ライフサイエンスコーパス: synergy

1 obacter baumannii demonstrated antimicrobial synergy.

2 or enhance the GATA4-NKX2-5 transcriptional synergy.

3 on complimentarily, leading to a significant synergy.

4 that could possibly be associated with this synergy.

5 orubicin (DOX) and gemcitabine (GEM) on drug synergy.

6 on, suggesting a mechanistic explanation for synergy.

7 um and platinum/palladium were indicative of synergy.

8 erroneous or misleading characterization of synergy.

9 ensity, which could explain the mechanism of synergy.

10 sulting in redundancy of efforts and lack of synergy.

11 bstructure profiles are useful in predicting synergy.

12 s appear to sensitize the tumors to Wnt-Rspo synergy.

13 f internal models, motor primitives or motor synergies.

14 esents a key step in understanding potential synergies.

15 ntext and popularization of intelligent food synergies.

16 ess and energy consumption in the context of synergies.

17 ir combined activities indicate inter-region synergies.

18 utions, including both positive and negative synergies.

19 pal components analysis to define kinematics synergies.

20 (sEH) as anti-inflammatory strategy promises synergies.

21 asons to dually specialize included clinical synergy (70%), procedural activity (50%), and less inter

22 d hydroxyurea or olaparib exhibited a strong synergy against lung cancer in vivo.

23 Synergy also requires recruitment to membrane-bound H-Ra

24 n "no burst" and "burst." The model predicts synergies among the inhibitors, both in terms of each in

25 l for parsing complex visual images, but the synergy among different layers in different cortical are

26 ween daf-7 and tph-1 regulate redundancy and synergy among neurons in food encoding through coordinat

27 mbined, may result in clinical and budgetary synergies and offsets.

28 nslation well in the past included: research synergies and opportunities for translation realized thr

29 , thereby creating altogether new scientific synergies and technological opportunities.

30 ur nominal 6-muscle planar arm model, muscle synergies and the desired size, shape, and orientation o

31 To understand this dualism of synergy and competition under growth conditions relevant

32 constituent organisms underlie polymicrobial synergy and dictate the community's pathogenic potential

33 ich alone had no effect, resulted in genetic synergy and led to abnormal kidney development with high

34 f the cocktail, as well as the high level of synergy and multi-functionality observed in multiple com

35 pharmacology in elucidating the mechanism of synergy and optimizing antibiotic pharmacokinetics/pharm

36 y, we recorded whole-body kinematics, muscle synergies, and hindlimb motor cortex modulation in freel

37 These emergent synergies, and the core hubs of interaction that they de

38 - and hypothesis-driven methods in a careful synergy, and the importance of carefully characterized b

39 identify particular mechanisms resulting in synergy, and to use the mechanistic knowledge to rationa

40 drug combinations were examined for zones of synergy, antagonism, and additivity based on a whole exp

41 e identified linezolid-moxifloxacin zones of synergy, antagonism, and additivity.

42 tensively analyzed for sensitivity patterns, synergy, anticancer activity, and were validated in low-

43 Other, unexpected synergies appear, including with the plasma membrane ani

44 The intricacies of this biological synergy are explored within this paper by examining the

45 Translation of food synergy as a strategy requires adaptation to the context

46 ant ace-1(R) and the T alleles act in strong synergy, as they elicited a resistance 100 times higher

47 technology be successful on its own, or can synergies be achieved by combining it with other technol

48 To address this, we examined BCR-NOTCH2 synergy because NOTCH has been shown to increase BCR res

49 ness a rational co-design approach-involving synergies between high-throughput computational screenin

50 Synergies between male circumcision and women's health p

51 ing the relative contributions and potential synergies between signals remains a challenge.

52 The analysis highlights synergies between transporters affecting the balance bet

53 to optimize treatment protocols and evaluate synergies between tumor-treating field treatment and che

54 dine treatment, despite the lack of in vitro synergy between ABBV-075 and these agents.

55 Synergy between adiposity and genotype promoted the full

56 Our data demonstrate a previously unknown synergy between AngII and BAFF in inducing IL-10 product

57 cir against resistant viruses, likely due to synergy between anti-HCV antibodies derived from differe

58 The synergy between bond formation and bond breaking that is

59 Here we demonstrate that (1) synergy between catecholic and guanidinium side chains s

60 -dependent cellular phagocytosis (ADCP), but synergy between CD47 blockade and ADCP has yet to be dem

61 ble account of the field to encourage future synergy between computation and experiment.

62 Synergy between CoRAs and FIs has been attributed to a C

63 Our results demonstrate the potential synergy between DNA origami technology and colloidal sci

64 ed species, and serve as model of productive synergy between ecological monitoring and conservation s

65 However, a developing synergy between emerging analysis techniques and data-sh

66 the SBP lipase to the membrane, suggesting a synergy between HELLP and SBP in membrane dismantling.

67 We further observed strong synergy between histone deacetylase inhibitors and EZH2

68 Moreover, SAA1(47-104) desensitized the synergy between intact SAA1alpha and CXCL8 in neutrophil

69 fter stimulation, which is consistent with a synergy between interleukin 6/STAT3 and BMP/SMAD signali

70 However, the striking synergy between LAG3 and PD1 observed in multiple settin

71 The emerging synergy between large-scale simulations and 3D printing

72 This study demonstrates the synergy between mouse and human models and validates the

73 er distinct groups of transcription factors, synergy between multiple pathways is necessary to activa

74 y synergistic effects, including a potential synergy between mutations in TP53 and the metastasis rel

75 We demonstrate the latter by describing the synergy between NF-kappaBeta and the corepressor JDP2.

76 Synergy between oxaliplatin and pyrolipid-induced PDT ki

77 embranes, and hypothesize about the observed synergy between oxidized membranes and membrane-active p

78 artery disease complexity as assessed by the Synergy Between PCI With Taxus and Cardiac Surgery (SYNT

79 ty analyses according to low to intermediate Synergy Between PCI With Taxus and Cardiac Surgery (SYNT

80 oronary artery disease, and the mean SYNTAX (Synergy Between PCI With Taxus and Cardiac Surgery) scor

81 2.50; 95% CI, 1.61-3.97; P<0.0001), SYNTAX (Synergy Between PCI With Taxus and Cardiac Surgery) scor

82 OCT 3D viability imaging revealed synergy between PDT and the standard-of-care chemotherap

83 The SYNTAX [Synergy Between percutaneous coronary intervention (PCI)

84 The SYNTAX (Synergy Between Percutaneous Coronary Intervention With

85 (Synergy Between Percutaneous Coronary Intervention With

86 SYNTAX (Synergy Between Percutaneous Coronary Intervention With

87 y was assessed at the sites and defined by a Synergy between Percutaneous Coronary Intervention with

88 In the SYNTAX (Synergy Between Percutaneous Coronary Intervention With

89 vitro and in vivo experiments confirmed the synergy between polymet and CDDP.

90 M) is a technology conceived as an effective synergy between sample preparation and ambient ionizatio

91 PFC neuronal ensembles arises from a complex synergy between single neuron coding properties and mult

92 Here we have identified a synergy between the anthelmintic albendazole (ABZ) and d

93 Not only does the synergy between the bond-forming and charge-delocalizing

94 tabilization power is a result of an unusual synergy between the conventional binding sites in the he

95 This was evidenced by a complete blockade of synergy between the COOH-terminal SAA1 fragments and CXC

96 l/oxide interface by taking advantage of the synergy between the metal nanoparticles and oxide suppor

97 at effective Pol II termination depends on a synergy between the NNS machinery and obstacles in chrom

98 the presence of a microbiota, demonstrating synergy between the pathobiont and microbiota in exacerb

99 ylboration of benzaldehyde to understand the synergy between the phosphoric acid OH...O hydrogen bond

100 This linkage suggests a synergy between the primary drivers of biodiversity loss

101 t safety effects of TSEC are associated with synergy between the selective recruitment of transcripti

102 tivity of this catalyst is attributed to the synergy between the small Lewis acidic NiO clusters and

103 In addition, TET2 knockout reduces the synergy between the two compounds.

104 and discovers a tandem peptide that displays synergy between the two domains and is able to kill Pseu

105 This direct interaction is required for the synergy between the two proteins in actin assembly.

106 cer patients in the adjuvant setting suggest synergy between the vaccines and trastuzumab, the mAb ta

107 her, which clearly demonstrates the powerful synergy between them.

108 ive properties are facilitated by functional synergy between theophylline and amphetamine.

109 Synergy between these factors has been suggested, but no

110 016) sheds new light on the mechanism of the synergy between these genetic alterations by modeling he

111 ceptor (PSGR), but the potential tumorigenic synergy between these lesions is unknown.

112 and optimal ILC2 activation reflects potent synergy between these pathways.

113 of the surfaces, demonstrating a remarkable synergy between these two mechanisms.

114 Insights into the mechanism of synergy between these two peptides are obtained via impl

115 These results provide a unique example of synergy between torsional and vibronic modes and their d

116 ular ruler to control the distance-dependent synergy between two peptides.

117 Hence, we demonstrated synergy between two stimulating cytokines, IL-15 and IFN

118 The synergy between two structural motifs--nanoscale brick-a

119 mentation of most practices but considerable synergy can be gained using the same structures for diff

120 This "immunophage synergy" contrasts with the paradigm that phage therapy

121 on synapses, but also in mediating vesicular synergy, contributing to regional differences in loading

122 amine the ability of experimentally-observed synergies--correlated muscle activations--to control bot

123 We show that the presence of synergies drastically decreases the ability of the CNS t

124 ompromises its availability for audio-visual synergy during adaptation to CI.

125 ighlights the consequences of redundancy and synergy during information transmission, suggesting a ra

126 solution containing 20muM of vitamin C had a synergy effect.

127 The proper architecture and synergy effects of multiple PI nanofibrils as a thermall

128 ased I(X 1; X 2; Y) and doublets can capture synergies efficiently.

129 ese discordant reports by demonstrating that synergy emerges when Env engages multiple coreceptors pr

130 that the stoichiometry required for CoRA/FI synergy exceeds that required for HIV-1 entry.

131 ovalent mass spectrometry provides excellent synergies for the analysis of membrane protein oligomeri

132 the photosystem II subunit S (PsbS) work in synergy for an optimized multilevel response.

133 s, collegial environment where collaborative synergy fueled meaningful progress that will impact scie

134 hat the benefits and disadvantages of muscle synergies go hand-in-hand with the structure of feasible

135 Understanding the fine details of this synergy has proven challenging to scientific research.

136 few compelling examples of gene-environment synergy have been documented.

137 Several efforts to discover pair-wise synergy have been made based on the information approach

138 The mechanistic basis of this polymicrobial synergy, however, has not been fully elucidated.

139 es a neuronal context for the long-standing "synergy hypothesis" of sodium appetite regulation.

140 Two key components account for this synergy: (i) a self-vaccinal effect mediated by dendriti

141 sing persistent controversies regarding drug synergies in the mycobacterial folate biosynthesis pathw

142 e greatest in newborns and infants with less synergy in adults and elders.

143 ed, proteasome inhibition and ART have shown synergy in ART-resistant parasites.

144 combination of both compounds showed potent synergy in cell viability assays and cooperatively induc

145 both efficient DNA cross-linking and potent synergy in combination with formaldehyde correlate with

146 e to be impactful for identification of drug synergy in context of other types of cancers.

147 identify an autophagy-independent cell death synergy in FGFR3-mutant cell lines between mTOR (mammali

148 experimentally, and seven of these exhibited synergy in human breast cancer cell lines.

149 Overall, our study highlights the synergy in molecular dynamics and FRET-based approaches

150 mbination screen we observed a highly potent synergy in neuroblastoma cells between the EGFR kinase i

151 of MDM2 and BCL-xL demonstrated significant synergy in p53 wild-type cell lines in vitro.

152 Mechanistically, C5a contributes to the synergy in PD-L1 expression by specifically activating E

153 when drug combinations exhibit additivity or synergy in pre-clinical models, patient-to-patient varia

154 Based on synergy in preclinical models of PTCL, we initiated a ph

155 ion of the EPE peptide and trametinib showed synergy in reducing the viability of some NRAS mutant me

156 Synergy in reducing tuberculosis transmission may be att

157 294 controls CREBH-PPARalpha interaction and synergy in regulating hepatic glucose metabolism in mice

158 C(X1; X2; Y) is employed to detect pair-wise synergy in simulation and cancer microarray data.

159 fibroblast migration individually but showed synergy in SSc cells.

160 this might be a common mechanism underlying synergy in the control of cardiac gene expression in viv

161 analysis to elucidate the metal/metal oxide synergy in the Ru/RuO2 catalyst, which enables up to 76%

162 strated that E proteins E2A and HEB acted in synergy in the thymus to establish T cell identity and t

163 oncurrent BCL2 and HDAC inhibition may offer synergy in the treatment of patients with advanced CTCL.

164 We also show marked synergy in tumor cell killing between MEK inhibitors (tr

165 prolongs mouse survival, suggesting a strong synergy in vivo and a potential avenue for therapeutic t

166 -2'-deoxycytidine (Aza) treatment models the synergy in vivo without evident toxicity.

167 The Synergy Index (SI=1.52; 95% CI: 1.07-2.17) suggested tha

168 The synergy index of both exposures was 1.34 (95% CI = 0.44-

169 ed and meta-analyzed the impact of additive (synergy index) and multiplicative (betainteraction) inte

170 s partial least squares (PLS), interval-PLS, synergy interval-PLS and moving windows-PLS, were applie

171 In this case, synergy involves cell-type specific suppression of an ad

172 It is then proposed that this synergy is due to the assembly of heteropores because (i

173 murine hosts revealed that neutrophil-phage synergy is essential for the resolution of pneumonia.

174 educes adhesion, and (3) the catechol-cation synergy is greatest when both functionalities are presen

175 In these transformed cells, no synergy is observed between JAK2 and PI3-K inhibitors in

176 mechanistic basis for homotypic binding site synergy is poorly understood.

177 r difference from JAK2V617F cells where such synergy is strong.

178 y tests the hypothesis that the mechanism of synergy is the azole decreasing the biotransformation ra

179 microRNA (miRNA) and gene expression in this synergy is unknown.

180 Underlying this was a striking molecular synergy manifested as a dramatically altered gene expres

181 This Ube3a-seizure synergy maps to glutamate neurons of the midbrain ventra

182 PDAC cells revealed that PAR2 and TGF-beta1 synergy may involve TGF-beta1 induction of enzymes that

183 Here, we describe a mechanism by which this synergy may occur.

184 ctions to experiments in vivo indicates that synergy may result from RF-induced cell phenotypic chang

185 gement, together with efficacy in a cellular synergy model, deeming them as a promising starting poin

186 We report that mice with a dysfunctional FN-synergy motif (Fn1(syn/syn)) suffer from surprisingly mi

187 tistically significant interactions (neither synergy nor interference) between interventions.

188 c habitat where interspecies competition and synergies occur to drive the disease process, which coul

189 the direction of the reaching motion and the synergies of joint coordination.

190 To fully exploit the possible synergies of the hybrid formation, however, precise know

191 184.4; approximately 0.0861) with an average synergy of 18.6%.

192 th HFrEF on GDMT, underscoring the important synergy of addressing hemodynamic and neurohormonal targ

193 We have previously shown the synergy of an agonistic anti-CD40 mAb (anti-CD40) and Cp

194 ream pathways of CSPGs and suggest potential synergy of blocking their two PTP receptors.

195 tic benefits of Bdellovibrio result from the synergy of both bacterial predation and host immunity, b

196 The synergy of circulating factor suPAR and APOL1 G1 or G2 o

197 efore, this new methodology demonstrates the synergy of combining subcellular fractionation proteomic

198 The study showed the synergy of combining ultrasonication and temperature for

199 idly growing field that has emerged from the synergy of computer science, statistics and biology.

200 ficance: These findings provide evidence for synergy of conventional anticancer therapy and CAR T cel

201 Our results highlight a synergy of Cu and ZnO at the interface that facilitates

202 The synergy of diabetes and SM16 in altering gene expression

203 This work demonstrates the synergy of direct ink writing and RF electronics for wir

204 (3) A synergy of diversity and decreasing density of connectiv

205 The synergy of doping of LMNO with iron combined with the co

206 Thus, a good synergy of dual catalysis by Pd(0) and Pd(II) was observ

207 rformed and supports our hypothesis that the synergy of Fenton reaction and manganese peroxidase migh

208 ics simulations, which revealed the critical synergy of halogen and hydrogen bonding interactions in

209 bsequent discussions regarding the potential synergy of high-throughput data acquisition, data-driven

210 The synergy of highly abundant, dendrite-free, multi-electro

211 Centaur radiologists, formed as a synergy of human plus computer, will provide interpretat

212 in-A and retinoids underscore the convergent synergy of insoluble and soluble cues in differentiation

213 The mechanistic synergy of L-DMTC with TFA to increase the rate and sele

214 In mice, a synergy of M. oralis and S. intermedius was observed.

215 Yet, the mechanisms underlying the synergy of prime-boost strategies remain incompletely de

216 ombination of these mitigation measures, the synergy of strategies fails to substantially lower food

217 The ERS resulted from a synergy of the 1997/1998 El Nino Southern Oscillation (E

218 ver a broad temperature range because of the synergy of the introduction of resonance states and conv

219 xperiments described for the first time that synergy of TLR3 and 7 ligands could significantly enhanc

220 and arsenic trioxide (ATO) have demonstrated synergy on MDS treatment, but the treatment can cause si

221 tamin C, gallic acid, caffeic acid, trolox), synergy or additivity effects were noticed.

222 ved drug combinations in the absence of drug synergy or additivity.

223 tuximab and irinotecan may reflect true drug synergy or persistent irinotecan sensitivity.

224 Such synergy originated from the dimerization of TAMRA on AuN

225 is manuscript we consider the NCI-DREAM Drug Synergy Prediction Challenge dataset to identify feature

226 ditionally, we validated previously untested synergy predictions involving anticancer molecules.

227 Additionally, as an example of positive synergy, production levels of CXCR3 cytokines IP-10 and

228 Synergy requires receptor phospho-Tyr and two anionic li

229 This therapeutic synergy resulted in the suppression of tumor-propagating

230 Cell-based studies revealed that the synergy site is dispensable for the initial contact of a

231 ional linkage for alpha5 and alphaIIb is the synergy site located in close proximity to the RGD motif

232 We determined that ligation of the synergy site of FN permits tumor cells to engage a zyxin

233 ant transformation through engagement of the synergy site that enhances integrin adhesion force.

234 dings demonstrate a critical role for the FN synergy site when external forces exceed a certain thres

235 re two or more components of a system act in synergy, sometimes leading to higher-order, emergent phe

236 have recently been made to detect gene-gene synergies, such as dendrogram-based I(X 1; X 2; Y) (mutu

237 the kinematics of both reaching and grasping synergies, suggesting that the division of reach and gra

238 the kinematics of both reaching and grasping synergies, suggesting that this classical division of re

239 By inductive inference, this synergy suggests that the cortical signal reflects struc

240 95%, with the exception of the boronic acid synergy test (88%) and modified Hodge test (91%).

241 oninfected patients and used the double disk synergy test for extended-spectrum beta-lactamase-produc

242 ivities ranged from 72% for the boronic acid synergy test for the detection of KPC producers to >/=98

243 he Modified Carba NP assay, the boronic acid synergy test, and the metallo-beta-lactamase Etest, had

244 pal components analysis to define kinematics synergies that maximized variance across either differen

245 - and nitrogen-doped graphenes, the possible synergy that arises from combining these electronically

246 n Africa, countries can create supranational synergies to develop their programmes and work together

247 the fact that platinum and alpha-MoC act in synergy to activate methanol and then to reform it.

248 , in which distinct CD4(+) Th subsets act in synergy to control the infection.

249 rmational change in subunit epsilon, work in synergy to fine-tune the enzyme during adverse condition

250 actions between diverse organisms may act in synergy to promote HTTs.

251 The aim of the SYNERGY trial was to investigate the effect of custirsen

252 e demonstrated that the magnitude of CoRA/FI synergy unexpectedly depends on FI-binding affinity and

253 The degree of synergy varied dramatically with age, and was the greate

254 FIs (clinically represented by enfuvirtide), synergy waned as binding strength decreased until inhibi

255 SYNERGY was a phase 3, multicentre, open-label, randomis

256 Curiously, this affinity dependence on synergy was absent for 5-Helix-type FIs.

257 Mechanistically, the synergy was based on a lapatinib induced inhibition of t

258 Synergy was demonstrated with NSC319726 and azoles, as w

259 In 2(nd) and 4(th) instars, synergy was noted in H. bacteriophora + B. bassiana comb

260 Dose-dependent synergy was observed in Non-Small Cell Lung Cancer (NSCL

261 Importantly, synergy was observed in some cases with suboptimal doses

262 0, 7 and 14 d intervals and in 6(th) instar synergy was observed only in H. bacteriophora + B. bassi

263 Lack of synergy was predicted by resistance to single-agent vene

264 Importantly, hand postural synergies were predicted by neural activation patterns w

265 Exposures associated with additivity or synergy were then combined and the regimen was compared

266 tural information, encoded through kinematic synergies, were represented in cortical areas devoted to

267 CV agents, and NeoB showed especially strong synergy when combined with interferon or an HCV NS5A inh

268 redicted distinct patterns of dose-dependent synergy when evaluating a combination of BRAF and MEK in

269 These homotypic binding sites often exhibit synergy, whereby the transcriptional output from two or

270 ation activity infrastructure, thus creating synergies with immunization systems approaches, in what

271 o review priorities, progress, and potential synergies with relevant stakeholders.

272 ch debate has arisen from research on muscle synergies with respect to both limb impedance control an

273 es identified in this study does not support synergies with Sb-R in the mechanisms of MIL resistance,

274 of innate immune cells, mechanisms of their synergy with adaptive immune responses against tumors, a

275 so exhibits nanomolar antifungal activity in synergy with amphotericin B.

276 ication may lead to increased DNA damage and synergy with an inhibitor of Chk1.

277 hed the tumorigenic potential of Src and its synergy with androgen receptor in mediating tumor invasi

278 ome aspects of PKD, with the possibility for synergy with current epithelially targeted approaches.

279 chemokine-inducing capacity, whilst keeping synergy with cytokine-induced chemokines to sustain limi

280 erable biotic change on islands by acting in synergy with direct human impacts.

281 nstrictive effects of depolarizations act in synergy with direct ischaemic effects of haemorrhage as

282 referential targeting of GSCs by CBL0137 and synergy with EGFR inhibitors support the development of

283 chondrial dysfunction in RGC degeneration in synergy with environmental factors such as aging and/or

284 f computational studies carried out in close synergy with experiments is summarized.

285 is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-alpha/beta.

286 e, iron oxides and hydrogen peroxide, act in synergy with irradiated perchlorates to cause a 10.8-fol

287 Furthermore, NFM lacked functional synergy with MOG to promote experimental autoimmune ence

288 minal degron, whose precise presentation, in synergy with multipartite contacts with the native core

289 Hence we propose that nebulette acts in synergy with nebulin to reinforce and temporally fine-tu

290 nprecedentedly, this safe analgesic showed a synergy with OXA in vitro and proved to inhibit CA IX, a

291 BMS-986126 also demonstrated synergy with prednisolone in assays of TLR7- and TLR9-in

292 We demonstrated their synergy with PTEN in preventing invasion in vitro and co

293 Compound 26 is also shown to work in synergy with rifampin.

294 the intrinsic apoptotic pathway, exhibiting synergy with the BCL-2 inhibitor venetoclax in preclinic

295 into retinal circuits at various points, in synergy with the cone signals.

296 wild-type allele was dominant and showed no synergy with the inhibitor.

297 these cytokines and chemokines alone and in synergy with the signature T helper cytokines of either

298 ffector function at the tumor site, where in synergy with tumor-redirected lymphocytes, they instruct

299 ccine and an anti-PD-1 antibody showed great synergy, with 100% survival over 60 days in a TC-1 tumou

300 wever, the precise mechanism underlying this synergy within NK cell clusters remains unclear.