ライフサイエンスコーパス: synovial

1 nced cartilage degradation, hypocellularity, synovial and cartilage fibrosis, synovial inflammation,

2 ostatic pressures can be transmitted between synovial capsules.

3 In the synovial cavity, a state of nonresolving inflammation is

4 ies or a T-cell receptor against NY-ESO-1 in synovial cell sarcoma and melanoma.

5 rylated VEGFR2 in articular chondrocytes and synovial cells and reduce levels of phosphorylated VEGFR

6 Of significance, Snail is overexpressed in synovial cells and tissues of CIA rats and RA patients,

7 induces extracellular matrix degradation in synovial cells by repressing PTEN, resulting in increase

8 r matrix-degrading invadosomal structures by synovial cells from collagen-induced arthritis (CIA) rat

9 FcgammaRII F(ab')2 treatment of inflammatory synovial cells from RA patients inhibited ROS production

10 of functional cardiomyocytes from pathogenic synovial cells in RA patients through iPSC reprogramming

11 Mutant glenoid fossa, disc, synovial cells, and condyles displayed higher Hyaluronan

12 uired for the prodestructive phenotype of RA synovial cells.

13 odestructive invadosome-forming phenotype of synovial cells.

14 with catabolic processes in chondrocytes and synovial cells.

15 er expression of PU.1 at B-cell level in the synovial compartment.

16 lpha, and were more efficient in suppressing synovial conventional T cell proliferation compared with

17 e explanation for arthritis and (2) negative synovial cultures (if obtained).

18 In both clinical and experimental RA, synovial ELS coincided with the heightened local express

19 The presence of synovial ELS was also noted in mice deficient in the IL-

20 ly observed that GILZ is highly expressed in synovial endothelial cells in rheumatoid arthritis.

21 full dose (r = 0.875), the formula, ratio of synovial enhancement to saline syringe at full dose = 0.

22 inge at full dose = 0.337 + 1.070 x ratio of synovial enhancement to saline syringe at half dose, can

23 ovitis in image quality and in assessment of synovial enhancement was detected between half-dose and

24 mice and showed that elevated serum LTB4 and synovial expression of 5-lipoxygenase correlated with in

25 ere, pathology was associated with increased synovial expression of pro-inflammatory cytokines, homeo

26 as compared between RASFs and osteoarthritic synovial fibroblast (OASFs) using quantitative polymeras

27 e, and that it is predominately expressed by synovial fibroblast (RASF) and macrophages in the lining

28 ion in both primary RA SF and the rheumatoid synovial fibroblast cell line, MH7A.

29 flammatory response, mediated by chondrocyte-synovial fibroblast cross-talk, was enhanced by the obes

30 TNF induced the production of soluble synovial fibroblast factors that suppressed the macropha

31 oth transient and longer duration changes in synovial fibroblast membrane potential.

32 nal diversity translates into joint-specific synovial fibroblast phenotypes with distinct adhesive, p

33 of ion channels that are expressed in human synovial fibroblast preparations have begun to provide i

34 nd activation of endothelial cells, and more synovial fibroblast proliferation.

35 CD4(+) T cells to TH17 cells was mediated by synovial fibroblast-derived IL-6.

36 ylated genes between RASF and osteoarthritis synovial fibroblasts (OASF) were identified by methylate

37 itro, exRNA (150-5000 nt) was released by RA synovial fibroblasts (RASF) under hypoxic conditions but

38 roinflammatory loop upon interaction with RA synovial fibroblasts (RASF), including increased autocri

39 s of human promoters in rheumatoid arthritis synovial fibroblasts (RASF).

40 of histone deacetylase (HDAC) enzymes in RA synovial fibroblasts (RASFs), a key cellular mediator of

41 itis (RA) is linked to functional changes in synovial fibroblasts (SF) and local infiltration of T ly

42 levels in relation to RANKL expression in RA synovial fibroblasts (SF) and the development of bone er

43 the TNF-alpha signaling pathway in human RA synovial fibroblasts (SFs).

44 howed opposite effects (e.g., osteoarthritis synovial fibroblasts [SF]; GF(-) versus GF(+): 10.7- ver

45 ified by real-time quantitative PCR in human synovial fibroblasts and murine mesenchymal stem cells.

46 he joint-specific origins of mouse and human synovial fibroblasts and synovial tissues.

47 herefore studied the production of ADAMTS by synovial fibroblasts and their contribution to cartilage

48 gen citrullination decreased the adhesion of synovial fibroblasts approximately 50% (P<0.05) and mese

49 treatment for rheumatoid arthritis (RA), and synovial fibroblasts are a major IL-6 producer in the in

50 system, and the availability of adult human synovial fibroblasts are likely to provide new pathophys

51 We reported that synovial fibroblasts constitutively express and release

52 found that human RA and osteoarthritis (OA) synovial fibroblasts derived from independent donors rep

53 During osteoarthritis, synovial fibroblasts exposed to anomalous mechanical for

54 Here we show transcriptomic differences in synovial fibroblasts from different joint locations and

55 However, synovial fibroblasts from obese OA patients were found t

56 1 and bone morphogenetic protein (BMP)-2, in synovial fibroblasts from RA patients.

57 (hyaluronan and lubricin) and cytokines from synovial fibroblasts have been identified.

58 circulating microparticles, which activated synovial fibroblasts in an IL-1-dependent manner.

59 d that gene expression programs regulated by synovial fibroblasts in our coculture system were also r

60 ranscriptome analysis showed that cocultured synovial fibroblasts modulate the expression of approxim

61 and BMP-2 decreased IL-34 expression in the synovial fibroblasts or in murine mesenchymal stem cells

62 Therefore, synovial fibroblasts provide the biochemical tools to th

63 We found that synovial fibroblasts strongly suppressed TNF-mediated in

64 f macrophage phenotype as a new function for synovial fibroblasts that may prove to be a contributing

65 nces the cross-talk between chondrocytes and synovial fibroblasts via raised levels of the pro-inflam

66 hanism demonstrated that IL-6 secretion from synovial fibroblasts was induced by chondrocyte-derived

67 Primary human synovial fibroblasts were also examined using flow cytom

68 types (human Saos2 osteosarcoma cells, human synovial fibroblasts, and rat mesenchymal stem cells) wi

69 ocytes/macrophages, B and T lymphocytes, and synovial fibroblasts, and TLR-induced MIF transcription

70 cytokine production, an ability to activate synovial fibroblasts, and to survive and persist in the

71 ophage response to TNF is regulated by human synovial fibroblasts, the representative stromal cell ty

72 al properties of key cells in RA, especially synovial fibroblasts.

73 potent inhibitors of IL-34 expression in RA synovial fibroblasts.

74 The concentration of histamine in synovial fluid (SF) and sera in patients with RA was mea

75 lly bound to C4d were identified from pooled synovial fluid (SF) from four rheumatoid arthritis (RA)

76 The infrapatellar fat pad (FP) and synovial fluid (SF) in the knee serve as reservoirs of m

77 + monocytes in the peripheral blood (PB) and synovial fluid (SF) of patients with RA were investigate

78 tly demonstrated that mechanical shearing of synovial fluid (SF), induced during joint motion, rapidl

79 nally strong biofilmlike aggregates in human synovial fluid (SF), to an extent significantly exceedin

80 ound that HA contributes to the formation of synovial fluid aggregates, and HysA can disrupt aggregat

81 endation: ACP recommends that clinicians use synovial fluid analysis when clinical judgment indicates

82 hic arthritis to both mononuclear cells from synovial fluid and PBMC fails to reduce the production o

83 The presence of rVSV in synovial fluid and skin lesions confirmed causality.

84 uingly, the repertoires of FOXP3(+) Tregs in synovial fluid are highly overlapping with CD25(+)FOXP3(

85 ensated polarized light microscope (CPLM) in synovial fluid aspirated from the patient's joint.

86 eived antibiotics within the month preceding synovial fluid aspiration (48 of whom had PJI), PCR pane

87 en the 2 patient groups were observed in the synovial fluid CD4+CD25(high) population, a cell subset

88 The cocultures of platelets with synovial fluid cells from rheumatoid arthritis patients

89 radiographic tests, such as serum urate and synovial fluid crystal analysis and radiographic or ultr

90 piration (48 of whom had PJI), PCR panel and synovial fluid culture sensitivities were 64.5% and 85.4

91 d tissue cultures and pre- and postoperative synovial fluid cultures were all negative.

92 Molecular profiling of synovial fluid derived exosomal miRNAs may increase our

93 In conclusion, synovial fluid exosomal miRNA content is altered in pati

94 The synovial fluid exosomes share similar characteristics (s

95 ling, and reports newly identified serum and synovial fluid FAs as predictive biomarkers of OA in obe

96 scent sera from 91 EM patients, in serum and synovial fluid from 141 LA patients, and in serum from 5

97 describe the evaluation of culture-negative synovial fluid from a 3-year-old boy by PCR and electros

98 nd this process was prevented by addition of synovial fluid from JIA patients, through an IL-6-indepe

99 RNase activity was increased in synovial fluid from RA and OA patients compared with pso

100 ated SOX5 levels were higher in synovium and synovial fluid from RA compared to osteoarthritis patien

101 Lubricin is a mucinous, synovial fluid glycoprotein that enables near frictionle

102 llular matrix of all body tissues, including synovial fluid in joints, in which it behaves as a filte

103 It is assumed that the interaction with synovial fluid in the biocompartment leads to significan

104 o determine the associations among serum and synovial fluid lipid levels with OA, synovitis, adipokin

105 RA synovial tissue and synovial fluid macrophages expressed CCR7, which was inc

106 of the medium such as that occurring in the synovial fluid of DRA patients.

107 lar traps (NETs) are found abundantly in the synovial fluid of gout patients.

108 essed on macrophages in vitro and in vivo in synovial fluid of inflamed paws, whereas expression is r

109 56(bright)CD16(-) NK cells isolated from the synovial fluid of juvenile idiopathic arthritis patients

110 SPADE was used to analyze EVs present in the synovial fluid of patients with inflammatory arthritis.

111 PBMC and mononuclear cells obtained from the synovial fluid of patients with juvenile idiopathic arth

112 nd which has been previously observed in the synovial fluid of patients with Lyme arthritis.

113 1alpha was found in peri-implant tissues and synovial fluid of people with failing Metal-on-Metal hip

114 d whether IgA immune complexes in plasma and synovial fluid of RA patients activate neutrophils.

115 The RANKL/OPG ratio was disrupted in the synovial fluid of RRV patients, and this was accompanied

116 We detected ITCs in the synovial fluid of the high glucosinolate group, but not

117 d the greater levels of IL-6 detected in the synovial fluid of the obese OA patients.

118 Sensitivities of the synovial fluid PCR panel and culture were 55.6% and 76.1

119 saminoglycan measurements from cartilage and synovial fluid regions.

120 duced suppression is due to resistance of RA synovial fluid responder T cells to Treg inhibition.

121 s from the responder T cell population in RA synovial fluid restored Treg-mediated suppression.

122 detected Streptobacillus moniliformis in the synovial fluid sample.

123 ic PCR assay panel using 284 prosthetic knee synovial fluid samples collected from patients presentin

124 The method was applied to human synovial fluid samples from osteo- and rheumatoid arthri

125 um-specific PCR testing was performed on all synovial fluid samples to confirm the U. parvum detectio

126 Blood and/or waste synovial fluid samples were collected from children with

127 Proteomic analysis of synovial fluid showed significantly distinct profiles be

128 -time PCR, we studied 24 blood samples and 2 synovial fluid specimens from 20 patients with persisten

129 pray ionization mass spectrometry applied to synovial fluid specimens had an 81% sensitivity and a 95

130 We quantitated NET levels in gout synovial fluid supernatants and detected enzymatically a

131 Tregs from RA synovial fluid suppressed autologous responder T cells;

132 ated mediators were often >10-fold higher in synovial fluid than serum.

133 flammatory cells involved in osteoarthritis, synovial fluid was collected early after disease inducti

134 Analysis of synovial fluid was consistent with infection, but cultur

135 Serum and synovial fluid were collected for lipidomic and adipokin

136 BCS serves as an in vitro substitute for the synovial fluid which forms a lubricant in the actual ort

137 nts derived from cartilage and released into synovial fluid will allow discrimination between differe

138 survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatme

139 e and (iv) exposure to body fluids (blood or synovial fluid) on release kinetics and efficacy of anti

140 les, six clinical specimens (five blood, one synovial fluid) yielded an atypical oppA1 PCR product, b

141 including the blood, peritoneal fluid, bone, synovial fluid, a perianal abscess, and an arm wound.

142 man body fluids such as cerebrospinal fluid, synovial fluid, and peritoneal fluid.

143 ation products have been measured in plasma, synovial fluid, and synovial tissues of patients.

144 eins are a prerequisite for agglomeration in synovial fluid, low activity of the Agr regulatory syste

145 Of the galectin family members present in synovial fluid, we find that galectin-3 is a specific, h

146 of both pathways can more strongly impair RA synovial fluid-driven monocyte migration and osteoclast

147 gradation and release of components into the synovial fluid.

148 imilar concentrations of IL-7 detected in RA synovial fluid.

149 sphatidylcholine type phospholipids in human synovial fluid.

150 lymph nodes, and later after infusion in the synovial fluid.

151 tics and were pre-coated with human blood or synovial fluid.

152 aracterization of exosomes miRNAs from human synovial fluid.

153 tic tool had low sensitivity when applied to synovial fluid.

154 The virus was identified in one synovial-fluid aspirate and in skin vesicles of 2 other

155 OA synovial fluids (SF) stimulated TLR2 and TLR4 receptors

156 CXCL10/CXCR3 axis, with CXCL10 increasing in synovial fluids after injury and Cxcr3(-/-) mice being p

157 d BMP-2 productions were measured in patient synovial fluids by enzyme-linked immunosorbent assay.

158 s with or without IL-1beta or osteoarthritic synovial fluids for 48 h.

159 were isolated by affinity chromatography of synovial fluids from patients with rheumatoid arthritis,

160 bowel disease (IBD), and reduced TNFalpha in synovial fluids from RA patients.

161 L-34, TGF-beta1, and BMP-2 were expressed in synovial fluids from RA patients.

162 Succinate is abundant in synovial fluids from rheumatoid arthritis (RA) patients,

163 d the effects of IL-1beta and osteoarthritic synovial fluids on anabolic gene expression and increase

164 lated with the total leukocyte counts in the synovial fluids.

165 Synovial hemangioma is benign tumor of the joints and is

166 -year-old male patient with the diagnosis of synovial hemangioma is reported and its radiologic findi

167 onstructed quantitative FMT signal, denoting synovial hyperperfusion, was used to differentiate betwe

168 artilage injury, Gdf5-lineage cells underpin synovial hyperplasia through proliferation, are recruite

169 hronic inflammatory disease characterized by synovial hyperplasia, inflammatory cell infiltration, ir

170 CD14(+) monocytes, another major producer of synovial IL-6.

171 s a wide group of diseases, characterized by synovial inflammation and joint tissue damage.

172 le of LTB4 and its receptor LTB4R1 (BLT1) in synovial inflammation and osteoclast differentiation.

173 Rheumatoid arthritis is characterised by synovial inflammation and proliferation of fibroblast-li

174 ages each partially counteract reductions in synovial inflammation imparted by rituximab.

175 COX-2/PGE2 pathway in driving Th17-mediated synovial inflammation in an IL-23- and monocyte-independ

176 w that LTB4 and its receptor BLT1 exacerbate synovial inflammation in vivo and bone resorption in vit

177 he accumulation of citrullinated proteins at synovial inflammation sites suggests that they are possi

178 ellularity, synovial and cartilage fibrosis, synovial inflammation, mononuclear cell influx in the sy

179 f osteoarthritis includes the involvement of synovial inflammation.

180 components on cartilage and indirectly from synovial inflammation.

181 s a chronic autoimmune disorder resulting in synovial inflammation.

182 iated by these cells participate directly in synovial inflammation.

183 s an autoimmune disease resulting in chronic synovial inflammation.

184 he fibroblast-like synoviocytes (FLS) in the synovial intimal lining of the joint are key mediators o

185 duction of cytokines and chemokines in human synovial intimal resident fibroblast-like synoviocytes (

186 n the cells across the entire surface of the synovial joint cavity, including chondrocytes in the sup

187 tand the aetiology and possible treatment of synovial joint disease.

188 osted digit cartilaginous anlaga elongation, synovial joint formation and interzone compaction, tendo

189 teract in interzone cell differentiation and synovial joint morphogenesis.

190 t reside in articular cartilage and line the synovial joint.

191 f the limb bud caused severe fibrosis of the synovial joints and formation of aggressive masses with

192 Synovial joints are the lubricated connections between t

193 Our data support lubricated synovial joints evolving much earlier than currently acc

194 It is assumed that synovial joints first evolved as vertebrates came to lan

195 The stem cells that safeguard synovial joints in adulthood are undefined.

196 olines to provide the extreme lubrication of synovial joints via the hydration-lubrication mechanism.

197 ts a subperiosteal hydrostatic connection of synovial joints, and that this "net" distributes excess

198 in boundary lubrication and movement in limb synovial joints, but its roles in temporomandibular join

199 a critical lubricating protein of mammalian synovial joints, Prg4/Lubricin, in diverse ray-finned fi

200 n and phospholipids, molecules ubiquitous in synovial joints, such as hips and knees, have separately

201 steoarthritis (OA)-like disorder in multiple synovial joints, underlying its importance in maintainin

202 e to the soft tissues that form and surround synovial joints.

203 in regulating chondrocyte activities in the synovial joints.

204 ar cartilage and in the meniscus, as well as synovial lining cells.

205 onal ablation in Gdf5-lineage cells prevents synovial lining hyperplasia and decreases contribution o

206 ynovium, exRNA was detectable only in the RA synovial lining layer, whereas extracellular DNA was det

207 the representative stromal cell type in the synovial lining of joints that become activated during i

208 self-organize three-dimensionally to form a synovial lining-like layer.

209 X5 expression was primarily localized to the synovial lining.

210 This study investigates synovial lipid adsorption on two different PE-UHMW mater

211 ether and how neutrophils can regulate their synovial localization in the disease.

212 ly regulates diverse pathologic processes in synovial macrophages including the cell cycle, apoptosis

213 of the Ig superfamily (CRIg) is expressed on synovial macrophages of RA patients, making it an intere

214 genes was expressed in rheumatoid arthritis synovial macrophages, confirming their expression under

215 (CRIg), found on tissue macrophages such as synovial macrophages, has promising potential to visuali

216 were also regulated in rheumatoid arthritis synovial macrophages, suggesting that these fibroblast-m

217 fects of sCT in joint tissues, including the synovial membrane and cartilage.

218 lammatory phenotype in fibroblasts from both synovial membrane and infra-patellar fat pad and therefo

219 from the sprouted sympathetic fibers in the synovial membrane and upper dermis contribute to the pai

220 Eighteen RA synovial membrane MNC suspensions were cultured for 2 da

221 rget genes in a dose-dependent manner in the synovial membrane of TMJ.

222 s observed between fibroblasts isolated from synovial membrane or infra-patellar fat pad.

223 fic for ADAMTS-4_v1 was found to bind to the synovial membrane surface on cryosections, and the prote

224 ssa articular cartilage, articular disc, and synovial membrane.

225 pha, interleukin (IL)-1beta, and IL-6 in the synovial membrane.

226 Fibroblasts isolated from synovial membranes and infra-patellar fat pad of patient

227 Finally, human synovial MSCs transduced with Bmp7 display morphogenetic

228 spontaneously forming NETs from JIA patient synovial neutrophils, and DEK-targeted aptamers reduce N

229 Synovial overexpression of Wnt8a and Wnt16 led to canoni

230 These irregularities include: synovial pathologies, effusion, tendon, cartilage and bo

231 s to elucidate the relationship of different synovial pathotypes/molecular signatures with therapeuti

232 intraobserver reliability for assessment of synovial patterns at MR imaging.

233 c resonance (MR) imaging for differentiating synovial patterns in patients with total knee arthroplas

234 Synovial sarcoma (SS) is a rare sarcoma driven by a tran

235 Synovial sarcoma (SS) is an aggressive soft-tissue malig

236 Synovial sarcoma (SS) is an aggressive soft-tissue sarco

237 Synovial sarcoma (SS) occurs in both children and adults

238 e the underlying mechanism, we studied human synovial sarcoma (SS), in which transformation results f

239 malignant tumors, such as parosteal sarcoma, synovial sarcoma and malignant fibrous histiocytoma.

240 cell growth and migration across a series of synovial sarcoma cell lines.

241 tified selective cytotoxicity of EA in human synovial sarcoma cells (SW982 cells) and investigated th

242 at EA has a potent cytotoxic effect on human synovial sarcoma cells which is mediated by heteromeric

243 Treatment of synovial sarcoma cells with dasatinib led to apoptosis a

244 enhanced sarcomagenesis without compromising synovial sarcoma characteristics.

245 Despite the name, synovial sarcoma does not typically arise from a synovio

246 investigated EZH2 as a therapeutic target in synovial sarcoma in vitro.

247 Synovial sarcoma is a deadly malignancy with limited sen

248 Synovial sarcoma is a soft-tissue malignancy characteriz

249 Synovial sarcoma is an aggressive soft tissue sarcoma ge

250 Meta-analysis of human synovial sarcoma patient series identified two tumor-gen

251 onfirmed EZH2 expression in the 76% of human synovial sarcoma samples.

252 ion of a novel centriolar satellite protein, synovial sarcoma X breakpoint-interacting protein 2 (SSX

253 lial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by cop

254 pid signaling associates with progression of synovial sarcoma, a deadly soft tissue malignancy initia

255 on embryonal and alveolar rhabdomyosarcoma, synovial sarcoma, and adult soft tissue sarcomas diagnos

256 ls with altered SWI/SNF complex (e.g., lung, synovial sarcoma, leukemia, and rhabdoid tumors).

257 traditional cytotoxic chemotherapy used for synovial sarcoma.

258 osarcoma, and one (10%) of ten patients with synovial sarcoma.

259 ing therapeutic strategy in the treatment of synovial sarcoma; clinical trials are initiating enrollm

260 Two possible roles for native SSX2 in synovial sarcomagenesis are explored.

261 SSX1 and SS18-SSX2 can each drive comparable synovial sarcomagenesis, independent from other genetic

262 cating a paracrine link between the bone and synovial sarcomagenesis.

263 sion oncogene expression characterizes human synovial sarcomas and drives oncogenesis in a mouse mode

264 Synovial sarcomas are aggressive soft-tissue malignancie

265 Moreover, in a large panel of human synovial sarcomas, enhanced PI3'-lipid signaling also co

266 Thus, both in the mouse model and in human synovial sarcomas, PI3'-lipid signaling drives CSF1 expr

267 Postcontrast synovial SIs showed high correlation between half dose a

268 ow that alpha2beta1 integrin is expressed on synovial Th17 cells from RA patients, and that its ligat

269 d synovitis, mixed- or solid-type synovitis, synovial thickening, and capsular dehiscence.

270 steoarthritis progression, cartilage damage, synovial thickening, and osteophyte formation were measu

271 mmation, including rheumatoid arthritis (RA) synovial tissue (ST), often contain high endothelial ven

272 Synovial tissue analysis has been instrumental in enhanc

273 Pathways Analysis and compared to published synovial tissue and cartilage messenger RNA profiles.

274 a, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell in

275 so analyzed the expression of neuropilins in synovial tissue and SF, as they may interact with vascul

276 RA synovial tissue and synovial fluid macrophages expressed

277 y expressed in RA B cells from patients with synovial tissue containing ectopic germinal centres comp

278 moglobin content reflecting the hyperemia in synovial tissue in metacarpophalangeal (MCP) joints of 1

279 The reduction of synovial tissue macrophages is a reliable biomarker for

280 gen (HLA)-DR molecules in patients' inflamed synovial tissue or joint fluid and tested each epitope f

281 thritis (RA), and macrophages are reduced in synovial tissue shortly after initiation of TNF inhibito

282 ed fibrinogen (CF) is abundant in rheumatoid synovial tissue, and anti-citrullinated protein Ab-posit

283 ynovium of RA patients compared with control synovial tissue, and that it is predominately expressed

284 ed with increased numbers of plasma cells in synovial tissue, greater numbers and activation of endot

285 topic germinal centres compared with diffuse synovial tissue.

286 lular DNA was detectable in various areas of synovial tissue.

287 uced serum amyloid A expression in ileum and synovial tissue.

288 he cells synthesizing MASP-1/3 and pro-FD in synovial tissue.

289 s the expression of CD40-downstream genes in synovial tissues from anti-citrullinated protein Ab-posi

290 ll genes were also significantly enriched in synovial tissues from arthralgia patients.

291 oducing predominantly GM-CSF are expanded in synovial tissues from patients with spondyloarthritis.

292 Through evaluation of synovial tissues from rheumatoid arthritis (RA) patients

293 naive B cells were significantly enriched in synovial tissues from UA, early RA, and established RA p

294 the liver and was found to be upregulated in synovial tissues of CIA mice.

295 FLS obtained from the synovial tissues of patients with RA or osteoarthritis w

296 been measured in plasma, synovial fluid, and synovial tissues of patients.

297 was significantly low in RA serum, SFs, and synovial tissues, as well as in the serum and joints of

298 of mouse and human synovial fibroblasts and synovial tissues.

299 n of PDGFR-alphabeta was also elevated in RA synovial tissues.

300 Furthermore, cultured synovial Tregs rapidly downregulated FOXP3 protein (but