ライフサイエンスコーパス: syncytia

1 n and the formation of multinucleated cells (syncytia).

2 aximum 5 days after transfection (100 nuclei/syncytia).

3 pathological induction of cell-cell fusion (syncytia).

4 the formation of multinuclear, fused cells (syncytia).

5 germ cells while joined in germline cysts or syncytia.

6 id not yield detectably increased numbers of syncytia.

7 sion, penetrated cells and induced extensive syncytia.

8 ffect and resulted in the formation of large syncytia.

9 MV glycoproteins did not form multinucleated syncytia.

10 for fusion of epidermal cells into discrete syncytia.

11 ker genes into the heart or other electrical syncytia.

12 proteins, with subsequent formation of cell syncytia.

13 cle, reenter mitosis, and form multicellular syncytia.

14 or cells are fused into large multinucleated syncytia.

15 pread, surface glycoproteins fuse cells into syncytia.

16 n, and degeneration, of large multinucleated syncytia.

17 d of glial tumor cells throughout astrocytic syncytia.

18 later times, the staining surrounded entire syncytia.

19 characterized by very large, multinucleated syncytia.

20 owever, effected the formation of only small syncytia.

21 ergo inappropriate fusion with the epidermal syncytia.

22 were able to detect and quantify HIV-induced syncytia.

23 eading to formation of lethal multinucleated syncytia.

24 ereas cells expressing F plus TM formed some syncytia.

25 r most conditions, without the appearance of syncytia.

26 nt correlated with the formation of enlarged syncytia.

27 ould be detected in multinucleated DC-T cell syncytia.

28 lytic infection with extensive formation of syncytia.

29 lls showed cytopathic effects, forming giant syncytia.

30 on of reverse transcriptase and formation of syncytia.

31 nt membrane and induced prominent epithelial syncytia.

32 erodera schachtii-induced feeding sites, the syncytia.

33 ased repression in unicellular organisms and syncytia.

34 ciently in both cell types and induced large syncytia.

35 CMV also spreads cell to cell and can induce syncytia.

36 al cell sloughing, apoptosis, and occasional syncytia.

37 ation and/or maintenance of nematode-induced syncytia.

38 ane breakdown and formation of multinucleate syncytia.

39 receptors are expressed in nematode-induced syncytia.

40 lature into specialized feeding sites called syncytia.

41 ncentrations of auxin increase in developing syncytia.

42 plant root to form feeding cells, so-called syncytia.

43 ion of the cellular antioxidant machinery in syncytia.

44 entral determinant of the local cytoplasm in syncytia.

45 animal viruses induce cells to fuse and form syncytia.

46 nd mediates adhesion with FMs and developing syncytia.

47 infected cells to form large multinucleated syncytia.

48 and cause multinucleated giant cells, termed syncytia.

49 -BL HeLa-based HIV-1 indicator cells to form syncytia.

50 ation of an electromechanical wave along the syncytia.

51 ein accumulation and by robust expansion via syncytia, a characteristic feature of JHM virus dissemin

52 Syncytia activate macrophages and fusogenic membrane gly

53 ity of vaccinia virus-infected cells to form syncytia after a brief exposure to a pH below 6, known a

54 ions were unable to mediate the formation of syncytia after low-pH treatment.

55 logically active, mediating the formation of syncytia, albeit at a reduced rate.

56 Both uncoordinated motility of syncytia and adhesion to CD4(+) lymph node cells led to

57 usion by the production of fluorescent green syncytia and allowed us to elucidate many aspects of HCV

58 but not their parental bulk viruses, induced syncytia and caused acute death of infected CD8(+) cells

59 VEM in Vero cells also resulted in increased syncytia and enhanced cell-to-cell spread in cells infec

60 d that HIV-infected T cells are motile, form syncytia and establish tethering interactions that may f

61 The infected cells were multinucleated syncytia and expressed the S100 and p55 dendritic cell m

62 mutants, Fcs-5B, formed protease-independent syncytia and grew to 10-fold-higher titers compared to t

63 usion of all seam cells with the surrounding syncytia and pronounced defects in molting.

64 In addition, HIV-1-infected T-lymphocyte syncytia and the significance of adhesion molecule/ligan

65 tion of cytosolic contents through the glial syncytia and to the extracellular space, respectively.

66 ly refractory cell lines, induction of large syncytia, and accelerated kinetic properties.

67 endent cell-mediated cytotoxicity, formed no syncytia, and neither underwent nor induced apoptosis in

68 of cell types induces the formation of giant syncytia, and that fusion of a human trophoblastic cell

69 However, it does not form syncytia, and the virus is avirulent in chickens.

70 s strongly activated in the nematode-induced syncytia, and transgenic plants overexpressing SPDS2 sho

71 igand interactions in the formation of these syncytia are described.

72 The consequences of ploidy variation in syncytia are difficult to predict because protein imbala

73 Here, we show that syncytia are highly ordered structures over 24-48 h but

74 rms large syncytia with XC cells, whereas no syncytia are reported for amphotropic virus.

75 is the principal mechanism of T cell death, syncytia are the main source of virus production, and bo

76 Quantitative syncytia assays showed that JPVTM was defective in promo

77 y to support infection still induced massive syncytia at low pH.

78 een delivered, consistent with the idea that syncytia, at least in vitro, are not required for HIV-1

79 hen combined, enabled formation of extensive syncytia by human cancer cell lines that express the tar

80 tor is required for the induction of XC cell syncytia by the R(+) Env protein.

81 Small syncytia can be readily identified by the two-color cyto

82 The multinucleate cells resembled the syncytia caused by physical wounding.

83 s results in the formation of multinucleated syncytia, causing mitochondrial failure with ATP depleti

84 cells infected with VZVgB-36 form extensive syncytia compared to the relatively small syncytia forme

85 Endothelial syncytia, comprised of multinucleated giant-endothelial

86 ence imaging revealed that the cell walls of syncytia contain cellulose and the hemicelluloses xylogl

87 alysis of various samples, we found that all syncytia contained large amounts of virions and that mos

88 The majority of these syncytia could be double labeled for HIV-1 RNA and a den

89 With these cells, the formation of syncytia could be induced by acidic medium.

90 s where HIV-1 replication can be enhanced in syncytia derived from dendritic cells.

91 g and resulted in the absence of RSV-induced syncytia despite no significant change in viral titer.

92 data suggest that the unique manner in which syncytia develop and die provides a highly effective pat

93 While visible syncytia do not form after MV infection of HAE, the cyto

94 secreted as an effector into the developing syncytia during early plant parasitism.

95 cteristically forms multinucleated cells, or syncytia, during the infection of human tissues, but lit

96 vL1Ri in the absence of inducer did not form syncytia following brief low-pH treatment even though ex

97 The observation of few and delayed syncytia following MHV-A59 infection of hepatocytes more

98 ulated and allowed to develop feeding sites (syncytia) for 8 days.

99 did not spread to neighboring cells nor did syncytia form after low-pH treatment.

100 In the case of CHO/rRAM-1 cells, syncytia form at foci of amphotropic 4070A virus infecti

101 Syncytia form by incorporating neighboring cells into a

102 How syncytia form remains poorly understood.

103 s as measured by inhibition of HIV-1 induced syncytia formation and HIV-1 reverse transcriptase activ

104 aling through this gBcyt motif regulates VZV syncytia formation and is essential for skin pathogenesi

105 fusion and viral replication as measured by syncytia formation and p24 levels, respectively.

106 onal antibodies that inhibit HTLV-1-mediated syncytia formation and recognize conformational epitopes

107 ys162Ser/gL-Cys144Ser mutations had impaired syncytia formation and reduced interference of HCMV entr

108 on human and rat HCC cells showed extensive syncytia formation and significantly enhanced cytotoxic

109 ficiently neutralized SARS-CoV and inhibited syncytia formation between cells expressing the S protei

110 ion of a recombinant VSV capable of inducing syncytia formation between tumor cells through membrane

111 3 and CKR-2b support HIV-1 89.6 env-mediated syncytia formation but do not support fusion by any of t

112 showed that an MMP inhibitor interferes with syncytia formation elicited by mutant F proteins and con

113 ocal HCC lesions in their livers resulted in syncytia formation exclusively within the tumors, and th

114 were generated to establish their effects on syncytia formation in replication in vitro and in the hu

115 Here, we showed that syncytia formation is dependent on proteins of the recen

116 These in vitro effects of aggressive syncytia formation translated to severely impaired skin

117 cells expressing MBG or EBO GP and mediated syncytia formation triggered by MBG GP.

118 helial cells results in cell-cell fusion and syncytia formation triggered by the fusion (F) and attac

119 However, syncytia formation was much greater with coexpression of

120 ddBCNAs also inhibit wild type measles virus syncytia formation with a TCID(50) of 7.5 muM for the le

121 IgM inhibited by >90% syncytia formation with the X4-IIIB infected SupT-1 cell

122 tive in promoting cell-to-cell fusion (i.e., syncytia formation) compared with JPV.

123 mination showed evidence of cytolysis, giant syncytia formation, and apoptotic changes evidenced by o

124 e, as indicated by exit from the cell cycle, syncytia formation, and the presence of muscle myosin fi

125 /920F substitutions in VZV caused aggressive syncytia formation, reducing cell-cell spread.

126 sed a four- to eightfold increase in RD cell syncytia formation, whereas anti-CD9 and anti-CD81 antib

127 hat Ck-17 expression localized to regions of syncytia formation.

128 and anti-CD81 antibodies markedly delayed RD syncytia formation.

129 V-infected cells into the CNS, and promoting syncytia formation.

130 progeny virions and prevent back-fusion and syncytia formation.

131 esis uncoupled from cytokinesis, whereas the syncytia formed by cyst nematodes arise from coordinated

132 ve syncytia compared to the relatively small syncytia formed during native VZV infection.

133 otif in GALV results in vectors with reduced syncytia forming capabilities.

134 omatitis virus, was previously shown to lose syncytia-forming ability if six residues (GLIIGL) were d

135 ted hepatic arterial infusion of recombinant syncytia-forming VSV vector in advanced multifocal hepat

136 Nuclei in syncytia found in fungi, muscles, and tumors can behave

137 on, and thus, by preventing the formation of syncytia, Gag helps to secure efficient transfer of vira

138 Similar DC-syncytia have been identified within the mucosal surface

139 This resulted in the formation of larger syncytia, higher production of infectious particles, and

140 gest that mixed ploidy is tolerated in these syncytia; however, there may be costs associated with va

141 ablation in RPE develop pigmentary changes, syncytia, hypoplasia, age-dependent centrifugal and non-

142 xpression, and a wild-type ability to induce syncytia in an XC cell cocultivation assay.

143 and -2 and assayed for the ability to induce syncytia in BJAB cells and HeLa cells.

144 sally linked to the development of extensive syncytia in brain capillary endothelial cells (BCEC).

145 The adapted virus induces large syncytia in cells containing either wild-type or mutant

146 ransported to the cell surface and to induce syncytia in cells expressing the ecotropic receptor.

147 This protein induced extensive syncytia in cells expressing the normal virus receptor C

148 rarity of clinical isolates able to produce syncytia in culture suggests that extensive cell fusion

149 t VZV-induced cell fusion continued to cause syncytia in cultured cells infected with rOka47DeltaC or

150 ral budding, and self-propagating ability of syncytia in HIV-infected SUP-T1 cell cultures and indivi

151 S protein can also mediate the formation of syncytia in infected cells.

152 halitis and analyzed their ability to induce syncytia in monocyte-derived macrophages (MDM) and neuro

153 ducing the formation of large multinucleated syncytia in Mus dunni cells.

154 pared gene expression profiles of developing syncytia in soybean near-isogenic lines differing at Rhg

155 characteristic cytopathic effect by forming syncytia in susceptible cells.

156 virus was impaired in its ability to induce syncytia in T-cell lines.

157 Adaptation of FIV to replicate and form syncytia in the Crandell feline kidney (CrFK) cell line

158 of multinucleated feeding structures termed syncytia in the roots of host plants.

159 The R(+) Env protein induced syncytia in XC cells expressing a mutant mCAT1 lacking b

160 formation and maintenance of feeding sites (syncytia) in host roots, and these processes are highly

161 345 prevented the formation of typical giant syncytia induced by HIV Bal strain replication in these

162 ed mice were able to reduce the formation of syncytia induced by the envelope glycoprotein of HTLV-1,

163 ficantly suppressed the formation of XC cell syncytia induced by the R(+) Env protein but not that in

164 These results indicate that syncytia induced in the resistant line are undergoing se

165 opic variants, also designated slow/low, non-syncytia-inducer or macrophage-tropic, which dominate th

166 (+) T cells acutely infected with either non-syncytia-inducing (NSI) or syncytia-inducing (SI) HIV-1

167 hat acute infection of CD4+ T cells with non-syncytia-inducing (NSI) viruses generally increased beta

168 is transmitted by macrophage (M)-tropic/non-syncytia-inducing (NSI) viruses, which hyperactivate the

169 d with either non-syncytia-inducing (NSI) or syncytia-inducing (SI) HIV-1 isolates.

170 ent of M-tropic viruses by T cell (T)-tropic/syncytia-inducing (SI) viruses, which are known to be hi

171 nstrated that IL-2 treatment inhibited HIV-1 syncytia-inducing ability and dose-dependently decreased

172 kin 4 (IL-4) inhibits the propagation of non-syncytia-inducing and increases the propagation of syncy

173 ia-inducing and increases the propagation of syncytia-inducing HIV-1 isolates by two mechanisms.

174 lution and in the phenotypic switch from non-syncytia-inducing to syncytia-inducing, which leads to a

175 notypic switch from non-syncytia-inducing to syncytia-inducing, which leads to accelerated disease pr

176 Envelope glycoprotein gp120 of syncytia-inducing/lymphocyte tropic HIV-1 strains induce

177 Death of syncytia is associated with nuclear fusion and premature

178 the longitudinal and circular smooth muscle syncytia is necessary to provide the "mixing" type of mo

179 e potential explanation for the formation of syncytia is viral adaptation for these CD4(+) CNS cells.

180 used methods do not allow quantification of syncytia, nor do they estimate the number of cells invol

181 le germ cells develop in full synchrony as a syncytia of interconnected cells called germline cysts (

182 Spl574 produces large syncytia of multinucleated giant cells in M. dunni cells

183 Thus, the syncytia of such germaria are filled with mitochondria.

184 Defense-related genes up-regulated within syncytia of the resistant line included those predominan

185 ls and a somewhat enhanced ability to induce syncytia on CHO-C8 cells.

186 DNA had a markedly reduced ability to induce syncytia on CHO-HVEM12 cells and a somewhat enhanced abi

187 d substitution in gK, induced numerous large syncytia on HveA-expressing Chinese hamster ovary cells

188 cystamine-treated cultures lacked the giant syncytia or CPE induced by HIV-1 infection.

189 Of 11 Env variants that failed to induce syncytia or did so poorly, 7 contained changes in amino

190 APMV-7 does not form syncytia or plaques in cell culture, but its replication

191 The Ban/AF vaccine virus did not produce syncytia or plaques in cell culture, even in the presenc

192 of the HIV-1 envelope glycoproteins to form syncytia or to support virus entry.

193 The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscle function, as

194 Both lower SLP and fewer syncytia positively correlated with fecal STEC numbers.

195 ial dysfunction occurred in GALV-FMG-induced syncytia prior to loss of viability with loss of the mit

196 Dying syncytia produce significantly more syncytiosomes than n

197 When around 50 cells were fused, the syncytia rapidly disintegrated and many of the infected

198 ssays and is debilitated in the formation of syncytia relative to the wild-type F protein, the F Tail

199 In Drosophila, the formation of muscle syncytia requires the cooperative participation of two t

200 ated with apoptosis and/or the generation of syncytia resulting from the direct cell-to-cell transmis

201 es fusion of infected endothelial cells into syncytia, resulting in endothelial disruption and hemorr

202 elopmentally upregulated within giant cells, syncytia, root tips, and lateral root primordia.

203 P-T1 cell cultures and individually isolated syncytia seeded in uninfected SUP-T1 cell cultures.

204 viral proteins, and fuse into multinucleated syncytia several days later.

205 d elevated levels of HIV-1, and formed large syncytia similar to untreated cells.

206 f either causes infected cells to form large syncytia spontaneously.

207 peutic repair or cellular delivery system to syncytia such as the myocardium.

208 ny is rarely observed in naturally occurring syncytia, such as the multinucleate fungus Ashbya gossyp

209 erminal epitope tag induced the formation of syncytia, suggesting partial interference with the funct

210 F or HN does not result in the formation of syncytia, suggesting serotype-specific protein differenc

211 Viruses that infect T-cell lines to form syncytia (syncytium-inducing, SI) are frequently found i

212 The mutant virus also formed larger syncytia than the wild-type virus, linking CKII-mediated

213 the passaged, pathogenic SHIVs induced more syncytia than those of the respective parental SHIV.

214 Cell fusions produce multinucleate syncytia that are crucial to the structure of essential

215 resulting in the formation of multinucleated syncytia that eventually became nonviable.

216 at low density, the BMP4-treated cells form syncytia that express chorionic gonadotrophin (CG).

217 resulted in the formation of multinucleated syncytia that reached a maximum 5 days after transfectio

218 d PLC-sensitive PI(4,5)P(2) pool in the cell syncytia that supports auditory hair cells; (ii) spatial

219 them to fuse with neighboring cells to form syncytia that ultimately die.

220 o target cells and for the cell-cell fusion (syncytia) that results from many paramyxoviral infection

221 ted at a low multiplicity were fused to form syncytia, thereby allowing capsids released from infecte

222 bset of infected cells formed multinucleated syncytia through HIV envelope-dependent cell fusion.

223 rus entry and fusion as well as formation of syncytia through interaction with the EFC.

224 Both giant cells and syncytia undergo extensive cell wall architectural modif

225 ix soybean GeneChip directly compared Peking syncytia undergoing a resistant reaction to those underg

226 nematode-induced feeding structures known as syncytia undergoing an incompatible interaction with the

227 ously by RNA-seq experiments as expressed in syncytia undergoing an incompatible reaction.

228 The cytological features of syncytia undergoing susceptible or resistant reactions a

229 NSF attachment protein gene specifically in syncytia undergoing their defense responses.

230 cal herpetic lesions typically contain large syncytia, underscoring the importance of cell-to-cell fu

231 erved that BDV-infected cells form extensive syncytia upon low-pH treatment.

232 ng CD4 and CCR5 formed multinucleated cells (syncytia) upon exposure to BaL, a macrophagetropic strai

233 ssed by counting multinucleated giant cells (syncytia) visualized by light microscopy.

234 tion of cyst nematode EGases into developing syncytia was not detected.

235 Formation of syncytia was observed in tumors treated with retargeted

236 Syncytia were detected by DNA staining with propidium io

237 SLP was lower (P < 0.05) and syncytia were fewer (P < 0.05) in STEC-treated sheep tha

238 ould not be recovered, even though transient syncytia were formed in transfected cells.

239 Instead, the S100+ infected syncytia were localized to the surface of tonsil invagin

240 Syncytia were markedly absent, and little or no viral an

241 Differences in the ability to induce syncytia were not due to differences in the levels of to

242 No increase in Ck-17 mRNA expression and no syncytia were observed in RSV-infected cells grown in th

243 After 24 h, syncytia were observed, and cell culture supernatants fr

244 e muscle MAP4 isotype, but the multinucleate syncytia were short and apolar, microtubules were disorg

245 The syncytia were smaller, and they were present in lower nu

246 ines that express the target receptor; these syncytia were substantially larger than the plaques form

247 The syncytia were viable for a period of 2 days and then rap

248 mutant in transfected cells was evident when syncytia were visualized and counted, it was not detecte

249 bridges, which characterize the formation of syncytia, were never observed.

250 their ability to form large, multinucleated syncytia when cocultured with the rat XC cell line.

251 1, respectively, and they then form abundant syncytia when exposed to these viruses.

252 xpressing F, G, TM, or F plus G did not form syncytia whereas cells expressing F plus TM formed some

253 factor genes were upregulated in developing syncytia, whereas in non-infected plants, these two prom

254 ical constraints govern the integrity of the syncytia which are formed upon extensive cell fusion.

255 of HEp-2 cells, the SH-minus virus produced syncytia which were at least equivalent in size to those

256 lls by fusing them into large multinucleated syncytia, which die by sequestration of cell nuclei and

257 ed (1) the formation of giant multinucleated syncytia, which eventually underwent necrotic lysis, and

258 s expressing the modified Env failed to form syncytia with CD4(+) permissive cells.

259 aging cell line, psi 422, psi 422 cells form syncytia with CD4-positive cells, correctly express HIV-

260 with CD4 enables nonpermissive cells to form syncytia with cells expressing M-tropic, but not T-tropi

261 ncy virus-1 receptors, formed multinucleated syncytia with cells expressing S protein.

262 or the chimeric HIV envelope protein formed syncytia with cells expressing the CD4 receptor for HIV.

263 e show that intact rotavirus and VLPs induce syncytia with cells that are permissive to rotavirus inf

264 contrast, arginine substitutions resulted in syncytia with only 2-fold more nuclei, a -0.5-log10 redu

265 Cells expressing the 89.6 env protein form syncytia with QT6 cells expressing CD4 and either Fusin

266 to correlate the ability of HTLV-2 to induce syncytia with the ability to replicate in BJAB cells.

267 ed to enhanced fusion and formation of giant syncytia with uninfected cells.

268 Ecotropic murine leukemia virus forms large syncytia with XC cells, whereas no syncytia are reported

269 ding domain, formed the large multinucleated syncytia with XC cells.