ライフサイエンスコーパス: syncytium

1 ce viral envelope-mediated cell-cell fusion (syncytium).

2 rted to change expression in the Arabidopsis syncytium.

3 enting transfating and for fusion of the PMC syncytium.

4 site of infection, a nurse cell known as the syncytium.

5 e in the blastocoel and fail to join the PMC syncytium.

6 site of infection, a nurse cell known as the syncytium.

7 ells, P(1-8).p, fuse with the hyp7 epidermal syncytium.

8 ium and in cells to be incorporated into the syncytium.

9 properties of the PM in the early embryonic syncytium.

10 maintained by the fusion of myoblasts to the syncytium.

11 r bridge interconnecting daughter cells in a syncytium.

12 -regulated genes in the H. schachtii-induced syncytium.

13 ins with 13 nuclear division cycles within a syncytium.

14 ithout LDA treatment on a model of placental syncytium.

15 ry signal" from the adjacent hyp7 hypodermal syncytium.

16 that enable the myocardium to function as a syncytium.

17 ls, inappropriately fuse into a single large syncytium.

18 sase enzyme can diffuse throughout the gonad syncytium.

19 parenchymal cells tightly juxtaposed to the syncytium.

20 id load to be transmitted across the stromal syncytium.

21 iently distribute the excess K(+) across the syncytium.

22 erneuron participates in a large, continuous syncytium.

23 pure mESC-CM patches did not form functional syncytium.

24 agonists are integrated responses of the SIP syncytium.

25 type of the SMC-ICC-PDGFRalpha(+) cell (SIP) syncytium.

26 e expression changes in the nematode-induced syncytium.

27 2+) or ATP were introduced to the astrocytic syncytium.

28 these cells affects the excitability of the syncytium.

29 ss needed to resolve individual sperm from a syncytium.

30 when no new cells are incorporated into the syncytium.

31 he heart to function as an electromechanical syncytium.

32 cytes with M bands assembled as a functional syncytium; (2) systolic twitch forces at a similar level

33 ying enzyme, are expressed in the developing syncytium and in cells to be incorporated into the syncy

34 re explicitly related to the geometry of the syncytium and kinetics of nucleocytoplasmic shuttling.

35 Using syncytium and luciferase reporter gene fusion assays, we

36 activity is required in the major hypodermal syncytium and not in the VPCs to inhibit vulval fates.

37 ised that BETL cell fate is specified in the syncytium and that cell files subsequently develop in re

38 s in part function as a coordinated cellular syncytium, and disruption of intercellular communication

39 eam cells, hypodermal cells of the main body syncytium, and the excretory cell, all of which are pola

40 at the pancreatic islet acts as a functional syncytium, and the whole islet [Ca2+]i response has been

41 The syncytium appears to undergo two developmental phases du

42 ks underlying gene expression control in the syncytium are poorly understood.

43 principles underlying nuclear dispersal in a syncytium are unclear.

44 ted stronger alpha-tubulin signal within the syncytium as compared to surrounding tissue.

45 mitting infection to all the nuclei within a syncytium as efficiently as the wild-type HSV-1 strain 1

46 elope glycoproteins were highly fusogenic in syncytium assays, and these all increased the efficiency

47 nd hemagglutinin expression plasmids or with syncytium-based assays in Vero, Vero-SLAM, and Vero-Nect

48 neously developing into an electromechanical syncytium by disassembling focal adhesions at the cell-c

49 o, it remains uncertain whether a functional syncytium can be formed between donor and recipient cell

50 A single fungal syncytium can harbor thousands or millions of mobile and

51 cell expressing HCN2 could create a two-cell syncytium capable of generating sustained pacing.

52 oRNA396 (miR396) in cells giving rise to the syncytium coincides with the initiation of the syncytial

53 A fungal colony is a syncytium composed of a branched and interconnected netw

54 n culture, CD166+ cells form an autorhythmic syncytium composed of cells morphologically similar to a

55 cells, stimulating cell wall hydrolysis for syncytium development.

56 overlapped with more than one-fourth of the syncytium differentially expressed genes and are of func

57 of 278 genes was identified as specifically syncytium differentially methylated genes.

58 ls and this activation was maintained in the syncytium during all sedentary stages of nematode develo

59 ignaling pathways locally at the site of the syncytium during the resistance phase of the resistant r

60 e localized gene expression occurring at the syncytium during the resistant reaction was studied.

61 tubulin (GmTubB4) and several other genes in syncytium-enriched samples as compared to samples extrac

62 in the zebrafish embryo is a multinucleated syncytium essential for embryo development, but the mole

63 e highly upregulated in the nematode-induced syncytium (feeding cells), and deliberate manipulations

64 , Nelson Bay virus, has been shown to induce syncytium formation (34).

65 In vitro, the F-L179V virus caused increased syncytium formation (cell-cell membrane fusion) yet had

66 irus from 10 of the treated patients induced syncytium formation (SI virus) when cultured with MT2 ce

67 hemifusion, cytoplasmic content mixing, and syncytium formation ability of the wild-type SER virus F

68 We observed syncytium formation activity with both the wild-type and

69 The XC cell line undergoes extensive syncytium formation after infection with ecotropic murin

70 V94A and MV F V94G viruses induce extensive syncytium formation and are relatively, or almost comple

71 ally inactivates RhoA, inhibited RSV-induced syncytium formation and cell-to-cell fusion, although si

72 ly increased membrane fusion, as measured by syncytium formation and content mixing.

73 /-) but not WT MEF cells displayed extensive syncytium formation and cytopathic effect (CPE) followin

74 ed levels of surface S protein could promote syncytium formation and direct cell-to-cell spread of th

75 ion mutant is hyperfusogenic as monitored by syncytium formation and in a quantitative fusion assay a

76 ults suggest that the HD is involved in both syncytium formation and in determining p10 transport and

77 of furin cleavability by APMV-7 resulted in syncytium formation and increased virus yield in vitro b

78 teraction with A56/K2 suppresses spontaneous syncytium formation and possibly "fuse-back" superinfect

79 restingly, the L161M mutant showed increased syncytium formation and promoted fusion at lower tempera

80 Here, we report that in both syncytium formation and viral entry assays, removal of m

81 (NiV-F) envelope glycoproteins mediate both syncytium formation and viral entry.

82 mRNA and protein synthesis, but it inhibited syncytium formation and virus assembly/release.

83 Syncytium formation and virus yield of the Fcs-5B virus

84 CAT-1 receptors, these results suggest that syncytium formation as well as altered host range may be

85 ant ability after trypsin cleavage to induce syncytium formation at pH 5.1; however, neither the chim

86 T gondii C-18 efficiently blocked syncytium formation between human T cells and effector c

87 s virus morphology, cell-to-cell fusion, and syncytium formation but is dispensable for the efficient

88 idence suggested that HERV-W Env can mediate syncytium formation by interacting with the human sodium

89 sites, and tunicamycin treatment suppressed syncytium formation by R(+) Env in those cells.

90 ycosylation is required for XC cell-specific syncytium formation by the R(+) Env protein.

91 Disruption of trophoblast syncytium formation consequently leads to developmental

92 Sequencing and mutagenesis demonstrated that syncytium formation could be attributed to a single amin

93 enhanced lipid mixing, calcein transfer, and syncytium formation even in the presence of the long SER

94 ected HCC cell lines, resulting in extensive syncytium formation followed by cell death.

95 Finally, the mechanism of epidermal syncytium formation following JNK hyperactivation and wo

96 th cell culture-adapted strains of FIV or to syncytium formation following transfection with a eukary

97 ive infection with primary strains of FIV or syncytium formation following transfection with primary

98 plex (EFC) and that the EFC is necessary for syncytium formation furnishes a strong connection betwee

99 (PRN) Abs, mainly IgG2a, that also inhibited syncytium formation in CD150(+) B95-8 cells.

100 cytotail mutations may additionally suppress syncytium formation in cells infected with syn HSV-1 by

101 n cultures of blood mononuclear cells and by syncytium formation in cocultures of the same with F-81

102 rLCMV/VSVG caused syncytium formation in cultured cells and grew to approx

103 f the respective HN and F proteins to induce syncytium formation in heterologous expression studies.

104 e 1 (HIV-1) infection and promote cytopathic syncytium formation in infected cells commence with the

105 glut-1 also markedly increased syncytium formation in MDBK cells after exposure to HTLV

106 F] mutant exhibited dramatically accelerated syncytium formation in melanoma cells caused by fusion o

107 (FIP) was shown to block MeV infections and syncytium formation in monkey kidney cell lines.

108 Syncytium formation in MT-2 cells and CCR5 or CXCR4 core

109 ved enhanced hemifusion, content mixing, and syncytium formation in SER virus F- and HN-expressing ce

110 plication rate, and did not cause observable syncytium formation in the lungs.

111 Live imaging of wound-induced syncytium formation in the pupal epidermis suggested dir

112 ociated with protease dependence and lack of syncytium formation in their respective native viruses,

113 d that TR1.3 and W102G Envs failed to elicit syncytium formation in these in vitro assays.

114 dependency on the HN attachment protein for syncytium formation in transfected cells.

115 virus induced remarkably rapid and extensive syncytium formation in Vero cells involving hundreds of

116 We assessed viral coreceptor use via syncytium formation in vitro and with a modified PhenoSe

117 se motif conferred increased replication and syncytium formation in vitro.

118 pression of either form of SYNCRIP inhibited syncytium formation induced by MHV infection.

119 h occurs upon wounding, also correlated with syncytium formation induced by PINCH knockdown.

120 Syncytium formation involves the redifferentiation and f

121 Although syncytium formation is a hallmark of VZV infection, infe

122 r efficacies in blocking membrane fusion and syncytium formation mediated by measles virus (MeV).

123 D4 expression protected cells from lysis and syncytium formation mediated by the HIV-1 envelope glyco

124 brain microvessels and causes cell-specific syncytium formation of brain capillary endothelial cells

125 on, although HERV-W Env mediates only slight syncytium formation or infection of mouse cells, it util

126 ly GTPases established that HIV Env-mediated syncytium formation relies on Rac-1 but not on Cdc42 or

127 Inhibition of syncytium formation requires that F100G5 be present conc

128 low CD46 density but requires less CD46 for syncytium formation than MV.

129 VZV-induced syncytium formation was markedly reduced by ATG5 knockdo

130 Low-pH-induced syncytium formation was observed in cells infected with

131 Levels of surface expression and syncytium formation were substantially higher at 33 degr

132 In contrast, viral replication and syncytium formation were unaltered in cells that express

133 nstrated by the failure of low pH to trigger syncytium formation when cells were infected with vA28-H

134 te for its human MuV counterpart in inducing syncytium formation when coexpressed in different mammal

135 efficiently cell surface expressed, exhibits syncytium formation when coexpressed with GhV-G protein,

136 The L539, 548A mutant also showed extensive syncytium formation when expressed without the SER virus

137 , there was as much as a 40-fold increase in syncytium formation when GS was coexpressed compared to

138 plasmic tail of glycoprotein B (gB), lead to syncytium formation will likely reveal how fusion is con

139 envelope protein (Env) in that it undergoes syncytium formation with cells expressing Env protein co

140 Both compounds inhibited syncytium formation with EC(50) values of 0.40 and 0.33

141 C, these fusion intermediates progressed to syncytium formation with enhanced kinetics compared with

142 Evidence of syncytium formation within the aggregates included the c

143 strains that produce extensive cell fusion (syncytium formation) in culture are regarded as variants

144 lt in virus-cell (viral entry) or cell-cell (syncytium formation) membrane fusion.

145 gK or UL20 gene cause extensive cell fusion (syncytium formation).

146 rpesvirus entry and cell-cell fusion induced syncytium formation, a characteristic of varicella-zoste

147 ly, cells expressing gH/gL showed pronounced syncytium formation, although expression of gH or gL alo

148 the gains in cleavability, replication, and syncytium formation, analysis of viral pathogenicity in

149 Coexpression of gag-pol with env restored syncytium formation, and accordingly, mutations within g

150 Infectivity, syncytium formation, and cytotoxicity of recombinant MV-

151 ession, release of infectious particles, and syncytium formation, and endogenous serine protease acti

152 all of them conferred protease independence, syncytium formation, and increased replication in cell c

153 Surprisingly, these mutated GP64s induced syncytium formation, and normalized fusion activities we

154 ited viral-initiated T-cell death and T-cell syncytium formation, at which time in the HIV life cycle

155 TRM did not induce syncytium formation, either in vivo or in vitro.

156 ghing of apical epithelial cells, occasional syncytium formation, goblet cell hyperplasia/metaplasia,

157 The lack of syncytium formation, however, correlated with a decrease

158 5 parainfluenza virus that does not exhibit syncytium formation, in contrast to most other paramyxov

159 No mode of syncytium formation, including that induced by wounding,

160 s of these viruses for replication in vitro, syncytium formation, mean embryo death time, intracerebr

161 tions in the viral genome caused exaggerated syncytium formation, reduced VZV titers (-1.5 log10), an

162 pression significantly increased the rate of syncytium formation, revealing a novel role for IL-2 sig

163 virus leads to extensive membrane fusion and syncytium formation, suggesting that the virus may sprea

164 98-1 with trypsin reversed its properties in syncytium formation, virus production, and genome transp

165 VZV syncytium formation, which has been implicated in the pa

166 raspanins in producer cells leads to reduced syncytium formation, while downregulation has the opposi

167 Rac GTPase activity is needed for syncytium formation, while the Hippo signaling effector

168 nforms the mechanism of cell dynamics during syncytium formation.

169 secondary to enhanced viral replication and syncytium formation.

170 t are enriched at HIV-1 exit sites, regulate syncytium formation.

171 which are otherwise resistant to MLV-induced syncytium formation.

172 absence of detectable extracellular virus or syncytium formation.

173 protein followed by the R peptide showed any syncytium formation.

174 d F protein surface expression and increased syncytium formation.

175 ative mutant of PKCepsilon (K437R) inhibited syncytium formation.

176 inhibited R5 (but not X4) envelope-mediated syncytium formation.

177 ignaling is important for RSV replication or syncytium formation.

178 also is required for A-MuLV envelope-induced syncytium formation.

179 Anti-gH neutralizing antibodies prevented syncytium formation.

180 rions were unable to induce low-pH-triggered syncytium formation.

181 rotein, and these mutants displayed enhanced syncytium formation.

182 e expression of p10 and delayed the onset of syncytium formation.

183 UL24-betagluc yielded cytopathic effect with syncytium formation.

184 f PiT2-mediated A-MuLV envelope (R-)-induced syncytium formation.

185 ith DENV-1 or DENV-2, as detected by reduced syncytium formation.

186 mutations of this domain result in enhanced syncytium formation.

187 (SV5), is unusual in that it fails to induce syncytium formation.

188 losely related to simian virus 5, induces no syncytium formation.

189 ible for the characteristic cytopathology of syncytium formation.

190 on or mutations of the CT result in enhanced syncytium formation.

191 formation of filamentous virus particles and syncytium formation.

192 n involved in HSV-1 entry and HSV-1-mediated syncytium formation.

193 rus simian virus 5 (SV5) but is defective in syncytium formation.

194 ouble mutation L539, 548A completely rescued syncytium formation.

195 d rafts may play an important role in HTLV-1 syncytium formation.

196 a second molecule critical for HTLV-induced syncytium formation.

197 pic JNK activation directly caused epidermal syncytium formation.

198 s in reduced production of progeny virus and syncytium formation.

199 nipavirus infections, which ultimately cause syncytium formation.

200 aternal interface, consistent with a role in syncytium formation.

201 luenced by the level of RSV F expression and syncytium formation.

202 o-fetal interface, consistent with a role in syncytium formation.

203 n contrast to an inhibitory effect in T-cell syncytium formation.

204 d migration and invasion, proliferation, and syncytium formation.

205 al protein that induces cell-cell fusion and syncytium formation.

206 ect in core entry and an inability to induce syncytium formation.

207 opathic effects of rounding, detachment, and syncytium formation.

208 Subunit association and syncytium-forming ability of the envelope glycoproteins

209 es were tested for efficacy against FIV in a syncytium-forming assay with FIV-infected CrFK cells and

210 ker is not transferred between PMCs when the syncytium forms.

211 ent of neighboring uninfected cells into the syncytium, further amplifying the CPE.

212 on over 200-fold in the main body hypodermal syncytium, hyp 7.

213 Pn.p cells, fuse with the growing epidermal syncytium hyp7.

214 am cells but not in the main body hypodermal syncytium (hyp7) that underlies, synthesizes, and releas

215 the VPCs do not fuse to the major hypodermal syncytium, hyp7.

216 ment, Drosophila melanogaster embryos form a syncytium, i.e., multiplying nuclei are not yet separate

217 tally perturbed cellular coupling in cardiac syncytium in vitro.

218 e coupling experiments indicate an extensive syncytium in which SNB motoneurons are coupled with each

219 Muscle cells are a syncytium in which the many nuclei are positioned to max

220 ine max) to establish its feeding structure, syncytium, in soybean roots.

221 A mature syncytium incorporates as many as 200 cells into one lar

222 am cells, rather than in the main hypodermal syncytium, indicating that seam cells play the major rol

223 evidence of primary HIV-1 variants that are syncytium inducing and acutely cytopathic for CD8(+) lym

224 All discordant responders had non-syncytium-inducing (CCR5-tropic) viruses.

225 Only non-syncytium-inducing (NSI) virus was cultured from the per

226 Clear groupings of non-syncytium-inducing (NSI), CCR5-tropic (R5), and SI/CXCR4

227 -gp140 envelope protein from the primary non-syncytium-inducing (R5) subtype B strain HIV-1(US4).

228 We recently isolated from an infant an X4-syncytium-inducing (SI) human immunodeficiency virus typ

229 To this end, we examined the capacity of the syncytium-inducing (SI) TR1.3 and W102G MLVs to overcome

230 ype C sequences of known phenotypes (228 non-syncytium-inducing [NSI] CCR5(+) and 51 SI CXCR4(+) sequ

231 Ten of 12 variants that retained wild-type syncytium-inducing ability clustered in the N-terminal h

232 HIV1084i is an R5, non-syncytium-inducing isolate that bears all known clade C

233 s that use CCR5 as a major coreceptor and 11 syncytium-inducing isolates that use only CXCR4 or both

234 of cell fusion compared to that with the non-syncytium-inducing MLV FB29.

235 ite-specific mutagenesis determined that the syncytium-inducing phenotype of F-S MLV can be attribute

236 uses utilized CCR5 exclusively and had a non-syncytium-inducing phenotype on MT-2 cells and in primar

237 Three viral parameters, syncytium-inducing phenotype, higher virus load, and mut

238 respectively, and in a frequent switch from syncytium-inducing to nonsyncytium-inducing virus.

239 mutations associated with the host range and syncytium-inducing variants map to a key region of VRA k

240 rates of disease progression; one harbored a syncytium-inducing virus and the second was heterozygous

241 eplication capacity, and preservation of non-syncytium-inducing virus strains.

242 have higher relative fitness values than non-syncytium-inducing, CCR5-tropic HIV-1 isolates, as deter

243 Syncytium-inducing, CXCR4-tropic HIV-1 isolates did have

244 3 was examined here in comparison to the non-syncytium-inducing, nonpathogenic MLV FB29, which displa

245 leukemia virus (MLV) that induces selective syncytium induction (SI) of brain capillary endothelial

246 ies of the mutant proteins were studied in a syncytium induction assay.

247 Syncytium induction by both F-S MLV and Spl574 is accomp

248 Syncytium induction by TR1.3 has been mapped to a single

249 nding was not affected by CA-074 Me, whereas syncytium induction was inhibited in a dose-dependent ma

250 d incorporation and to viral replication and syncytium induction, site-directed LLP mutants of a prim

251 he infection events starting with successful syncytium induction.

252 l (200 mIU/ml) but were short-lived, had low syncytium inhibition capacity, and lacked avidity matura

253 called cellularization, finally divides the syncytium into individual cells.

254 We show that diffusion within the germline syncytium is a critical control of stem cell differentia

255 The syncytium is a nurse cell formed within the roots of Gly

256 The syncytium is a unique plant root organ whose differentia

257 The syncytium is formed within the vascular bundle by partia

258 The size of each syncytium is larger in VSV-FH-infected cells at a specif

259 nclude that nematode-activated miR827 in the syncytium is necessary to suppress immune responses in o

260 cells regulate their differentiation into a syncytium is not well understood.

261 Precise transcript distribution in the syncytium is recovered via straightforward spatiotempora

262 This three-dimensional syncytium is thought to be necessary to maintain viabili

263 a monax, at the level of cells fusing into a syncytium; it can trigger cell-cell and virus-cell fusio

264 here they are involved in the formation of a syncytium layer at the fetomaternal interface via tropho

265 inantia where the placenta lacks an extended syncytium layer but displays a heterologous cell-fusion

266 se response, the second phase is a period of syncytium maintenance (susceptible reaction) or failure

267 ecific miR396 up-regulation in the developed syncytium marks the beginning of the maintenance phase,

268 e contraction rate (CR) of the cardiomyocyte syncytium monitored by video microscopy.

269 ced titers and small plaques but differed in syncytium morphology.

270 Drosophila embryo is the process by which a syncytium of approximately 6000 nuclei is subdivided int

271 The model demonstrates that a syncytium of electrically coupled astrocytes can maintai

272 ructure and the continuity of the electrical syncytium of the adjacent myocardium.

273 It is believed to operate as a homogeneous syncytium of transmitter-specific cells that regulate br

274 ls often fuse with the surrounding epidermal syncytium or undergo fewer than normal cell divisions, r

275 ant establishment of a functional electrical syncytium plays a significant role in the development an

276 New data reveal that cellularisation of this syncytium requires the SPATZLE protein and involves the

277 erived embryoid body (EB) based cardiac cell syncytium served as a biorecognition element coupled to

278 icrovasculature is not simply a well-coupled syncytium since we detected significant voltage dissipat

279 actor (GRF) target genes resulted in reduced syncytium size and arrested nematode development.

280 umbers of the MV receptor CD46, we evaluated syncytium size in MV- or VSV-FH-infected cells.

281 While syncytium size reached a plateau and did not increase fu

282 /cell, there was a corresponding increase in syncytium size with increases in CD46 levels in VSV-FH-i

283 ed a decrease in both nematode infection and syncytium size.

284 l fusion activity, strongly correlating with syncytium size.

285 sters of villous trophoblasts underlying the syncytium, suggesting that the receptor initiates the in

286 gans uterine seam cell (utse) is an H-shaped syncytium that connects the uterus to the body wall.

287 Skeletal muscle is a multinucleated syncytium that develops and is maintained by the fusion

288 Besides fusing into a multinuclear syncytium, the exchange surface between mother and fetus

289 flowering plants involves the formation of a syncytium through successive rounds of nuclear division

290 i remain connected to a shared cytoplasm, or syncytium, through incomplete cytokinesis.

291 cyst nematodes form a feeding site, termed a syncytium, through which the nematode obtains nutrients

292 While rodent beta cells act as a coordinated syncytium to drive insulin release, this property is une

293 , was post-transcriptionally silenced in the syncytium to permanently suppress its activity during al

294 ation can modulate the enteric neuromuscular syncytium to restore function, at the organ level, in a

295 in a normal nucleocytoplasmic ratio across a syncytium up to the centimeter scale.

296 constriction was blunted when the astrocytic syncytium was loaded with BAPTA (chelating intracellular

297 The integrated syncytium was responsive to the beta-adrenergic agonist

298 lls near the wound site fuse to form a giant syncytium, which sends lamellae under the scab to re-epi

299 rmation of a multinucleated feeding site, or syncytium, whose etiology includes massive gene expressi

300 planted cardiomyocytes can form a functional syncytium with the host myocardium.