ライフサイエンスコーパス: synonymous mutation

1 ange at the protein level (i.e. 'silent' or 'synonymous' mutations).

2 orders of magnitude greater than the rate of synonymous mutation.

3 se mutations were found, as well as a linked synonymous mutation.

4 onymous rates reflect purifying selection on synonymous mutations.

5 tional tendencies and complete neutrality of synonymous mutations.

6 ntified and revealed both synonymous and non-synonymous mutations.

7 cing different patterns on nonsynonymous and synonymous mutations.

8 e distribution and ages of nonsynonymous and synonymous mutations.

9 ion, one chain-termination mutant, and three synonymous mutations.

10 trees branches following synonymous and non-synonymous mutations.

11 ations as well as between synonymous and non-synonymous mutations.

12 We observe three nonsynonymous and two synonymous mutations.

13 diverse methods to understand the effects of synonymous mutations.

14 by an almost complete lack of noncoding and synonymous mutations.

15 ake functional predictions possible even for synonymous mutations.

16 thods, its performance is not limited to non-synonymous mutations.

17 generated 24 different nonsynonymous and 13 synonymous mutations.

18 g of all MAP2K7 exons did not reveal any non-synonymous mutations.

19 engineered capsid sequences with hundreds of synonymous mutations.

20 s (1.15), and the ratio of non-synonymous to synonymous mutations (1.18) was less than half of that e

21 n, we found that potentially deleterious non-synonymous mutations (9566 SNPs) explained as much genet

22 Moreover, the ratio of nonsynonymous to synonymous mutations, a measure of positive selection pr

23 library in SMN1 exon 7, we show that 23% of synonymous mutations across the exon decrease exon inclu

24 several estimates of selection intensity on synonymous mutations all suggest a detectable influence

25 hIP) variants, we recently discovered 18 non-synonymous mutations, all with frequencies less than 2%

26 me and supported by a neutral clock based on synonymous mutations alone.

27 tions identified were biallelic and included synonymous mutations altering splicing of physiological

28 A novel heterozygous non-synonymous mutation and a novel polymorphism in OMI/HTRA

29 e regions had higher ratios of nonsynonymous/synonymous mutations and encompassed immunodominant epit

30 election coefficient (s) against unpreferred synonymous mutations and found the value (s >or= 10(-5))

31 , especially those arising from selection on synonymous mutations and from the choice of genes, are d

32 y of 1.9 x 10(7) with over 8500 possible non-synonymous mutations and inferred the effects of each mu

33 sceptibility testing, after the exclusion of synonymous mutations and nonsynonymous mutations previou

34 es differed by one or two reverse engineered synonymous mutations, and measured the transmission of t

35 tory events include nonsynonymous mutations, synonymous mutations, and mutations at splice sites.

36 terogeneity or lower ratios of nonsynonymous/synonymous mutations, and none except one of these regio

37 n protein and numerous spliced variants, non-synonymous mutations, and post-translational modificatio

38 hypothesis is that selection coefficients on synonymous mutations are inversely related to the total

39 s of codon bias in Drosophila indicates that synonymous mutations are not neutral, but rather are sub

40 Missense or non-synonymous mutations are nucleotide substitutions that a

41 However, synonymous mutations are rarely investigated in the canc

42 variable effects model, we infer that 11% of synonymous mutations are subject to strong purifying sel

43 onymous to synonymous mutations; however, if synonymous mutations are under purifying selection, this

44 how conserving, or radically different, non-synonymous mutations are with respect to some key amino

45 occurring mutations, both nonsynonymous and synonymous mutations, as well as mutation combinations i

46 ur study identified an independent risk of a synonymous mutation at HLA-DOA, a non-classical HLA gene

47 for estimating the intensity of selection on synonymous mutations based on the frequencies of unprefe

48 variant under selection in Europeans (a non-synonymous mutation, C282Y) has been relatively well-stu

49 formation specific and provide evidence that synonymous mutations can alter the drug sensitivity of p

50 7T/1101A, demonstrating that combinations of synonymous mutations can have functional consequences dr

51 Assuming all non-synonymous mutations cause resistance, we report 90% sen

52 ions, we found that de novo near-splice site synonymous mutations changing exonic splicing regulators

53 bases) of 200 other GPCRs, with recorded non-synonymous mutations, confirmed a high frequency of Arg-

54 er 260 000 somatic alterations including non-synonymous mutations, copy number variants and structura

55 Molecular modeling predicts that these non-synonymous mutations could disrupt NADPHO complex assemb

56 er of other single-sample reports of IDH non-synonymous mutation, did not elevate cellular 2HG levels

57 This effect implies that synonymous mutations disrupting mRNA secondary structure

58 Synonymous mutations do not alter amino acids and are ge

59 Synonymous mutations do not alter the encoded protein, b

60 ting between neutral and disease-causing non-synonymous mutations documented in the human population

61 ut detectable signature of weak selection on synonymous mutations during mammalian evolution, likely

62 hypothesis that the mean age of segregating synonymous mutations equals the mean age of segregating

63 We systematically analyzed ~10(6) non-synonymous mutations extracted from COSMIC, involving ~8

64 lternative RNA splicing effect as a reported synonymous mutation for Crouzon syndrome.

65 of the additional mutation PB2 628R and/or a synonymous mutation from an A to a G nucleotide at nucle

66 ymorphisms, there is a significant excess of synonymous mutations from preferred to unpreferred codon

67 Synonymous mutations have been shown to alter gene expre

68 Several mouse models harboring synonymous mutations have shown alterations in synaptic

69 sites with high ratios of non-synonymous to synonymous mutations; however, if synonymous mutations a

70 We analyze de novo synonymous mutations identified in autism spectrum disor

71 een linked to epithelial malignancy with non-synonymous mutations identified in both MTG8 and MTG16 i

72 We identified a synonymous mutation in affected individuals that alters

73 fic immune response against the virus; a non-synonymous mutation in an epitope region of the virus is

74 eport shows selection of a recurrent somatic synonymous mutation in cancer.

75 Another synonymous mutation in the same exon, c.321C>T (p.D107D)

76 This identified 52 somatic non-synonymous mutations in 32 genes, many of which were nov

77 sing temperature, a CPD RSV containing 2,692 synonymous mutations in 9 of 11 ORFs did not lose temper

78 Significant excess of non-synonymous mutations in AKAP4 (p<0.02), a gene mediating

79 This selection pressure against synonymous mutations in alternatively spliced exons was

80 ierarchy is reflected in the fitness cost of synonymous mutations in amino acid biosynthesis genes an

81 These data suggest that non-synonymous mutations in ASB10 do not cause Mendelian for

82 nza PR8 viruses containing codon-deoptimized synonymous mutations in coding regions comprising the en

83 Given the role of synonymous mutations in disease and drug codon optimizat

84 of the pre-mRNA as well as 29 variants with synonymous mutations in exon 12.

85 he patterns and rates of the accumulation of synonymous mutations in isolates collected from the pati

86 s of evidence suggest that selection acts on synonymous mutations in mammals.

87 Synonymous mutations in Rv3792 increased the expression

88 We identify Asian-derived non-synonymous mutations in the AHR gene that associate with

89 vious study identified 3 nonsynonymous and 6 synonymous mutations in the entire mosquito sodium chann

90 In two OS cases, we found de novo non-synonymous mutations in the genes KCNQ2 and SCN2A.

91 We report here that some synonymous mutations in the human DRD2 have functional e

92 ic analysis revealed the existence of higher synonymous mutations in the intronless divergents of ReC

93 g the co-existence of both nonsynonymous and synonymous mutations in the sodium channel of resistant

94 In this study we identified deleterious non-synonymous mutations in two cilia genes, Dnah11 and Mks1

95 ints, contributing also to the evidence that synonymous mutations in viral ssRNA genomes are not stri

96 dentified within the groups, only three were synonymous mutations, indicating strong positive selecti

97 t the bioinformatics analysis, we introduced synonymous mutations into conserved codons within known

98 oach, we introduce a barcoded library of non-synonymous mutations into hotspot codons 12 and 13 of Kr

99 Introduction of 54 synonymous mutations into the insert had no detectable e

100 liced exons and a decrease in the density of synonymous mutations (Ks).

101 outheast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-

102 10 unique clones that differ by two or three synonymous mutations (molecular tags).

103 ata indicate that selection coefficients for synonymous mutations must vary by a minimum of one or tw

104 reduced cAMP production arising from the non-synonymous mutations (n = 23) with patients with non-syn

105 the vaccine and its parent, as well as five synonymous mutations, none of which involves cis-acting

106 t CUG codons within the +1 reading frame: 1) synonymous mutation of CUG codons in the M2-reading fram

107 The non-synonymous mutation of the H5 hemagglutinin (HA) gene ha

108 Synonymous mutations or protein expression losses in ACT

109 crepancies indicate that, in contrast to the synonymous mutations, parts of STEC O157 genomes have ev

110 noncoding mutations or a difference between synonymous mutations potentially advantageous or deleter

111 Synonymous mutation progressively optimized human codons

112 two rare potentially disease-associated non-synonymous mutations, Q170H and R181G, in the ADAM10 pro

113 coded by genes that have a non-synonymous to synonymous mutation rate even greater than immune-relate

114 the rate of mutation, such that the average synonymous mutation rate is 20-30% higher than in noncod

115 ining 40 genome pairs, we estimated that the synonymous mutation rate was 1.38 x 10(-5) per site per

116 Accordingly, the synonymous mutation rate was consistently greater than t

117 ons are detected using the synonymous to non-synonymous mutations ratio.

118 and non-coding regions and synonymous-to-non-synonymous mutation ratios suggest the neutral drift bei

119 hypothesis proposes that interference among synonymous mutations reduces the efficacy of selection o

120 contiguous subsegment mutant viruses having synonymous mutations revealed that subsegments SS8195-82

121 Analysis of synonymous mutations showed the same pattern.

122 However, a CPD RSV containing 1,378 synonymous mutations solely in the polymerase L ORF quic

123 Synonymous mutations, such as I507-ATC-->ATT, in deletio

124 significantly lower than the average age of synonymous mutations, suggesting the presence of slightl

125 Several synonymous mutations that abolish secretion of hybrid pr

126 nted for by localised purifying selection on synonymous mutations that affect splicing.

127 es, and weak selection influence the fate of synonymous mutations that are present today as polymorph

128 cular, plays any role in shaping the fate of synonymous mutations that are present today in human pop

129 Also, multiple synonymous mutations that changed the mRNA sequence of y

130 on may show a relatively large number of non-synonymous mutations that conserve a particular property

131 gene on de novo tumorigenesis, we introduced synonymous mutations that converted rare codons into com

132 us mutations (n = 23) with patients with non-synonymous mutations that had no reduction in cAMP (n =

133 lus (mRNA) and minus (vRNA) strands and used synonymous mutations to ablate m(6)A on both strands of

134 The estimated contribution of these synonymous mutations to disease liability is comparable

135 n we measure the effect of four adaptive non-synonymous mutations to the glycerol kinase (glpK) gene

136 pattern of differences in synonymous and non-synonymous mutations, under the assumption of neutrality

137 1 to 10, generated by a combination of nine synonymous mutations, was defective in secretion signali

138 packaging signals were inactivated by serial synonymous mutations, was flanked by the NA segment-spec

139 orrection mechanisms and the consequences of synonymous mutations, we analyzed the effect of mechanis

140 ipoprotein A-V (APOA5), carriers of rare non-synonymous mutations were at 2.2-fold increased risk for

141 rotein receptor (LDLR), carriers of rare non-synonymous mutations were at 4.2-fold increased risk for

142 Several synonymous mutations were detected in exons 4 and 5 for

143 d repetitively in different patients, and no synonymous mutations were found, indicating that the obs

144 the mean ratio of nonsynonymous mutations to synonymous mutations were greater in clones derived from

145 ence which are important for vRNA packaging, synonymous mutations were introduced into the full-lengt

146 Synonymous mutations were the primary discriminatory var

147 Synonymous mutations, which do not alter the protein seq

148 trong increase in selection pressure against synonymous mutations, which propagates into the adjacent

149 spite the fact that it would be disrupted by synonymous mutations, which raises the possibility of ev

150 s, we have rescued mutant viruses containing synonymous mutations within these highly conserved regio