ライフサイエンスコーパス: synaptic vesicle

1 eleased with neurotransmitter from acidified synaptic vesicles).

2 tophagy in neurons that specifically targets synaptic vesicles.

3 he subsequent step involved association with synaptic vesicles.

4 e phosphoproteins reversibly associated with synaptic vesicles.

5 which may promote the priming or docking of synaptic vesicles.

6 h restricts flux to acidic membranes such as synaptic vesicles.

7 scription of three filament types connecting synaptic vesicles.

8 endocytosis and recycling of the membrane of synaptic vesicles.

9 tments, including significantly fewer docked synaptic vesicles.

10 etween calcium channels and glutamate-filled synaptic vesicles.

11 brane, thereby restricting VGLUT activity to synaptic vesicles.

12 onal differences in loading of dopamine into synaptic vesicles.

13 tween neurons requires precise management of synaptic vesicles.

14 enabling alphaS to induce the clustering of synaptic vesicles.

15 ller synapses, and abnormally low numbers of synaptic vesicles.

16 y with the normal readily releasable pool of synaptic vesicles.

17 red to promote stronger interactions between synaptic vesicles.

18 the first description of this unique pool of synaptic vesicles.

19 erve pool and the readily releasable pool of synaptic vesicles.

20 mulate serotonergic accumulation in cortical synaptic vesicles.

21 esence of a novel pathway for degradation of synaptic vesicles.

22 y released at the same site or from the same synaptic vesicles.

23 ng the large number of v-SNAREs available in synaptic vesicles.

24 veled a nonuniform distribution of VGLUT3 in synaptic vesicles.

25 of synapses relies on efficient recycling of synaptic vesicles.

26 cellular Ca(2+) and diminution of releasable synaptic vesicles.

27 ing membrane potential, cytosolic Ca(2+) and synaptic vesicles.

28 ain, Ca(2+)-binding transmembrane protein of synaptic vesicles.

29 so found in cytoplasm, including on neuronal synaptic vesicles.

30 corelease of neurotransmitter and H(+) from synaptic vesicles.

31 tic nano-domains that position release-ready synaptic vesicles adjacent to Ca(2+) channels.

32 ed to a conformation that is juxtaposing the synaptic vesicle and plasma membranes.

33 onic anhydrase (CA), (2) release from acidic synaptic vesicles and (3) Na(+) /H(+) exchangers (NHEs).

34 dual function as a conduit for diffusion of synaptic vesicles and a platform for vesicles to fuse di

35 e, the synaptic ribbon, which organizes both synaptic vesicles and calcium channels at the active zon

36 It is unclear how autophagy of synaptic vesicles and components of presynaptic active z

37 assay, and a decrease in the density of both synaptic vesicles and dense core vesicles at presynaptic

38 HCA1 and HCA2 entered the same population of synaptic vesicles and entered cells at similar rates.

39 occurs from presynaptic membranes other than synaptic vesicles and involves a distinct molecular mech

40 porters, mediates transport of monoamines to synaptic vesicles and storage organelles in a process th

41 sly decreasing the number of VGLUT3-positive synaptic vesicles and the amount of VGLUT3 per synapses.

42 the formation of the SNARE complexes between synaptic vesicles and the plasma membrane.

43 ecrease in the accumulation of release-ready synaptic vesicles and their release probability caused b

44 The tight spatial coupling of synaptic vesicles and voltage-gated Ca(2+) channels (CaV

45 y tail-anchored proteins are associated with synaptic vesicles, and both vesicles and synaptic ribbon

46 ons of alphaS that mediate the clustering of synaptic vesicles, and indicate their relevance in both

47 Neurotransporters located in synaptic vesicles are essential for communication betwee

48 uming that a small fraction of "superprimed" synaptic vesicles are in a state of elevated release pro

49 elated organelle biogenesis, and in neurons, synaptic vesicle assembly, neurotransmission, and plasti

50 In Cplx3/4 WT photoreceptors, the number of synaptic vesicles associated with the ribbon base close

51 an atypical member of the synapsin family of synaptic vesicle-associated phosphoproteins that is prec

52 Rph3A is known as a synaptic vesicle-associated protein involved in the regu

53 in the adaptation-dependent availability of synaptic vesicles at mouse photoreceptor ribbon synapses

54 tron microscopy, we quantified the number of synaptic vesicles at presynaptic ribbons after light or

55 Active zone proteins cluster synaptic vesicles at presynaptic terminals and coordinat

56 enge the vision of a uniform distribution of synaptic vesicles at synapses.

57 he actin network regulates the exocytosis of synaptic vesicles at the mouse auditory hair cell.

58 Ca(2+) influx triggers the fusion of synaptic vesicles at the presynaptic active zone (AZ).

59 g of L-type Ca(2+) channels to release-ready synaptic vesicles at the presynaptic active zone, which

60 d Ca(2+) channels with primed, release-ready synaptic vesicles at the presynaptic active zone.

61 . elegans genes, including genes involved in synaptic vesicle biology and neuropeptide signaling, we

62 Acyt was not due to transmitter leakage from synaptic vesicles but rather to competitive MPP(+)-depen

63 loss reduces the readily releasable pool of synaptic vesicles by up to 75%.

64 The synaptic vesicle Ca(2+) sensor Synaptotagmin binds Ca(2+

65 cla-1 mutants exhibit defects in synaptic vesicle clustering, active zone structure and s

66 ure neurons, as well as SynI dispersion from synaptic vesicle clusters present at axonal growth cones

67 lls, fusion of the initial ribbon-associated synaptic vesicle cohort was not blocked by the SNARE com

68 on the physical distance between CaV2.1 and synaptic vesicles (coupling).

69 nscriptional markers of proteins involved in synaptic vesicle cycle were selectively altered, and the

70 ption of the glycolytic metabolon blocks the synaptic vesicle cycle, impairs synaptic recovery, and a

71 sponses, as well as pathways responsible for synaptic vesicle cycle, long-term potentiation and depre

72 To decipher the role of otoferlin in the synaptic vesicle cycle, we produced knock-in mice (Otof(

73 ndrially derived ATP that uses the extent of synaptic vesicle cycling as a surrogate for ATP level.

74 ctin 1, an intracellular protein involved in synaptic vesicle cycling.

75 it sustains the ATP production required for synaptic vesicle cycling.

76 ignificant decrease in number and density of synaptic vesicles, decreased expression of several presy

77 2) Synaptic vesicle density at AZs is increased in old flie

78 and RBPs eliminate tethering and priming of synaptic vesicles, deplete presynaptic Ca(2+) channels,

79 The priming of a docked synaptic vesicle determines the probability of its membr

80 We observed a near-complete lack of synaptic vesicle docking and a strong reduction in vesic

81 associated protein SNAP25 is a key player in synaptic vesicle docking and fusion and has been associa

82 rmation may be triggered at an early step in synaptic vesicle docking and positions Syt1 to synchroni

83 In a nerve terminal, synaptic vesicle docking and release are restricted to a

84 Thus, the active zone is necessary for synaptic vesicle docking and to enhance release probabil

85 SNARE-complexin-synaptotagmin-1 complex at a synaptic vesicle docking site has to be unlocked for tri

86 We show that cell depolarization increases synaptic vesicle dopamine content prior to release via v

87 .SIGNIFICANCE STATEMENT Mechanisms governing synaptic vesicle dynamics during recycling remain poorly

88 We demonstrate long-term imaging of synaptic vesicle dynamics in cultured neurons as well as

89 ular CA nor blocking loading of protons into synaptic vesicles eliminated feedback.

90 ensive research, the speed and mechanisms of synaptic vesicle endocytosis have remained controversial

91 er, which mediates the calcium dependence of synaptic vesicle endocytosis in Drosophila melanogaster

92 Synaptic vesicle endocytosis sustains communication betw

93 n, syt1 acted as an essential determinant of synaptic vesicle endocytosis time course by delaying the

94 a major presynaptic phosphatase that couples synaptic vesicle endocytosis to the dephosphorylation of

95 Synaptojanin, a protein with a known role in synaptic vesicle endocytosis, is phosphorylated at S1029

96 GTPase that mediates vesicle fission during synaptic vesicle endocytosis.

97 vous system, using VGLUT-pHluorin to monitor synaptic vesicle exocytosis and retrieval in intact anim

98 pre-synaptic HCN channels alter the rate of synaptic vesicle exocytosis and thereby enhance neurotra

99 gmin-7 also functions as a Ca(2+) sensor for synaptic vesicle exocytosis but operates during delayed

100 issociated from syt1 function to synchronize synaptic vesicle exocytosis upon stimulation.

101 d dense core vesicle exocytosis, spontaneous synaptic vesicle exocytosis, and Ca(2+)-synaptotagmin-en

102 plexin, a synaptic protein known to regulate synaptic vesicle exocytosis.

103 e nano-domain coupling of Ca(2+) channels to synaptic vesicle exocytosis.

104 l-induced Ca(2+) influx to Ca(2+)-stimulated synaptic vesicle exocytosis.

105 vealed an acid efflux mechanism reliant upon synaptic vesicle exocytosis.

106 napses and conventional chemical synapses in synaptic vesicle exocytosis.SIGNIFICANCE STATEMENT RAB3A

107 ses that are specialized for rapid sustained synaptic vesicles exocytosis.

108 modulation of the readily releasable pool of synaptic vesicles following inhibition of postsynaptic g

109 n involved in the control of availability of synaptic vesicles for exocytosis, as the key target of S

110 phoprotein that controls the availability of synaptic vesicles for exocytosis.

111 ecognized functions in tethering and priming synaptic vesicles for exocytosis.

112 in the adaptation-dependent availability of synaptic vesicles for release at photoreceptor ribbon sy

113 e of FM1-43, a dye that is incorporated into synaptic vesicles, from EC synaptic terminals using two

114 Synaptic vesicles fuse at morphological specializations

115 and controlled SNARE zippering required for synaptic vesicle fusion and neurotransmission.

116 of the SNARE four-helix bundle that mediates synaptic vesicle fusion and used it to study vesicle fus

117 Synaptic vesicle fusion at active zones of chemical syna

118 eous fusion, with the protein serving as the synaptic vesicle fusion clamp at Drosophila synapses.

119 ccordingly, MAP1B KO neurons present altered synaptic vesicle fusion events, as shown by FM4-64 relea

120 een shown to act cooperatively to enable the synaptic vesicle fusion in neuronal transmission at mill

121 se of neurotransmitter via alteration of the synaptic vesicle fusion machinery.

122 ctions with SNAP-25, a core component of the synaptic vesicle fusion machinery.

123 tagmin that promote Ca(2+) activation of the synaptic vesicle fusion machinery.

124 Synaptic vesicle fusion requires assembly of the SNARE c

125 main of synaptotagmin-1, the Ca(2+)sensor in synaptic vesicle fusion, indicating that a common mechan

126 In contrast, after single synaptic vesicle fusion, syt1 acted as an essential dete

127 eed and Ca(2+) sensitivity of SNARE-mediated synaptic vesicle fusion.

128 promoted the influx of calcium necessary for synaptic vesicle fusion.

129 eves a bolus of plasma membrane deposited by synaptic vesicle fusion.

130 release machinery triggers Ca(2+)-dependent synaptic vesicle fusion.

131 to voltages necessary for calcium influx and synaptic vesicle fusion.

132 They mediate the priming step that renders synaptic vesicles fusion-competent, and their genetic el

133 Explanations of the release of synaptic vesicles generally begin with the movement of v

134 Members of the synaptic vesicle glycoprotein 2 (SV2) family of proteins

135 euron surface polysialoganglioside (PSG) and synaptic vesicle glycoprotein 2 (SV2).

136 The synaptic vesicle glycoprotein 2A (SV2A) is found in secr

137 ([(18)F]7), a PET tracer for the imaging of synaptic vesicle glycoprotein 2A (SV2A).

138 The formation and release of synaptic vesicles has been extensively investigated.

139 biological systems: blood plasma, cytoplasm, synaptic vesicles, HIV and a mycoplasma cell.

140 ly member 5 (Plekhg5) modulates autophagy of synaptic vesicles in axon terminals of motoneurons via i

141 complex with Munc13 and RAB3A, which brings synaptic vesicles in close proximity to Ca(2+) channels

142 nanoscale-resolution tracking of individual synaptic vesicles in cultured hippocampal neurons from r

143 report three filament types associated with synaptic vesicles in glutamatergic synapses revealed by

144 nanoscale resolution tracking of individual synaptic vesicles in hippocampal synapses and advanced m

145 phate (ATP) and the accumulation of terminal synaptic vesicles in isolated rat DRG neurons.

146 dence that a mutant transmembrane protein of synaptic vesicles in neurons is etiologically linked to

147 n of secretory/recycling vesicles, including synaptic vesicles in neurons.

148 ted by the release of neurotransmitters from synaptic vesicles in response to stimulation or through

149 ted by the release of neurotransmitters from synaptic vesicles in response to stimulation or through

150 Synaptic vesicles in rodent neurons are recycled using a

151 of SVPs, leading to ectopic accumulation of synaptic vesicles in the proximal axon.

152 pontaneous recycling preferentially involves synaptic vesicles in the vicinity of AZs, whereas vesicl

153 r vesicles with lipid composition similar to synaptic vesicles, in addition to diminished membrane-in

154 l and a 10 d recovery period, the density of synaptic vesicles increased, vesicles were also larger,

155 e, which is associated with the mediation of synaptic vesicle interactions and assembly.

156 ly, we also find that the number of released synaptic vesicles is limited at each active zone.

157 ptors, and the reserve pool of glutamatergic synaptic vesicles is selectively expanded in Adar mutant

158 urotransmitter and neuropeptide release from synaptic vesicles, is a critical PKC-2 effector in AFD.

159 e, we observed an increased acidification in synaptic vesicles isolated from mice overexpressing SLC1

160 lassic neurotransmitters, we have found that synaptic vesicles isolated from the electric organ of To

161 napses, and this localization depends on the synaptic vesicle kinesin, KIF1A/UNC-104.

162 pecific scaling of several components of the synaptic vesicle machinery, including the vesicular glut

163 Expression of the synaptic vesicle marker SV2 was significantly increased

164 Remarkably, staining for synaptic vesicle markers was enhanced in these neurons c

165 tion and inhibition, cellular autophagy, and synaptic vesicle-mediated trafficking as well as proteom

166 rferes with presynaptic functions, including synaptic vesicle mobility and release rate, lowering neu

167 Cplx3/4 double knock-out mice and quantified synaptic vesicle number at the ribbon after light and da

168 We discovered that synaptic vesicles of 4-dpf zebrafish larvae are larger t

169 Zn(2+) is released from synaptic vesicles of certain nerve terminals in the hipp

170 Zn(2+) is most abundant in the synaptic vesicles of hippocampal mossy fibers.

171 -137 gain of function resulted in changes in synaptic vesicle pool distribution, impaired induction o

172 errogation of the link between this putative synaptic vesicle pool heterogeneity and neurotransmissio

173 We also found that synaptic vesicle pool recovery from depletion was sensit

174 pecific presynaptic molecules, including the synaptic vesicle pool regulator Synapsin, depend on Sir2

175 ion with the presynaptic plasma membrane and synaptic vesicle pool replenishment in the IHC active zo

176 l a new role for Synaptojanin in maintaining synaptic vesicle pool size and in reserve vesicle endocy

177 the synapse and the nature of the different synaptic vesicle pools mediating neurotransmission.

178 s participation in the recycling of distinct synaptic vesicle pools.

179 maintain endocytosis of distinct functional synaptic vesicle pools.

180 Axonal transport of synaptic vesicle precursors (SVPs) is essential for syna

181 ransporters of cargos, such as mitochondria, synaptic vesicle precursors, neurotransmitter receptors,

182 ction involves Ca(2+) channel clustering and synaptic vesicle priming and docking through interaction

183 -specific RIM variants are not essential for synaptic vesicle priming at photoreceptor ribbon synapse

184 ial for SNARE complex formation in vitro and synaptic vesicle priming in neuronal cultures.

185 nventional chemical synapses with respect to synaptic vesicle priming mechanisms.

186 it adds the neuronal Munc13 proteins and the synaptic vesicle priming process that they control to th

187 portant roles for ELKS N-terminal domains in synaptic vesicle priming.

188 surface because Nrxns comigrate as cargo on synaptic vesicle protein transport vesicles (STVs).

189 y the exocytotic machinery by activating the synaptic vesicle protein VAMP2 to form SNARE fusion comp

190 ly-expressed cytoskeletal, mitochondrial and synaptic vesicle proteins (SV), including synaptotagmin-

191 Abnormal processing of synaptic vesicle proteins important for ribbon synapses

192 Notch signaling maintains the expression of synaptic vesicle proteins in a cell-autonomous manner.

193 Levels of several synaptic vesicle proteins including synaptophysin 1 and

194 retase inhibitor, abolished the elevation of synaptic vesicle proteins, suggesting that generation of

195 h of the three filament types interacts with synaptic vesicles, providing a means to traffic reserved

196 both dopaminergic MN9D cells and mouse brain synaptic vesicles, purified Hsc70 facilitated an increas

197 lease downstream of Nrxn activation, leaving synaptic vesicle recruitment unaltered.

198 in high-frequency activity rely on sustained synaptic vesicle recycling and coordinated recruitment f

199 s and synaptic membrane proteins, disrupting synaptic vesicle recycling and neurotransmission.

200 ormation, synaptic activity, plasticity, and synaptic vesicle recycling at distinct developmental and

201 rocesses, including being a key regulator of synaptic vesicle recycling at nerve terminals.

202 etic ablation of GLUT4 leads to an arrest of synaptic vesicle recycling during sustained AP firing, s

203 Synaptic vesicle recycling is essential for maintaining

204 We examined synaptic vesicle recycling pathways at complexin null ne

205 Synaptic vesicle recycling studies suggested functional

206 and engage in rapid membrane fission during synaptic vesicle recycling.

207 min is a large GTPase with a crucial role in synaptic vesicle regeneration.

208 ified a region that directly controlled fast synaptic vesicle release and vesicle docking at the acti

209 and reversal of homeostatic upregulation of synaptic vesicle release can occur within seconds of blo

210 and reversal of homeostatic upregulation of synaptic vesicle release can occur within seconds.

211 Finally, Cplx3/4 increased synaptic vesicle release evoked by electrical stimulatio

212 ns induced by amphetamine (AMPH), we blocked synaptic vesicle release from these neurons using Cre-in

213 bons are presynaptic structures that mediate synaptic vesicle release in some sensory cells of the au

214 did not affect the electrical properties or synaptic vesicle release of juvenile hair cells, unlike

215 le is known about the energy requirements of synaptic vesicle release or whether these energy require

216 c vesicles, which leads to increased initial synaptic vesicle release probability and abnormal short-

217 er expression, and membrane conductances and synaptic vesicle release properties consistent with poss

218 Synaptic vesicle release properties vary between neurona

219 synaptic active zones play a pivotal role as synaptic vesicle release sites for synaptic transmission

220 e that Fife organizes active zones to create synaptic vesicle release sites within nanometer distance

221 me neuronal subtypes modulate myelination by synaptic vesicle release to a striking degree in vivo, o

222 the discrepancies in previous studies about synaptic vesicle release using those pH-sensors or other

223 al reticulospinal or CoPA neurons to prevent synaptic vesicle release.

224 r subunit disrupts homeostatic regulation of synaptic vesicle release.

225 ., [5-9]) through local axon-oligodendrocyte synaptic-vesicle-release-mediated signaling [10-12].

226 synapse function is to analyze the number of synaptic vesicles released in such structures per action

227 rs, in which the number of ribbon-associated synaptic vesicles remained unchanged regardless of the a

228 Patch-clamp of IHCs revealed impaired synaptic vesicle replenishment.

229 Interestingly, synaptic vesicle resupply and several other synaptic pro

230 sicle recycling studies suggested functional synaptic vesicle retrieval.

231 egregation of the readily releasable pool of synaptic vesicles (RRP) in sub-pools that are differenti

232 usion between proteoliposomes containing the synaptic vesicle SNARE synaptobrevin (with or without th

233 Here we targeted the non-canonical synaptic vesicle SNAREs Vps10p-tail-interactor-1a (vti1a

234 Syntaxin-1 (Stx1) is a component of the synaptic vesicle soluble N-ethylmaleimide-sensitive fact

235 d, their synaptic terminals contain numerous synaptic vesicles, some of which are ribbon associated,

236 e activity and localization of the enzyme to synaptic vesicles, suggesting an important role for Hsc7

237 romolecules, could underlie the formation of synaptic vesicle (SV) clusters in proximity to presynapt

238 the expression level of active zone (AZ) and synaptic vesicle (SV) components.

239 Presynaptic calcium influx triggers synaptic vesicle (SV) exocytosis and modulates subsequen

240 identical to the corresponding reactions in synaptic vesicle (SV) exocytosis.

241 he function of the SH3 domain interaction in synaptic vesicle (SV) organization at the synaptic activ

242 Synaptic vesicle (SV) pools must maintain a functional r

243 nated recruitment from functionally distinct synaptic vesicle (SV) pools.

244 equency neural activity requires coordinated synaptic vesicle (SV) recycling, the mechanism(s) by whi

245 function relies on fast and precisely timed synaptic vesicle (SV) release at active zones (AZs).

246 s of cholinergic motor neurons and regulates synaptic vesicle (SV) release kinetics upon evoked relea

247 a network of specific proteins that control synaptic vesicle (SV) tethering, priming, and fusion.

248 the most frequent familial PD, in regulating synaptic vesicle (SV) trafficking.

249 ins Piccolo and Bassoon triggers the loss of synaptic vesicles (SVs) and compromises synaptic integri

250 The accurate formation of synaptic vesicles (SVs) and incorporation of their prote

251 of neurotransmitters from readily releasable synaptic vesicles (SVs) at the active zone.

252 rotein Atto647N-tagged nanobodies trapped in synaptic vesicles (SVs) from live hippocampal nerve term

253 Synaptic vesicles (SVs) fuse at active zones (AZs) cover

254 Synaptic vesicles (SVs) fuse with the presynaptic membra

255 Recycling of synaptic vesicles (SVs) is a fundamental step in the pro

256 Their main role is to cluster synaptic vesicles (SVs) to each other and anchor them to

257 Pr ) and/or readily-releasable pool (RRP) of synaptic vesicles (SVs), but the role of SV endocytosis

258 e release of chemical neurotransmitters from synaptic vesicles (SVs).

259 s) modulates release probabilities (P(r)) of synaptic vesicles (SVs).

260 sory cells, and that disrupted processing of synaptic vesicle TA proteins explains much of the mutant

261 R profiles that were Argonaute precipitated, synaptic vesicle target enriched, or differentially expr

262 with TH to regulate the enzyme activity and synaptic vesicle targeting.

263 Conversely, a second pool of synaptic vesicles that cannot be released by a single st

264 of intravesicular free radical generation on synaptic vesicles that fuse spontaneously or in response

265 to its established function in regenerating synaptic vesicles, the endocytosis protein dynamin-1 may

266 The rapid replenishment of synaptic vesicles through endocytosis is crucial for sus

267 bility that Syt1 rings could pre-form on the synaptic vesicle to facilitate docking.

268 26, a small GTPase that specifically directs synaptic vesicles to preautophagosomal structures.

269 that facilitates the supply of release-ready synaptic vesicles to support neurotransmitter release at

270 hine serving the storage and mobilization of synaptic vesicles to the active zone remains unclear.

271 osis was due to selective targeting of fused synaptic vesicles toward slow retrieval by the asynchron

272 ng that enhanced autophagy flux and abnormal synaptic vesicle trafficking contribute to early lipofus

273 Disease-linked TMEM230 mutants impair synaptic vesicle trafficking.

274 ompensate for reduced dynamic MTs to promote synaptic vesicle transport during remodeling.

275 MEK1, and mediated developmental changes and synaptic vesicle transport in vivo using light.

276 ment utilizes a "waterfall" mechanism gating synaptic vesicle transport polarity by promoting anterog

277 thylmaleimide-Sensitive Factor essential for synaptic vesicle turnover.

278 ed motion analysis tools we demonstrate that synaptic vesicles undergo complex sets of dynamical stat

279 During neurotransmission, synaptic vesicles undergo multiple rounds of exo-endocyt

280 There is growing evidence that synaptic vesicles undergoing spontaneous fusion versus t

281 romoting the uncoating of clathrin following synaptic vesicle uptake.

282 Here we show that pathogenic Tau binds to synaptic vesicles via its N-terminal domain and interfer

283 Glutamate is loaded into synaptic vesicles via the vesicular glutamate transporte

284 s of Hsc70, the amount of TH associated with synaptic vesicles was decreased.

285 Two pools of synaptic vesicles were detected: a small, rapidly releas

286 on in the presynaptic terminal decreased and synaptic vesicles were smaller.

287 nsmitter release processes are maintained by synaptic vesicles which are segregated into functionally

288 nsmitter release processes are maintained by synaptic vesicles which are segregated into functionally

289 ective axon growth and impaired autophagy of synaptic vesicles, which can be rescued by constitutivel

290 racterized by increased fusion propensity of synaptic vesicles, which leads to increased initial syna

291 ation or through the spontaneous fusion of a synaptic vesicle with the presynaptic plasma membrane.

292 ation or through the spontaneous fusion of a synaptic vesicle with the presynaptic plasma membrane.

293 ) couple their stepwise folding to fusion of synaptic vesicles with plasma membranes.

294 ents may spatially organize a subfraction of synaptic vesicles with respect to the calcium channels.

295 continued after this initial depression, via synaptic vesicles with slower exocytotic kinetics.

296 The energy required to fuse synaptic vesicles with the plasma membrane ('activation

297 Neurotransmitter release involves fusion of synaptic vesicles with the plasma membrane in response t

298 eased from nerve terminals via the fusion of synaptic vesicles with the plasma membrane.

299 ted by the fast, calcium-triggered fusion of synaptic vesicles with the presynaptic plasma membrane,

300 mechanism to transport neurotransmitter into synaptic vesicles without promoting non-vesicular efflux