ライフサイエンスコーパス: synaptogenic

1 ndicating that Drosophila astrocytes are pro-synaptogenic.

2 receive, indicating that Pcdh-gammaC5 is not synaptogenic.

3 ed cells, indicating that collybistin is not synaptogenic.

4 tured neurons, suggesting that neurexins are synaptogenic.

5 ected by MEN1 knockdown, indicating that the synaptogenic actions of menin are specific to cholinergi

6 an assay system that permits examination of synaptogenic activities of individual cell-surface prote

7 Furthermore, this anti-synaptogenic activity is interchangeable with that of LI

8 ent in cultured neurons and in vivo, and the synaptogenic activity of LRRTM4 requires the presence of

9 binding to recombinant neurexins, blocks the synaptogenic activity of neuroligin-1, and reduces the d

10 model in which Narp can regulate the latent synaptogenic activity of NP1 by forming mixed pentraxin

11 affinity for GluRdeltas and exhibits greater synaptogenic activity than Cbln2.

12 eal the neurexin binding interface mediating synaptogenic activity to be composed primarily of residu

13 MDGA binding and suppression of synaptogenic activity was selective for neuroligin-2 and

14 mily members (APP, APLP1, and APLP2) exhibit synaptogenic activity, involving trans-synaptic dimeriza

15 hat NT-3 modulates TrkC/PTPsigma binding and synaptogenic activity.

16 ding affinity of Cb, which limits its normal synaptogenic activity.

17 differentiating neurons strongly impairs its synaptogenic activity.

18 Significance statement: Although many synaptogenic adhesion complexes have been identified in

19 lly analyzing synaptic membranes lacking the synaptogenic adhesion molecule SynCAM 1.

20 Synaptogenic adhesion molecules play critical roles in s

21 Given the links of synaptogenic adhesion molecules to autism and schizophre

22 esults in basal synaptic deficits and blocks synaptogenic and antidepressant actions of ketamine in P

23 role of the GSK-3 pathway in modulating the synaptogenic and antidepressant responses to ketamine.

24 edial prefrontal cortex (mPFC) show that the synaptogenic and antidepressant-like effects of a single

25 Here, we found that the synaptogenic and antidepressant-like effects of a single

26 This pair of media are pro-synaptogenic and generate authentic, mature synaptic net

27 s the hUTC-secreted factors that mediate the synaptogenic and growth-promoting functions of these cel

28 SPARC is not synaptogenic, but specifically antagonizes synaptogenic

29 neuronal networks to test whether predicted synaptogenic capabilities were affected by previous syna

30 y changes in knock-out (KO) mice lacking the synaptogenic cell adhesion protein SynCAM 1.

31 nctions as a glutamatergic synapse-inducing (synaptogenic) cell adhesion molecule trans-interacting w

32 th short-term data, which is indicative of a synaptogenic compensatory mechanism of the abducens inte

33 dendrites are thought to facilitate initial synaptogenic contact with axons.

34 opodia may be actively involved in mediating synaptogenic contact.

35 at dendritic filopodia may actively initiate synaptogenic contacts with nearby (5-10 micron) axons an

36 Structural, functional and molecular synaptogenic defects are all phenocopied by Wg overexpre

37 p mutants prevents structural and functional synaptogenic defects.

38 Mechanistically, the synaptogenic deficiency of R215H mutant was due to its r

39 the interaction involving the thrombospondin synaptogenic domain and the alpha2delta-1 von-Willebrand

40 oprecipitation between alpha2delta-1 and the synaptogenic domain of thrombospondin-2 was prevented by

41 ses in glutamatergic neurons, suggesting its synaptogenic effect is specific to GABAergic interneuron

42 In Met/Met mice the synaptogenic effect of ketamine was markedly impaired, c

43 Our results indicate that Fz5 mediates the synaptogenic effect of Wnt7a and that its localization t

44 ological inhibition, prevented the TGF-beta1 synaptogenic effect.

45 der neuronal preparations, morphogenetic and synaptogenic effects of 5-HT(7)/G(12) signaling are abol

46 The synaptogenic effects of SC-CM were abolished if SC-CM wa

47 r to frog SC-CM, mammalian SC-CM also showed synaptogenic effects, which were prevented by immunodepl

48 in-1 played an important role in ACM-exerted synaptogenic effects.

49 gabapentin binding was not reproduced by the synaptogenic EGF-domain of thrombospondin-4.

50 t a noncanonical function of GABA as a local synaptogenic element shaping the early establishment of

51 ously decreases the time required to capture synaptogenic events by an order of magnitude.

52 Our work identifies a novel glia-derived synaptogenic factor by which glia modulate synapse forma

53 beta1, previously identified as an important synaptogenic factor secreted by astrocytes, abrogated th

54 egulating synaptogenesis and that SRPX2 is a synaptogenic factor that plays a role in the pathogenesi

55 studies have begun to identify glial-derived synaptogenic factors [1], but neuron-glia signaling even

56 ology, we identified the major hUTC-secreted synaptogenic factors as the thrombospondin family protei

57 Although astrocyte-secreted synaptogenic factors have been identified, the molecules

58 TGF-beta1 thus joins other astrocyte-derived synaptogenic factors in further strengthening the emergi

59 APP synaptogenic function depends on trans-directed dimeriza

60 This synaptogenic function has been conserved across evolutio

61 gous cholinergic mechanism underlies menin's synaptogenic function in the vertebrate CNS.

62 The synaptogenic function of alpha(2)delta-3 required only t

63 t synaptogenic, but specifically antagonizes synaptogenic function of hevin.

64 Here we demonstrate a synaptogenic function of netrin-1 in rat and mouse corti

65 small RNA interference, eliminated both the synaptogenic function of these cells and their ability t

66 Our results reveal a synaptogenic function of TRPV1 in a specific interneuron

67 verall, our studies suggest that besides its synaptogenic function that could promote integration of

68 APP cis-/trans-directed dimerization and APP synaptogenic function.

69 ng axons of cocultured neurons, suggesting a synaptogenic function.

70 Here, we investigate synaptogenic functions of the secreted extracellular dea

71 circuit connections and form the basis of a synaptogenic hypothesis of depression and treatment resp

72 s regulated by presynaptic expression of the synaptogenic immediate early gene NPTX2 by pyramidal neu

73 Furthermore, this study identifies a novel synaptogenic mechanism in which a single gene product co

74 These results establish FGF22 as a synaptogenic mediator in the adult nervous system and a

75 ta4, which complexes with CaV1.4 and the rod synaptogenic mediator, ELFN1, for trans-synaptic alignme

76 pecific expression pattern of genes, such as synaptogenic modulator sparc and transcriptional factors

77 Although agrin is the best-characterized synaptogenic molecule, its mechanism of action remains u

78 tic process formation and re-expression of a synaptogenic molecule, thrombospondin-1 (TSP-1), apart f

79 s process is controlled by a balance between synaptogenic molecules and proteins that negatively regu

80 The present study aimed to identify the synaptogenic molecules in SC-CM.

81 reactive oxygen species and lower levels of synaptogenic molecules.

82 nal synapse differentiation, consistent with synaptogenic MTG functions.

83 l networks were not those predicted based on synaptogenic outcomes in two-cell networks.

84 factor beta (TGF-beta) signaling is a novel synaptogenic pathway for cortical neurons induced by mur

85 the mammalian target of rapamycin complex 1 synaptogenic pathway; the CRF-induced EPSCs required an

86 loss of synapses: pathological reduction of synaptogenic PKC isozymes and their downstream synaptoge

87 Second, the results demonstrate that a synaptogenic process that controls excitatory inputs to

88 neuromuscular junction, steps regulating the synaptogenic program at central cholinergic synapses rem

89 d extrinsic trophic factors in executing the synaptogenic program.

90 Although they display synaptogenic properties in heterologous systems, the fun

91 e show that dimerization is required for the synaptogenic properties of neuroligin and likely serves

92 ligand thrombospondin-1, responsible for the synaptogenic properties of the alpha2delta-1 receptor, w

93 f postsynaptic neuroligin with regard to its synaptogenic properties: its basal state as a constituti

94 and emphasize the evolutionary aspect of the synaptogenic property of astrocytes, thus shedding light

95 First, the data support that synaptogenic proteins guide connectivity and can functio

96 A, have been recently demonstrated to act as synaptogenic proteins that can single-handedly induce th

97 These studies identify TSPs as CNS synaptogenic proteins, provide evidence that astrocytes

98 brain depends on the coordinated activity of synaptogenic proteins, some of which have been implicate

99 exposure level, BPA completely abolishes the synaptogenic response to estradiol.

100 training and lesions resulted in an enhanced synaptogenic response.

101 Together, our findings suggested a novel synaptogenic role of NRG1 in excitatory synapse developm

102 r, alpha2-1 has also been proposed to play a synaptogenic role, independent of calcium channel functi

103 These results suggest the involvement of a synaptogenic signal common to glutamate and GABA synapse

104 Furthermore, we identify BDNF as the synaptogenic signal produced by these nonneuronal cells.

105 d has been found that modulates a retrograde synaptogenic signal.

106 restrain synaptic growth by downregulating a synaptogenic signal.

107 a Rac1 activator previously identified as a synaptogenic signaling protein, contributes to establish

108 ts show that actin polymerization induced by synaptogenic signals is necessary for the movement and f

109 cell-permeant F-actin-binding toxin, before synaptogenic stimulation, and then probing new actin ass

110 naptogenic PKC isozymes and their downstream synaptogenic substrates, such as brain-derived neurotrop

111 elicits spontaneous somatic Ca2+ transients, synaptogenic thrombospondin 1 (TSP-1) release, and synap

112 Ultrastructural evidence for synaptogenic triggers during slice preparation was inves