ライフサイエンスコーパス: synaptic membrane

1 zation of numerous signaling proteins in the synaptic membrane.

2 sis for activity-associated replenishment of synaptic membrane.

3 tion, thus inhibiting their recycling to the synaptic membrane.

4 boutons, indicating an inability to retrieve synaptic membrane.

5 PICK1-dependent transport of GluR2 from the synaptic membrane.

6 he functional signaling nanostructure of the synaptic membrane.

7 ustering or a selective stabilization in the synaptic membrane.

8 from the subsynaptic nuclei to the overlying synaptic membrane.

9 ic interactions with the lipid matrix of the synaptic membrane.

10 phatidylinositol trisphosphate (PIP3) in the synaptic membrane.

11 ultiple protein kinase (PK)C isozymes to the synaptic membrane.

12 and Rab4-mediated recycling of AMPARs to the synaptic membrane.

13 a reduced rate of recycling of internalised synaptic membrane.

14 by Rab8, drives receptor insertion into the synaptic membrane.

15 mediated by reverse signaling into the post-synaptic membrane.

16 on clusters of interacting receptors in the synaptic membrane.

17 l nitric oxide synthase (nNOS) from the post-synaptic membrane.

18 acetylcholine receptors (AChRs) at the post-synaptic membrane.

19 of NMDA receptors to both extrasynaptic and synaptic membranes.

20 low values, such as in synaptic vesicles or synaptic membranes.

21 y of alkylphenol-based anesthetic binding to synaptic membranes.

22 0.2 +/- 1.8%, respectively, of that in crude synaptic membranes.

23 ween the two processes typically observed in synaptic membranes.

24 a KD value (12 nM) which was 9-fold that for synaptic membranes.

25 other constituents of Torpedo electric organ synaptic membranes.

26 ion of lipid composition and organization in synaptic membranes.

27 s alpha1 and alpha7 integrins are present in synaptic membranes.

28 g PDE10A to a specific functional context at synaptic membranes.

29 on is particularly reduced in frontal cortex synaptic membranes.

30 s to exocytosis of GluN1-GluN2B receptors to synaptic membranes.

31 s system, particularly in photoreceptors and synaptic membranes.

32 zing phosphatides, the major constituents of synaptic membranes.

33 elial cells, cultured neurons, and rat brain synaptic membranes.

34 in clustering the transmembrane proteins in synaptic membranes.

35 N-cadherin may reflect dynamic regulation of synaptic membrane adhesion, which, in turn, might modula

36 ubcellular fractionation was used to isolate synaptic membranes; alternatively, membrane receptors we

37 f proteins that target NMDA receptors to the synaptic membrane and couple it to numerous signal trans

38 rm depression by stabilizing cadherin at the synaptic membrane and impairing AMPA receptor endocytosi

39 function as cell-adhesion molecules at post-synaptic membrane and play critical roles in synaptogene

40 cluding components of the basal lamina, post-synaptic membrane and post-synaptic cytoskeleton.

41 bution studies show that SALM1 is present in synaptic membrane and postsynaptic density fractions but

42 of developmental remodeling in reconstituted synaptic membranes and observe remarkably stable microdo

43 ion of STEP prevents the loss of NMDARs from synaptic membranes and reverses behavioral deficits in N

44 4.16; Nln) was first identified in rat brain synaptic membranes and shown to ubiquitously participate

45 nal transit through the actin-rich IS to the synaptic membrane, and can be defective in the context o

46 by the insertion of AMPAR subunits into the synaptic membrane, and we found that repeated systemic a

47 of receptors occurs at both synaptic and non-synaptic membranes, and glutamate receptors can exchange

48 Mammalian synaptic membranes appear to contain high proportions of

49 t target AMPA receptors for removal from the synaptic membrane are incompletely understood.

50 utamate-binding protein complex in rat brain synaptic membranes are described.

51 the fusion of neurotransmitter vesicles with synaptic membranes, are also needed for the prior tether

52 drebrin A in 2xKI mice was located near the synaptic membrane, as compared to those of WT mice.

53 ed due to increased levels of both total and synaptic membrane-associated dopamine transporters.

54 s, but not NMDARs, cycle into and out of the synaptic membrane at a rapid rate and that certain forms

55 STX-3 is a synaptic membrane-bound protein involved in the effects

56 laced nearly all of the [35S]TBPS binding to synaptic membranes but had no effect on binding to coate

57 tion may underlie the removal of AMPARs from synaptic membrane by Abeta.

58 ectodomain, which is released from the post-synaptic membrane by the SUP-17/ADAM10 protease.

59 ilar to corresponding structures observed in synaptic membranes can be generated on protein-free lipo

60 Relative to the levels in synaptic membranes, CCVs contained 110 +/- 14% and 29.5

61 w affinity phencyclidine-binding entity in a synaptic membrane complex.

62 demonstrate that a treatment that increases synaptic membrane content can enhance cognitive function

63 ransport of NMDA receptors in and out of the synaptic membrane contributes to several forms of long-l

64 rch3.0, eNpHR3.0) tools to create a slow non-synaptic membrane current in bystander neurons, which ma

65 slices with Tat-H-Ras depleted NR2A from the synaptic membrane, decreased endogenous Src activity and

66 glutamatergic terminals display asymmetrical synaptic membrane densities with postsynaptic dense bodi

67 pleomorphic synaptic vesicles and symmetric synaptic membrane densities.

68 tic cell adhesion molecule Fasciclin II, and synaptic membrane detachment at active zones.

69 f vesicles containing TCRzeta and LAT at the synaptic membrane determines not only the nanoscale orga

70 e quantify the comprehensive lipidome of rat synaptic membranes during postnatal development and obse

71 2+)-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis.

72 ab3A has been postulated to cycle on and off synaptic membranes during the course of neurotransmissio

73 and of proteins that are concentrated within synaptic membranes (e.g., PSD-95, synapsin-1), improved

74 -ir (i.e., within 60 nm of the pre- and post-synaptic membranes), E treatment increased synaptic ERbe

75 a key omega-3 polyunsaturated fatty acid in synaptic membranes, enhances the agonist-induced transit

76 when the plasma membrane was separated into synaptic membrane-enriched and extrasynaptic membrane-en

77 ased throughout the neuron, including in the synaptic membrane-enriched fraction.

78 1 on GluR1 was decreased specifically in the synaptic membrane-enriched fraction.

79 d by approximately 100%; (ii) similarly, the synaptic membrane expression of the alpha1 subunit prote

80 aminobutyric acid receptor regulation in the synaptic membrane fraction of the rat mPFC following ext

81 on of pp60c-src with insulin receptor in the synaptic membrane fraction, however, was temporally decr

82 d with its tyrosine dephosphorylation in the synaptic membrane fraction.

83 ation of IR protein in the hippocampal crude synaptic membrane fraction.

84 the microsomal fraction but insoluble in the synaptic membrane fraction.

85 oligomers, and oligomers are enriched in the synaptic membrane fraction.

86 Orb2A is also found enriched in the synaptic membrane fraction.

87 of Shc-66, Shc-52, and Grb-2 in hippocampal synaptic membrane fractions following training.

88 luble in Triton X-100 in both microsomal and synaptic membrane fractions, while NR1 was readily solub

89 in coimmunoprecipitates with syndecan-2 from synaptic membrane fractions.

90 brane fusion is constitutively active, while synaptic membrane fusion is regulated, consistent with t

91 this process is implicated in regulation of synaptic membrane fusion that may be altered by aggregat

92 Syntaxin 1, an essential protein in synaptic membrane fusion, contains a helical autonomousl

93 nts of the protein machinery responsible for synaptic membrane fusion.

94 For [3H]flunitrazepam binding to synaptic membranes, GABA gave an EC50 = 2.0 microM and a

95 Mechanisms that target PSD-95 to synaptic membranes, however, are unknown.

96 DiTC binding to human brain synaptic membranes identifies channels composed of other

97 interaction of the peptidic conantokins with synaptic membranes in conjunction with a high affinity b

98 ulin also can cause Rab3A to dissociate from synaptic membranes in vitro.

99 been shown to cause Rab3A to dissociate from synaptic membranes in vitro.

100 Rs1 was associated with the outer surface of synaptic membranes in wild-type (Wt) retinas.

101 Rab8 is localized in close proximity to the synaptic membrane, including the postsynaptic density.

102 , long-term depression (LTD) promoted ADAM10 synaptic membrane insertion and stimulated its activity.

103 MPA-type glutamate receptors (AMPARs) to the synaptic membrane is a key mechanism to determine the st

104 ivery of neurotransmitter receptors into the synaptic membrane is essential for synaptic function and

105 CLASP2-mediated microtubule capturing at the synaptic membrane is essential for the maintenance of a

106 e binding of [(3)H]flumazenil to hippocampal synaptic membranes is decreased.

107 dopamine D4 receptor (hD4R) is maintained in synaptic membranes is not known.

108 f these processes by proteomically analyzing synaptic membranes lacking the synaptogenic adhesion mol

109 ation of NR2A and retention of NR2A into the synaptic membrane leading to inhibition of NMDA receptor

110 ARs) from Rab11-recycling endosomes into the synaptic membrane, leading to synaptic potentiation.

111 olumns that had been loaded with solubilized synaptic membranes; lesser concentrations of three polyp

112 ber of factors, including stimulus strength, synaptic membrane noise and especially whether or not th

113 forms protein accumulations that localize to synaptic membranes, nuclei and endosomes.

114 cellular fractions, homogenate, cytosol, and synaptic membranes, obtained from F344/BNF1 rats of 5-6,

115 show that APP/Bri2 complexes are reduced in synaptic membranes of FDD(KI) mice.

116 d enriched progressively in synaptosomes and synaptic membranes of sheep brain, as assessed by immuno

117 s are relatively fixed, AMPA receptors cycle synaptic membranes on and off.

118 ent the structural abnormalities of the post-synaptic membrane or the abnormal oxidative properties o

119 s by which clathrin-coated vesicles retrieve synaptic membranes or take up endocytic receptors have b

120 aptically, being frequently localized on the synaptic membranes or the synaptic junctional complex.

121 the postsynaptic density (30-60 nm from the synaptic membrane) positively correlated with DR perform

122 is modified when it is incorporated into the synaptic membrane, possibly by strengthening its interac

123 1) and GluR2/3 subunits of AMPA receptors in synaptic membrane preparations, whereas no change was ob

124 ls, transfected HEK-293 cells, and rat brain synaptic membrane preparations.

125 Hence, the quantity of synaptic membrane probably increased.

126 erations in cochlear mechanics, hair cell or synaptic membrane properties, hair cell innervation, or

127 ntribute to autistic phenotype by modulating synaptic membrane protein expression and neurotransmitte

128 proteins synaptophysin and synaptotagmin; a synaptic membrane protein, plasma membrane-associated pr

129 pose that a presynaptic Ank2-L lattice links synaptic membrane proteins and spectrin to the underlyin

130 The synaptic membrane proteins synaptobrevin, syntaxin, and

131 The synaptic membrane proteins syntaxin, 25K synaptosome-ass

132 We demonstrate here that turnover of synaptic membrane proteins via the endolysosomal pathway

133 ccumulate K63-polyubiquitylated proteins and synaptic membrane proteins, disrupting synaptic vesicle

134 axonal transport cargoes including vesicles, synaptic membrane proteins, mitochondria and prelysosoma

135 plays an instructive role in the turnover of synaptic membrane proteins.

136 nt role in the targeting and localization of synaptic membrane proteins.

137 or optimal TCR-induced actin polymerization, synaptic membrane raft polarity, and function in CD8, bu

138 Thus, as with exocytosis, mechanisms of synaptic membrane retrieval may be tuned by the precise

139 neity in the molecular mechanisms underlying synaptic membrane retrieval, even among synapses with si

140 Photoreceptor and synaptic membranes share the highest content of DHA of a

141 In the nervous system, modification of synaptic membrane size has a major impact on synaptic fu

142 poE KO mice to determine the role of apoE in synaptic membrane structure and to determine susceptibil

143 NSF's synaptic membrane substrate, the ternary SNARE complex c

144 calcium channels and as a regulator of post-synaptic membrane targeting for alpha-amino-3-hydroxyl-5

145 now identified a novel alphaGDI complex from synaptic membranes that contains three chaperone compone

146 implicated in regulating NMDAR stability in synaptic membrane, the role of microtubules in regulatin

147 acilitated by the recruitment of PTPalpha to synaptic membranes, the compartment where Fyn resides.

148 But, in synaptic membranes, there was an age-related decrease in

149 Thus, in comparison to GABAA receptors on synaptic membranes, those on CCVs have a reduced alpha 1

150 governed by receptor cycling on and off the synaptic membrane through its interaction with glutamate

151 ate that Rab3 is not in itself essential for synaptic membrane traffic but functions to modulate the

152 ught to play an important regulatory role in synaptic membrane traffic.

153 on of Shrub levels in the FXS model prevents synaptic membrane trafficking defects and strongly resto

154 We analyzed whether synaptic membrane trafficking proteins are substrates fo

155 of AMPA receptors are rapidly upregulated in synaptic membranes under conditions associated with pote

156 ttachment of [125I]DTXk bound to channels in synaptic membranes unveiled subunits of Mr = 78 000 and

157 Clathrin and alpha-adaptin relocalization to synaptic membranes upon nerve stimulation.

158 Association of beta8 with synaptic membranes was further supported by its enrichme

159 [(3)H]Fluorowillardiine binding to rat synaptic membranes was increased by D1 by a factor of 3.

160 GLR-1 is localized on synaptic membranes, where it regulates reversals of loco

161 horylated enzyme preferentially localizes to synaptic membranes, whereas phosphorylated GRK5 is found

162 els of GluN2B subunits were decreased in the synaptic membrane, while levels of C2'-containing GluN1

163 e, ephrinB ligands are localized to the post-synaptic membrane, while their cognate Eph receptors are

164 Treatment of synaptic membranes with calpain I resulted in truncation

165 Pre-incubation of synaptic membranes with phosphatase inhibitors significa

166 e accumulation of recycled AChRs in the peri-synaptic membrane without affecting the pre-existing ACh