ライフサイエンスコーパス: synaptic transmission

1 causal (defects in syntaxin-1 targeting and synaptic transmission).

2 g dampen the suppressive effect of leptin on synaptic transmission.

3 sely, cultured GKI neurons exhibit increased synaptic transmission.

4 Kctd13 gene in mice and demonstrate reduced synaptic transmission.

5 in homeostatic downscaling of glutamatergic synaptic transmission.

6 important for synaptogenesis and for tuning synaptic transmission.

7 eally suited for high-resolution analyses of synaptic transmission.

8 netic elimination causes a complete block of synaptic transmission.

9 on of toxic oligomers that impaired neuronal synaptic transmission.

10 ter:sodium:symporters, which are crucial for synaptic transmission.

11 dually silenced, leading to full blockage of synaptic transmission.

12 for ribbon organization, synaptogenesis, or synaptic transmission.

13 specialized regions called active zones for synaptic transmission.

14 ckins decreased and increased, respectively, synaptic transmission.

15 ng new bright sensors for these key steps of synaptic transmission.

16 acking IgSF21 exhibit deficits in inhibitory synaptic transmission.

17 that mediate a slow component of excitatory synaptic transmission.

18 S to date, associated with genes involved in synaptic transmission.

19 bellin-1 and neuroligin-3 severely decreased synaptic transmission.

20 independent of classical amino-acid mediated synaptic transmission.

21 tidepressant therapies may enhance GABAergic synaptic transmission.

22 possible given the inherent unreliability of synaptic transmission.

23 ey localize, and whether all are involved in synaptic transmission.

24 receptors, greatly influences the glutamate synaptic transmission.

25 that AChBP may have a function in modulating synaptic transmission.

26 tic membrane, contributing to downregulating synaptic transmission.

27 o short- and long-term changes in excitatory synaptic transmission.

28 native receptors involved in fast excitatory synaptic transmission.

29 akdown of acetylcholine, thereby terminating synaptic transmission.

30 al determinants of neuronal excitability and synaptic transmission.

31 known about the role of mammalian RIM-BPs in synaptic transmission.

32 ial memory deficits and normalizes the basic synaptic transmission.

33 in, in modulating astrocytic ATP release and synaptic transmission.

34 restore total vesicle pool size and sustain synaptic transmission.

35 blishment reveals that Cdc42 does not affect synaptic transmission.

36 this SNARE complex is involved in excitatory synaptic transmission.

37 e signaling system that regulates excitatory synaptic transmission.

38 ht stimuli transiently facilitate excitatory synaptic transmission.

39 yt underlie the control of distinct forms of synaptic transmission.

40 g the study of diseases affecting inhibitory synaptic transmission.

41 e in inhibitory and a decrease in excitatory synaptic transmission.

42 w local changes in blood flow are coupled to synaptic transmission.

43 IFN-alpha in regulating pain sensitivity and synaptic transmission.

44 nobutyric acid (GABA)ergic and glutamatergic synaptic transmission.

45 ces on the C2B domain that are important for synaptic transmission.

46 y at the end of APs and therefore stabilizes synaptic transmission.

47 no reduction in GluN2B-mediated component of synaptic transmission.

48 nd, BRAG1 is required for the maintenance of synaptic transmission.

49 emerging role of Pin1 as a key modulator of synaptic transmission.

50 of lgc-46 shortens evoked release to reduce synaptic transmission.

51 ctivity-dependent and persistent increase in synaptic transmission.

52 essed Ca(2+) influx explained loss of evoked synaptic transmission.

53 mpact of these cellular phenomena in shaping synaptic transmission.

54 tic cell biological processes, including the synaptic transmission.

55 both dendritic spine density and excitatory synaptic transmission.

56 mouse only marginally perturbs photoreceptor synaptic transmission.

57 ity to scavenge excess glutamate, regulating synaptic transmission.

58 and Ca(2+) into postsynaptic neurons during synaptic transmission.

59 y, probably due to impairments in inhibitory synaptic transmission.

60 n via pre-synaptic control of NMDAR-mediated synaptic transmission.

61 ptic plasticity without any effects on basal synaptic transmission.

62 MAP1B-LC expression depresses AMPAR-mediated synaptic transmission.

63 elta is a conserved mechanism for regulating synaptic transmission.

64 t low-frequency dentate to CA3 glutamatergic synaptic transmission.

65 ential step in PKC-dependent potentiation of synaptic transmission, acting downstream of the two othe

66 ovel framework of analysis and comparison of synaptic transmission alterations in neurodegenerative d

67 ceptors (mGluRs) regulate cone photoreceptor synaptic transmission, although the mechanisms and funct

68 in astrocytes and how this shapes excitatory synaptic transmission among neurons.

69 al tasks, which have been linked to abnormal synaptic transmission and an imbalance between cortical

70 ual tasks, which has been linked to abnormal synaptic transmission and an imbalance between cortical

71 ibit increased mobility in synapses, depress synaptic transmission and are unable to sustain long-ter

72 of the present study show that reductions in synaptic transmission and Cdk5 function are related to d

73 and how resveratrol alters basal inhibitory synaptic transmission and cocaine-induced inhibitory syn

74 Activity-invariant synaptic transmission and conduction delays were present

75 y life stressor leads to enhanced excitatory synaptic transmission and decreased levels of long-term

76 fts the balance of excitatory and inhibitory synaptic transmission and decreases dopamine release and

77 loss of CDKL5 results in the enhancement of synaptic transmission and disruptions in neural circuit

78 High-frequency dentate to CA3 glutamatergic synaptic transmission and feedforward inhibition are sig

79 resulted in a significant reduction in basal synaptic transmission and impaired expression of LTP.

80 ckdown-induced suppression of AMPAR-mediated synaptic transmission and increased surface mobility of

81 onset) does not require the participation of synaptic transmission and is mediated by diffusion of po

82 s vital for activity-dependent modulation of synaptic transmission and long-term changes in synaptic

83 throughout the brain, manifesting in reduced synaptic transmission and long-term plasticity in the hi

84 ptic seizure, and dramatically reduces basal synaptic transmission and long-term potentiation (LTP).

85 r stage of neurodegeneration (6 month) basal synaptic transmission and LTD were also affected.

86 ether, these data show that leptin regulates synaptic transmission and might be important for maintai

87 Synaptic transmission and morphological changes of NMJs

88 cking is a critical regulatory mechanism for synaptic transmission and neural function.

89 ted the mechanisms underlying differences in synaptic transmission and plasticity at dorsal and ventr

90 ignificant role in modulating NMDAR-mediated synaptic transmission and plasticity in many brain areas

91 se hippocampal CA1 pyramidal neurons impairs synaptic transmission and plasticity in vivo, resulting

92 lts suggest that IgSF11 regulates excitatory synaptic transmission and plasticity through its tripart

93 tsynaptic scaffolding proteins with roles in synaptic transmission and plasticity.

94 ses rely on AMPA receptors (AMPARs) for fast synaptic transmission and plasticity.

95 ptically released glutamate are critical for synaptic transmission and plasticity.

96 tance of kinesin-3 based axonal transport in synaptic transmission and provide novel insights into th

97 ssical neurobiological knowledge of neuronal synaptic transmission and regulation of electrical excit

98 manner and with sleep-wake cycle, modulating synaptic transmission and short-term plasticity.

99 ol or neuroligin-deficient neurons increased synaptic transmission and synapse density but not spine

100 Thus, synaptic transmission and the expression of LTP are depe

101 (AMPARs) mediate the majority of excitatory synaptic transmission and their function impacts learnin

102 whose associated gene function is related to synaptic transmission, and (2) testing for association b

103 maintaining normal neuronal excitability and synaptic transmission, and a mutation has recently been

104 tic spine density, the molecules involved in synaptic transmission, and age-related reductions in whe

105 gh analyses of synapse protein localization, synaptic transmission, and animal behaviors, we find tha

106 pocampal neuronal cultures showed that basal synaptic transmission, and both long-term and homeostati

107 by alterations in excitatory and inhibitory synaptic transmission, and intrinsic excitability in the

108 by alterations in excitatory and inhibitory synaptic transmission, and intrinsic excitability in the

109 on of genes related to memory and cognition, synaptic transmission, and neuron projection.

110 t on lateral OFC (lOFC) neuron excitability, synaptic transmission, and plasticity.

111 ate key aspects of neurotransmitter release, synaptic transmission, and synaptic plasticity, which ar

112 he influence that the neck resistance has on synaptic transmission, and the extent to which spines co

113 ne deletion produces a deficit in inhibitory synaptic transmission, and this defect is thought to cau

114 CEM responses are enhanced in the absence of synaptic transmission, and worms with only one intact CE

115 types in specific neuronal functions such as synaptic transmission are unclear.

116 , the principal mediators of fast excitatory synaptic transmission, are specifically exchanged.

117 the unc-104(bris)mutation causes defects in synaptic transmission as manifested by reduced amplitude

118 urons, the YHRD mutant yielded reductions in synaptic transmission, as compared with the wild-type pr

119 g protease BoNT/A inhibited L-AP4 effects on synaptic transmission, as did introduction of a peptide

120 ent in activated processes in brain, such as synaptic transmission, as well as critical tumor-associa

121 vely control synaptic plasticity rather than synaptic transmission at a major afferent pathway to the

122 The finding that synaptic transmission at cone ribbon synapses is regulat

123 striking differences in multiple aspects of synaptic transmission at dorsal and ventral SC synapses

124 -protein coupled receptors (GPCRs) influence synaptic transmission at ribbon synapses of cones and ot

125 erties of CA1 pyramidal neurons, deficits in synaptic transmission at Schaffer collateral synapses, a

126 Synaptic transmission at the endbulb of Held was assesse

127 KEY POINTS: Synaptic transmission at the endbulb of Held was assesse

128 old (20-26 months) CBA/CaJ mice, we studied synaptic transmission at the endbulb of Held.

129 ynaptic transmission or low frequency evoked synaptic transmission at the endbulb of Held.

130 to the postsynaptic modulation of excitatory synaptic transmission at the larval neuromuscular juncti

131 ult in overt deficits in basal glutamatergic synaptic transmission at the mossy-fibre synapse because

132 T2D, we sought to determine whether weakened synaptic transmission at the neuromuscular junction (NMJ

133 we find that long-term potentiation (LTP) of synaptic transmission at the Schaffer collateral-CA1 syn

134 esensitization accounted for the majority of synaptic transmission at this synapse.

135 a result, the excitatory-inhibitory ratio of synaptic transmission becomes imbalanced in a manner tha

136 Anatomical evidence for synaptic transmission between cone photoreceptor termina

137 e also show that MYO acts in vivo to inhibit synaptic transmission between neurons in the escape resp

138 apses and cannabinoid-mediated modulation of synaptic transmission between neurons, whereas presynapt

139 ive modeling investigation of representative synaptic transmission bias impacts would help to better

140 stsynaptic current does not increase overall synaptic transmission but instead sustains reliable gene

141 lls induces long-lasting-depression (LTD) of synaptic transmission but long-term-potentiation (LTP) o

142 fects of risk variants at loci implicated in synaptic transmission by (1) identifying GWAS schizophre

143 e that presynaptic released protons modulate synaptic transmission by activating ASIC-1as at the caly

144 nd reveal structural bases for regulation of synaptic transmission by auxiliary subunits.

145 ssion, preserving the fidelity of high-speed synaptic transmission by dynamically shifting the restin

146 inum neurotoxin (BoNT), all of which disrupt synaptic transmission by endoproteolytic cleavage of SNA

147 Glutamate receptors mediate excitatory synaptic transmission by forming cation channels through

148 opic neurotransmitter receptors mediate fast synaptic transmission by functioning as ligand-gated ion

149 Inhibition of synaptic transmission by GABAB receptors is more sensiti

150 SIGNIFICANCE STATEMENT Dynamic regulation of synaptic transmission by presynaptic G-protein coupled r

151 Excessive levels of Abeta disrupt excitatory synaptic transmission by promoting the removal of synapt

152 genes involved in long-term potentiation and synaptic transmission, cancer and neurodegeneration.

153 genes associated with this model, including synaptic transmission, cell signalling and transcription

154 However, it remains unclear how synaptic transmission changes at the first central audit

155 that resveratrol modulates basal inhibitory synaptic transmission, cocaine-induced synaptic plastici

156 Synaptic transmission controls brain activity and behavi

157 Reduced synaptic transmission correlates with increased levels o

158 D-linked InsG3680 mutation manifest striatal synaptic transmission defects before weaning age and imp

159 we report the finding of activity-invariant synaptic transmission delays as a functional adaptation

160 In contrast, synaptic transmission delays in mice varied depending on

161 onal conduction velocity and the duration of synaptic transmission delays within a pathway.

162 ar level, pregabalin inhibited glutamatergic synaptic transmission differentially in WT, R192Q, and S

163 plaques similar to AD patients, cholinergic synaptic transmission, dNGI survival and spatial pattern

164 TOR in regulating neuronal morphology, basal synaptic transmission, dopamine dynamics, and cocaine-in

165 urons and blood vessels and shape excitatory synaptic transmission due to their abundant expression o

166 hrough endocytosis is crucial for sustaining synaptic transmission during intense neuronal activity.

167 BS) that alleviates the decay in cholinergic synaptic transmission effectively protects against spati

168 Their effects on ethanol-stimulated synaptic transmission; ethanol, sucrose, and quinine con

169 ction, revealing plasticity of glutamatergic synaptic transmission evoked by the strong activation of

170 Bidirectional scaling of synaptic transmission, expressed as a compensatory chang

171 tent long-term potentiation of glutamatergic synaptic transmission following a spike-timing-dependent

172 form of short-term plasticity that enhances synaptic transmission for less than a second.

173 phosphorylation alone sustained basal evoked synaptic transmission for up to 20 min.

174 These significant differences in inhibitory synaptic transmission form an important basis for the di

175 be phenocopied by selective inactivation of synaptic transmission from local GABAergic neurons of th

176 specific psychostimulant drugs, we examined synaptic transmission from mice following repeated amphe

177 Long-term potentiation (LTP) of excitatory synaptic transmission has long been considered a cellula

178 Changes in synaptic transmission have been reported in animal model

179 The changes in synaptic transmission in aged mice can be partially resc

180 were genes related to neuron projections and synaptic transmission in agreement to the significantly

181 enhancement and long-lasting potentiation of synaptic transmission in CA1 ex vivo.

182 les, such as ATP, for the slow modulation of synaptic transmission in central neurones.

183 Blocking synaptic transmission in CIII neurons inhibits CT.

184 ity of our model to discriminate and measure synaptic transmission in cultured neuronal networks.

185 ogy was employed to measure excitability and synaptic transmission in DMS and midbrain neurons.

186 vides hitherto the most detailed analysis of synaptic transmission in HD.

187 radiatum, and also diminishes GABA-mediated synaptic transmission in hippocampal CA1 neurons without

188 ation, abolishes DAG-induced potentiation of synaptic transmission in hippocampal neurons.

189 c ablation blocks nociception and changes in synaptic transmission in mice overexpressing Cavalpha2de

190 naptic homeostatic plasticity (PHP) controls synaptic transmission in organisms from Drosophila to hu

191 ro model for assessing neuronal function and synaptic transmission in primary rodent neurons.

192 We found that AMPAR-mediated synaptic transmission in pyramidal neurons of prefrontal

193 hts the importance of considering electrical synaptic transmission in studies of intrinsic chemosensi

194 severely affected inhibitory and excitatory synaptic transmission in the amygdala, hippocampus, and

195 eceptors (AChRs), (2) enhances glutamatergic synaptic transmission in the BLA, and (3) induces LTP of

196 nism to determine the strength of excitatory synaptic transmission in the brain.

197 the R451C knockin, and the R704C knockin, on synaptic transmission in the calyx of Held, a central sy

198 ls activated by glutamate mediate excitatory synaptic transmission in the central nervous system.

199 ice led to the suppression of AMPAR-mediated synaptic transmission in the dentate gyrus and long-term

200 fast-spiking interneuron (FSI)-MSN GABAergic synaptic transmission in the DLS.

201 aptic localization of GABAARs and inhibitory synaptic transmission in the hippocampus.

202 These data revealed that leptin may regulate synaptic transmission in the LHA-to-VTA neurocircuitry i

203 Synaptic transmission in the LSO matures by postnatal da

204 Functional maturation of synaptic transmission in the medial nucleus of the trape

205 endent signaling, but reveal a disruption of synaptic transmission in the mouse dentate gyrus.

206 l how nanomolar concentrations of KYNA alter synaptic transmission in the PFC of male adult rats.

207 icosterone application attenuated inhibitory synaptic transmission in the PL via cannabinoid receptor

208 dent effects of corticosterone on inhibitory synaptic transmission in the rat PL were determined usin

209 mate receptors that underlie fast excitatory synaptic transmission in the SDH.

210 naling plays an important role in regulating synaptic transmission in the striatum, a brain region im

211 Chronic nicotine exposure (CNE) alters synaptic transmission in the ventral tegmental area (VTA

212 report that nicotine potentiates excitatory synaptic transmission in ventral tegmental area dopamine

213 Here we characterize DG-CA3 synaptic transmission in vivo using targeted optogenetic

214 ed with de novo mutations in genes mediating synaptic transmission, including GABAA receptor subunit

215 -term depression-like state of glutamatergic synaptic transmission, indicating DREADD-induced changes

216 e contribution of specific NMDA receptors to synaptic transmission, integration and plasticity.

217 t cis-SNPs and highlighted genes involved in synaptic transmission, ion transport, epilepsy, behavior

218 Synaptic transmission is degraded in aged mice, which ma

219 ons are greatly decreased, and neuromuscular synaptic transmission is enhanced.

220 In ON-BCs, synaptic transmission is initiated by the metabotropic g

221 ynaptic action potential (AP), in modulating synaptic transmission is less clear.

222 Excitatory synaptic transmission is mediated by AMPA-type glutamate

223 Synaptic transmission is mediated by the release of chem

224 KEY POINTS: Synaptic transmission is mediated by the release of neur

225 lepsy, basket cell-to-granule cell (BC-->GC) synaptic transmission is more likely to fail, but the un

226 High-fidelity synaptic transmission is possible due to large conductan

227 We find that, although basal synaptic transmission is similar, SC synapses in the dor

228 om spinal microcircuits by eliminating their synaptic transmission left locomotion more or less uncha

229 e intrinsic properties of the neurons, basal synaptic transmission, long-term potentiation or express

230 Synaptic transmission mediated by AMPA-type glutamate re

231 To enhance synaptic transmission, mice inhaled CO2 to induce an aci

232 ertebrate nervous system: action potentials, synaptic transmission, neuropeptides, and neurotransmitt

233 r, the impairments in cognitive function and synaptic transmission observed in 7-month-old five famil

234 Modest defects in GABAergic synaptic transmission of gamma2(+/-) mice resulted in a

235 Here we show that disrupting synaptic transmission of select PVT neurons with tetanus

236 its widely characterized ability to depress synaptic transmission on short- and long-term scales.

237 -containing NMDARs participate in excitatory synaptic transmission onto hippocampal interneurons.

238 , Wang and coworkers show that glutamatergic synaptic transmission onto striatal projection neurons i

239 t long-term potentiation (LTP) of excitatory synaptic transmission onto ventral tegmental area (VTA)

240 no difference in either spontaneous quantal synaptic transmission or low frequency evoked synaptic t

241 estored normal cis-Golgi morphology, but not synaptic transmission or syntaxin-1 targeting.

242 ting selectively depressed AMPA receptor (R) synaptic transmission, or silenced excitatory synapses,

243 uring this process are reminiscent of neural synaptic transmission pathways.

244 ession mechanisms and functions of long-term synaptic transmission plasticity.

245 into the function of brain ncRNAs regulating synaptic transmission, plasticity and behavior, with pot

246 otropic glutamate receptors that function in synaptic transmission, plasticity and cognition.

247 It plays an important role in synaptic transmission, plasticity, neuronal proliferatio

248 ads to destabilization of mRNAs encoding for synaptic transmission proteins, which may contribute to

249 ession of Syt1 and Syt7 did not impair basal synaptic transmission, reduce levels of synaptic or extr

250 Almost all known forms of fast chemical synaptic transmission require the synaptic hub protein M

251 The quantal nature of synaptic transmission requires a mechanism to transport

252 ure the GAP complex and completely abolishes synaptic transmission, resulting in a novel mouse model

253 During HFS, the lack of functional ASICs in synaptic transmission results in an enhanced short-term

254 otoreceptor GPCRs is also likely to regulate synaptic transmission.SIGNIFICANCE STATEMENT Dynamic reg

255 e important for the regulation of inhibitory synaptic transmission.SIGNIFICANCE STATEMENT Synaptic in

256 synaptic insertion, with a direct impact on synaptic transmission.SIGNIFICANCE STATEMENT The ability

257 es of vSCN cells through increased GABAergic synaptic transmission.SIGNIFICANCE STATEMENT The intrace

258 y states seem to affect how leptin regulates synaptic transmission since both the depletion of energy

259 nhibitory neurotransmitters involved in fast synaptic transmission, so we explored differences betwee

260 , we detect ASIC1a-dependent currents during synaptic transmission, suggesting an acidification of th

261 NMDAR-Ab from psychotic patients alter NMDAR synaptic transmission, supporting a pathogenically relev

262 d profound defects, including alterations in synaptic transmission, synaptic plasticity, and spine de

263 the absence of specific proteins involved in synaptic transmission (syntaxin-1, Munc18-1, SNAP-25), w

264 (LTP) is a rapid and persistent increase in synaptic transmission that is thought to be affected in

265 eurons to determine the impact of lithium on synaptic transmission that may underlie the behavioral e

266 n part caused by degeneration of cholinergic synaptic transmission that modulates the dNGIs survival.

267 nel activity in nociceptors and reduce their synaptic transmission, the effects of noradrenaline and

268 tic connection.SIGNIFICANCE STATEMENT During synaptic transmission, the influx of Ca(2+) into the pre

269 For terminals fixed during repetitive evoked synaptic transmission, the normal distribution of contac

270 ntaneous barrage of fast, amino-acid-mediate synaptic transmission, this was not predominantly respon

271 tion, SALM5 regulates AMPA receptor-mediated synaptic transmission through mechanisms involving the i

272 Mitochondria support synaptic transmission through production of ATP, sequest

273 al activity with calcium waves and modulates synaptic transmission through the release of gliotransmi

274 essential platform for the stabilization of synaptic transmission throughout the developing and matu

275 Gbetagamma/SNARE interactions in regulating synaptic transmission throughout the nervous system.

276 e neurons and a concomitant increase in AMPA synaptic transmission to ex vivo dopamine neurons were f

277 neurogenesis in adult mice alters excitatory synaptic transmission to mature dentate neurons.

278 hese results show that neurogenesis modifies synaptic transmission to mature neurons in a manner cons

279 ta4 in mice abolishes rod synaptogenesis and synaptic transmission to rod ON-bipolar cells, and disru

280 Mitochondrial mutants often cannot maintain synaptic transmission under demanding conditions, but sh

281 ABSTRACT: During excitatory synaptic transmission, various structurally unrelated tr

282 f FMRP in regulating neural excitability and synaptic transmission via both translation-dependent mec

283 glutamate receptor (mGluR), can reduce cone synaptic transmission via Gbetagamma in tiger salamander

284 nction and inhibiting both underlies loss of synaptic transmission via massive vesicle release and su

285 Thus, fly astrocytes can modulate fast synaptic transmission via neurotransmitter transport wit

286 Anaesthetic molecules act on synaptic transmission via the allosteric modulation of l

287 imilar results were obtained when excitatory synaptic transmission was eliminated in a low calcium so

288 Surprisingly, D2R inhibition of synaptic transmission was larger at axon collaterals fro

289 High-fidelity synaptic transmission was possible due to large conducta

290 nformation on Cplx function in photoreceptor synaptic transmission, we investigated Cplx function usi

291 mice or after the blockade of proprioceptive synaptic transmission, we observed a decrease in the mot

292 te contact cocultures, synapse formation and synaptic transmission were significantly reduced when ei

293 ompeting actions of these receptors modulate synaptic transmission when co-activated, as is likely in

294 tagmin-1, -2, or -9 is thought to drive fast synaptic transmission, whereas asynchronous release indu

295 ckout of cerebellin-1 only modestly impaired synaptic transmission, whereas in contrast to the indivi

296 mline knockout of neuroligin-3 did not alter synaptic transmission, whereas the neuroligin-3 R451C an

297 lasting, activity-dependent strengthening of synaptic transmission widely regarded as a cellular mech

298 mice are ameliorated by enhancing inhibitory synaptic transmission with a GABAAR agonist.

299 elative to other mPFC pathways and establish synaptic transmission with BLA excitatory and inhibitory

300 nonymous mutations have shown alterations in synaptic transmission within the striatum, which has key