ライフサイエンスコーパス: synergistic

1 eir contributions are cumulative rather than synergistic.

2 B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P2, which correlated

3 Studies have documented a synergistic action of expansins for cellulose digestion

4 ssociated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1alph

5 activation, including Spry2, thereby causing synergistic activation of MAPK signaling by epigenetic s

6 tyrosine kinase) and H-Ras generates strong, synergistic activation of PI3Kalpha, yielding a large in

7 8-protein composition, their individual and synergistic activities, and assembly in vitro and in viv

8 th dexamethasone or vincristine demonstrated synergistic activity against pre-BCR(+) ALL.

9 n murine lung cancer models displayed strong synergistic activity and overcame rapalog resistance in

10 nstrate efficacy, long-term persistence, and synergistic activity in combination with radiotherapy, p

11 on with chNKG2D T-cell treatment resulted in synergistic activity in two independent syngeneic mouse

12 The sensor used the synergistic activity of the catalytically active Pt nano

13 nd CD8(+) T cells, were indispensible to the synergistic activity of the combination treatment.

14 proved chemotherapeutic compounds possessing synergistic activity with leucovorin against colorectal

15 eometry of these rings is essential for this synergistic activity.

16 g sites on Env trimers resulted in a loss of synergistic activity.

17 get ROR1 and Bcl2, may have additive, if not synergistic, activity in patients with this disease.

18 th IL-17A (r = 0.74, P < .001) and IL-17/TNF-synergistic/additive gene expression.

19 novel air filter was designed to possess the synergistic advantages of porous filters and fibrous fil

20 ericin B at subinhibitory concentration were synergistic against C. neoformans.

21 YK uses AMP and glucose-6-phosphate (G6P) as synergistic allosteric activators that function as a mol

22 ition or S1P receptor 2 antagonism triggered synergistic AML cell death.

23 Similarly, synergistic and antagonistic co-regulators modulate the

24 Network analysis was employed to elucidate synergistic and antagonistic relationships between Micro

25 ty of the Cpf1 platform, we demonstrate both synergistic and combinatorial gene expression in human c

26 This combination was synergistic and effective both in vitro and in vivo.

27 nhibitor) and SAR405838 (MDM2 inhibitor) was synergistic and induced the expression of PUMA and BIM,

28 ontributions may be hard to determine due to synergistic and masking effects.

29 teraction of SZT2 with GATOR1 and GATOR2 was synergistic, and an intact SOG complex was required for

30 mbined inhibition of IKr and IKur produced a synergistic anti-arrhythmic effect in both forms of SQT3

31 itamin D-enriched mushrooms extracts exert a synergistic anti-inflammatory effect.

32 GAT211 produced synergistic antiallodynic effects with fatty acid amide

33 ting that cell culture results indicative of synergistic anticancer drug interactions rarely translat

34 This combination resulted in a remarkable synergistic anticancer effect on intracranial human and

35 Synergistic anticancer effects of combined bortezomib an

36 demonstrated the strongest cytotoxic and GSI-synergistic antileukemic effects in vitro and in vivo.

37 Synergistic antileukemic interactions between AZ20 and c

38 paclitaxel/nutlin-3, all of which exhibited synergistic antiproliferative and apoptotic activity in

39 baclofen and muscimol produced a significant synergistic antipruritic effect, with no sedation.

40 ors with BRAF mutation rather than showing a synergistic antitumor effect.

41 y to diminish pathway cross-talk and display synergistic antitumor effects.

42 elfinavir in combination is expected to have synergistic antitumor efficacy and significant potential

43 s great potential for generating durable and synergistic antitumor response.

44 nd, or GITR ligand fusion proteins, produced synergistic antitumor responses.

45 -stage preclinical candidate by establishing synergistic antiviral activity with existing HIV-1 drugs

46 Unfortunately, synergistic application of more than a single molecular

47 We demonstrate here that the synergistic application of two such principles in the de

48 th aerobic biodegradation may be a promising synergistic approach for the treatment of mixed contamin

49 ier combinations, revealing the existence of synergistic as well as adverse effects of chromatin modi

50 By means of synergistic atmospheric and oceanic measurements in the

51 ol interacts with sphingolipids promotes the synergistic balance between the flexibility and rigidity

52 There may be a synergistic benefit between LAMA and LABA as a consequen

53 renoprotection equivalent to ramipril but no synergistic benefits of combining these agents were show

54 In this Review, we highlight synergistic biological pathways through which co-occurri

55 esearch directions that may originate from a synergistic blend of all the herein discussed topics.

56 has been for the first time constructed for synergistic cancer starving-like/gas therapy without the

57 l and biological impact, which can lead to a synergistic chemical imbalance.

58 photoacoustic (PA) dual-modal imaging-guided synergistic chemo-photothermal therapy (PTT).

59 d death of cancer cells in vitro, and showed synergistic chemo-PTT efficiency in vivo as evidenced by

60 se: redundant codes can be very fragile, and synergistic codes can-in some cases-optimize robustness

61 Overall, the LINORel approach provides a synergistic combination of active and passive non-foulin

62 r activation, an activation best achieved by synergistic combination of E2-derived catalytic domain a

63 Specifically, the synergistic combination of high strain load stemmed from

64 e us toward rationally-guided new therapies: synergistic combination of selective TRPV4 blockers and

65 Multimodal imaging-guided synergistic combination therapy has shown great potentia

66 In synergistic combination with a Lewis acid that helps seq

67 ese reservoirs through the administration of synergistic combinations of latency reversing agents (LR

68 broad computational approach for predicting synergistic combinations using easily obtainable single

69 t a generalizable method to screen for novel synergistic combinations, to identify particular mechani

70 several strain-transcending targets that had synergistic combinatorial effects in vitro, while studie

71 d exceptional functionalities enabled by the synergistic components.

72 he DTT assay is important to incorporate the synergistic contribution from different aerosol componen

73 nd disease by S. pneumoniae, in part via the synergistic contributions of the viral neuraminidase.

74 lhydrolase Sse and streptolysin S (SLS) have synergistic contributions to inhibition of neutrophil re

75 Here, we establish the mechanism of synergistic cooperation between these activities.

76 trate the need to evaluate these extremes as synergistic costressors to accurately quantify their imp

77 id state precipitation route that provides a synergistic coupling of two different types of precipita

78 ells as well as macrophages are required for synergistic curative activity.

79 was loaded into the nanoparticles to confer synergistic cytotoxic activity, further highlighting the

80 The synergistic cytotoxicity of tyramine and histamine shoul

81 of selinexor with doxorubicin demonstrated a synergistic decrease in the cellular proliferation of se

82 These synergistic directional forces generated during cell mot

83 effect release rates have on the efficacy of synergistic drug carriers and motivate the use of HA as

84 s drug equivalence classes and, in one case, synergistic drug interactions.

85 .The choline-binding protein ChoX exhibits a synergistic dual-site binding mode that allows it to dis

86 On average, workers whose skills are synergistic earn more than jacks-of-all-trades.

87 urements showed that TCNQ and GO triggered a synergistic effect and exhibited an unexpected electroca

88 Notably, the hybrid CPT-Cap prodrug showed a synergistic effect and significantly enhanced potency ag

89 3D-hierarchical BRG nanoconstruct exhibited synergistic effect by combining enhanced electrical prop

90 al molecular stability and also allows for a synergistic effect during collagen folding.

91 However, it is unknown whether a synergistic effect exists.

92 Our analyses also suggest a large synergistic effect from river-ocean mixing, global and l

93 mostly inactive in DTT oxidation, but shows synergistic effect in (*)OH formation in the presence of

94 ticoid treatment in dystrophic muscle have a synergistic effect in alleviating the dystrophic phenoty

95 neous inhibition of p300/CBP and Notch has a synergistic effect in esophageal adenocarcinoma.

96 TGF-beta/Fc and nonlytic IL-2/Fc exert a synergistic effect in promotion of alloengraftment and d

97 Combining LPS and CX3CL1 displayed a strong synergistic effect in vitro, but HMOX-1 levels were sign

98 tivity of cancer cells with a supra-additive synergistic effect of "0 + 1 > 1." Noteworthy is that "D

99 ensitive electrochemical sensor based on the synergistic effect of 7,7,8,8-tetracyanoquinodimethane (

100 INTERPRETATION: Our study identified a synergistic effect of amyloid and tau deposits and demon

101 The synergistic effect of anti-ADAMTS13 IgG antibody in the

102 her with HsRAD51, potentially explaining the synergistic effect of attenuating the expression of both

103 r performance was mainly originated from the synergistic effect of B and N co-doping, high N content

104 This is the first study to investigate the synergistic effect of colistin/doripenem combination on

105 We observed a synergistic effect of FASN inhibitors with gemcitabine i

106 ated SUMOylation drives GA by regulating the synergistic effect of GATA2 and NF-kappaB and consequent

107 ivity of this sensor was good as a result of synergistic effect of graphene and AuNPs (2D and 0D nano

108 The synergistic effect of graphene and AuNPs, which facilita

109 The synergistic effect of LTC4 with IL-33 was completely dep

110 on dystrophic muscle, but also revealed the synergistic effect of RhoA/ROCK inhibition and glucocort

111 electrocatalytic activities originate from a synergistic effect of the N, S heteroatom doping and uni

112 A synergistic effect of the two metals was found.

113 by etoposide in AIRE-expressing cells had a synergistic effect on genes with low expression levels.

114 A synergistic effect on hD4R levels is noted when cytoplas

115 s, and end products of lipid oxidation had a synergistic effect on TLR2 activation.

116 on of nonlytic IL-2/Fc and TGF-beta/Fc had a synergistic effect to promote engraftment and resulted i

117 The magnitude of the synergistic effect varied between 1.06 and 1.24 dependin

118 This synergistic effect was evident only when the two vaccine

119 mutants were similarly impaired, a dramatic synergistic effect was found for the double mutant acros

120 A synergistic effect was observed between aminophylline an

121 low" protein intake or 2) dietary protein's synergistic effect with Ca+/-D intake on bone health out

122 Notably, glutamine starvation has a synergistic effect with cisplatin, a component of the cu

123 In particular, MMAR showed a strong synergistic effect with the PR-D212N,F234S double mutant

124 scavenging capacity of carotenoids, such as synergistic effects and solubility, are sometimes overlo

125 The synergistic effects between the hierarchically porous 1D

126 tro and in vivo Consistent with the in vitro synergistic effects between the SK1-specific inhibitor S

127 ences compared to the wild-type enzyme, with synergistic effects for combinations of interaction site

128 n with zoledronic acid displayed additive or synergistic effects in cell growth assays in 10 of 11 ce

129 Hit 7a and lead 7ii both showed synergistic effects in combination with existing HCV dru

130 and memantine (triple combination) produces synergistic effects in extracellular levels of acetylcho

131 howed that PTEN loss and activated Kras have synergistic effects in promoting development of IPMN and

132 -1R, Src and c-Met/ALK, respectively) led to synergistic effects in some of the cell lines examined.

133 ures the range of other phenotypes that show synergistic effects is usually unknown.

134 Such synergistic effects lead to superior HER catalytic activ

135 r structural engineering contributing to the synergistic effects of 2D morphology, amorphous structur

136 Our findings demonstrate the synergistic effects of calcipotriol and 5-FU treatment i

137 Synergistic effects of contact-killing and protein-repel

138 0 unique diets; we quantified individual and synergistic effects of dietary macronutrients and the mi

139 e and may promote understanding of potential synergistic effects of disparate stresses in this critic

140 l emphasis on preparative techniques and the synergistic effects of enzymes and MOFs.

141 ic community-to quantify the independent and synergistic effects of genetic, lifestyle, and other env

142 Furthermore, we evaluated the synergistic effects of itraconazole and paclitaxel using

143 In particular, we report synergistic effects of mitogen-activated protein kinase

144 In the study, we aimed to explore the synergistic effects of multiple risk factors on birth de

145 reatment for MDR-related tumors based on the synergistic effects of P-gp inhibition, enhanced endocyt

146 Theoretical calculations reveal that the synergistic effects of Se vacancies and subsequent P dis

147 T calculations, which highlight the powerful synergistic effects of the Si:-->Ni moiety in the breaki

148 roadband photodetection is attributed to the synergistic effects of the spatial nonuniform collective

149 In addition, synergistic effects of US on EC treatments were evaluate

150 cted to identify which gene combinations had synergistic effects on clinical outcome in lung cancer s

151 n roots, mycorrhizal fungi and PGPR can have synergistic effects on growth and systemic priming of wh

152 h defects, and examine temporal trend of the synergistic effects over time.

153 Synergistic effects were observed between (beta-carotene

154 inhibitors targeting histone methylation for synergistic effects while still maintaining selectivity.

155 e pleuromutilin derivative 1 displays strong synergistic effects with doxycycline in a wide range of

156 They also exhibit strong synergistic effects with standard chemotherapy.

157 echanisms have the potential for additive or synergistic effects, but experimental design and analyse

158 enhanced conductivities, or even to unclear synergistic effects, but the importance of the defects,

159 s to uncover pairs of genes with potentially synergistic effects, including a potential synergy betwe

160 in and AaIT (Na(+) channel blocker) produced synergistic effects, requiring 45% fewer spores to kill

161 Our data revealed complex synergistic effects, whereby tN-Ras binding was higher o

162 , their ecological roles, and their possible synergistic effects.

163 eated with venetoclax and romidepsin showing synergistic effects.

164 The synergistic efficacy of gum arabic and sage polyphenols

165 In addition, we identify intracohort synergistic epistasis between alleles of hsl7 and kel1,

166 Mechanistic studies involving synergistic experiment and theory were performed on the

167 ted the anti-MRSA activity of oxacillin in a synergistic fashion, resulting in an 8-fold increase in

168 e drug delivery systems in a bioinspired and synergistic fashion.

169 e design of hybrid materials that accumulate synergistic functionalities.

170 These events collectively result in rapid synergistic gene expression and higher hepatic glucose p

171 This facilitates STAT3 binding and synergistic gene expression.

172 tor occupancy (using ChIP-seq), we show that synergistic gene induction is achieved by assisted loadi

173 by the application of a recently introduced synergistic gold(I)-silicon catalysis concept capable of

174 combinatorial HDACi/(+)-JQ1 treatment spurs synergistic Golgi dispersal in several cancer cell lines

175 bitor and Akt inhibitor causes apoptosis and synergistic growth inhibition in multiple EGFR tyrosine

176 and HER-family member inhibitors resulted in synergistic growth inhibition of MDA-MB453 cells, implic

177 These observations, together with the synergistic growth phenotype of the double mutant rh50-1

178 The term syndemic refers to synergistic health problems that affect the health of a

179 nse packing of SO2 clusters through multiple synergistic host-guest and guest-guest interactions by c

180 a reductionist in vitro system, we show that synergistic IFN-gamma and tumor necrosis factor (TNF) st

181 iple adjuvants at the same time to mimic the synergistic immune-stimulation of pathogens, while being

182 a novel two-pronged modality referred to as Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) h

183 genetic duet showed a strong incremental and synergistic impact over either mutation alone.

184 This synergistic improvement in the anticancer activity was a

185 n and spinal cord also produced dramatic and synergistic improvements in motor function with an unpre

186 Specific combinations of these probes were synergistic in enhancing efficacy.

187 Inhibition of CDK4/6 and autophagy is also synergistic in other solid cancers with an intact G1/S c

188 tments with 3,4-DAP and VGCC agonists proved synergistic in restoring suprathreshold endplate potenti

189 with high mycorrhizal compatibility showed a synergistic increase in callose responsiveness following

190 We earlier demonstrated synergistic increase in the proliferation of pulmonary s

191 stingly, Ung (-/-) Smug1 (-/-) mice showed a synergistic increase in uracil levels with up to 25-fold

192 w-dose IL-33 to naive wild-type mice, led to synergistic increases in airway Th2 cytokines, eosinophi

193 llobiose with flg22 or chitooligomers led to synergistic increases in gene expression.

194 ell cycle checkpoint both contributed to the synergistic induction of apoptosis and proliferation inh

195 This effect is related to a synergistic induction of apoptosis as seen in the combin

196 lly enhanced migration persistence through a synergistic induction of NF-kappaB-dependent MMP1 expres

197 this excessive proliferation depends on the synergistic induction of Ras target genes.

198 a-24-RGDOX and an anti-PD-L1 antibody showed synergistic inhibition of gliomas and significantly incr

199 tes AMP-activated protein kinase, leading to synergistic inhibition of human leukemia cell viability.

200 n a complex molecular setting also delivered synergistic insights in the arena of enantioselective ca

201 The synergistic interaction between copper and cadmium was n

202 imodal image-guided therapy in vivo, and (3) synergistic interaction between CuS-mediated phototherma

203 ols was demonstrated, and we found that this synergistic interaction may be mostly responsible for th

204 hand, double bglc1 bglc3 mutants revealed a synergistic interaction that supports a role for membran

205 A synergistic interaction was observed between the two iso

206 ing Dehalococcoides subpopulations depend on synergistic interaction with other organohalide-respirin

207 olecular mechanism underlying small-molecule synergistic interactions allows the rational design of a

208 Bti's efficacy is due to synergistic interactions among four proteins, Cry4Aa, Cr

209 Ignoring delayed effects, synergistic interactions between contaminants and warmin

210 w that PTEN-loss is a crucial determinant of synergistic interactions between MAPK and PI3K pathway i

211 odor tuning in the antennal lobe and drives synergistic interactions between two ecologically releva

212 nature, the balance between antagonistic and synergistic interactions has evolved to avoid kinetic tr

213 The most potent of these synergistic interactions is with the antiviral drug azid

214 a biological ligand is mediated by multiple synergistic interactions of its constituent functional g

215 Among 2,172 individuals, there were synergistic interactions of smoking with infant respirat

216 .e., 50 mg/L) due to unknown additive and/or synergistic interactions that likely occur between the v

217 In combined treatments, additive and synergistic interactions were observed.

218 /STAT3 activation as a potential mediator of synergistic interactions.

219 Although it is highly likely that multiple (synergistic) interactions may be at work, change in the

220 h the porous polymer network, as well as the synergistic interfacial interaction at the metal/polymer

221 es of control experiments demonstrate that a synergistic interplay between the supramolecular capsule

222 pairs for which corresponding drugs exhibit synergistic killing.

223 phage/ciprofloxacin combinations were highly synergistic, killing >6 log CFUs/g of vegetations in 6 h

224 to elevated PCO2 indicate additive (fV ) and synergistic (M O2) interactions occurred in combination

225 inib-TPP blunted cellular proliferation in a synergistic manner by massive activation of intrinsic ap

226 nano-delivery system (SUNb-PM), working in a synergistic manner with vaccine therapy in an advanced m

227 tive splicing pathways regulate p53beta in a synergistic manner, and NMD plays a critical role in the

228 om the NPVF preproprotein promote sleep in a synergistic manner, and that stimulation of npvf-express

229 metastatic growth in vitro and in vivo, in a synergistic manner.

230 -6 and IL-8 in a concentration-dependent and synergistic manner.

231 mutagenicity is highly complex and driven by synergistic mechanisms of a complex compound mixture (of

232 t can be attributed to three independent and synergistic mechanisms of action, only one of which requ

233 antimicrobial potency and provide additional synergistic mechanisms of action.

234 e that the channel kinase TRPM7 and SOCE are synergistic mechanisms regulating intracellular Ca(2+) h

235 biological processes occurs through complex, synergistic mechanisms.

236 s in expression in suicidality may provide a synergistic mechanistical corrective target, as do SLC4A

237 functionalization has been achieved via the synergistic merger of photoredox, nickel, and hydrogen a

238 Here, we show that the synergistic merger of three catalytic processes-photored

239 ic (TK) and toxicodynamic (TD) model for the synergistic mixture of the azole fungicide, propiconazol

240 However, as single-molecule drugs or synergistic mixtures, these remedies have faced obstacle

241 egy is presented to achieve simultaneous and synergistic modulation of crystal phase and disorder in

242 generally MX2 -based electrocatalysts via a synergistic modulation strategy.

243 w the same phenotype when treated with known synergistic molecules allows us to pinpoint additional m

244 Observed synergistic mortality occurred during the larval-pupal m

245 es, aryl triflates, and vinyl bromides under synergistic nickel- and organic-dye-mediated photoredox

246 nduces extreme thermal lability and leads to synergistic nucleotide and DNA binding defects, which se

247 Syndemics investigates synergistic, often deleterious interactions among comorb

248 Finally, some representative systems of synergistic optimization are also presented, which can s

249 e ability of respiratory viruses to act in a synergistic or additive manner with TH2 pathways will be

250 g responses further identified corresponding synergistic or antagonistic drug combinations.

251 diauxic growth, other combinations result in synergistic or unaltered growth relative to bacteria exp

252 ion between medication classes for additive, synergistic, or antagonistic effects on IOP was not iden

253 In this study, we discovered the synergistic orchestration of multiple mechanisms regulat

254 gent on two nonredundant but immunologically synergistic p53-dependent processes: reversal of immunos

255 c efficacy, polymer drug conjugates carrying synergistic pairs of chemotherapy drugs can be used to r

256 set for our approach, and identified 37 new synergistic pairs.

257 reveals an adaptive mechanism that harnesses synergistic paracrine signalling via IL-6/8, which is am

258 frequently occur simultaneously and may have synergistic pathological effects.

259 PSMA-directed RLT combined with potentially synergistic pharmacologic approaches.

260 conazole) were selected to investigate their synergistic potential and their CYP inhibition strength

261 The study showed that the synergistic potential of azoles could be explained by th

262 /or trimer gallate) suggested the absence of synergistic potential.

263 y of intact MTORC1 signaling to regulate two synergistic processes required for clearance of damaged

264 branching of Purkinje cells, with no obvious synergistic relationship with Bcl7b.

265 functional roles, mechanisms of action, and synergistic relationships among the different PDEs that

266 VA and the complex food odor vinegar evoke a synergistic response in the cVA-responsive glomerulus DA

267 ons, captures of H. halys adults indicated a synergistic response to traps baited with the two compon

268 f activin and myostatin inhibitors induced a synergistic response, resulting in muscle mass increasin

269 y, primary and metastatic CRPC showed robust synergistic responses when immune checkpoint blockade wa

270 or RNA binding, thus revealing a potentially synergistic role for it in self- versus nonself-mRNA dis

271 and a promotor (typically sulfur, S), their synergistic roles are not fully understood.

272 I) --> Cu(II) oxidation and exploiting three synergistic roles of boric acid has allowed the developm

273 ermined that rapid mobilization results from synergistic signaling on neutrophils, resulting in enhan

274 effects are mediated through differential or synergistic signaling pathways.

275 hroughput method for rapid identification of synergistic small-molecule pairs, the overlap2 method (O

276 ing and sequestering, playing a key parallel synergistic step in sustaining the function of ERK, a no

277 ations and provide a path toward a superior, synergistic strategy of constructing tissues that will t

278 This synergistic strategy results in a material with superior

279 This results in synergistic strengthening via TRIP, grain boundary stren

280 tivity, compared to monometallic NPs, due to synergistic substrate activation.

281 able new porphyrin-mediated theranostics and synergistic therapeutic capabilities will be explained a

282 dal imaging and light-activated chemothermal synergistic therapy.

283 We propose that synergistic TLR9/IFN-gammaR activation of T-bet(+) B cel

284 /peptide triple-co-delivery nanocarriers and synergistic tumor immunotherapeutic nanovaccines.

285 ombined treatment with AKT inhibitors causes synergistic tumour growth inhibition in vitro and in viv

286 In addition, a synergistic underexpression of the gamma-protocadherin c

287 e inhibitor to tumors can be used in a novel synergistic way to enhance the therapeutic efficacy of e

288 Finally, we demonstrate that MTI-101 is synergistic when combined with bortezomib, using both my

289 confined to specific non-sialylated HMOs and synergistic with a number of conventional antibiotic age

290 110alpha and p110delta activation by Ras was synergistic with activation by a soluble phosphopeptide

291 r-tPA alone did not dissolve emboli, but was synergistic with alpha2-antiplasmin inactivation, causin

292 s active against P. aeruginosa EE and highly synergistic with ciprofloxacin.

293 C8 was also synergistic with colistin, substantially improving survi

294 induction of tyloses by JA, whereas ACC was synergistic with JA.

295 and the formation of nanoDVD are shown to be synergistic with phototherapy to improve antitumor effic

296 relevant doses of sunitinib in vitro and was synergistic with sunitinib in impairing tumor growth in

297 d PI3Kdelta inhibitor idelalisib, was highly synergistic with the proteasome inhibitor carfilzomib in

298 on maturation by a mechanism parallel to and synergistic with the RhoA signaling pathway.

299 llular iron mobilization more than additive (synergistic) with deferasirox.

300 d independently on a wide range of jobs, and synergistic workers, whose skills are useful in combinat