ライフサイエンスコーパス: synaptically

1 signaling exhibits spatial specificity post-synaptically.

2 gulating neuronal excitability pre- and post-synaptically.

3 se of cells that are quiescent until excited synaptically.

4 e photoreceptor synapses, both pre- and post-synaptically.

5 risomatic-targeting interneurons communicate synaptically.

6 ined asynchronous firing switched on and off synaptically.

7 nd Nav 1.6 were expressed both pre- and post-synaptically.

8 teolytic release of Endostatin signals trans-synaptically, acting in concert with the presynaptic CaV

9 majority of individual AON neurons could be synaptically activated by several mixtures of structural

10 SK channels are tightly coupled to synaptically activated Ca(2+) sources, and their activit

11 We examined the effects of synaptically activated Ca(2+) waves and NMDA spikes on s

12 in postsynaptic somatic [Ca2+]i produced by synaptically activated glutamate receptors was the resul

13 The absence of this control causes the synaptically activated group I mGluRs to elicit translat

14 ux through voltage-gated Ca(2+) channels and synaptically activated NMDA receptors.

15 eromeric GluN1/GluN2A/GluN2B NMDARs and with synaptically activated NMDARs in brain slices from wild-

16 ing tonically activated NMDARs while leaving synaptically activated NMDARs intact.

17 is more potent at inhibiting tonically than synaptically activated NMDARs.

18 Synaptically activated, rapid and dendritic synthesis of

19 Synaptically activated, transporter-mediated currents (S

20 Synaptically activating waves in the presence of low con

21 The major synaptically active component inhaled from cigarettes is

22 Our findings suggest that, in synaptically active neurons, modest "basal" levels of po

23 nstrated excitatory GABA signaling, remained synaptically active, and facilitated network activity as

24 improved the proportion of neurons that were synaptically active.

25 tiple types of retinal neurons, resulting in synaptically amplified responses and center-surround ant

26 xposure, and DORs and MORs are synergic both synaptically and behaviorally in producing analgesic eff

27 as more prominent post-synaptically than pre-synaptically and both age and E treatment affected its s

28 and impair many facets of organization trans-synaptically and cell autonomously.

29 ain slices, we examined interactions between synaptically and ER-evoked calcium release at glutamater

30 t with the emerging functional importance of synaptically and extrasynaptically localized DCVs.

31 e SIFs, the gamma subunit was expressed both synaptically and extrasynaptically within the MIFs.

32 lpha5 subunits are predominantly found extra-synaptically and seem to interact with radixin for ancho

33 more active zones that transfer information synaptically at higher rates.

34 hree cardinal oscillators: one predominantly synaptically based cortical oscillator and two intrinsic

35 e ON cell population, compared intrinsic and synaptically based receptive fields, and quantified the

36 ), the output cells of the retina, is driven synaptically, because retinal photoreceptors and second-

37 Exerting its actions pre-, post- and peri-synaptically, brain-derived neurotrophic factor (BDNF) i

38 JG cells are thought to interact synaptically, but little is known about the circuitry li

39 and are thought to bind to each other trans-synaptically, but such interactions have not been demons

40 ted at short latencies, whereas those driven synaptically by AF stimulation (type A cells) were conce

41 Presumed granule cells driven synaptically by LOT stimulation (type L cells) were conc

42 ed mitral cells by odor mixtures is read out synaptically by neurons in higher-level olfactory struct

43 GABA(C) receptors are highly unlikely to be synaptically colocalized.

44 ssuades wiring with the minor input and with synaptically compatible but functionally mismatched affe

45 Another synaptically concentrated laminin receptor, Bcam, is dis

46 rillary tangles that progressively spread to synaptically connected brain regions.

47 Similarly, synaptically connected cell assemblies or "engrams" are

48 aphtyl acetyl spermine using recordings from synaptically connected cell pairs, NPEC-AMPA uncaging an

49 -10 ms before burst onset, consistent with a synaptically connected chain of neurons in HVC.

50 In contrast, other synaptically connected elements of the MTL did not exhib

51 g triple and dual whole-cell recordings from synaptically connected human neocortical layers 2-3 neur

52 By using paired recordings of synaptically connected interneurons in slice preparation

53 potentiated inhibitory transmission between synaptically connected interneurons.

54 synaptic neurons during paired recordings of synaptically connected layer 4 and layer 2/3 neurons in

55 Using paired recordings from synaptically connected molecular layer interneurons (MLI

56 he origins of sensory transformations across synaptically connected neural populations.

57 fect the behavior of both single neurons and synaptically connected neuronal assemblies.

58 dy investigated whether modifications in the synaptically connected neuronal network of GnRH neurons

59 ay demonstrate a tendency to be expressed by synaptically connected neuronal populations.

60 s show that Cbln2 is frequently expressed by synaptically connected neuronal populations.

61 deling occurs, in particular whether and how synaptically connected neurons coordinate their reorgani

62 The specific partnering of synaptically connected neurons is central to nervous sys

63 found that Cbln2 is frequently expressed by synaptically connected neurons, although there are excep

64 tracellular release and subsequent uptake by synaptically connected neurons, but little is known abou

65 hat correlated activity drives plasticity in synaptically connected neurons.

66 ped into a powerful approach for visualizing synaptically connected neurons.

67 rvous system in a directional manner between synaptically connected neurons.

68 trating that PRV transmission is confined to synaptically connected neurons.

69 n up, axonally transported, and passed on to synaptically connected neurons.

70 pread at both the inoculation site and among synaptically connected neurons.

71 , finding minimal covariation when comparing synaptically connected or developmentally related cell t

72 rs similarly regardless of whether they were synaptically connected or not.

73 Recordings from synaptically connected pairs of EGFP-TH(+) interneurons

74 In synaptically connected pairs, CCh reduced the short-term

75 atic inhibition change with distance between synaptically connected partners in the rodent hippocampu

76 o explore this possibility, we recorded from synaptically connected PC-CN neuron cell pairs in rats.

77 erm synaptic modifications, we recorded from synaptically connected pyramidal neurons (presynaptic) a

78 dual whole-cell recordings from identified, synaptically connected Renshaw cell-motoneuron pairs in

79 ade simultaneous single-unit recordings from synaptically connected retinal ganglion cells and LGN ne

80 creased the amplitude of I(Ca) recorded from synaptically connected rods and caused hyperpolarizing s

81 ted that these catecholaminergic neurons are synaptically connected to BAT.

82 e excitatory MC4R-expressing PVH neurons are synaptically connected to neurons in the parabrachial nu

83 n of the simulated hippocampus to all of the synaptically connected units that were coactive during a

84 tral spinal progenitors, produced BFCNs that synaptically connected with endogenous neurons, whereas

85 ariety of CNS tissues, where they can become synaptically connected with host circuitry.

86 Because TRCs are not synaptically connected with the afferent nerve fibers, w

87 We also demonstrated that severed axons synaptically contacted NPCs, most of which were VEGF imm

88 These glutamatergic ARC projections synaptically converge with GABAergic ARC(AgRP) projectio

89 opulation of LepRb mPOA neurons) project and synaptically couple to rostral raphe pallidus neurons, c

90 Our analysis suggests that, unlike synaptically coupled assemblies, independent neurons fle

91 ng the virus can move by axonal transport to synaptically coupled brain loci.

92 photoreceptors with voltage steps applied to synaptically coupled HCs and found that feedback is too

93 s evoked by hyperpolarizing steps applied to synaptically coupled HCs.

94 Furthermore, paired recordings between synaptically coupled Ivy and pyramidal cells show that I

95 d to a decrease in synaptic strength between synaptically coupled layer 2/3 cortical pyramidal neuron

96 el expression of any gene of interest in the synaptically coupled neurons, and robustly labels connec

97 performed paired whole-cell recordings from synaptically coupled nRT and TC neurons of the ventrobas

98 l neuron, suggesting that these neurons were synaptically coupled or received common input from the c

99 al neurons, suggesting that these cells were synaptically coupled or received common input from the c

100 e examined these questions by recording from synaptically coupled pairs of cartwheel cells, neurons w

101 We addressed these issues by recording from synaptically coupled pairs of glycine/GABA coreleasing i

102 To investigate this, we made recordings from synaptically coupled pairs of pyramidal neurons in rat v

103 ls had no effect on evoked IPSCs measured in synaptically coupled Purkinje cells.

104 ansiently inhibit action potential firing of synaptically coupled PV cells.

105 Using paired recordings from synaptically coupled RBs and AIIs, we found that a volta

106 s of a deterministic finite-sized network of synaptically coupled spiking neurons and present a forma

107 rons, thereby confirming that pacemakers are synaptically coupled to motor networks in the spinal ven

108 veraging indicated that a subset of C-INs is synaptically coupled to phrenic motoneurons and excitato

109 As of 18 days in vitro (DIV 18), ESNs were synaptically coupled, exhibited spontaneous network acti

110 number of synapses are not likely to remain synaptically coupled.

111 itioned axonal and dendritic branches can be synaptically coupled.

112 cated in SNc, revealing the existence of two synaptically distinct and region-specific subcellular do

113 Light stimulation evoked in all ipRGCs both synaptically driven ('extrinsic') and autonomous melanop

114 ed melanopsin-based ('intrinsic') as well as synaptically driven ('extrinsic') light responses.

115 es of depolarization to LTP induction during synaptically driven action potential firing in hippocamp

116 ations elicited significant increases in the synaptically driven activation of the adjacent, environm

117 When tDCS is of sufficient length, synaptically driven after-effects are induced.

118 , we find that fast tonic firing intensifies synaptically driven burst firing output in dopamine neur

119 of intrinsic and synaptic properties renders synaptically driven firing of interneurons essentially i

120 The spatial extent of the synaptically driven light responses was comparable to th

121 2 cells, M4 cells exhibit robust, sustained, synaptically driven ON responses and dendritic stratific

122 Their synaptically driven photoresponses lack direction select

123 PAR response duration at SC-CA1 synapses and synaptically driven postsynaptic discharge of CA1 pyrami

124 athway and as a relay for rod/cone input via synaptically driven responses.

125 Under low light intensities, where only synaptically driven rod/cone input activates ipRGCs, the

126 of the SON, and results in the inhibition of synaptically driven spiking activity in magnocellular ne

127 ty were physiologically relevant and largely synaptically driven.

128 Here, we show that synaptically-driven reaction-diffusion pathways on dendr

129 tudy evaluates the central circuits that are synaptically engaged by very small subsets of the total

130 rthermore, we provide evidence that SNX27 is synaptically enriched and its level of expression regula

131 Syndapin I (PACSIN 1) is a synaptically enriched membrane tubulating protein that p

132 tivated hypothesis that these organelles are synaptically enriched.

133 hamphetamine (METH) or cocaine exposure both synaptically evoked and baclofen-activated GABA(B)R-GIRK

134 l; however, in vivo experiments fail to link synaptically evoked astrocyte Ca(2+) transients and imme

135 Synaptically evoked Ca(2+) influx through N-methyl-D-asp

136 y of CA1 neurons where they are activated by synaptically evoked Ca(2+) influx to limit the size of E

137 In contrast, synaptically evoked Ca(2+) transients are limited to the

138 itionally, blocking NO reduces the augmented synaptically evoked dendritic calcium release mediated b

139 the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a t

140 Using whole-cell voltage-clamp recording of synaptically evoked EPSCs in adult rat hippocampal slice

141 In addition, the amplitude of synaptically evoked EPSPs recorded from SK2+/T CA1 neuro

142 T Our study examines rebound, postburst, and synaptically evoked inhibitory pauses in subpopulations

143 d rebound delays and, importantly, shortened synaptically evoked inhibitory pauses, thereby demonstra

144 found evidence of Kv4.2 internalization upon synaptically evoked LTP in CA1 neurons of hippocampal sl

145 e to females, CbN cells of males had smaller synaptically evoked mGluR1/5-dependent currents, slower

146 rain slices directly showed DHPG-induced and synaptically evoked mitochondrial superoxide production.

147 y their strong effects on both exogenous and synaptically evoked NMDA receptor-mediated currents in m

148 ubtypes, kinetic modeling, and recordings of synaptically evoked NMDAR responses in acute brain slice

149 In addition, synaptically evoked postsynaptic calcium responses were

150 function of Kv3.3 channels in regulating the synaptically evoked Purkinje cell complex spike, the mas

151 annels control the amplitude and duration of synaptically evoked regenerative activity in the distal

152 locked inhibition improves the precision of synaptically evoked responses in individual TC neurons b

153 In addition, dendritically and synaptically evoked responses showed a corresponding dec

154 ebellar stellate cells diffusionally isolate synaptically evoked signals in dendrites and are capable

155 Under physiological conditions, LTP of synaptically evoked spike output was expressed preferent

156 hloride pump can increase the probability of synaptically evoked spiking after photoactivation; this

157 ed in response to optogenetic stimulation or synaptically evoked spiking of NPY+ cells, suppresses bo

158 c spiking, with network state encoded in the synaptically evoked spine Ca(2+) responses.

159 Both DSE and synaptically evoked suppression of excitation (SSE) trig

160 distance information can also be provided by synaptically-evoked BAPs.

161 A synaptically generated form of burst firing has been sho

162 h propagation failing due to the dilution of synaptically generated IP3 as it diffuses into the large

163 requires new transcription, indicating that synaptically generated signals must be transported to th

164 ts intracellular domain in the regulation of synaptically generated signals.

165 We conclude that information derived from synaptically-generated BAPs can indicate synapse locatio

166 ecrete cytokines in one of two modes: either synaptically (i.e., toward antigenic target cells) or mu

167 rons through axon terminals and spread trans-synaptically in a retrograde direction between neurons.

168 dence suggests these channels also exist pre-synaptically in a subset of synaptic terminals within th

169 found that alpha1ARs are found mainly extra-synaptically in axons and axon terminals in the NAc and

170 s required for SIS in vivo, is expressed non-synaptically in several wake-promoting neurons, and like

171 mal fractions revealed that NgR1 is enriched synaptically in the hippocampus.

172 observations that tauopathy can spread trans-synaptically in vivo, via cell-to-cell transfer.

173 ologically suppress RA synthesis, whereas in synaptically inactive neurons, decreases in the resting

174 um ion (Ca(2+)) uptake by mitochondria after synaptically induced Ca(2+)-release from ER and thereby

175 Paradoxically, synaptically induced depolarization will suppress this C

176 m channels and NMDA receptors contributes to synaptically induced LMO4-mediated transactivation.

177 that displacement of PKA from AKADs occludes synaptically induced long term depression.

178 that the mechanism for this adaptation is a synaptically induced long-lasting shift in intrinsic neu

179 Synaptically induced LTD was deficient in Eif4ebp2(-/-)

180 CA1 of adult rat hippocampus, mechanisms of synaptically induced mGluR-LTD.

181 tase (PTP) is essential for the induction of synaptically induced mGluR-LTD.

182 -phosphorylation, underlies the induction of synaptically induced mGluR-LTD.

183 These cells synaptically integrate into olfactory bulb circuits afte

184 l cells suggests that individual AON neurons synaptically integrate several functionally distinct mit

185 d that, shortly after they differentiate and synaptically integrate, the population of adult-born olf

186 ed cortical excitatory neurons that appeared synaptically integrated into the circuitry.

187 received synaptic inputs identifying them as synaptically integrated neurons.

188 onship with motor axons with whom they later synaptically interact.

189 SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and

190 From this work a dispersed but synaptically interconnected network of reinforcement cir

191 The migration of synaptically interconnected neurons that may occur in re

192 ng in slice cultures to analyze migration of synaptically interconnected, cholecystokinin-immunoposit

193 ng the possibility that the interneurons are synaptically interconnected.

194 d to odor stimulation and how they integrate synaptically into local circuits.

195 tatistics and spike train reproducibility in synaptically isolated cortical neurons were measured in

196 inated LLDs in FTNs, and NMDAR activation in synaptically isolated FTNs induced repetitive LLDs.

197 connect, to define differential patterns of synaptically linked neurons in the taste pathway.

198 d conditional reporter expression in neurons synaptically linked to the Cre-expressing catecholamine

199 urotropic virus that transneuronally infects synaptically-linked chains of neurons in the anterograde

200 bly because of the reduction in the level of synaptically localized AMPA-type glutamate receptors.

201 ated in AD-associated neurodegeneration, and synaptically localized caspase activity could play a rol

202 aMKII is to promote the retrieval-dependent, synaptically localized enhancement of protein synthesis

203 However, the molecular mechanisms regulating synaptically localized ERK1/2 signaling are poorly under

204 ted peptides that activate two different and synaptically localized G-protein-coupled receptors, CRF1

205 Interestingly, synaptically localized GABAA receptors remained relative

206 We propose that at FS cell terminals synaptically localized Kv3 channels keep APs brief, limi

207 ith actin depolymerizing agents disrupts the synaptically localized nectin-1 and afadin cluster at an

208 whose RNAs have been found to interact with synaptically localized proteins.

209 e rate of internalization, leading to larger synaptically localized receptor clusters that increased

210 Activity-dependent transport of synaptically localized transcriptional regulators provid

211 pposed to bassoon immunoreactivity and hence synaptically localized.

212 s predicts that glutamine-glutamate cycle is synaptically localized.

213 N connectivity is preserved, no regenerative synaptically mediated activity indicative of a dynamic n

214 Optical recording of synaptically mediated calcium responses identifies LVST-

215 tern of glutamatergic activity that produced synaptically mediated death of rat hippocampal neurons i

216 ect photosensitivity through melanopsin with synaptically mediated drive from classical photoreceptor

217 Large, synaptically mediated outward currents were evoked in SG

218 indicating that the increase in activity was synaptically mediated.

219 vious studies have shown that norepinephrine synaptically mediates this Prostaglandin E(2) (PGE(2))-d

220 cerbated loss of synaptophysin compared with synaptically more active brain in AD transgenic but not

221 ic cell population to both locally and trans-synaptically offset neurophysiological disruptions produ

222 Thus synaptically positioned Ca2+-permeable AMPA receptors di

223 However, these neurons also synaptically release non-peptide neurotransmitters.

224 We evaluated the contribution of synaptically released acetylcholine (ACh) to executive f

225 al dentate gyrus granule cells, we show that synaptically released acetylcholine preferentially lower

226 GABA(B) receptor dimer (GBB-1/2) that detect synaptically released ACh and GABA, respectively.

227 Synaptically released ATP acts at these P2Y(1) receptors

228 polarization activates I(h) current in ETCs; synaptically released DA increases I(h), which enhances

229 m by mediating the high-affinity reuptake of synaptically released DA, making it a crucial regulator

230 rmacological approaches, we demonstrate that synaptically released dopamine inhibits CINs through typ

231 Clearance of synaptically released dopamine is regulated by the plasm

232 (COMT) gene, whose protein product degrades synaptically released dopamine.

233 Synaptic GABAA receptors respond to synaptically released GABA and are considered to be unaf

234 Thus, the opposing actions of synaptically released GABA and DA are functionally integ

235 The spillover of synaptically released GABA can also activate extrasynapt

236 Whole-cell recordings further showed that synaptically released GABA in response to extracellular

237 acellular recording to monitor the effect of synaptically released GABA on the DGC population.

238 onsequently, under whole-cell current clamp, synaptically released GABA produced short- and long-last

239 y, I(tonic) may be activated by spillover of synaptically released GABA.

240 of a low-voltage-activated L-type current by synaptically released glutamate accounted nearly fully f

241 Synaptically released glutamate activated mGluR1 recepto

242 sts, suggesting high, but not low, levels of synaptically released glutamate activated mGluRs.

243 Excitatory amino acid transporters remove synaptically released glutamate and maintain its concent

244 rigin that is essential for the clearance of synaptically released glutamate and prevention of excito

245 sporter activation are insufficient to clear synaptically released glutamate at immature calyces, res

246 Perisynaptic AMPARs do not normally detect synaptically released glutamate but can do so when the g

247 kedly prolongs the extracellular lifetime of synaptically released glutamate by reducing GLT-1 surfac

248 tivation of presynaptic kainate receptors by synaptically released glutamate contributes to large sho

249 fore the second postnatal week, clearance of synaptically released glutamate depends primarily on dif

250 lectrophysiological approaches, we find that synaptically released glutamate fails to trigger GABA re

251 Efficient clearance of synaptically released glutamate from the extracellular s

252 te transporters are responsible for clearing synaptically released glutamate from the extracellular s

253 ters terminate neurotransmission by clearing synaptically released glutamate from the extracellular s

254 he ionotropic and metabotropic receptors for synaptically released glutamate have been extensively mi

255 Furthermore, synaptically released glutamate induced by electrical st

256 in which the function of FMRP is suppressed, synaptically released glutamate induced prolonged epilep

257 Synaptically released glutamate is taken up at the same

258 ng neuronal NMDA receptors with exogenous or synaptically released glutamate led to Miro1 positioning

259 To further determine whether synaptically released glutamate mediates VGluT1(+) synap

260 was able to manipulate negative feedback of synaptically released glutamate on transmitter release.

261 As D-serine is localized in glia, synaptically released glutamate presumably stimulates th

262 synaptic structure to regulate the time that synaptically released glutamate remains in the extracell

263 mate reuptake and attenuates the increase in synaptically released glutamate that accompanies cocaine

264 Glutamate transporters clear synaptically released glutamate to maintain precise comm

265 er supplies the precursor for generating the synaptically released glutamate, we measured miniature E

266 n increases, potentially speeding removal of synaptically released glutamate, whereas extracellular s

267 to neurons and glia terminate the actions of synaptically released glutamate.

268 to mature, processes that are influenced by synaptically released glutamate.

269 Synaptically released glycine also enhanced tonic glycin

270 ransduction, trafficking, and structural, to synaptically released molecules.

271 tane-1,5-dioic acid, would elevate levels of synaptically released NAAG and reduce PCP-induced increa

272 activation of G protein-coupled receptors by synaptically released neurotransmitters demonstrated not

273 hrine transporter (NET) mediates reuptake of synaptically released norepinephrine in central and peri

274 a membrane protein that mediates reuptake of synaptically released norepinephrine.

275 nigrostriatal projections that may modulate synaptically released striatal glutamate.

276 hermore, these receptors may be activated by synaptically released transmitter during patterns of act

277 deficient in zinc transporters to show that synaptically released zinc inhibits postsynaptic kainate

278 extrasynaptic NMDARs that are not reached by synaptically released zinc, but which are inhibited by a

279 Our data indicate that synaptically released Zn2+ enables long-term potentiatio

280 e brain areas may impair normal clearance of synaptically-released glutamate and contribute to neural

281 which is associated with faster clearance of synaptically-released glutamate from the extracellular s

282 This capacity to signal across such a large synaptically relevant bandwidth enhances the response to

283 del of glaucoma, C1q becomes upregulated and synaptically relocalized in the adult retina early in th

284 This paradigm predicts that synaptically secreted cytokines such as IFN-gamma will p

285 usion, defining a period where excitable but synaptically silent neurons are present.

286 n of active arbors and local degeneration of synaptically silent ones.

287 urons in the upper layers of pOFC, which are synaptically suited to suppress noise and enhance signal

288 Teevra cells synaptically target GABAergic axo-axonic and some CCK in

289 In vivo imaging of transmission using synaptically targeted GCaMP3 to detect Ca(2+) influx thr

290 reduce post-synaptic assembly, whereas post-synaptically targeted RNAi has no effect, indicating tha

291 ERbeta-ir was more prominent post-synaptically than pre-synaptically and both age and E tr

292 Synaptically, the wake-promoting neurons were organized

293 rated that EES engages spinal circuits trans-synaptically through the recruitment of myelinated affer

294 ke in the adult, where this transmitter acts synaptically to inhibit neurons, during development, GAB

295 n-expressing interneurons that are connected synaptically to the Grp+ neurons.

296 Olfactory bulb granule cells are activated synaptically via two main pathways.

297 lpha2, or alpha3 subunits are mainly located synaptically where they interact with the submembranous

298 er between neurons transneuronally and trans-synaptically, which is thought to explain the progressiv

299 cell adhesion molecules that interact trans-synaptically with neurexins to mediate synapse developme

300 ic neuroligins are thought to interact trans-synaptically with presynaptic neurexins.