amplify the synaptic input.

3 a changing E/I ratio and the tuning of total synaptic input.

4 kes, can act as cell-intrinsic amplifiers of synaptic input.

5 her NG2 glial cells integrate and respond to synaptic input.

6 ilter mode, depending on the variance of the synaptic input.

7 y driving ON-BC depolarization to changes in synaptic input.

8 rons respond to magnetic fields even without synaptic input.

9 tes, and were more sensitive to depolarizing synaptic input.

10 echanism to dynamically regulate the gain of synaptic input.

11 L1 INs and L2-5 PNs provide near synchronous synaptic input.

12 are electrically responsive cells receiving synaptic input.

13 iring patterns, and received weak excitatory synaptic input.

14 dendritic L-type channels amplify excitatory synaptic input.

15 elicits a paradoxical increase in inhibitory synaptic input.

16 ons by integrating excitatory and inhibitory synaptic inputs.

17 ing generated in an intrinsic manner without synaptic inputs.

18 t unbalancing of glutamatergic and GABAergic synaptic inputs.

19 compensatory adjustments in the strength of synaptic inputs.

20 s on the principal neurons receiving the new synaptic inputs.

21 ct with a systematic topographic gradient of synaptic inputs.

22 ormation by detecting coincident arrivals of synaptic inputs.

23 s, to which they provide highly synchronized synaptic inputs.

24 table and receiving visuotopically organized synaptic inputs.

25 on model, and a model of highly synchronized synaptic inputs.

26 ducing a bimodal distribution for the neuron synaptic inputs.

27 ptic neurons, boosting cooperativity between synaptic inputs.

28 rization, which boosts cooperativity between synaptic inputs.

29 erior olive actively integrate glutamatergic synaptic inputs.

30 ory can be tested experimentally by blocking synaptic inputs.

31 itability but also the temporal filtering of synaptic inputs.

32 ability to differentiate and receive normal synaptic inputs.

33 ity inferred from spikes relate to simulated synaptic input?

34 ing that can be started and stopped by brief synaptic inputs?

35 pines that are strongly depolarized by their synaptic input, a process requiring a high spine neck re

36 receiving several hundred thousand discrete synaptic inputs across a non-linear dendritic tree, Purk

37 t capture the local non-linear processing of synaptic inputs allowed for by dendrites.

38 Neurons receive a multitude of synaptic inputs along their dendritic arbor, but how thi

39 ates NMDARs, even when the delay between the synaptic input and ADPs is relatively long (e.g., severa

40 1D channels, which activate upon cholinergic synaptic input and amplify EPSPs, thus indicating a cons

41 nonphysiological innervation receive similar synaptic input and could be voluntary controlled as moto

42 itic spine stabilization depends on afferent synaptic input and requires changes in actin cytoskeleto

43 on can be directly read out from mossy fiber synaptic input and spike output in single granule cells.

44 cessing, we used recordings at the levels of synaptic input and spiking output in the in vitro mouse

45 .e., the slope of the transformation between synaptic input and spiking output, is also modulated to

46 ures of CaMKII dynamics observed during both synaptic input and spine depolarization.

47 ld structure was shaped by direct excitatory synaptic input and strong presynaptic and postsynaptic i

48 uli is a consequence of rectified excitatory synaptic input and that accounting for nonlinear spatial

49 But spatial correlations in synaptic input and those introduced by network connectiv

50 positive interneuron receives early thalamic synaptic input and, using laser-scanning photostimulatio

51 e network mechanisms underlying synchronized synaptic inputs and account for irregular neural dynamic

52 integrating a large number of male-specific synaptic inputs and conveying them to both male-specific

53 Neurons within clusters received stronger synaptic inputs and displayed increased membrane potenti

54 eing activated by somatic activity, boosting synaptic inputs and enabling bursting, and somatic calci

55 which pyramidal neurons integrate excitatory synaptic inputs and fire action potentials, but in a man

56 e dentate gyrus integrate rapidly correlated synaptic inputs and generate short-duration action poten

57 ns are recruited systematically according to synaptic inputs and intrinsic cellular properties and co

58 s and to explore the spatial distribution of synaptic inputs and outputs on these arbors.

59 resynaptic site, and spatial distribution of synaptic inputs and outputs.

60 Cs located in the dendrites can boost distal synaptic inputs and promote burst firing.

61 temporal components due to ongoing activity, synaptic inputs and recurrent connectivity.

62 perform linear integration of glutamatergic synaptic inputs and respond with increasing dendritic ca

63 ation and analyzed the relationships between synaptic inputs and spike generation.

64 d dysregulates neurotransmitter release from synaptic inputs and that these alterations occur prior t

65 ich neurones in the inferior olive integrate synaptic inputs and the roles of particular ion channels

66 es orientation selectivity of the inhibitory synaptic inputs and the spiking responses.

67 electrophysiological features reflecting the synaptic inputs and/or integrating properties of the neu

68 n, neurons are thought to integrate multiple synaptic inputs and/or selectively amplify specific syna

69 drive seizures, receive elevated excitatory synaptic input, and have abnormal dendrites.

70 itic KChs found at sites reflecting specific synaptic input, and KChs defining novel neuronal compart

71 In turn, the raphe receives a vast array of synaptic inputs, and a remaining challenge lies in under

72 opy is required to examine specific types of synaptic inputs, and application of these methods to qua

73 release dopamine in response to light-driven synaptic inputs, and are critical to retinal light adapt

74 terogeneous; subpopulations receive distinct synaptic inputs, and project to anatomically and functio

75 itial segment orientation, markedly abnormal synaptic inputs, and selective death of alpha- but not o

76 d by both action potentials and subthreshold synaptic inputs, and that conversion level is correlated

77 te nuclear calcium transients in response to synaptic inputs, and the subsequent induction of express

78 t hyperpolarization and a dual regulation of synaptic inputs appeared sufficient in pacing the activi

79 dynamically so that adaptation currents and synaptic inputs are balanced.

80 We find that individual current-based synaptic inputs are detectable over a broad range of amp

81 a(2+)channels and NMDA receptors occurs when synaptic inputs are either clustered onto individual den

82 Therefore, early synaptic inputs are powerfully converted into reliable s

83 This study demonstrates how different synaptic inputs are regulated to tune a neuron to respon

84 tracellular transformation of information as synaptic inputs are translated into action potentials.

85 neurons, and mGluR-dependent tetanization of synaptic input - are separate pathways that converge at

86 ns across all subject groups received common synaptic input as identified by coherence analysis of th

87 ing activity of VP neurons in the absence of synaptic inputs as neither the mean intraburst frequency

88 This work addresses the role of cholinergic synaptic inputs as well as the contribution of the musca

89 are coordinated with neuronal activation and synaptic input, as evidenced by UNC-3 also regulating th

90 changes that preserved the fraction of total synaptic input associated with each pre-synaptic partner

91 Additionally, the persistence of substantial synaptic input at least to P60 suggests that this pathwa

92 anule cell number, morphology and excitatory synaptic inputs at 7 dpi are modified by voluntary wheel

93 uronal compartments, ranging from changes to synaptic inputs at both excitatory and inhibitory compar

94 g neurons receive large, coherent inhibitory synaptic inputs at gamma frequency.

95 turn modulated by the organization of their synaptic inputs, but the principles governing the develo

96 ere we investigate the spatial patterning of synaptic inputs by directly monitoring presynaptic activ

97 th models that predict active integration of synaptic inputs by inferior olive neurones, we find that

98 nt data revealed that an aberrant readout of synaptic inputs by kainate receptors triggered a long-la

99 show how, via this D2R-dependent phenomenon, synaptic input can enhance the excitability of prefronta

100 Local signals such as synaptic input can regulate cargo trafficking, motivatin

101 Thus, synaptic input delivers remarkably rich information to s

102 aptic partners and the allocation of precise synaptic input densities.

103 urons show different in vitro properties and synaptic inputs depending on their specific projections

104 nonlinearity that is optimal for integrating synaptic inputs depends on the statistics of its presyna

105 te action potentials (spikes) in response to synaptic input determines whether a neuron participates

106 cting the coincidence of binaural excitatory synaptic inputs distributed along the dendrites.

107 omuscular activity and elimination of excess synaptic input during development.

108 t, mid-thoracic interneurons receive intense synaptic input during scratching and behave like neurons

109 ting MN morphology and glutamatergic central synaptic inputs during late embryonic development.

110 These results suggest an emergence of novel synaptic inputs during MD that disrupt the representatio

111 will be non-linear dendritic integration of synaptic inputs during synchronous activation.

112 Spatial and temporal features of synaptic inputs engage integration mechanisms on multipl

113 The direct inhibitory synaptic input engages mitral cell intrinsic membrane pr

114 mporal profiles of excitatory and inhibitory synaptic inputs evoked by the same sound stimuli in laye

115 s permissive for the efficient generation of synaptic input-evoked nuclear calcium transients driving

116 Knowledge of the synaptic input fields of individual neurons, including t

117 We used this platform to map inhibitory synaptic input fields of On-Off direction-selective gang

118 estrict the loss of intracortical excitatory synaptic input following MD in adult mice, and this disi

119 that the control of motor neurons and their synaptic input, following reinnervation, was remarkably

120 and require coincident timing of excitatory synaptic inputs for the generation of dendritic plateau

121 ID ripples were associated with depolarizing synaptic inputs frequently reaching the threshold for bu

122 reactive puncta suggesting that they receive synaptic input from bipolar cells.

123 releasing peptide (Grp), that receive direct synaptic input from both pain and itch primary sensory n

124 t one projection neuron type received direct synaptic input from both temperature and dry-air glomeru

125 he first (L1) larval stage and receive their synaptic input from cholinergic motor neurons in the dor

126 bipolar cells are interneurons that receive synaptic input from cone photoreceptor cells and provide

127 rvation of ventral muscles and receive their synaptic input from dorsal cholinergic motor neurons.

128 icated that LC-NE neurons receive convergent synaptic input from many regions previously identified a

129 Cortical cells integrate synaptic input from multiple sources, but how these diff

130 selectivity could result from heterogeneous synaptic input from neighboring neurons, we examined how

131 a intrinsic proton receptors (TASK-2, GPR4), synaptic input from peripheral chemoreceptors and signal

132 ignificant change in area postrema volume or synaptic input from PHOX2B-derived neurons.

133 20 show a significant increase in volume and synaptic input from PHOX2B-derived neurons.

134 Odd neurons receive synaptic input from projection neurons in the calyx of t

135 bilities and outline the limits of inferring synaptic input from spikes.

136 expectedly long dendrites, which may receive synaptic input from the cerebral cortex and other brain

137 mary visual cortex of cats while controlling synaptic input from the corresponding contralateral hemi

138 and the isthmic complex that receives strong synaptic input from the ICX and projects broadly upon th

139 t the lateral habenula (LHb) receives direct synaptic input from the PFC and that activation of LHb n

140 which subpopulation of SCN neurons receives synaptic input from the retina and how the SCN receives

141 s (GCs), the retinal output neurons, receive synaptic inputs from bipolar and amacrine cells in the i

142 aoptic nucleus has been attributed mainly to synaptic inputs from circunventricular organs.

143 th corticospinal output and its facilitatory synaptic inputs from cortical and sub-cortical sites con

144 s are matched to dendrite size, and by which synaptic inputs from different transmitter systems are c

145 ctively decreased spine numbers and impaired synaptic inputs from entorhinal but not Schaffer-collate

146 rcuits collaborate to select combinations of synaptic inputs from multiple pathways?

147 ectivity both from excitatory and inhibitory synaptic inputs from other neurons and from their own in

148 Thus enhancing GABAergic inhibitory synaptic inputs from SST(+) interneurons to pyramidal ce

149 Here, we explored whether KORs modify synaptic inputs from the BLA to the mPFC using in vivo e

150 neurons (SPNs) receive convergent excitatory synaptic inputs from the cortex and thalamus.

151 By solving an inverse problem to uncover synaptic inputs from Ve patterns we provide a new perspe

152 Somatically recorded AOB synaptic inputs had slower kinetics than CoA inputs, sug

153 ons receive both GABAergic and glutamatergic synaptic inputs, however, the developmental time course

154 nterneurons receive large, phasic excitatory synaptic inputs immediately before spike generation foll

155 that were associated with greater excitatory synaptic input in females.

156 ate how these mechanisms cooperate to filter synaptic input in hippocampal area CA1.

157 tory synchrony is evident in the spontaneous synaptic input in mitral cells (MCs) separated up to 220

158 re critical for the efficient integration of synaptic inputs in circuits performing analog computatio

159 prominent role for functional clustering of synaptic inputs in dendritic nonlinearities that shape o

160 ecreased inhibitory and increased excitatory synaptic inputs in hippocampal neurons of Fgf13 mutants.

161 lbumin interneurons receive fewer excitatory synaptic inputs in individuals with schizophrenia.

162 g of intracortical excitatory and inhibitory synaptic inputs in relation to principal excitatory neur

163 Excitatory or inhibitory synaptic inputs in the recurrent inhibitory loop induced

164 Cortical neurons integrate thousands of synaptic inputs in their dendrites in highly nonlinear w

165 ations during song production did not affect synaptic inputs in these neurons.

166 on intrinsic excitability, in the absence of synaptic input, in hippocampal CA3 neurons, a classical

167 The proportion of dendrites with synaptic input increased from 50% to 80% by 6 months.

168 ifferential tuning selectivity of inhibitory synaptic input: inhibition in complex cells is more narr

169 But how are synaptic inputs integrated in the intact brain?

170 apse function, and show increased excitatory synaptic input into spinal neurons, and a lowered thresh

171 isplayed an altered pattern of long-distance synaptic inputs into a cortical area important for cogni

172 sponsible for integrating a diverse array of synaptic inputs into discrete contractions of skeletal m

173 garding the spatial distribution of thalamic synaptic inputs into layer 4, the model predicted charac

174 putation they perform is clear: they convert synaptic inputs into spatially modulated, periodic firin

175 demonstrate that the frequency of excitatory synaptic input is decreased in D1-MSNs and increased in

176 s, the input-output function for synchronous synaptic input is linear but shows enhanced gain due to

177 ctive ganglion cells (ON-OSGCs) reveals that synaptic input is mediated almost exclusively through th

178 simple model in which a fraction of the pre-synaptic input is silenced can reproduce this reduction

179 Precise timing of synaptic inputs is a fundamental principle of neural cir

180 The level of conversion by subthreshold synaptic inputs is correlated to the strength of input,

181 reported modulation that Up states impose on synaptic inputs is disparate in the literature, includin

182 dence detection of excitatory and inhibitory synaptic inputs is essential for LSO neurons to encode b

183 lar excitability in a manner that depends on synaptic input, is mediated at the cellular level throug

184 determined largely by the number and type of synaptic inputs it receives, and these, in turn, are gre

185 bility is presumed to arise from overlapping synaptic input, its precise relationship to local circui

186 Therefore, synaptic input locally directs dendrite growth, but intr

187 Dendritic integration of synaptic inputs mediates rapid neural computation as wel

188 n identified Drosophila neuron, we show that synaptic inputs of two different transmitter classes loc

189 memory accuracy and the number of excitatory synaptic inputs on dendritic spines of pyramidal neurons

190 Neurons receive synaptic inputs on extensive neurite arbors.

191 ntage of symmetrical, presumably inhibitory, synaptic inputs on somata was significantly higher on sp

192 the "modulatory" effects of corticothalamic synaptic inputs on thalamocortical neuron membrane poten

193 The spatial organization of synaptic inputs on the dendritic tree of cortical neuron

194 and a deficit in the formation of excitatory synaptic inputs on to these neurons in neonatal Fmr1 KO

195 reversible method for modulating inhibitory synaptic input onto genetically determined cells.

196 convergence of muscle and cutaneous afferent synaptic input onto individual projection neurons.

197 ic spines are the primary site of excitatory synaptic input onto neurons, and are biochemically isola

198 orporated biological detail using sequential synaptic input onto spines in morphologically, electrica

199 on of any neuron is to uncover the source of synaptic input onto the cell, its intrinsic physiology a

200 mously in VIP neurons to increase inhibitory synaptic input onto these neurons.

201 ion, may reflect near-synchronous excitatory synaptic inputs onto cortical pyramidal neurons.

202 el indicates that the spatial arrangement of synaptic inputs onto dendrites could play a significant

203 fic and reversible elimination of inhibitory synaptic inputs onto genetically determined neurons.

204 reorganizations of excitatory and inhibitory synaptic inputs onto glutamatergic and GABAergic neurons

205 ncreased excitatory and decreased inhibitory synaptic inputs onto granule cells of Pafah1b1(+/-) mice

206 ones suppress both excitatory and inhibitory synaptic inputs onto layer 2/3 cells ("network suppressi

207 opment of local versus long-range excitatory synaptic inputs onto layer 2/3 neurons in the somatosens

208 Emerging evidence suggests that central synaptic inputs onto motor neurons (MNs) play an importa

209 io of the overall excitatory over inhibitory synaptic inputs onto NAc principle neurons after SDe.

210 , NMDAR signaling via activity of long-range synaptic inputs onto neurogliaform cells is required for

211 patiotemporal origin, and contributions from synaptic input or action potential (AP) output.

212 es control over the nonlinear integration of synaptic input or the initiation and backpropagation of

213 s, however, the developmental time course of synaptic input organization of NAG neurons in mice is un

214 These experiments show that integration of synaptic inputs over time by Nav1.7 is critical for body

215 Simulations of such constrained synaptic input patterns predicted that inactivation of L

216 rises from highly specialized spatiotemporal synaptic input patterns.

217 Alterations in synaptic input, persisting for hours to days, elicit hom

218 hearing loss, which reveal that cholinergic synaptic inputs re-emerge during aging.

219 ct with subsequent excitatory and inhibitory synaptic inputs remains unknown.

220 Loss of inhibitory synaptic input resulted in increased excitability of SST

221 and K(+) conductances suppress low-frequency synaptic inputs, so cells with larger voltage-gated cond

222 We find that synaptic input sources of excitatory neurons span the ra

223 KO mice showed a greatly enhanced excitatory synaptic input strength in neurons of the lateral superi

224 e into GABAergic neuron subtypes and receive synaptic inputs, suggesting functional integration into

225 Therefore, our study on spontaneous synaptic inputs suggests a different extent of synaptic

226 Neurons outside clusters had weaker synaptic input than neurons within clusters, in which in

227 erent pyramidal neuron subtypes also receive synaptic inputs that are dissimilar in frequency and in

228 porally structured excitatory and inhibitory synaptic inputs that are driven by ipsi- and contralater

229 eceive barrages of excitatory and inhibitory synaptic inputs that depolarize many neurons to spike th

230 ion conductances, inhibitory and excitatory synaptic inputs that differ among this cell population.

231 d position-specific patterns of granule cell synaptic inputs that do not strictly match with anatomic

232 respond closely to differences in excitatory synaptic input the cells receive.

233 als in a pacemaker pattern in the absence of synaptic input, the intrinsic properties that underlie t

234 In addition, for two near-simultaneous synaptic inputs, the window of coincidence detection wid

235 elated well with the spatial organization of synaptic input: the inhibitory visual RF in complex cell

236 ntaneous activity of GoCs and the excitatory synaptic input they receive.

237 ndividual neurons integrate the thousands of synaptic inputs they receive is critical to understandin

238 tentiation and depression, so that the total synaptic input to a cell remains preserved despite poten

239 mechanisms best tuned to temporal pattern of synaptic input to achieve long-lasting LTP and memory st

240 natomy with targeted genetic manipulation of synaptic input to an identified Drosophila neuron, we sh

241 different levels of voluntary and tremulous synaptic input to antagonistic motoneuron pools on the t

242 ediate separate components of the excitatory synaptic input to AOFF-S RGCs.

243 eurons, it is proposed that this occurs when synaptic input to cortex is strong yet decorrelated.

244 results provide the first evidence that late synaptic input to corticospinal neurons may represent a

245 at, during periods of basal respiration, the synaptic input to GCs was strongly phase modulated, lead

246 y in the olfactory bulb, and perturbation of synaptic input to granule cells significantly alters olf

247 The summed synaptic input to individual neurons reliably predicted

248 des an accurate representation of the common synaptic input to motoneurons.

249 ll signaling in shaping the excitability and synaptic input to motor neurons.SIGNIFICANCE STATEMENT W

250 xia caused a loss of GABAA receptor-mediated synaptic input to NG2 cells, extensive proliferation of

251 may contribute to potentiated glutamatergic synaptic input to PVN presympathetic neurons and elevate

252 However, the numerically dominant synaptic input to thalamocortical neurons comes from the

253 s, which supply the sole descending cortical synaptic input to thalamocortical relay cells and reticu

254 we determined the neuronal classes providing synaptic input to the CSDns within the antennal lobe (AL

255 The largest synaptic input to the sleep-promoting ventrolateral preo

256 receptors, and decreases afferent excitatory synaptic input to these neurons.

257 rotransmission in which the strengths of all synaptic inputs to a cell are multiplicatively scaled up

258 ative increase in the strength of excitatory synaptic inputs to a neuron as a compensatory response t

259 We found that the excitatory synaptic inputs to both orexin- and melanin-concentratin

260 multiple presynaptic neurons at thousands of synaptic inputs to control downstream communication to t

261 othesized that BOLD reflects the strength of synaptic inputs to cortex, whereas NBG is more dependent

262 in the balance of excitatory and inhibitory synaptic inputs to dopamine neurons.

263 tic tracing, since it permits the mapping of synaptic inputs to genetically marked neurons.

264 ons also included interneurons that provided synaptic inputs to motor neurons, but the pharmacologic

265 pects of inferred inputs are consistent with synaptic inputs to MSO neurons including the tendencies

266 r deprivation) is a rapid loss of excitatory synaptic inputs to parvalbumin-expressing (PV) inhibitor

267 hy by mapping the locations and strengths of synaptic inputs to pyramidal and parvalbumin (PV)-expres

268 Synaptic inputs to rate-coding neurons arose in part fro

269 te uncaging to map excitatory and inhibitory synaptic inputs to single excitatory neurons throughout

270 ON cell loses proportionately more SNR from synaptic inputs to spike output than the OFF cell does.

271 rientation tuning and spatial arrangement of synaptic inputs to the dendritic spines of individual py

272 The spatiotemporal pattern of synaptic inputs to the dendritic tree is crucial for syn

273 te that optogenetically activated long-range synaptic inputs to the inferior olive, including project

274 t the vHPC projects functional glutamatergic synaptic inputs to the lateral septum (LS) and optogenet

275 RX-1/Iroquois, allowing the repositioning of synaptic inputs to the ventral side.

276 o examine whether changes in the strength of synaptic inputs to these circuits contribute to this imb

277 he ventral tegmental area (VTA), potentiated synaptic inputs to VTA dopaminergic neurons, and induced

278 utput' method (or TRIO method) enables trans-synaptic input tracing from specific subsets of neurons

279 cally attributed to an increase in GABAergic synaptic input triggered by non-preferred stimuli.

280 independent dual-channel photostimulation of synaptic inputs using ChR2 together with ReaChR, a red-s

281 nally, we examined spiking and motor-related synaptic inputs using intracellular recordings during si

282 chelators, CaMKII activation dynamics due to synaptic input via n-methyl-d-aspartate receptors are qu

283 The potentiated synaptic input was not initially coincident with action

284 n weakening (>/=5 d), whereas whisker-evoked synaptic input was reduced during both periods.

285 which CCK increased excitatory glutamatergic synaptic inputs was reduced; (iii) the tonic activation

286 Because NO acts independently of synaptic inputs, we hypothesized that ion channels prese

287 inal dendritic branches, and total number of synaptic inputs were accompanied by cell type-specific c

288 that an ON-Alpha ganglion cell's excitatory synaptic inputs were described by a divisive interaction

289 l, visually evoked excitatory and inhibitory synaptic inputs were potentiated by visual experience an

290 Synaptic inputs were preferentially located on numerous

291 Synaptic inputs were reliably induced by repetitive stim

292 al discharge, and received strong excitatory synaptic input, whereas the remainder exhibited hyperpol

293 These D2R-induced ADPs only occur following synaptic input, which activates NMDARs, even when the de

294 to light decrements; and (5) distribution of synaptic inputs, which generate a color-opponent recepti

295 states promote the weakening of subthreshold synaptic inputs, while suprathreshold inputs are preserv

296 enshaw cells received spontaneous inhibitory synaptic input with a reduced frequency, showed lower in

297 Active integration of synaptic input within the inferior olive may play a cent

298 ated with the spatial clustering of co-tuned synaptic inputs within the dendritic field.

299 stence of a scaffold of neurons that receive synaptic inputs within the rat, mouse, and human fetal R

300 This depression of inhibitory synaptic input would be expected to increase excitabilit