ライフサイエンスコーパス: synaptic receptor

1 re limited by their ability to only modulate synaptic receptors.

2 nock-out mice as templates for diheteromeric synaptic receptors.

3 mediated by dynamic regulation of excitatory synaptic receptors.

4 or by altering the functional properties of synaptic receptors.

5 synapse and not a decrease in the amount of synaptic receptors.

6 expression do not change the total number of synaptic receptors.

7 is to establish the activation mechanism of synaptic receptors.

8 he activity mediated by synaptic release and synaptic receptors.

9 chanism for controlling Ca2+ permeability of synaptic receptors.

10 tics may reflect a functional fingerprint of synaptic receptors.

11 SHR is due to the altered expression of post-synaptic receptors.

12 Synaptic receptor accumulation is regulated by the trans

13 this study, we identified the principal post-synaptic receptors activated in cardiac vagal neurons up

14 ay permit rapid Ca(2+) influx in response to synaptic receptor activation.

15 cological modulators targeting pre- and post-synaptic receptors (AMPA, NMDA, GABA-A, mGluR2/3 recepto

16 hort-lived to long-lasting binding between a synaptic receptor and its transducer.

17 efines the molecular diversity of a critical synaptic receptor and provides evidence that neurexin di

18 , YEKL, significantly increase the number of synaptic receptors and allow the synaptic localization o

19 ntracellular receptors is related to that of synaptic receptors and suggest that a mechanism exists i

20 These changes led to near-complete loss of synaptic receptors and synaptic depression.

21 compatible with physiology, the occupancy of synaptic receptors and the depletion of Ca(2+) in the cl

22 nflux of Ca2+ ions into such spines--through synaptic receptors and voltage-sensitive Ca2+ channels (

23 We used reversible infusion of synaptic receptor antagonists to show that blocking inhi

24 resence of a large panel of onconeuronal and synaptic receptor antibodies.

25 eature of the brain, yet routine turnover of synaptic receptors appears to be intrinsically paradoxic

26 Synaptic receptors are allosteric proteins that switch o

27 rons in slices of rat visual cortex in which synaptic receptors are blocked pharmacologically, while

28 e whenever the ligand-binding sites of their synaptic receptors are buried in the lipid bilayer.

29 Other synaptic receptors are completely unaffected by the AAbs

30 ogical, and pharmacological conditions where synaptic receptors are transiently exposed to GABA agoni

31 Induction requires activation of synaptic receptors as well as voltage-gated Ca channels.

32 In contrast, few synaptic receptors associate with SAP97, suggesting that

33 emantine based on differential extrasynaptic/synaptic receptor blockade.

34 und that extrasynaptic receptors outnumbered synaptic receptors by 3:1; thus whole-cell currents were

35 lated addition and continuous replacement of synaptic receptors can stabilize long-term changes in sy

36 nding of neurotransmitter triggers gating of synaptic receptor channels, but our understanding of the

37 The extent to which agonists activate synaptic receptor-channels depends on both the intrinsic

38 topes do not result in a loss of surface and synaptic receptor clusters, suggesting specific effects

39 mmon vesicles onto spatially segregated post-synaptic receptors clusters, but a pre-synaptic segregat

40 ween intracellular protein mediators and the synaptic receptor complex composed of cellular prion pro

41 Finally, we provide evidence linking synaptic receptor composition and cycling, showing that

42 elevant light stimuli can induce a change in synaptic receptor composition of ON RGCs, providing a me

43 icity of synapses require dynamic changes in synaptic receptor composition.

44 We suggest that rather early in development synaptic receptors comprising NR1/NR2B subunits could be

45 erties and single-channel conductance of the synaptic receptors, consistent with an upregulation of t

46 ete synaptic domains and cause a decrease of synaptic receptor content.

47 rast, GluR2/GluR3 receptors replace existing synaptic receptors continuously; this occurs only at syn

48 en the glutamate source is synaptic and when synaptic receptor contributions are rigorously defined.

49 Normally, synaptic receptor densities were maintained by rapid exc

50 ma membrane receptor pools in the control of synaptic receptor density.

51 ighly dynamic and are involved in regulating synaptic receptor density.

52 mechanisms, such as vesicle depletion, post-synaptic receptor desensitization, and autoreceptor inhi

53 g pathways that promote rapid importation of synaptic receptors do not involve insertion from intrace

54 s in the alpha-bungarotoxin-labeled ACh post-synaptic receptor elements of the trunk skeletal muscles

55 a family of neuronal proteins implicated in synaptic receptor endocytosis and recycling, as well as

56 However, the development of synaptic receptor expression and colocalization has been

57 ole in organizing signaling complexes around synaptic receptors for efficient signal transduction.

58 ing through an unexpected pathway, activates synaptic receptors for one of the brain's primary trophi

59 While the regulatory mechanisms governing synaptic receptors have begun to be defined, little is k

60 TS that activates NMDA and kainate/AMPA post-synaptic receptors in cardiac vagal neurons.

61 Our results also establish that TARPed synaptic receptors in granule cells require both gamma-2

62 mbient light can modulate the composition of synaptic receptors in ON ganglion cells.

63 In contrast, synaptic receptors included both a highly ifenprodil-sen

64 A provides a gateway for cellular control of synaptic receptor internalization through second messeng

65 MDA receptors, indicating that the number of synaptic receptors is tightly regulated.

66 bunit of GABA(A)Rs, preferentially enhancing synaptic receptors largely composed of alpha(1-3, 5), be

67 GABA(A)R residency time at EZs, steady-state synaptic receptor levels, and pathological loss of GABA(

68 Moreover, AP-activated synaptic receptor-mediated phasic currents were not affe

69 neuronal isoform content of the polymorphic synaptic receptors neurexin-1, -2, and -3.

70 is thought to depend on cues provided by pre-synaptic receptor neurons.

71 or these synaptic changes are alterations in synaptic receptor number and density.

72 endent variation in the mean and variance of synaptic receptor numbers for a variety of initial condi

73 its extrasynaptic anchor, thereby enriching synaptic receptor numbers.

74 to 250 Hz, leaving a substantial fraction of synaptic receptors occupied persistently by GABA.

75 AII and A17 amacrines, diabetes changes the synaptic receptors on A17, but not AII amacrine cells.

76 n slice preparation we studied appearance of synaptic receptors on second order rNST neurons and inve

77 independent approaches suggest strongly that synaptic receptors participate prominently in hypoxic ex

78 ng stimulus can induce a long-term change in synaptic receptor phenotype and may alter the activity o

79 DARs is stable and does not shuttle into the synaptic receptor pool, as we observe no recovery of syn

80 ing AMPA receptors between extrasynaptic and synaptic receptor pools is critically involved in establ

81 In contrast, after selective inhibition, the synaptic receptor population rapidly recovers by the imp

82 eting of a distinct NMDA receptor subtype to synaptic receptor populations in cerebellar granule neur

83 erve pool by exocytosis or from nearby extra-synaptic receptors pre-existing on the neuronal surface.

84 e interplay between binding and unbinding of synaptic receptor proteins at synapses plays an importan

85 cts synaptic translation, transcription, and synaptic receptor regulation.

86 Synaptic receptors respond to neurotransmitters by openi

87 ver, after ganglion cell axons were crushed, synaptic receptors showed greater lateral mobility and t

88 y their shapes, subcellular composition, and synaptic receptor subtypes.

89 This is particularly true for synaptic receptors such as the alpha(2A)-adrenergic rece

90 These findings demonstrate that BAI1 is a synaptic receptor that can activate both the Rho and ERK

91 BDNF receptor TrkB and beta1-integrins, two synaptic receptors that engage actin regulatory RhoA sig

92 ches to exogenous GABA applications and fast synaptic receptors that generate rapid IPSCs.

93 orting receptor SorCS1 as a key regulator of synaptic receptor trafficking.

94 PICK1 is a modular scaffold implicated in synaptic receptor trafficking.

95 p mechanism involving extrasynaptic and then synaptic receptor transport.

96 outside the context of normal circuits, and synaptic receptor turnover has not been measured at indi

97 The composition of the synaptic receptors was not uniform: clusters distributed

98 However, synaptic receptors were not altered by the patch excisio

99 seizure activity may result in expression of synaptic receptors with altered properties driven by an

100 fenprodil block of EPSCs was attributable to synaptic receptors with lower ifenprodil sensitivity rat