ライフサイエンスコーパス: synergism

1 quired MRSA USA300 strain, indicating strong synergism.

2 recombinant lFBPase exhibits AMP/Fru-2,6-P2 synergism.

3 g degrees of nonlinear blending and additive synergism.

4 with at least another compound, suggesting a synergism.

5 thma due to interaction was 7.2%, indicating synergism.

6 nses and provide insights into monocot viral synergism.

7 dy PMV- and SPMV-host interactions and viral synergism.

8 rostatic pressure significantly enhanced the synergism.

9 signaling pathways that modulate leptin/CCK synergism.

10 ted feedback loops display the mechanisms of synergism.

11 the effect of these molecules on leptin/CCK synergism.

12 xpression of one of the GRs involved in this synergism.

13 hown great advantages due to their catalytic synergism.

14 both motifs appear important for functional synergism.

15 gh silica zeolite synthesis via a guest/host synergism.

16 ctions indeed played a role for the observed synergism.

17 s were also elevated, but only MMP-12 showed synergism.

18 ls and transcription rates also demonstrated synergism.

19 IL-1 RI by TNF-alpha partially explains the synergism.

20 orms of JNK and p38 delta and gamma did show synergism.

21 ory systems can operate cooperatively and in synergism.

22 bacterial membranes and exhibit an exemplary synergism.

23 comutated driver genes suggesting functional synergism.

24 ithromycin resistance and subsequent loss of synergism.

25 y Taxol treatment was found to show the best synergism among all combination strategies.

26 This leads to the conclusion that synergism among cellulases is morphology-dependent and g

27 apacity for different cancer treatments with synergism and multidrug resistance inhibition, which has

28 nature of site 2 account for the DksA-ppGpp synergism and suggest mechanisms for ppGpp enhancement o

29 hlight the importance of validating in vitro synergism and the challenge of matching drug exposures t

30 s the pivotal determinant of the OX(1)-CB(1) synergism and thus suggest a functional rather than a mo

31 rithms for automated computer simulation for synergism and/or antagonism at any effect and dose level

32 ntified concurrent variations that maximized synergism, and examined the ways in which it was affecte

33 ptosis induced by serum starvation, cytokine synergism, and glucolipotoxicity, through phosphatidylin

34 f developmental and anatomical traits; trait synergisms; and (interspecies) root competition.

35 combinatorially with documented examples of synergism, antagonism and redundancy.

36 ach for successive relapses considering drug synergism are highlighted.

37 ombined blockade, details of CXCR3 and CXCR4 synergism are not understood.

38 documented, the mechanisms that govern this synergism are poorly understood.

39 Although both mechanisms of synergism are used in parallel, the contribution of conv

40 The apparent functional synergism arising from TRPM8 activation and M-current bl

41 n incorporation with antagonism switching to synergism at higher doses, while the CA model indicated

42 To evaluate potential synergism at lower concentrations (near or below 1 part

43 at fails to capture essential aspects of the synergisms at highly active Ni-Fe sites.

44 molecular mechanisms and consequences of the synergism between 2 cell surface receptor systems, growt

45 Finally, a synergism between Abeta/APP and human tau seems to be re

46 Synergism between ABT-737 and chemotherapy was associate

47 )-specific antibody, we define a therapeutic synergism between ALK and IGF-1R inhibitors.

48 Previously, we have shown that statistical synergism between amino acid variants in thyroglobulin (

49 Synergism between amino acids and tocopherols was demons

50 ol neutrophils, but there was no evidence of synergism between AMX and neutrophils.

51 nt potential of bread; however, caffeine and synergism between antioxidants are also important consid

52 oxicity of the mixture, as well as potential synergism between arsenic and manganese.

53 ys, the latter confirming strong to moderate synergism between B2088 and various classes of antibioti

54 nce that uniquely human cognition depends on synergism between both representational and motivational

55 The results revealed substantial synergism between BRGA and RHL/D.

56 Finally, synergism between C12/C14 and POS were confirmed by time

57 nium chloride is used with the BTU receptor, synergism between C4P and Aliquat 336 is so pronounced t

58 Highlighted in this Perspective are the synergism between calculations and experiments in the au

59 f Hh activity is in part responsible for the synergism between cAMP and GC.

60 tion between CBM-linker and Trp-38 indicates synergism between CBM-linker and CD in feeding the cellu

61 aptive value of beneficial mutations through synergism between cell-to-cell variability and genetic v

62 Synergism between CHK1 inhibition and RRM1-dependent gem

63 ant e-e mixing, thus reaching a new level of synergism between computational and formal treatments.

64 ese large T-cell responses were generated by synergism between CpG and IL-2.

65 Indeed, the synergism between cryogenic electron microscopic and X-r

66 This includes specific synergism between cytokinin and salicylic acid pathways

67 RATIONALE: The relative actions and synergism between distinct myocardial-derived stem cell

68 tion when excision is effectively absent and synergism between elements is weak.

69 These results unveil synergism between ethanol and AA to the mechanism whereb

70 Possible synergism between female sex hormones and vitamin D on p

71 This bidirectional synergism between fly genetics and human genomics facili

72 We find a synergism between function of the PEPR and Flagellin Sen

73 In addition, we discovered synergism between hBD-3 and LL-37 in killing S. aureus.

74 n is one of the molecular mechanisms for the synergism between HCV and alcohol abuse in liver disease

75 In blood cancers, the synergism between HIF overexpression and stabilization w

76 Our data provide strong evidence of synergism between IFN-gamma and TNF- alpha in inflammato

77 l models, which can illustrate the potential synergism between immune checkpoint inhibitors and radio

78 These results suggest synergism between increased RyR sensitivity and decrease

79 bserved under any other condition suggesting synergism between increased RyR sensitivity and decrease

80 We investigated the synergism between influenza virus and Streptococcus pneu

81 We investigated synergism between inositol 1,4,5-trisphosphate (Ins(1,4,

82 The synergism between ISC-4 and cetuximab was retained indep

83 We observed evidence of synergism between lead and manganese, whereby lead toxic

84 The potential synergism between ligand and reductant for iron (hydr)ox

85 This study investigated the potential synergism between ligands (desferrioxamine B (DFOB) or N

86 The synergism between light and heat shocks was deficient in

87 The synergism between low-frequency sonophoresis (LFS) and c

88 wards higher free NADH suggesting a possible synergism between metabolic dysfunction and transcriptio

89 Second, the well-known synergism between metals and warming was manifested not

90 gs highlight the potential of exploiting the synergism between miR-9/9*-124 and transcription factors

91 This study shows that modular synergism between miRNAs and neuronal subtype-specific t

92 +)-handling defect is the result of negative synergism between mitochondrial depolarization and alter

93 These results do not provide evidence for synergism between mutation and stress.

94 with our previous observation of significant synergism between Notch and EGFR-ras-MAPK signaling.

95 e of adaptation or horizontal migration, the synergism between ocean acidification, global warming, a

96 ducts (AGEs) and glaucoma based on the known synergism between oxidative stress with AGEs and the evi

97 ntiapototic p21 also seemed to contribute to synergism between PD98059 and Nutlin-3a because (a) the

98 is combinatorial screening identified strong synergism between peptides.

99 er, these findings suggest that antileukemic synergism between PI3K/AKT/mTOR inhibitors and BH3 mimet

100 We reported a functional synergism between PU.1 and other transcription factors t

101 nventional mechanistic interpretation of the synergism between randomly acting endoglucanases (EGs) a

102 recombination, a possibility consistent with synergism between recG and ruv null alleles and reinforc

103 er, the results support the novel finding of synergism between REST and NFkappaB in the suppression o

104 research provides epidemiologic evidence for synergism between rotavirus and other enteric pathogens.

105 This demonstrates synergism between sense-antisense EPO-R transcripts in r

106 gree to which this improvement may represent synergism between sorafenib and doxorubicin remains to b

107 ion groups with each other, and there was no synergism between text messages and calls.

108 oma can contribute to carcinogenesis through synergism between TGF-beta, SDF-1, and CXCR4.

109 d murine tumors, which reveals an unexpected synergism between the autophagy pathway and p62 in drivi

110 Our results indicate a synergism between the base excision repair pathway and d

111 ivation mechanism, and previously unexpected synergism between the covalent and non-covalent ubiquiti

112 study, we extend this principle to a strong synergism between the dectin-1 agonist curdlan and an in

113 might give rise to the behaviorally observed synergism between the direct/indirect pathway neurons.

114 Thus, our work identifies a synergism between the DNA methylation and Aurora kinase

115 t least in part the mechanism underlying the synergism between the Pim kinases and c-Myc in tumorigen

116 plasmid encoding MdtM suggested a functional synergism between the single-component MdtM transporter

117 t osteoinductive agent (BMP-7), suggesting a synergism between the soluble factor and GJIC.

118 ecrosis factor-alpha (TNF-alpha), suggesting synergism between the two cytokines.

119 the hot plate test to determine if there is synergism between the two drugs in reducing pain.

120 rated a FIC index of <0.5, suggesting strong synergism between the two drugs.

121 ty of individual ASL antimicrobials, impairs synergism between them, and thus may disrupt an importan

122 ole in southern-AF than northern-AF, and the synergism between thermal and water-related conditions i

123 To investigate potential synergism between these factors, we used a global proteo

124 redicted to be the best strategy to maximize synergism between these two drugs.

125 her, its expression is required for the full synergism between these two pathogens.

126 o Cry2Ab caused by selection with Cry1Ac and synergism between these two toxins against resistant ins

127 d higher than expected mortality, reflecting synergism between these two toxins.

128 This synergism between TP and M' P elements also appears to p

129 More importantly, we uncovered genetic synergism between Twist1 and the ETS family transcriptio

130 iencies in innate immunity and evidence of a synergism between viral infection and allergic mechanism

131 equired for cancer progression, indicating a synergism between VP-16 treatment and the loss of Star-P

132 The authors prospectively evaluated synergisms between effects of arsenic exposure and those

133 However, little is known about potential synergisms between halide and nitrate ions.

134 f IGF1R and EGFR suggested the potential for synergism by a combination of therapy directed at the tw

135 t C/EBPalpha plays an important role in such synergism by directly interacting with PXR; enhancing RI

136 veal an important role for Noxa in mediating synergism by these agents.

137 Synergism can be explained by a simple and general mecha

138 This synergism can be explained entirely by the suppression o

139 ive definition for additive effect (CI = 1), synergism (CI < 1), and antagonism (CI > 1) in drug comb

140 ompounds from GCB and WF demonstrated slight synergism (CI=0.92), while potentially bioaccessible and

141 instead of valine in B2088) displayed better synergism compared to other substitutions.

142 is of this combination demonstrated superior synergism, compared with each individual treatment at lo

143 re (S)-selective, which points to pronounced synergism (cooperative nonadditivity) when they interact

144 EGF-C-induced angiogenic and lymphangiogenic synergism could be potentially important approaches for

145 Expression of synergism demands that an enzyme display low basal activ

146 We show that cellular G(i)-G(q) synergism derives from direct supra-additive stimulation

147 rimary arylamine group is indispensable, but synergism due to hydrophobic contacts between the rest o

148 mpaired upon miR-125b repression, suggesting synergism during leukemic transformation in GATA1s-mutat

149 studied for the first time whether a similar synergism exists between P11L and three other mutations

150 To determine the specificity of this synergism, Exp.

151 This synergism extended to androgen-sensitive and androgen-in

152 Only a subset of architectures exhibited synergism following paired changes in parameters.

153 on suggested an additive effect and moderate synergism for NPS-OA.

154 The effects of motifs on synergism for this biologically realistic model were con

155 icistronic reporter mRNA revealed functional synergism for translation efficiency.

156 ver, characterizing the underlying molecular synergisms for the combination of drugs remains a challe

157 health--heteroencapsidation, recombination, synergism, gene flow, impact on nontarget organisms, and

158 Accordingly, synergism has been observed between DNA-damaging drugs a

159 This synergism, however, does not appear at the input level o

160 There was no evidence of synergism (i.e., excess risk due to interaction) between

161 independently activate Mec1, but substantial synergism in activation was observed when both activator

162 as in REM sleep for memory consolidation and synergism in awake states for cognitive control.

163 This may be attributed to a pertinent synergism in between the positively charged functionaliz

164 ose (8 mmol/l) produced a striking degree of synergism in combination with GSK-3 inhibition to enhanc

165 Thus, proinflammatory synergism in disease may be driven by the diverse biolog

166 xpressed in these same cells, accounting for synergism in double mutants discovered almost 100 years

167 Isobologram analyses showed synergism in dsRNA combinations (CI=0.4-0.82) vs. an add

168 ions suggest the evolution of AMP/Fru-2,6-P2 synergism in eukaryotic FBPases from an ancestral FBPase

169 m to the central cavity and the evolution of synergism in FBPases.

170 diate state can account for AMP/Fru-2,6-P(2) synergism in mammalian FBPases.

171 D decreases LT protein levels and eliminates synergism in MCV DNA replication as well as sT-induced c

172 This synergism in mixtures containing an azole has mostly bee

173 Synergism in outflow facility was observed with TNF-alph

174 AMP/Fru-2,6-P2 synergism in pFBPase is absent in eFBPase.

175 tend earlier observations of organophosphate synergism in salmon and reveal an unusually steep concen

176 be these two approaches and illustrate their synergism in several particularly appealing case studies

177 lly patterned and that, in contrast to their synergism in shoots, BR and auxin interact antagonistica

178 ence information indicates the likelihood of synergism in the FBPase from Leptospira interrogans (lFB

179 e first glimpse into the citrate-transferrin synergism in the regulation of Ti(IV) bioactivity and of

180 NRM in vivo also produced a PLA(2)-dependent synergism in their antinociceptive effects.

181 fectively coupled, can result in significant synergism in their electrical, mechanical, and biocompat

182 d Cap with a combination of siTNFalpha shows synergism in treating skin inflammation.

183 ion posaconazole-tacrolimus therapy displays synergism in vitro and improved antifungal efficacy in v

184 the PARP-1 inhibitor PJ34 were assessed for synergism in vitro by combination-index analysis in SK-N

185 mmunity development, which can contribute to synergisms in litter decomposition.

186 s to investigate pharmacological evidence of synergisms in nicotinic/muscarinic interactions on cogni

187 oot elongation was more than additive (i.e., synergism) in soils with high and medium cation-exchange

188 ry proteins, exhibits an additional level of synergism, inducing enhanced odorant receptor responses

189 The synergism is attributed to the remarkably 30-70x higher-

190 Such synergism is commonly assumed to be complex, requiring r

191 Whereas synergism is comparatively weak when either methyltri(C(

192 This powerful synergism is explained by blockade of a P2Y12 receptor-d

193 ough DNA methylation, and that the degree of synergism is increased in cells lacking functional BRCA2

194 The absence of synergism is likely the result of stressor treatments th

195 Additionally, we uncovered that this synergism is mediated through Gi, protein kinase G, and

196 wheat straw suggested that this mechanism of synergism is operative also in the degradation of lignoc

197 stic with that of progesterone and that this synergism is potentially highly significant in gamete in

198 Synergism is quantitatively explained by the classical a

199 This synergism is reduced by the RNA polymerase mutations ide

200 tumorigenesis, the mechanism underlying the synergism is still not well understood.

201 e of the identifying that the origin of this synergism is the increased penetration and subsequent di

202 The two-state mechanism also explains why synergism is unique to PLC-beta3 among the four PLC-beta

203 d so-called "competing response types," with synergism itself conceived of as causal co-action within

204 t higher doses, while the CA model indicated synergism, mainly driven by effects at high doses of gam

205 Phene synergism may be common in plant biology and can have su

206 These synergisms may enable 'special' tolerance of intracellul

207 efore, we hypothesized that this statistical synergism mirrors a biochemical interaction between Tg p

208 et, providing a possible explanation for the synergism observed between these two compounds.

209 The neutralization synergism obtained when pooling the most potent HMAbs co

210 tively predicted and ranked the efficacy and synergism of all possible combinatorial inhibitions of e

211 r enhanced activity, selectivity, and mutual synergism of antimicrobial biosurfactants and reduced de

212 echanistically, we provide evidence that the synergism of ATRA and FLT3 TKIs is at least in part due

213 n the basis of binding results and CR11-MPED synergism of Cry4Ba toxicity, AgCad1 is probably a Cry4B

214 can be involved with the reported behavioral synergism of D1R and D3R agonists.

215 to foster a healthy working relationship as synergism of each department's aptitude and talents may

216 We conclude that the synergism of IL-1beta and IFN-gamma to induce expression

217 ivation of T cells and required a tripartite synergism of interferon-gamma, tumor necrosis factor and

218 The synergism of large surface area, multiscale porous struc

219 The results serve to illustrate the synergism of long-time-scale molecular dynamics simulati

220 362 or aldosterone replacement, suggesting a synergism of mineralocorticoid and glucocorticoid recept

221 This synergism of Msx1 with Pax9 is significant, because it i

222 ly complex diseases with the interaction and synergism of multiple genetic and environmental factors.

223 Results of mixture tests showed a strong synergism of the identified aromatic amines not only wit

224 The reported synergism of the precursor spectinomycin with other anti

225 ir pollutant exposure, which may be due to a synergism of these factors acting on innate immune recog

226 cs of CPS double-site mutants reinforced the synergism of Tyr-Glu in catalysis.

227 707 (1 mum) and OMDM-2 (5 mum), a functional synergism on cellular AEA and 2-AG uptake was observed.

228 There is, however, no overall synergism or antagonism between and within the trxG and

229 ents in complex hormone disease networks and synergism or antagonism between pathways.

230 ly depending on the polarity, mild to strong synergism or antagonism was observed by combining ecdyst

231 nteraction are sometimes used to assess such synergism or mechanistic interaction, but testing for po

232 Synergism (or antagonism) was quantified using degrees o

233 To examine this food synergism, papaya and strawberry nectars and their respe

234 found that epinephrine signaling changes the synergism pattern and decreases efficacy of combination

235 d with RUNX1B on TBLV enhancer activity, and synergism required the RUNX1B-binding site.

236 The synergism requires Snf1 and Adr1 but not Cat8.

237 Synergism requires the presence of both Smad and AP-1 re

238 In a narrow pH range around 2.5 the synergism resulted in a 10-fold higher survival rate.

239 The synergism results from LfcinB-mediated activation of Sp1

240 ve action between GRs may further add to the synergism seen in germination triggered by multiple GRs.

241 The antitumor synergism showed by the combination treatment with syste

242 NCPD displays much stronger synergism than its free drug counterpart, which suggests

243 the case when two or more species exhibit a synergism that produces a disease state not seen with an

244 This provides two types of synergism that strongly potentiated cAMP-mediated fluid

245 plored here is the linkage of AMP/Fru-2,6-P2 synergism to the central cavity and the evolution of syn

246 ons ranges from cooperation and coexistence (synergism) to mutual exclusion (antagonism).

247 de "synergy under recoding of an exposure," "synergism under recoding of the outcome," and so-called

248 sional dynamics and ecological interactions (synergism versus competition) between populations in PB-

249 at locust mortality increased as a result of synergism via a mechanism related to Ca(2+) disruption i

250 The synergism was already evident for the tendency for radic

251 This synergism was also evident at the protein level, with in

252 This synergism was also not seen between the germinant L-vali

253 However, synergism was also observed as in the case of D. magna e

254 On the other hand, this synergism was attenuated by disrupting the C/EBP binding

255 Synergism was demonstrated when extracts were combined w

256 Synergism was determined by calculating fractional inhib

257 bited XO, and for their combination moderate synergism was found.

258 Also, the synergism was independent of Chk2 both in Chk2-complemen

259 This synergism was not observed with the reverse treatment or

260 lower concentrations, and a modest degree of synergism was observed at higher concentrations.

261 No synergism was observed between alpha(1)- and beta-recept

262 However, synergism was observed between HELZJ and the antibiotics

263 However, no synergism was observed in vivo.

264 Synergism was observed more frequently in H. bacteriopho

265 istically; however, after digestion in vitro synergism was observed.

266 Synergism was obtained for the binary mixtures of (TOH+A

267 However, synergism was only observed for prochloraz at environmen

268 The inter-domain synergism was pre-requisite for the efficient degradatio

269 single stimulation in U-CLL, whereas BCR/TLR synergism was required in M-CLL, in which the effect was

270 ects were observed at the lower doses, while synergism was seen at the highest doses.

271 Similar synergism was seen with agents targeting Akt in combinat

272 Synergism was the main effect observed among the tested

273 for therapeutic resistance and the switch in synergism were explored by analyzing a network model of

274 Accordingly, synergisms were only seen in leukemia cells expressing w

275 more, these antibodies elicit robust in vivo synergism when combined with oseltamivir, thus highlight

276 ABT-737 showed synergism when combined with the proteasome inhibitors b

277 at a time, but interact cooperatively and in synergism when rats concurrently learn two types of task

278 We propose a mechanism of endo-exo synergism whereby the degradation of amorphous regions b

279 ose a molecular mechanism based on PARP1-Erk synergism, which may underlie this phenomenon.

280 le and triple mutations significantly reduce synergism while retaining other wild-type kinetic proper

281 P-response element, and C/EBP half-sites, in synergism with C/EBP family members, whereas the MMP13 p

282 ecific inhibitor bicyclomycin failed to show synergism with either aza-C or streptolydigin.

283 finity, on- and off-rates, processivity, and synergism with endoglucanase.

284 SHS exposure has dose-dependent synergism with family history of asthma, the joint effec

285 key source of CCN1-induced ROS critical for synergism with FasL.

286 ate that PKA is responsible for the observed synergism with GC, whereas Epac exerts a weak antagonist

287 In addition to a direct antiviral effect and synergism with IFN, the SOCS antagonist also exhibits ad

288 onism similarly promoted IGF-driven pAkt and synergism with IGF-IR inhibition.

289 o abrogate cell-cycle inhibition and produce synergism with LMP-400.

290 anti-malarials, we observe growth inhibition synergism with low doses of this beta2-selective inhibit

291 ation of a biological role for D-DT, and its synergism with MIF suggests that the combined therapeuti

292 This synergism with mixtures of nutrient germinants was not s

293 vation; instead, a loss of responsiveness to synergism with MSX1 in target promoter activation and a

294 res exploration, particularly in view of the synergism with other phytochemicals.

295 n skipping may constitute a key strategy for synergism with other splicing regulators in establishing

296 ts in an apparently mechanistically distinct synergism with quinine and with piperaquine.

297 colony formation revealed that LCA exhibits synergism with the alkylating agent temozolomide, which

298 uid exerted direct antibacterial activity in synergism with the antimicrobial human neutrophil peptid

299 IFN-beta in RelA(-/-) MEFs, transcriptional synergism with the coactivator CREB-binding protein, and

300 anistic interaction is often conceived of as synergism within Rothman's sufficient-cause framework.