ライフサイエンスコーパス: syncytiotrophoblast

1 iformly bind to chondroitin sulfate A on the syncytiotrophoblast.

2 ial cells that may be analogous to the human syncytiotrophoblast.

3 ociated with the microvilli of the placental syncytiotrophoblast.

4 to the pH-neutral basolateral surface of the syncytiotrophoblast.

5 essed in the basal membrane of the placental syncytiotrophoblast.

6 rentiation program: fusion into an overlying syncytiotrophoblast.

7 phoblasts compared to that in differentiated syncytiotrophoblast.

8 MMP-14 was predominately localized to the syncytiotrophoblast.

9 several placental cell types, including the syncytiotrophoblast.

10 esence of both ET-1 and its receptors in the syncytiotrophoblast.

11 ding the transcriptome of the multinucleated syncytiotrophoblast.

12 a, that is a unique compartment known as the syncytiotrophoblast.

13 hoblast and coordinately lost in postmitotic syncytiotrophoblast.

14 space and also at significant levels to the syncytiotrophoblasts.

15 ffecting differentiation of the labyrinthine syncytiotrophoblasts.

16 ramatically as cytotrophoblasts fuse to form syncytiotrophoblasts.

17 tissue, and at very high levels by placental syncytiotrophoblasts.

18 tiate to either extravillous trophoblasts or syncytiotrophoblasts.

19 n/nodal inhibition leads to the formation of syncytiotrophoblasts.

20 mediates adherence to CSA on the surface of syncytiotrophoblasts.

21 pment and is expressed, like CS and GH-V, in syncytiotrophoblasts.

22 galectins are predominantly expressed by the syncytiotrophoblast, a primary site of metabolic exchang

23 the hypothesis that release occurs from the syncytiotrophoblast after the induction of apoptotic cha

24 onstrated that TRAIL protein is prominent in syncytiotrophoblast, an uninterrupted placental cell lay

25 They are secreted by the syncytiotrophoblast and are detected around day 14 postf

26 EPI64 colocalizes with EBP50 and ezrin in syncytiotrophoblast and cultured cell microvilli, and th

27 ey spontaneously fuse to form a multinuclear syncytiotrophoblast and CYP19 expression is markedly ind

28 vestigate the possibility that the placental syncytiotrophoblast and deported trophoblastic debris se

29 rst and second-trimester placenta as well as syncytiotrophoblast and extravillous cytotrophoblast of

30 ytotrophoblast cells but not in post-mitotic syncytiotrophoblast and invasive extravillous cytotropho

31 Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear c

32 during cytotrophoblast differentiation into syncytiotrophoblast and the impact of any changes on PlG

33 MT1-MMP was expressed predominantly in the syncytiotrophoblast and the villous and extravillous cyt

34 bs show extensive expression of hFcRn in the syncytiotrophoblast and traces in the endothelium and ot

35 to investigate the presence of mHAgs in the syncytiotrophoblast and trophoblast debris shed from fir

36 duce mesoderm progeny, APA(+) cells generate syncytiotrophoblasts and CD87(+) cells give rise to vasc

37 s)-precursors of the mature placental cells, syncytiotrophoblasts and cytotrophoblasts, in chorionic

38 ndistinguishable results were obtained using syncytiotrophoblasts and in experiments using trophoblas

39 and in situ in 18- to 20-week-old placental syncytiotrophoblasts and invasive trophoblasts.

40 o the formation of multinucleated myofibers, syncytiotrophoblasts and osteoclasts, allowing their res

41 nclude cytotrophoblasts differentiating into syncytiotrophoblasts) and anchoring villi (which include

42 ignal sequence receptor 1) were found in the syncytiotrophoblast, and one antigen (DDX3Y) was found i

43 ned to the late endosomal compartment of the syncytiotrophoblast, and tightly associated to the gener

44 G glycoprotein also was expressed in villous syncytiotrophoblasts, and accumulation of Mamu-AG glycop

45 rescence staining of the endogenous RBCs and syncytiotrophoblasts, and co-localization of CSPG and IR

46 fferentiated into chorionic trophoblasts and syncytiotrophoblasts, as demonstrated by their expressio

47 onitis and increased TNF-alpha production by syncytiotrophoblasts assessed by immunohistochemistry (a

48 domains where trophoblast cells fuse into a syncytiotrophoblast at the fetomaternal interface, consi

49 insights into the defense mechanisms used by syncytiotrophoblasts at various stages of human gestatio

50 For example, HVEM was identified on syncytiotrophoblast but not in villous mesenchymal cells

51 PL is normally only expressed in placental syncytiotrophoblasts, but PL genes are amplified and exp

52 In the human placental syncytiotrophoblast, C(19) steroids are converted to est

53 ified decreased Fpn1 expression in placental syncytiotrophoblast cells at late gestation as the mecha

54 The protein was highly expressed in the syncytiotrophoblast cells of the labyrinth layer of the

55 lls, and in the case of pregnancy, placental syncytiotrophoblast cells) and several forms of chaperon

56 developed 3D cell-line-based models of human syncytiotrophoblasts, cells that lie in direct contact w

57 The antigens were detected in the placental syncytiotrophoblasts, chorionic trophoblasts, decidual c

58 he maternal vessels and endometrium, whereas syncytiotrophoblasts covering trophoblastic lacunae or n

59 tal trophoblast to ZIKV: cytotrophoblast and syncytiotrophoblast derived from placental villi at term

60 In chorionic villi, syncytiotrophoblasts did not become infected, although c

61 Overexpression of Mash-2 prevents syncytiotrophoblast differentiation and induction of CYP

62 en cytotrophoblasts are cultured in 2% O(2), syncytiotrophoblast differentiation and induction of CYP

63 teasomal degradation of USF1/2, resulting in syncytiotrophoblast differentiation and induction of hCY

64 USF2 and DNA-binding activity declined with syncytiotrophoblast differentiation and were maintained

65 otein binding to these E boxes declined with syncytiotrophoblast differentiation in 20% O(2) and was

66 ich are indicative of spongiotrophoblast and syncytiotrophoblast differentiation, respectively.

67 to define mechanisms for O(2) regulation of syncytiotrophoblast differentiation, we found that hypox

68 at elevated levels by hypoxia, declines with syncytiotrophoblast differentiation.

69 cytotrophoblasts dramatically decreased upon syncytiotrophoblast differentiation.

70 ression of these microRNAs (miRNAs) impaired syncytiotrophoblast differentiation.

71 5, that are significantly downregulated upon syncytiotrophoblast differentiation.

72 binding activity to the Gcm1 promoter during syncytiotrophoblast differentiation.

73 ng the surface of villi that float in blood, syncytiotrophoblasts express the neonatal Fc receptor (F

74 In placental villi, syncytiotrophoblasts express the virion receptor epiderm

75 PE), there is increased release of placental syncytiotrophoblast extracellular vesicles (STBEVs) and

76 ed a consistent pattern of MIF expression in syncytiotrophoblasts, extravillous trophoblasts, IVB mon

77 f MT1-MMP and MT2-MMP, which is critical for syncytiotrophoblast formation and in turn for fetal vess

78 cm1) in trophoblast cells, preventing excess syncytiotrophoblast formation and permitting normal plac

79 in the process of cell fusion necessary for syncytiotrophoblast formation and that during this physi

80 equired for increased expression of Gcm1 and syncytiotrophoblast formation as well as impaired placen

81 this interaction regulates Gcm1 expression, syncytiotrophoblast formation, placental vascularization

82 whereas lack of Plet1 preferentially induces syncytiotrophoblast formation.

83 In contrast, syncytiotrophoblasts from placentas with high neutralizi

84 reconstituted apical membranes of term human syncytiotrophoblast (hST), containing endogenous PC2 (PC

85 enerates all labyrinth trophoblast subtypes, syncytiotrophoblasts I and II, and sinusoidal trophoblas

86 ells in first trimester placentas and to the syncytiotrophoblast in term placentas.

87 acenta, HO-2 immunostaining was prominent in syncytiotrophoblast in the first trimester and reduced t

88 placenta, able to differentiate either into syncytiotrophoblasts in floating chorionic villi or extr

89 totrophoblasts in the first trimester and to syncytiotrophoblasts in the third trimester.

90 al cytotrophoblasts were differentiated into syncytiotrophoblasts in vitro to examine AP-2 expression

91 nscytosed by the neonatal Fc receptor across syncytiotrophoblasts, infect underlying cytotrophoblasts

92 kness, and the apical plasma membrane of the syncytiotrophoblast interacts directly with maternal blo

93 villous cytotrophoblasts with the overlying syncytiotrophoblast is essential for the maintenance of

94 Syncytiotrophoblast is the multinucleated epithelium of

95 Syncytiotrophoblast is the primary barrier regulating th

96 d2 in sinusoidal trophoblast giant cells and syncytiotrophoblasts is likely to have a non-cell autono

97 IgG transport across the first layer, the syncytiotrophoblast, is almost certainly mediated by the

98 ion chorionic villous explants, we show that syncytiotrophoblasts isolated from the second trimester

99 cells, including villous macrophages and the syncytiotrophoblast layer of placenta, Kupper cells in t

100 al zone, where trophoblast cells fuse into a syncytiotrophoblast layer to form the maternofetal inter

101 these genes were primarily localised to the syncytiotrophoblast layer, and showed decreased expressi

102 cental defects in the spongiotrophoblast and syncytiotrophoblast layers, resulting in an arrest of va

103 terminal differentiation and polarization of syncytiotrophoblasts, leading to intrauterine fetal grow

104 ate cytotrophoblast cells (18 h culture) and syncytiotrophoblast-like cells (66 h culture).

105 lycan chondroitin sulfate A (CSA) present on syncytiotrophoblasts lining the placental blood spaces.

106 activity, could have major implications for syncytiotrophoblast metabolism and function as well as f

107 lucose transporter isoform 1 (GLUT-1) on the syncytiotrophoblast microvillous and basal plasma membra

108 ral amino acid transporter (LAT) isoforms in syncytiotrophoblast microvillous membranes (MVMs).

109 r sites of syncytin expression are placental syncytiotrophoblasts, multinucleated cells that originat

110 Western blotting, and immunolocalized to the syncytiotrophoblast; necrosis was also evidenced by rele

111 Whereas eNOS was expressed by syncytiotrophoblast, neither eNOS or iNOS was expressed

112 in non-excitable tissue, is apparent in the syncytiotrophoblast of both first trimester and term hum

113 TRPC6 staining was present in the syncytiotrophoblast of both first trimester and term pla

114 Whereas B7-DC was prominent on the syncytiotrophoblast of early placenta, it was absent fro

115 Furthermore, ET-1 levels increased in the syncytiotrophoblast of explants from normal placentas af

116 ophoblast, cytotrophoblast cell columns, and syncytiotrophoblast of first and second-trimester placen

117 [Ca2+]i in syncytiotrophoblast of first trimester and term placenta

118 we show that aquaporin-4 is expressed in the syncytiotrophoblast of human and mouse placenta.

119 okine fractalkine, which is expressed in the syncytiotrophoblast of human placenta, from where it is

120 ere significantly reduced in brush border of syncytiotrophoblast of infected placentas; (b) amounts o

121 channel that controls PC2 function in human syncytiotrophoblast of term placenta.

122 e an important route for Ca2+ entry into the syncytiotrophoblast of term, but not first trimester pla

123 expression of NKB was confined to the outer syncytiotrophoblast of the placenta, significant concent

124 er of tissues, including ovary, adipose, and syncytiotrophoblast of the placenta.

125 lope genes were found to be expressed in the syncytiotrophoblasts of human and mouse placenta and to

126 immunoreactive protein(s) was present in the syncytiotrophoblasts of the chorionic villi of the rhesu

127 xcept for keratinocytes of the hair bulb and syncytiotrophoblasts of the placenta, but was present in

128 1 confirmed high expression in the cyto- and syncytiotrophoblasts of the placenta.

129 to the mature cell types of chorionic villi-syncytiotrophoblasts on the surfaces of floating villi a

130 on as well as improving knowledge of how the syncytiotrophoblast operates.

131 ent by promoting differentiation towards the syncytiotrophoblast or giant cell pathway in Plet1-low a

132 We recently demonstrated that PC2 from human syncytiotrophoblast (PC2hst) but not the in vitro transl

133 m a preparation of apical membranes of human syncytiotrophoblast (PC2hst) reconstituted in a lipid bi

134 The placental syncytiotrophoblast releases micro and nanovesicles (STB

135 (CT) ends in formation of the multinucleated syncytiotrophoblast representing the fetal-maternal inte

136 ore, we also identify that loss of Cited2 in syncytiotrophoblasts results in the subcellular mislocal

137 The syncytiotrophoblast (SCT) at the maternal-fetal interfac

138 TB), precursors to terminally differentiated syncytiotrophoblast (STB) in chorionic villi and extravi

139 s are responsible for gas/nutrient exchange (syncytiotrophoblasts, STBs) and invasion and maternal va

140 EL, Annexin V binding and ADP:ATP in CTs and syncytiotrophoblasts (STs).

141 e that all three isoforms are present in the syncytiotrophoblast suggesting each plays a role in amin

142 1 is found at the basal surface of placental syncytiotrophoblasts, suggesting that it also transports

143 xpressed in the apical membrane of placental syncytiotrophoblasts, suggesting that it may protect the

144 nt both in the intervillous space and on the syncytiotrophoblast surface, HA is absent in these locat

145 and secondly, maternal blood surrounding the syncytiotrophoblast (SYN).

146 (CytT), before and after differentiation to syncytiotrophoblast (SynT) in primary culture, revealed

147 l placenta, maternal blood directly contacts syncytiotrophoblasts that cover chorionic villi and cyto

148 he microvillous plasma membrane (MVM) of the syncytiotrophoblast, the transporting epithelium of huma

149 First, the syncytiotrophoblast, the transporting epithelium of the

150 ture and villous cytotrophoblasts underlying syncytiotrophoblasts, then reaches blood vessels in the

151 oss the basal membrane (BM) of the placental syncytiotrophoblast to the fetus, although vital for ami

152 suggesting a role for this pathway in murine syncytiotrophoblast turnover.

153 d maternal immunoglobulin G were detected in syncytiotrophoblasts, villus core macrophages, and dendr

154 cental IL-1beta, and TNF-alpha production by syncytiotrophoblasts was independently associated with d

155 In vitro studies demonstrated that syncytiotrophoblasts were not a major source of sTNFR.

156 villi that were infected with CMV in utero, syncytiotrophoblasts were often spared, whereas cytotrop

157 underlying villus cytotrophoblasts, whereas syncytiotrophoblasts were spared.

158 lacenta in the apical plasma membrane of the syncytiotrophoblasts, where the transferrin-bound iron i

159 by conversion to trophoblast, and especially syncytiotrophoblast, whereas an A83-01/PD173074 combinat

160 se, and differentiate to form multinucleated syncytiotrophoblast with induction of aromatase (hCYP19A

161 (2), human cytotrophoblasts fuse to form the syncytiotrophoblast with marked induction of hCYP19 (aro

162 of CMV transmission to the fetus: (i) across syncytiotrophoblasts with subsequent infection of the un

163 These cells, particularly areas of syncytiotrophoblast within the colonies, quickly become