ライフサイエンスコーパス: synaptic protein

1 latory cascade ensuring adequate delivery of synaptic proteins.

2 of dendritic spine, neuronal structures and synaptic proteins.

3 ed by studies of patients lacking individual synaptic proteins.

4 des a powerful tool to study the function of synaptic proteins.

5 e lesion core and express reduced amounts of synaptic proteins.

6 changes coincide with altered expression of synaptic proteins.

7 mics analysis of kinesin complexes are known synaptic proteins.

8 cription factors, other splicing factors and synaptic proteins.

9 closely expression is associated with other synaptic proteins.

10 ts, resulting in increased levels of several synaptic proteins.

11 ta dimers or amyloid-beta trimers and tau or synaptic proteins.

12 showing a significant difference between the synaptic proteins.

13 Abeta oligomer level, and inhibited loss of synaptic proteins.

14 t (within 10 min) in the rate of addition of synaptic proteins.

15 omers, and marked down-regulation of several synaptic proteins.

16 cts were formed on cysteine residues of some synaptic proteins.

17 ophore assisted light inactivation (CALI) of synaptic proteins.

18 are commonly found in genes that encode for synaptic proteins.

19 cription factors, other splicing factors and synaptic proteins.

20 th concomitant increases in cAMP, pCREB, and synaptic proteins.

21 iate with antibodies against cell-surface or synaptic proteins.

22 bens neurons to glutamate, and through other synaptic proteins.

23 retrieve and to recycle vesicle membrane and synaptic proteins.

24 morphology, or the distribution of essential synaptic proteins.

25 f amyloid precursor protein, amyloid-beta or synaptic proteins.

26 tant for trafficking and function of several synaptic proteins.

27 d glutamatergic marker VGluT1, pre- and post-synaptic proteins.

28 glutamatergic synapses and interact with key synaptic proteins.

29 ion of the Golgi apparatus and missorting of synaptic proteins.

30 synaptic adhesion and recruitment of diverse synaptic proteins.

31 ole in the localization and function of many synaptic proteins.

32 c postsynaptic proteins and of glutamatergic synaptic proteins.

33 o chronic pain by regulating the turnover of synaptic proteins.

34 nscriptional and translational regulators to synaptic proteins.

35 s, involving recycling and/or degradation of synaptic proteins.

36 eins expressed in hair cells, including many synaptic proteins.

37 the expression levels of a subgroup of other synaptic proteins.

38 What came first: neurons or synaptic proteins?

39 ted to two distinct classes of transmembrane synaptic proteins: (1) ion channel auxiliary factors suc

40 ochondrial dynamics, biogenesis proteins and synaptic proteins, (3) soluble Abeta levels and immunore

41 Immunoblotting findings of mitochondrial and synaptic proteins agreed with mRNA findings.

42 Immunoblotting findings of mitochondrial and synaptic proteins agreed with the mRNA findings.

43 Synaptic protein alpha-synuclein (alpha-SYN) modulates n

44 These synaptic protein alterations are associated with a defic

45 Similar synaptic protein alterations were also retrospectively s

46 monstrate SubSynMAP, a fast, multiplexed sub-synaptic protein analysis method using wide-field data f

47 owever, the influence of ovarian hormones on synaptic protein and opioid peptide levels in the aging

48 Furthermore, stress-induced deficits in synaptic proteins and decreases in dendritic density and

49 decreased fusion, abnormal mitochondrial and synaptic proteins and defective mitochondrial function i

50 This proteolysis decreases levels of synaptic proteins and diminishes synaptic transmission.

51 un to quantify morphine-regulated changes in synaptic proteins and facilitate the generation of netwo

52 Research has identified synaptic proteins and function as primary contributors t

53 spectrometry, we quantified more than 7,000 synaptic proteins and identified 89 significantly reduce

54 lation of tau and promoted the expression of synaptic proteins and insulin signaling in the brain.

55 st that TOP1 controls the levels of multiple synaptic proteins and is required for normal excitatory

56 constitution of vesicle fusion from purified synaptic proteins and lipids has played a major role in

57 ir cell-like cells had hair bundle proteins, synaptic proteins and membrane proteins characteristic o

58 airs neuronal differentiation, expression of synaptic proteins and neuronal morphology, whereas reduc

59 loss of basal CA1 synaptic strength and key synaptic proteins and reduced the susceptibility to indu

60 vior in female rats, the decline observed in synaptic proteins and spine density in IS and in diestru

61 The diversity of synaptic proteins and synapse types demands synapse anal

62 The images revealed individual synaptic proteins and synaptic protein complex densities

63 observed distinct morphologies of individual synaptic proteins and their complexes.

64 sets of genes including both those encoding synaptic proteins and those expressed during early devel

65 regulates the clustering and recruitment of synaptic proteins and vesicles to the synapse, adjusting

66 synaptic dysfunction, preventing the loss of synaptic proteins and/or have a positive effect on the i

67 s, autophagic/lysosomal dysfunction, loss of synaptic protein, and reduced life-span.

68 of CaMKII are mediated by interactions with synaptic proteins, and activity-triggered translocation

69 (seen by EM in the CA1 region), reduction of synaptic proteins, and localization to the nucleus.

70 ears earlier than the outer plexiform layer, synaptic proteins, and ribbons are first reliably recogn

71 antibodies against neuronal cell surface or synaptic proteins, and the differential diagnosis with i

72 xpression results in increased levels of the synaptic protein Arc and a concomitant impaired synaptic

73 Whereas synaptic proteins are correctly trafficked, photorecepto

74 nhibitory src homology 3 domain, and several synaptic proteins are known to bind to this SH3 domain a

75 -expressed genes enriched for those encoding synaptic proteins are liable to change with age.

76 Other synaptic proteins are normal.

77 early postnatal regulation of mRNAs encoding synaptic proteins are not altered in Fmr1 knockout mice.

78 regulating the surveillance and clearance of synaptic proteins are not well understood.

79 Furthermore, because key synaptic proteins are O-GlcNAcylated, this modification

80 nd signaling also becomes activated when pre-synaptic proteins are over-expressed, suggesting the exi

81 endent proteins is highly induced while some synaptic proteins are repressed in neurons missing the T

82 endent proteins is highly induced while some synaptic proteins are repressed.

83 evidence points toward aberrant activity of synaptic proteins as a critical contributing factor.

84 s a result of decreased levels of functional synaptic proteins as found in autopsied brains of patien

85 et that mediates intermolecular binding with synaptic proteins as resolved in complexes with TARPgamm

86 We used iExM to visualize synaptic proteins, as well as the detailed architecture

87 ctural plasticity of GCNs, and expression of synaptic proteins associated with learning and memory in

88 promoter usage can change the function of a synaptic protein at excitatory synapses.

89 clathrin-specific co-chaperone, such as the synaptic protein auxilin.

90 or-like protein 1 (APLP1) is a transmembrane synaptic protein belonging to the amyloid precursor prot

91 brane molecules (Neurotactin/Neuroglian) and synaptic proteins (Bruchpilot/N-Cadherin).

92 CDKL5 was shown to interact with synaptic proteins, but an in vivo analysis of the role o

93 SD)-linked mutations disrupt the function of synaptic proteins, but no single gene accounts for >1% o

94 s associated with survival and expression of synaptic proteins by nearby second-order neurons.

95 The abundant synaptic protein CaMKII is necessary for long-term poten

96 onstruction microscopy, the distributions of synaptic proteins can be measured with nanometer precisi

97 Previously, we showed that some GABAergic synaptic proteins change across the lifespan, but most s

98 an unbiased proteomic screen and identified synaptic protein changes in alphabetagamma-synuclein kno

99 These patterns of widespread, but diverse synaptic protein changes in response to global perturbat

100 detail the disease caused by absence of the synaptic protein CNKSR2 in 8 patients ranging from 6 to

101 Synaptic protein co-expression was significantly decreas

102 es revealed individual synaptic proteins and synaptic protein complex densities at prefusion contact

103 proteomics data sets, systematic analysis of synaptic protein complexes showed that, compared with co

104 rograms that shape molecular repertoires and synaptic protein complexes.

105 taking advantage of preparations lacking the synaptic protein complexin, which have elevated spontane

106 urons but rather reflect specific changes in synaptic protein composition and axonal structure.

107 k3 gene in adult mice led to improvements in synaptic protein composition, spine density and neural f

108 Immunolabeling detected synaptic proteins, cone and rod opsins, and Muller glial

109 ions of rapid estrogen-mediated signaling on synaptic proteins, connectivity, and synaptic function i

110 tional brake on the synthesis of a subset of synaptic proteins contributes to FXS.

111 However, other synaptic proteins could be added and their function exam

112 erences in developmental trajectory of these synaptic proteins could contribute to long-term differen

113 the CaMK family with unknown function, as a synaptic protein crucial for dendritic spine maintenance

114 several signaling molecules, receptors, and synaptic proteins currently implicated in ARM operate in

115 proteolytic processing did not accompany the synaptic protein declines, ADAMTS1 may play a nonproteol

116 Furthermore, this treatment prevented pre-synaptic protein deficit, decreased glycogen synthase ki

117 ly in deprived synapses, suggesting targeted synaptic protein degradation under sensory deprivation.

118 ein synapsin I, while antibodies to 16 other synaptic proteins discriminate among 4 subtypes of gluta

119 es reveals distinct, quantitative changes in synaptic proteins distributed across over 6,000 pairwise

120 vealed disease-specific modifications of sub-synaptic protein distributions across synapse classes an

121 by distinctly different firing features and synaptic protein distributions of neurons that innervate

122 an important mechanism for the generation of synaptic protein diversity, but few factors governing th

123 findings indicate that SUMO1-conjugation of synaptic proteins does not occur or is extremely rare an

124 distinct mutations within BRAG1, an Arf-GEF synaptic protein, each led to X-chromosome-linked intell

125 learning of a complex environment activates synaptic proteins essential for the stabilization of lon

126 , whereas inhibition mimics, the increase in synaptic proteins evoked by the knockdown of NP1.

127 expression in schizophrenia has an impact on synaptic protein expression and cognition and that these

128 t of mTORC1 whose translation and consequent synaptic protein expression are increased in the nucleus

129 h exhibit strong caspase3 signal and reduced synaptic protein expression by 3 weeks of age.

130 induced increases in tyrosine hydroxylase or synaptic protein expression.

131 nsmembrane protein 3 (LRRTM3) is member of a synaptic protein family.

132 Stoichiometric labeling of endogenous synaptic proteins for high-contrast live-cell imaging in

133 Key synaptic proteins from the soluble SNARE (N-ethylmaleimi

134 pain-dependent degradation of the inhibitory synaptic protein gephyrin subsequently exacerbated SSC-m

135 promote mTORC1-dependent translation of the synaptic proteins GluA1 and Homer.

136 halitis with autoantibodies directed against synaptic proteins has become an important component of t

137 Dysregulated synthesis of synaptic proteins has been implicated in the pathophysio

138 hine effects nor changes in the abundance of synaptic proteins have been clearly delineated.

139 bodies to ion channels, receptors, and other synaptic proteins have been recognised over the past 10

140 We conclude that synaptic proteins have evolved to limit possible contact

141 oline receptors are some of the most studied synaptic proteins; however, many questions remain that c

142 apses causes a loss instead of the gain of a synaptic protein (i.e., GABAARs).

143 rity was assessed by electron microscopy and synaptic protein immunohistochemical distribution.

144 rt that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral a

145 boutons in NMJs lacking synapsin [Syn(-)], a synaptic protein important for vesicle clustering, neuro

146 isease, less is known about the role of this synaptic protein in AD.

147 e deficits, CST sprouting, and expression of synaptic proteins in an experimental model of closed hea

148 alpha-synuclein and the expression of other synaptic proteins in cholinergic axons in the guinea pig

149 rt the localization and amount of endogenous synaptic proteins in living neurons and thus may be used

150 depression-like behavior, spine density, and synaptic proteins in male and female rats.

151 r in concert with its regulation of numerous synaptic proteins in NAc as well as with SIRT1-mediated

152 Six synaptic proteins in NDE extracts were quantified by ELI

153 tion concomitantly suppresses the buildup of synaptic proteins in neuronal cell bodies, hence may pla

154 Decreased synaptic proteins in neuronal exosomes of frontotemporal

155 Using this method, we analyzed 15 synaptic proteins in normal and Fragile X mental retarda

156 Notch signaling is involved in expression of synaptic proteins in postmitotic neurons.

157 evidence for autoantibodies to cell surface synaptic proteins in psychosis and schizophrenia.

158 aging on expression of prefrontal GABAergic synaptic proteins in relation to working memory decline,

159 encing, implicating the degradation of vital synaptic proteins in silencing by GPCR activation.

160 set of dendritic spines and colocalized with synaptic proteins in specific nanodomains, as determined

161 raining, combined treatment had no effect on synaptic proteins in the aged hippocampus.

162 s in multiple transcripts encoding important synaptic proteins in the brain's reward circuitry.

163 letion results in altered levels of multiple synaptic proteins in the hippocampus, using both male an

164 tory pathway that controls the expression of synaptic proteins in the rostral-caudal neuraxis.

165 lation, MAP2 overexpression and reduction of synaptic proteins in the spinal cord of diabetic rats, s

166 d to examine the localization of ciliary and synaptic proteins in Tmem67(bpck) mice and controls.

167 approach to study the dynamics of endogenous synaptic proteins in vivo.

168 3/Deltaex13 mice compared to control are key synaptic proteins including CaMK2a.

169 54% of palmitoylation sites map to synaptic proteins including many GPCRs, receptors/ion ch

170 aptic release sites, and a redistribution of synaptic proteins including the vesicle-associated prote

171 ulates the localization and function of many synaptic proteins, including AMPARs and PSD-95.

172 striking reduction in the levels of several synaptic proteins, including CaMKII alpha/beta, AMPA, an

173 interacts with a variety of PDZ domains from synaptic proteins, including MAGI-3.

174 crease in the cluster size and number of key synaptic proteins, including N-methyl-d-aspartate recept

175 UPS) is known to regulate expression of many synaptic proteins, including presynaptic elements, to op

176 r localization and mediated large changes in synaptic proteins, including proteins implicated in fami

177 orted that estrogens increase levels of post-synaptic proteins, including PSD-95, and opioid peptides

178 ease risk factors and their placement within synaptic protein interaction networks.

179 not impair GluN2B binding, another important synaptic protein interaction of CaMKII.

180 ular determinants that are distinct from the synaptic protein interaction site (synprint) found in sy

181 1 in NAc D1+ neurons and increases levels of synaptic proteins involved in glutamatergic signaling.

182 post-transcriptional regulation of critical synaptic proteins involved in maintaining mature neurona

183 oing research efforts are largely focused on synaptic proteins involved in membrane fusion-and-fissio

184 ll as decreased expression of genes encoding synaptic proteins involved in neurotransmitter release i

185 of these substrates, such as N-cadherin, are synaptic proteins involved in synapse remodeling and mai

186 that a striking induction of VGLUT2 mRNA and synaptic protein is triggered by a prolonged increase in

187 n that phosphorylation of serine residues on synaptic proteins is a major regulator of synaptic stren

188 asticity, suggesting that O-GlcNAcylation of synaptic proteins is likely as important as phosphorylat

189 Synthesis of many synaptic proteins is under local control and much of thi

190 ic GTPase-Activating Protein (SynGAP), a key synaptic protein, is determined by the combination of it

191 of this regulatory mechanism is Complexin, a synaptic protein known to regulate synaptic vesicle exoc

192 Whereas synaptic protein labeling in the young hippocampus was s

193 The effects on synaptic protein levels and inhibitory neurotransmission

194 months of age, wildtype mice showed altered synaptic protein levels and relatively superior cognitiv

195 However, whether topotecan alters synaptic protein levels and synapse function is currentl

196 More prominently, there were declines in synaptic protein levels in the ADAMTS1 null female, but

197 the existence of a feedback circuit to match synaptic protein levels to the transport capacity of the

198 ory, hippocampal long-term potentiation, and synaptic protein levels were assessed.

199 u dysregulation, which causes a reduction in synaptic protein levels, may be responsible for the cogn

200 -responsive changes in dendritic complexity, synaptic protein levels, spine density and morphology, a

201 leads to sexual dimorphism in frontal cortex synaptic protein levels.

202 molecules and their interactions with other synaptic proteins likely affect not only on synapse form

203 that nonpathogenic HTT can indeed influence synaptic protein localization and uncover a novel role o

204 rologic outcomes, such as protection against synaptic protein loss and synaptic plasticity impairment

205 ected against TBI-induced motor deficits and synaptic protein loss.

206 emonstrate that epigenetic regulation of key synaptic proteins may be an underlying, yet reversible,

207 NDE synaptic proteins may be useful preclinical indices and

208 Synaptic proteins may have evolved to select this immedi

209 that ASD-associated mutations in a subset of synaptic proteins may target core cellular pathways that

210 nt depended on a direct interaction with the synaptic protein Munc13, because expression of the II-II

211 The synaptic protein Neuroligin 1 (NLGN1), a cell adhesion m

212 The synaptic protein neuroligin-3 (NLGN3) was identified as

213 L BDNF to regulate excitatory and inhibitory synaptic proteins neuroligin 1 and neuroligin 2, which p

214 r expression of other glutamate receptors or synaptic proteins, number of synapses, dendritic spines,

215 hat ON-bipolar cell signaling depends on the synaptic protein nyctalopin.

216 ts were integrated into a software platform, Synaptic Protein/Pathways Resource (SyPPRes), enabling t

217 suggesting that MeCP2 likely regulates these synaptic proteins post-transcriptionally, directly or in

218 y, we demonstrate that SR interacts with the synaptic proteins, postsynaptic density protein 95 (PSD-

219 sis and the calpain-dependent degradation of synaptic proteins, potentially ameliorating the observed

220 tination-directed proteasomal degradation of synaptic proteins, presumably mediated by lysine 48 (K48

221 nd synaptic transmission implying changes in synaptic protein profile.

222 ogic alpha-syn led to selective decreases in synaptic proteins, progressive impairments in neuronal e

223 e association also impaired synthesis of the synaptic protein PSD-95, suggesting that this phenomenon

224 ent TimeSTAMP tag reveals that copies of the synaptic protein PSD95 are synthesized in response to lo

225 The synaptic proteins PSD95 and NR2B were reduced in dendrit

226 We visualized functionally active synaptic proteins reconstituted into proteoliposomes and

227 ply a convergent molecular pathway involving synaptic protein recycling that may also be involved in

228 Postsynaptic density 95 (PSD-95) is a synaptic protein regulating glutamate receptor anchoring

229 CPT1C-overexpressing neurons, whereas other synaptic proteins remain unaltered.

230 Importantly, the mRNA levels of these synaptic proteins remains unchanged, suggesting that MeC

231 ersible, and activity-dependent insertion of synaptic proteins required during the induction and expr

232 nly those with antibodies to cell-surface or synaptic proteins, respond to immunotherapy.

233 The downstream synaptic protein response to HDACi administration is sim

234 Next, we tested whether the synaptic protein response to HDACi treatment is similarl

235 Analogous experiments applied to the synaptic protein RIBEYE suggest that monomers can oligom

236 nvolved in translational regulation of major synaptic proteins; scaffolding proteins in excitatory sy

237 CaMKII is an abundant synaptic protein strongly implicated in plasticity.

238 % of quantified proteins, including abundant synaptic proteins such as PSD-95 and gephyrin, exhibited

239 Synthesis of many synaptic proteins, such as GluR and PSD-95, is under loc

240 Neurotransmitter release is orchestrated by synaptic proteins, such as SNAREs, synaptotagmin, and co

241 ignificant decrease in expression of several synaptic proteins, suggesting a functional deficit of re

242 g/kg, and 5 mg/kg) on behavior and levels of synaptic proteins synapsin-1, postsynaptic density prote

243 Our findings implicate a role for synaptic proteins synapsin-1, postsynaptic density prote

244 oligodendrocytes, enhanced expression of the synaptic proteins synaptophysin and PSD95 in the hippoca

245 synaptic plasticity and a reduced density of synaptic proteins (synaptosomal-associated protein 25, s

246 spines, while disrupting the distribution of synaptic proteins (synaptotagmin 2 and gephyrin) associa

247 emonstrate defects in the trafficking of the synaptic proteins Syntaxin1a and PSD-95 and the TrkB and

248 retardation protein (FMRP), which regulates synaptic protein synthesis and is a key player to limit

249 GluR1/5 have yielded deeper insight into how synaptic protein synthesis and plasticity are regulated

250 target a key mediator of activity-dependent synaptic protein synthesis downstream of mechanistic tar

251 Altered regulation of synaptic protein synthesis has been hypothesized to cont

252 ine-induced increases in mTOR activation and synaptic protein synthesis were mimicked and occluded in

253 report that expression of a key regulator of synaptic protein synthesis, the metabotropic glutamate r

254 (mTORC1), a signaling pathway that regulates synaptic protein synthesis.

255 yperactivity, seizures, and elevated de novo synaptic protein synthesis.

256 nd cleavage, exchange and religation using a synaptic protein tetramer.

257 synaptic density protein 95 (PSD95), a major synaptic protein that clusters glutamate receptors and i

258 These results suggest that CARM1 is a post-synaptic protein that plays roles in dendritic maturatio

259 Densin-180 (densin) is an excitatory synaptic protein that promotes Ca(2+)-dependent facilita

260 ent by controlling the degradation of Arc, a synaptic protein that promotes the internalization of th

261 esynaptic Ca(2+) channels, K(+) channels, or synaptic proteins that affect transmitter release.

262 primary cortical neurons, topotecan depleted synaptic proteins that are encoded by extremely long gen

263 s expansion of the number of cell surface or synaptic proteins that are targets of autoimmunity.

264 We found adaptations in synaptic proteins that control glutamatergic signaling i

265 Complexins (Cplxs) are small synaptic proteins that cooperate with SNARE-complexes in

266 linked to synapse loss and/or alterations of synaptic proteins that impair function in regions such a

267 report an in vitro system with reconstituted synaptic proteins that meets the long-sought goal to pro

268 y pathway, endocytosis, and the stability of synaptic proteins, the nature of how this mutation affec

269 neurons by targeting two well-characterized synaptic proteins, the obligatory GluN1 subunit of the N

270 ynaptic candidates and assign numerous known synaptic proteins to a specific cleft type.

271 K(+) channels interact with separate sets of synaptic proteins to affect distinct growth steps.

272 Polarized trafficking of synaptic proteins to axons and dendrites is crucial to n

273 clerosis and the altered expression of three synaptic proteins to cognitive status and global cogniti

274 rms complexes with the clustering of various synaptic proteins to construct postsynaptic signaling ne

275 we use acute in vivo genetic manipulation of synaptic proteins to investigate the molecular basis for

276 This kinase interacts with various synaptic proteins to regulate expression and function of

277 ted with intellectual disability (ID) encode synaptic proteins, transcriptional defects leading to ID

278 foci constitute large RNP granules harboring synaptic protein transcripts.

279 How FMRP impacts synaptic protein translation and which mRNAs are most im

280 e Rap1b small GTPase and an associated local synaptic protein translation network in this process.

281 translation of Dgkkappa, indirectly controls synaptic proteins translation and membrane properties by

282 However, the mechanisms by which synaptic proteins turn over remain elusive.

283 ing that their action depends on concomitant synaptic protein turnover.

284 hought: NMDA receptors, L-VDCCs, CaMKII, and synaptic protein turnover.

285 of a specific serine residue (Ser322) on the synaptic protein UNC-18 as an end point for the Galphas-

286 Additionally, the synaptic protein UNC-31 [calcium-activated protein for s

287 icroglial activation, and loss of excitatory synaptic proteins under conditions in which no viable ba

288 Additionally, abnormal expression of synaptic proteins was observed in amygdala and prefronta

289 GABAergic markers and synaptic proteins were mainly abnormal in schizophrenia

290 One hundred fifty-five selected synaptic proteins were quantified by targeted mass spect

291 PrP(C), residues 95-110), a highly expressed synaptic protein which mediates the neuronal binding and

292 er or similar autoimmune disorders affecting synaptic proteins, which are therefore treatable with im

293 le of LRP1 in the regulation and turnover of synaptic proteins, which may contribute to the reduced d

294 The loss of Brd4 function affects critical synaptic proteins, which results in memory deficits in m

295 positioning of non-neuronal cells expressing synaptic proteins, while allowing neurites to grow freel

296 Importantly, this screen identified synaptic proteins whose levels were affected by sensory

297 Thus, PNKD is a novel synaptic protein with a regulatory role in neurotransmit

298 pproaches were used to identify and validate synaptic proteins with novel links to heavy drinking in

299 We modified genomic loci encoding synaptic proteins within bacterial artificial chromosome

300 characterized target transcripts of FMRP are synaptic proteins, yet targeting these proteins has not