ライフサイエンスコーパス: synaptic potentiation

1 , endosome recycling, AMPAR trafficking, and synaptic potentiation.

2 LP-12 secretion and blocked aldicarb-induced synaptic potentiation.

3 panied by a decrease in the initial phase of synaptic potentiation.

4 ic transmission, adjusting the threshold for synaptic potentiation.

5 ion inhibited neuroligin-mediated excitatory synaptic potentiation.

6 minished by nicotine during the induction of synaptic potentiation.

7 in the dentate gyrus during the drug-induced synaptic potentiation.

8 nit composition to occur in conjunction with synaptic potentiation.

9 hift to a high-conductance state, leading to synaptic potentiation.

10 ity of CA1 pyramidal cells in the absence of synaptic potentiation.

11 rafficking routes to the temporal profile of synaptic potentiation.

12 ynapse stabilization after initial phases of synaptic potentiation.

13 lecules are involved in a single pathway for synaptic potentiation.

14 , uncovering the full extent of 5-HT-induced synaptic potentiation.

15 term potentiation, blocked experience-driven synaptic potentiation.

16 f action potentials were necessary to induce synaptic potentiation.

17 occluded both tetanus and forskolin-induced synaptic potentiation.

18 ired for the expression of multiple forms of synaptic potentiation.

19 croM) enhanced EPSCs and occluded PS-induced synaptic potentiation.

20 ry and sufficient to mediate the NT3-induced synaptic potentiation.

21 n are implicated in this rapamycin-sensitive synaptic potentiation.

22 eby prevented or diminished the induction of synaptic potentiation.

23 n of BAPTA (10 mM) with adenophostin blocked synaptic potentiation.

24 yanodine receptors, prevents the NT3-induced synaptic potentiation.

25 Thus, NO is necessary for Ca(2+)/CaM-induced synaptic potentiation.

26 E with Ca(2+)/CaM blocked Ca(2+)/CaM-induced synaptic potentiation.

27 D-Fe or carboxy-PTIO blocked tetanus-induced synaptic potentiation.

28 a retrograde messenger in Ca(2+)/CaM-induced synaptic potentiation.

29 ellular) messenger during Ca(2+)/CaM-induced synaptic potentiation.

30 ory behavior, boosting of calcium entry, and synaptic potentiation.

31 ties for synaptic tagging and maintenance of synaptic potentiation.

32 sant effect of ketamine results from delayed synaptic potentiation.

33 ished activity-induced spine enlargement and synaptic potentiation.

34 somes into the synaptic membrane, leading to synaptic potentiation.

35 e firing threshold remained unchanged during synaptic potentiation.

36 t, AMPA receptor synaptic incorporation, and synaptic potentiation.

37 s to the plasma membrane, and maintenance of synaptic potentiation.

38 ns, and a lowered threshold for induction of synaptic potentiation.

39 suppressed rCASP6 but not TNF-alpha-induced synaptic potentiation.

40 al conditions and conditions that can induce synaptic potentiation.

41 ating release of the Zn(2+) from vesicles in synaptic potentiation.

42 reduction in neuroligin-mediated excitatory synaptic potentiation.

43 pply of a mobile pool of AMPARs required for synaptic potentiation.

44 ution of the receptors, and favors long-term synaptic potentiation.

45 educing the threshold for activity-dependent synaptic potentiation.

46 , both seizures and interictal spikes induce synaptic potentiation.

47 amidal neurons show attenuation of long-term synaptic potentiation, a model for neuronal information

48 ly widespread changes accompanying long-term synaptic potentiation also reduced the neuron's ability

49 ment (NREM) sleep enhance previously induced synaptic potentiation, although synaptic de-potentiation

50 Following synaptic potentiation, AMPARs in intracellular pools con

51 lyculin A, this treatment induced a LTP-like synaptic potentiation and a persistent increase in autop

52 cellular excitability necessary for inducing synaptic potentiation and accelerates the decay of long-

53 slational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.

54 medial perforant path, which induced normal synaptic potentiation and Arc in rats with fornix lesion

55 rol were more susceptible to cocaine-induced synaptic potentiation and behavior.

56 lular studies of protein synthesis-dependent synaptic potentiation and behavioural studies of memory

57 LTP induction are necessary for stabilizing synaptic potentiation and by inference may be required f

58 ss modulates neuronal transcription to favor synaptic potentiation and counteract cellular stress, wh

59 sponsible primarily for generating long-term synaptic potentiation and depression, AMPARs are the mai

60 otransmitter release, induction of long-term synaptic potentiation and depression, and activity level

61 NMDA receptors are necessary for both synaptic potentiation and depression, but the precise lo

62 removal of GluR2-containing AMPA-Rs mediate synaptic potentiation and depression, respectively.

63 ve or instructive role on activity-dependent synaptic potentiation and depression, which depends on t

64 behavior, manifested in part by dysregulated synaptic potentiation and extracellular glutamate homeos

65 precede and may initiate this developmental synaptic potentiation and functional tuning.

66 Synaptic potentiation and GluR1 delivery were dissociabl

67 that the enduring cocaine-induced changes in synaptic potentiation and glutamate homeostasis are mech

68 es that are known to contribute to long-term synaptic potentiation and hypothesized to subserve learn

69 echanism will be a key target for modulating synaptic potentiation and learning.

70 uA4 in CA1 neurons conferred a PKA-dependent synaptic potentiation and LTP regardless of the developm

71 r LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during syn

72 hreshold for hippocampal-dependent long-term synaptic potentiation and memory storage in mice.

73 ependent kinase II (CaMKII) has key roles in synaptic potentiation and memory storage in neurons and

74 reward signal, broadens the time window for synaptic potentiation and modulates the outcome of hippo

75 e suppression of both previously established synaptic potentiation and old spatial memory.

76 lower induction threshold for both long-term synaptic potentiation and plasticity-induced spine growt

77 nteractions in mechanisms underlying sensory synaptic potentiation and provide insights into the path

78 ally is sufficient to recapitulate transient synaptic potentiation and reinstate cocaine seeking.

79 nstrate the sequence of events that mediates synaptic potentiation and reinstated cocaine seeking ind

80 evidence that waking is associated with net synaptic potentiation and sleep with depression, direct

81 accompanied by impairments in CA1 long-term synaptic potentiation and spatial memory consolidation.

82 ng evidence that BDNF plays a causal role in synaptic potentiation, and exogenous application of BDNF

83 tion-induced LTP, both spine enlargement and synaptic potentiation are transient.

84 tch recordings suggested that the deficit in synaptic potentiation arose from shunting of dendritic E

85 AEPs after drug elimination, consistent with synaptic potentiation as a mechanism for antidepressant

86 Interestingly, reversal of synaptic potentiation as well as de novo synaptic depres

87 In particular, whisker experience drives synaptic potentiation as well as the incorporation of CP

88 wakefulness, many cortical circuits undergo synaptic potentiation, as evidenced by the widespread in

89 e concurrent stresses resulting from loss of synaptic potentiation associated with disrupted structur

90 n-derived neurotrophic factor (BDNF) induces synaptic potentiation at both neuromuscular junctions (N

91 rsting activity is necessary for associative synaptic potentiation at CA1 excitatory synapses in adul

92 These data demonstrate that synaptic potentiation at CA1 synapses is more complex th

93 GluR1 AMPA receptors underlies many forms of synaptic potentiation at glutamatergic synapses througho

94 f beta2-adrenoceptors promoted STD long-term synaptic potentiation at mouse hippocampal excitatory sy

95 Synaptic potentiation at PF-PC synapses, induced by the

96 n also significantly reduce the magnitude of synaptic potentiation at SC-CA1 synapses.

97 We find that aSyn induces synaptic potentiation at the larval neuromuscular juncti

98 dence for an unusual mechanism that mediates synaptic potentiation at the neuromuscular junction (NMJ

99 tes for BDNF-induced Ca2+ elevation and full synaptic potentiation at the NMJ, suggesting a previousl

100 cluding GABA receptors, glutamate signaling, synaptic potentiation, axon guidance, clathrin-mediated

101 learning-induced enhancement limits further synaptic potentiation, but not synaptic depression.

102 fore, the contribution of CLC-3 is to reduce synaptic potentiation by approximately 40%.

103 tic cytosolic Ca2+ ([Ca2+]i) accompanied the synaptic potentiation by BDNF, whereas no change in [Ca2

104 by a cocaine-priming injection, coordinated synaptic potentiation by both NAcore afferents is necess

105 eas no change in [Ca2+]i was observed during synaptic potentiation by CNTF.

106 on, RAP also blocked the enhancing effect of synaptic potentiation by exogenous tPA in hippocampal sl

107 sGRF2's Rac-GEF activity to be essential for synaptic potentiation by using a molecular replacement s

108 ling models have more recently proposed that synaptic potentiation can occur by the recruitment of ad

109 nd sufficient to drive spine enlargement and synaptic potentiation concomitantly.

110 Synaptic potentiation correlates with an animal's helple

111 se M1 slices that DCS induces a long-lasting synaptic potentiation (DCS-LTP), which is polarity speci

112 ne neurons are necessary for cocaine-induced synaptic potentiation, demonstrating that cell type-spec

113 mature death) and showed impaired short-term synaptic potentiation; downregulation of photoreceptor-s

114 ram slow wave activity during sleep reflects synaptic potentiation during wake, and that its homeosta

115 Another possibility is net synaptic potentiation during wake: stronger coupling amo

116 ARs, CamKII and GSK3beta are consistent with synaptic potentiation during wakefulness and depression

117 that sleep SWA homeostasis may be related to synaptic potentiation during wakefulness.

118 It has been postulated that synaptic potentiation during waking is offset by a homoe

119 proteasome inhibition on the early phase of synaptic potentiation (E-LTP) induced by theta-burst sti

120 als, but clustered in bursts, induced robust synaptic potentiation (EPSP amplitude 163%; P < 0.01, St

121 molecular mechanism underlying BDNF-induced synaptic potentiation, especially the regulation of Ca2+

122 ted that D1-type receptor activation enabled synaptic potentiation even when postsynaptic activity pr

123 y-PTIO) did not attenuate Ca(2+)/CaM-induced synaptic potentiation, even though MGD-Fe or carboxy-PTI

124 spaced training regimen designed to maximize synaptic potentiation facilitates recognition memory in

125 begins in the axon, but which can influence synaptic potentiation following active backpropagation i

126 ipation of protein kinase Mzeta (PKMzeta) in synaptic potentiation following cocaine exposure.

127 re, the relative effect of a single spike on synaptic potentiation grows as radicalN.

128 aptic plasticity (specifically, long-lasting synaptic potentiation) have been demonstrated to accompa

129 lated by endogenous estradiol, which favored synaptic potentiation in a GluN2B-dependent manner.

130 activity--postsynaptic bursting--accompanies synaptic potentiation in adults.

131 and VAMP7 occludes NMDAR antagonist-induced synaptic potentiation in an intact circuit, confirming t

132 ng the previous waking period, of widespread synaptic potentiation in cortical and subcortical areas.

133 caine-elicited, but not the stress-elicited, synaptic potentiation in DA neurons was blocked by a D1-

134 ceptor beta (ERbeta) but not ERalpha rescued synaptic potentiation in diestrus mice by enhancing GluN

135 ue method for inducing spine enlargement and synaptic potentiation in dispersed hippocampal neurons,

136 FK-506 or an autoinhibitory peptide induced synaptic potentiation in hippocampal slices, which occlu

137 aining integrins are required for persistent synaptic potentiation in hippocampus and regulate hippoc

138 d Ca(2+) channels were involved in mediating synaptic potentiation in oriens, whereas NMDA and adenos

139 Hebbian plasticity to facilitate associative synaptic potentiation in prefrontal excitatory circuits.

140 d activation of NMDA receptors, facilitating synaptic potentiation in response to stimulation at 10-1

141 the balance from synaptic depression towards synaptic potentiation in sleep-promoting neurons underli

142 get of rapamycin kinase activity, suppressed synaptic potentiation in slices from fear-conditioned ra

143 mature spine morphology but can also enhance synaptic potentiation in some cases.

144 of PS-, adenophostin- or Ca(2+)-CaM-induced synaptic potentiation in SP non-pyramidal neurons increa

145 that up-regulated GluN2A, GluN2B, and rapid synaptic potentiation in the accumbens contribute to cue

146 eftriaxone also reversed the cocaine-induced synaptic potentiation in the accumbens core, evidenced b

147 suggest that 11beta-HSD1 deficiency enhances synaptic potentiation in the aged hippocampus and this m

148 CREB activation by fear conditioning and synaptic potentiation in the amygdala and cortical areas

149 tly, the high frequency stimulation-mediated synaptic potentiation in the hippocampal CA1 region was

150 Moreover, impaired synaptic potentiation in the hippocampal CA1 subregion w

151 n early, projection-specific, cocaine-evoked synaptic potentiation in the LHb that may represent a pe

152 ne receptor stimulation is necessary for the synaptic potentiation in the NAcore during cocaine-induc

153 hat CREB-mediated pathways may contribute to synaptic potentiation in these cells.

154 g changes implicated previously in models of synaptic potentiation in vitro.

155 Such persistent synaptic potentiation in VTA DA neurons may represent a

156 Specifically, network synaptic potentiation increases dramatically with high c

157 a(2+) chelators blocks LTD and drives strong synaptic potentiation, indicating that basal Ca(2+) leve

158 but that PKC activators produce a reversible synaptic potentiation, indicating that PKC activation is

159 , ceftriaxone did not reverse stress-induced synaptic potentiation, indicating that this effect of st

160 In parallel, synaptic potentiation induced by a single tetanic stimul

161 Rapamycin also blocks the synaptic potentiation induced by brain-derived neurotrop

162 Synaptic potentiation induced by brain-derived neurotrop

163 Synaptic potentiation induced by FK-506 was significantl

164 way that is mechanistically very similar to synaptic potentiation induced by oxytocin, Avpr1b agonis

165 T-type current blockade also prevented synaptic potentiation induced by postsynaptic action pot

166 nant negative TrkB.T1 inhibited two forms of synaptic potentiation induced by the neurotrophin brain-

167 also sharpened the STDP curve, with reliable synaptic potentiation induced only when EPSPs and action

168 as necessary for reinstatement, it inhibited synaptic potentiation initiated by an acute cocaine inje

169 stimulation that normally induces long-term synaptic potentiation instead promoted development of ca

170 Our study suggests that BDNF-induced synaptic potentiation involves coordinated presynaptic a

171 mediated glutamatergic neurotransmission via synaptic potentiation is central to the antidepressant e

172 The results show that CP-AMPAR-mediated synaptic potentiation is common in hippocampal interneur

173 and translation-dependent phase of long-term synaptic potentiation (L-LTP) at the Schaffer collateral

174 PKR increases the late phase of long-lasting synaptic potentiation (L-LTP) in hippocampal slices.

175 tions in synaptic strength such as long-term synaptic potentiation (LTP) and depression (LTD) underli

176 xplain the selective activation of long-term synaptic potentiation (LTP) and long-term depression (LT

177 the UPS to mediate the effects on long-term synaptic potentiation (LTP) has not been investigated.

178 In addition, social interaction induces synaptic potentiation (LTP) in the ventral tegmental are

179 es of synaptic contacts) and block long-term synaptic potentiation (LTP), a form of synaptic plastici

180 e, we explored the hypothesis that long-term synaptic potentiation (LTP), potentially able to minimiz

181 selective loss of GluR1-dependent long-term synaptic potentiation (LTP).

182 MPAR) currents are associated with long-term synaptic potentiation (LTP).

183 d genetic manipulations to examine long-term synaptic potentiation (LTP)/long-term synaptic depressio

184 At the cellular level, reversal of synaptic potentiation may be important for neurons to ac

185 in neurons expressing PI3K* elicits a marked synaptic potentiation, mimicking the NT3 effect.

186 ds in hippocampal area CA1 are produced by a synaptic potentiation notably different from Hebbian pla

187 Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we concl

188 is complex is not critical for mechanisms of synaptic potentiation occurring in immature animals.

189 The synaptic potentiation occurs postsynaptically and probab

190 Here, we investigated whether E2-induced synaptic potentiation occurs via presynaptic and/or post

191 We also found that disruption of PNNs allows synaptic potentiation of normally plasticity-resistant e

192 ith AMPAR surface diffusion markedly impairs synaptic potentiation of Schaffer collaterals and commis

193 nicotine directly cause in vivo hippocampal synaptic potentiation of the kind that underlies learnin

194 ered to freely moving mice induces long-term synaptic potentiation of the perforant path connection t

195 of that association is the nicotine-induced synaptic potentiation of the perforant path that was fou

196 adenylyl cyclase activator forskolin induced synaptic potentiation of this pathway that also was asso

197 addition, Abeta oligomers blocked long-term synaptic potentiation only in neurons that expressed Glu

198 Indeed, we observed D1 receptor-dependent synaptic potentiation only when odor-like bursts and opt

199 Sensory experience preferentially produced synaptic potentiation onto nearby dendritic synapses.

200 ers associated with excitatory or inhibitory synaptic potentiation onto principal cells, respectively

201 y an impairment in fear-conditioning-induced synaptic potentiation onto somatostatin-expressing (SOM(

202 In particular, preventing synaptic potentiation onto somatostatin-positive neurons

203 hippocampal neurons, induction of long-term synaptic potentiation or depression by repetitive synapt

204 ro amygdala slice can induce either enduring synaptic potentiation or depression, depending on whethe

205 ng cleavable or uncleavable pro-BDNF elicits synaptic potentiation or depression, respectively.

206 cling processes in basal conditions and upon synaptic potentiation or depression, spatially and tempo

207 aptic neurotransmitter release, resulting in synaptic potentiation or depression.

208 regulated during, other forms of short-term synaptic potentiation or long-lasting synaptic depressio

209 deas about cellular consolidation concerning synaptic potentiation, particularly the relationship bet

210 predictions of dynamic value assignment, the synaptic potentiation persisted after the phasic dopamin

211 Clustered synaptic potentiation produced by experience could bind

212 plasticity provides a natural constraint on synaptic potentiation, regulating the inherent instabili

213 Some forms of activity-dependent synaptic potentiation require the activation of postsyna

214 The induction of synaptic potentiation required excitation of DA neurons

215 eurons in mouse barrel cortex, we found that synaptic potentiation requires postsynaptic, but not pre

216 This cAMP-driven synaptic potentiation requires the activation of both pr

217 a sustained, alpha7*nAChRs-mediated phase of synaptic potentiation seen in comparable WT/WT circuits

218 berrant appearance of spike-timing-dependent synaptic potentiation (STDP) in PFC slices derived from

219 sion loci of the hippocampal and neocortical synaptic potentiation studies we examined.

220 d of inactivity can reduce the threshold for synaptic potentiation such that subsequent visual experi

221 r with the finding that mature BDNF promotes synaptic potentiation, suggest a bidirectional regulatio

222 s correlated with the induction of transient synaptic potentiation (t-SP) at glutamatergic synapses o

223 cue-induced drug seeking requires transient synaptic potentiation (t-SP) of cortical glutamatergic s

224 ic spikes participate generally in a form of synaptic potentiation that does not require postsynaptic

225 present evidence for localized BDNF-induced synaptic potentiation that is accompanied by spatially r

226 ocretin neurons undergo experience-dependent synaptic potentiation that is distinct from that reporte

227 Mature BDNF facilitates hippocampal synaptic potentiation through TrkB.

228 tion contributed to nicotine-induced in vivo synaptic potentiation, thus, likely contributed to drug-

229 erve terminals prevented the tetanus-induced synaptic potentiation (TISP).

230 estriction of putative neurotrophin-mediated synaptic potentiation to active synapses.

231 tatic mechanism that can prevent the runaway synaptic potentiation to which Hebbian networks are vuln

232 sized that increases in cortical SWA reflect synaptic potentiation triggered by learning.

233 ring, which was otherwise too weak to induce synaptic potentiation, triggered a long-lasting increase

234 interneurons received passive propagation of synaptic potentiation via the recurrent collaterals of C

235 om spontaneously recycling vesicles triggers synaptic potentiation via the same pathway as NMDAR bloc

236 This enhancement of synaptic potentiation was absent in mice lacking Egr1.

237 This synaptic potentiation was associated with an increase in

238 FK-506-induced synaptic potentiation was expressed in adult but not you

239 Whereas synaptic potentiation was linked to learned helplessness

240 Synaptic potentiation was normal in these associational

241 A chemical form of synaptic potentiation was produced with a brief bath app

242 lucidate mechanisms underlying CaN-inhibited synaptic potentiation, we co-injected certain agents aff

243 The biologically relevant rules of synaptic potentiation were investigated in hippocampal s

244 y, neural pathways, namely axon-guidance and synaptic potentiation, were also over-represented in MS.

245 etwork firing patterns alter overall network synaptic potentiation when synaptic strengths evolve thr

246 e action potentials was sufficient to induce synaptic potentiation when the presynaptic activity prec

247 akefulness appears to be associated with net synaptic potentiation, whereas sleep may favor global sy

248 to hippocampal CA1 pyramidal neurons induces synaptic potentiation, which can occlude tetanus-induced

249 addition, Ca(2+)-CaM (40:10 microM) induced synaptic potentiation, which occluded PS-induced potenti

250 ted AMPA receptor (AMPAR) trafficking during synaptic potentiation, which was distinct from actin's s

251 ly reduced the magnitude of timing-dependent synaptic potentiation while leaving the magnitude of tim

252 c Ca2+ elevation and restricted BDNF-induced synaptic potentiation, while knockdown of the TrkB recep

253 cy (0.2 Hz), which does not by itself induce synaptic potentiation, will produce long-lasting synapti

254 Thus, the synaptic potentiation within the BNST in response to ILC

255 f carboxy-PTIO alone blocked tetanus-induced synaptic potentiation without affecting basal synaptic t

256 on in cellular excitability in parallel with synaptic potentiation would be a negative feedback mecha