ライフサイエンスコーパス: synthase

1 atalysis of the putative enzyme capsaicinoid synthase.

2 imately 1%) expressing neuronal nitric oxide synthase.

3 m module 2 of the bongkrekic acid polyketide synthase.

4 of natural evolution for modular polyketide synthases.

5 osaminoglycan synthesis catalyzed by various synthases.

6 parosan, or chondroitin using polysaccharide synthases.

7 se susceptibility 1 (EDS1) and isochorismate synthase 1 (ICS1) was identified.

8 mall subunit 2 (AHASS2), and isopropylmalate synthase 1 (IPMS1).

9 in E2 (PGE2)-forming enzymes microsomal PGE2 synthase 1 (mPGES1) and COX2.

10 Instead, depletion of cardiolipin synthase 1 abolished abacavir-induced IL-1beta secretion

11 cting predominantly at the level of phytoene synthase-1 (PSY1), and feed-forward mechanisms inducing

12 hibiting COX-2 or microsomal prostaglandin E synthase-1 suppressed the 6-OHDA-triggered PGE2 producti

13 ACBP increases the activity of ceramide synthase 2 (CerS2) by more than 2-fold and CerS3 activit

14 s (including IgE, Bank1, chondroitin sulfate synthase 2, Cmip, and Fth1) were exclusively identified

15 -negative breast cancer (TNBC), nitric oxide synthase-2 (NOS2) and cyclooxygenase-2 (COX2) have been

16 ls of maternal transcripts encoding ceramide synthase 2b (Cers2b), and loss of Cers2b in sphk2(MZ) em

17 at 11p14, potentially affecting nitric oxide synthase 3 (NOS3) expression, as shown by means of in vi

18 mediate nitric oxide signaling (Nitric Oxide Synthase 3 [NOS3] and Guanylate Cyclase 1, Soluble, Alph

19 nt-binding protein 1c target gene fatty-acid synthase (3.0-fold), early growth response-1 (3.2-fold),

20 thaliana) leaf chloroplasts requires STARCH SYNTHASE 4 (SS4).

21 A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.

22 senescence-associated proteins, resveratrol synthase, 9s-lipoxygenase, pathogenesis-related proteins

23 Escherichia coli holo-(acyl carrier protein) synthase (ACPS) catalyzes the coenzyme A-dependent activ

24 The acetyl coenzyme A synthase (ACS) enzyme plays a central role in the metabo

25 1-aminocyclopropane-1-carboxylic acid (ACC) synthases (ACS), generally the rate-limiting step in eth

26 ecific endothelial and neuronal nitric oxide synthase activation and nitric oxide production.

27 CKS1 also affects chitin and glucan synthase activity during cell wall differentiation and f

28 1 inhibits ATP synthase activity from isolated mitochondria and trigger

29 e tolerance, liver NAD(+) levels and citrate synthase activity in offspring.

30 lin and catecholamine signaling and glycogen synthase activity in skeletal muscle.

31 ty was not associated with enhanced glycogen synthase activity or proximal insulin signaling.

32 tent was approximately 50% greater, glycogen synthase activity was approximately 50% greater, glycoge

33 herbicide families inhibit acetohydroxyacid synthase (AHAS, E.C. 2.2.1.6), which is the first enzyme

34 diabetic mice by an endothelial nitric oxide synthase/Akt/vascular endothelial growth factor receptor

35 /arteriole density, endothelial nitric oxide synthase/Akt/vascular endothelial growth factor receptor

36 hesis by activation of delta-aminolevulinate synthase (ALAS), which catalyzes the first step of heme

37 plication of the gene encoding deoxyhypusine synthase, an enzyme involved in the posttranslational ac

38 osphate-oxidase 2 and inducible nitric oxide synthase and enhanced lung concentrations of superoxide

39 IRT1-regulated Akt, endothelial nitric oxide synthase and GLUT4 levels were also induced in hypertrop

40 one levels, increased inducible nitric oxide synthase and heme-oxygenase 1 expression, and increased

41 remarkably, unlike tuberculosinol adenosine synthase and other cis-prenyl transferases (e.g. cis-far

42 the pore is associated with the dimeric ATP synthase and the oligomycin sensitivity conferral protei

43 s where dual enzymatic activities of the DSF synthase and the use of various substrates have been des

44 y of BH4 leads to uncoupling of nitric oxide synthases and production of highly oxidative radicals.

45 Are PGE2 terminal synthases and receptors feasible therapeutic targets for

46 wn by gene expression analyses of polyketide synthases and the determination of the secondary metabol

47 ary acidic protein and neuronal nitric-oxide synthase, and Abeta and p-Tau(Ser-202) also increased du

48 RHM1 encodes a UDP-L-rhamnose synthase, and rhm1 mutations affect synthesis of the pec

49 tron transport chain membrane complexes, ATP synthase, and the mitochondrial contact site and cristae

50 acterized as copalyl diphosphate (diterpene) synthases, and those belonging to the TPS-e/f subfamily

51 Over-expression studies confirmed tryptophan synthase as the biological target.

52 Aldosterone synthase (AS, cytochrome P450 11B2, cyp11B2) is the sole

53 were able to identify putative molybdopterin synthase association pathways and near-crystal structure

54 transcript expression of CYSTATHIONINE gamma-SYNTHASE (AtCGS), Met's main regulatory enzyme.

55 ATP synthases (ATPases) are enzymes that produce ATP and con

56 ctional ortholog of other trimethylguanosine synthases based both on its in vitro methyltransferase a

57 f several upstream receptors, cyclic GMP-AMP synthase, binds to cytosolic DNA and generates dicyclic

58 -receptor antagonist or various nitric oxide synthase blockers.

59 Vasodilator responses after inhibition of NO synthase blunted acetylcholine responses in KK and lean

60 Inactivation of citrate synthase, but not down-stream enzymes suppressed Deltada

61 on and extent of PTMs in the chloroplast ATP synthase (cATPase) purified from spinach leaves.

62 uced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzym

63 T), which consists of two cystathionine beta-synthase (CBS) domains (IPR000664) and represents an int

64 by deficient activity of cystathionine beta-synthase (CBS), resulting in an accumulation of homocyst

65 ion and anaplerotic pathways) and Re-citrate synthase (Ccar_06155) was a key enzyme in its tricarboxy

66 The subtype ceramide synthase (CerS)6 was specifically up-regulated in experi

67 pid metabolism, is generated by six ceramide synthases (CerS) that differ in substrate specificity.

68 ng mechanism by targeting the cyclic GMP-AMP synthase (cGAS) and the stimulator of interferon (IFN) g

69 we determined that STING and cyclic GMP-AMP synthase (cGAS) are important to engage the type I IFN p

70 factor targets the DNA sensor cyclic GMP-AMP synthase (cGAS) for lysosomal degradation to avoid the d

71 sion of the antiviral protein cyclic GMP-AMP synthase (cGAS) in neuronal SH-SY5Y cells, which is the

72 cGMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates

73 Mice genetically deficient in cyclic GMP-AMP synthase (cGAS), its adaptor STING, IRF3, or the type I

74 gh the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyc

75 ) and caspase-1, and requires cyclic GMP-AMP synthase (cGAS)-dependent interferon-beta production and

76 interfering RNAs (siRNAs) targeting chalcone synthase (CHS) mRNAs.

77 s comparable to that of the E. coli cysteine synthase complex (K d 6 nM), and both complexes bind t

78 est that the pore is associated with the ATP synthase complex and specifically with the ring of c-sub

79 ively displace CysE from pre-formed cysteine synthase complexes, enabling toxin activation even in th

80 itochondrial extracts, identified as citrate synthase (CS).

81 tionship between age and adrenal aldosterone synthase (CYP11B2) expression was evaluated in 127 norma

82 In PA, hypomethylation of aldosterone synthase (CYP11B2) is associated with aldosterone overpr

83 ent protein (GFP, 27 kDa) and the polyketide synthase DEBS1 (394 kDa).

84 ovalbumin aerosol-challenged leukotriene C4 synthase-deficient and control mice.

85 Leukotriene C4 synthase-deficient eosinophils exhibited impaired chemot

86 veolar lung was diminished in leukotriene C4 synthase-deficient mice compared with wild-type mice, wi

87 f eosinophils in the lungs of leukotriene C4 synthase-deficient mice.

88 steinemic human cells and cystathionine beta-synthase-deficient mouse brains, we find an acute and ch

89 substrate of TREX1 triggers a cyclic GMP-AMP synthase-dependent type I IFN response and systemic auto

90 f oxidants or genetic inhibition of glycogen synthase depletes glycogen stores and extends the lifesp

91 24A>G, p.K42E in dehydrodolichol diphosphate synthase (DHDDS) (33%).

92 two enzymatic steps involving deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH).

93 aracterization of two S. divinorum diterpene synthases (diTPSs), the ent-copalyl diphosphate (ent-CPP

94 ltransferases of the dimethylallyltryptophan synthase (DMATS) superfamily catalyze the attachment of

95 f procoagulant MPs, endothelial nitric oxide synthase downregulation, and reduced nitric oxide-mediat

96 The enzyme 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) is a key enzyme in the methylerythritol

97 mino acid residues in a bacterial lanosterol synthase enabled synthesis of pentacyclic arborinols in

98 nd the relevance of the identified diterpene synthases, enabling future studies of the biosynthesis o

99 strategy showed that a nonribosomal peptide synthase, encoded by mps1, contains three amino acid spe

100 Although polyketide synthase encoding genes have been successfully engineere

101 Endothelial nitric-oxide synthase (eNOS) and its bioactive product, nitric oxide

102 and activity of the endothelial nitric-oxide synthase (eNOS) and that Cavin-2 knockdown cells produce

103 dothelium, insulin stimulates endothelial NO synthase (eNOS) to generate the antiatherosclerotic sign

104 which is caused by endothelial nitric oxide synthase (eNOS) uncoupling, is an initial step in athero

105 tead, expression of endothelial nitric oxide synthase (eNOS), which generates the potent vasodilator

106 y phosphorylates and inhibits endothelial NO synthase (eNOS).

107 tid via posttranslational inhibition of MGDG synthase enzymatic activity by NO.

108 oduced in our system by changing the terpene synthase enzyme.

109 long-standing paradigm in modular polyketide synthase enzymology, namely the definition of a module,

110 ite gene, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), was identified as the mechanism of gly

111 Moreover, glycogen synthase expression was greatly enhanced, consistent wit

112 /2 and p65/RelA (NF-kappaB) and inducible NO synthase expression, suggesting that AnxA1 may be involv

113 rmation and increased inducible nitric oxide synthase expression.

114 ess responses, whereas the mitochondrial ATP synthase F0 subunit component is a vasoactive peptide on

115 ected by increased mRNA levels of fatty acid synthase (Fas) and acetyl-CoA carboxylase (Acc1).

116 bserved a significant increase in fatty acid synthase (FASN) expression with increasing disease progr

117 and pharmacological inhibition of fatty acid synthase (FASN) suppresses toxicity induced by PINK1 def

118 gnature and specific induction of fatty acid synthase (FASN).

119 icilin, a protease inhibitor, and a flavonol synthase/flavanone 3-hydroxylase.

120 ssing rates of hepatic mitochondrial citrate synthase flux (V CS) and pyruvate carboxylase flux (V PC

121 trans-polyisoprene via farnesyl diphosphate synthases (FPSs).

122 f limonene was two-fold higher with limonene synthase from M. spicata than that from C. limon.

123 We applied this strategy to the F-type ATP synthase from spinach chloroplasts (cATPase) providing a

124 Here we have discovered that norcoclaurine synthase from Thalictrum flavum (TfNCS) can catalyse the

125 ere overexpressed, and a geranyl diphosphate synthase from the plant Abies grandis was expressed to o

126 Limonene synthases from the plants Mentha spicata and Citrus limo

127 ular mechanism whereby vacuolar (V-type) ATP synthase fulfills its biological function remains largel

128 In addition to their synthase function most F-ATP synthases possess an ATP-hy

129 Glucosylceramide synthase (GCS) is a rate-limiting enzyme catalyzing cera

130 Among other genes, a beta-ketoacyl CoA synthase gene (PotriKCS1) was downregulated in leaves fr

131 demonstrate that ablating the cyclic GMP-AMP synthase gene abolishes the deleterious phenotype.

132 here were striking increases in both citrate synthase gene expression and enzymatic activity in skele

133 ssion of aminocyclopropane-1-carboxylic acid synthase gene, the first committed step in ethylene bios

134 DHFR-TS (dihydrofolate reductase-thymidylate synthase) gene family that implements the penultimate st

135 didomain from module 1 of the nanchangmycin synthase generates exclusively the corresponding (2R)-2-

136 allow the identification of new monoterpene synthase genes using transient expression in N. benthami

137 terogeneous promoter activity of autoinducer synthase genes, suggesting that some of the isogenic cel

138 in key genes such as 16S rRNA and polyketide synthase genes.

139 te (GGDP), is the product of the enzyme GGDP synthase (GGDPS) that condenses farnesyl diphosphate (FD

140 GALACTINOL SYNTHASE (GOLS), RAFFINOSE SYNTHASE (RS), and STACHYOSE

141 nic tobacco by elevating geranyl diphosphate synthase (GPS) activity.

142 conserved in plant SS and bacterial glycogen synthase (GS) isoforms.

143 PTGES, which encodes the prostaglandin E synthase, has also been linked to asthma, where deficien

144 S2 expression, although the other hyaluronan synthases (HAS1, HAS3) and hyaluronidases (HYAL1, HYAL2)

145 Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between

146 biosynthesis is catalyzed by homospermidine synthase (HSS), which has been recruited several times i

147 secondary septa that are catalyzed by chitin synthase-II (Chs2) and chitin synthase-III (the catalyti

148 d on genetic variants of the Waxy and Starch Synthase IIa genes, respectively.

149 yzed by chitin synthase-II (Chs2) and chitin synthase-III (the catalytic subunit Chs3 and its activat

150 , we have functionally reconstituted the ATP synthase in giant unilamellar vesicles and tracked the m

151 They activate glycogen synthase in insulin receptor-expressing CHO-IR cells and

152 ms when transiently co-expressed with a GFPP synthase in Nicotiana benthamiana.

153 ctors IFN-gamma, TNF-alpha, and inducible NO synthase in the TME merely 4 d postinfection, before sig

154 cellular distribution of aromatase (estrogen synthase) in several species suggest that mechanisms for

155 mmatory cytokines and inducible nitric-oxide synthase induction in BV2 cells in a concentration-depen

156 OV and was eliminated following nitric oxide synthase inhibition.

157 capitulated by treatment with the fatty acid synthase inhibitor cerulenin and is rescued by addition

158 2 receptor agonist increased, whereas a PGE2 synthase inhibitor decreased, the levels of IL-17A and I

159 Importantly, infusion of the nitric oxide synthase inhibitor l-N(G)-monomethyl-l-arginine acetate

160 and these were inhibited by the nitric oxide synthase inhibitor L-NNA.

161 th is impaired after treatment with a chitin-synthase inhibitor.

162 tatin is potentiated by farnesyl diphosphate synthase inhibitors or geranylgeraniol transferase I inh

163 tic inhibitor, 2-deoxyglucose, or fatty acid synthase inhibitors to perturb the metabolic alterations

164 E also had higher NO, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) inhibitory ac

165 TORC1), HIF1alpha and inducible nitric oxide synthase (iNOS) coordinates DC metabolism and function t

166 ppaB subunit p65; and inducible nitric oxide synthase (iNOS) expression.

167 eletion of inducible isoform of nitric oxide synthase (iNOS) from VCP TG mouse and by pharmacological

168 Inducible nitric oxide synthase (iNOS) generates nitric oxide (NO) in myeloid c

169 al-1 targets cellular inducible nitric oxide synthase (iNOS) in a miRNA manner, leading to attenuatio

170 of NADPH oxidase and inducible nitric oxide synthase (iNOS) in a murine model of A. actinomycetemcom

171 de (NO) or upregulate inducible nitric oxide synthase (iNOS) mRNA following Toll-like receptor (TLR)

172 inhibitory effect on inducible nitric oxide synthase (iNOS).

173 0% of which expressed inducible nitric oxide synthase (iNOS).

174 r control of M. tuberculosis is inducible NO synthase (iNOS).

175 ory factor 1 (IF1) is a nuclear-encoded, ATP synthase-interacting protein that selectively inhibits t

176 ld ring arrangement typical of all other ATP synthases investigated so far.

177 The three groups are cyclodipeptide synthases involved in diketopiperazine synthesis, LanB-l

178 ATP synthase is a rotating membrane protein that synthesizes

179 Cyclic GMP-AMP synthase is essential for innate immunity against infect

180 diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacteriu

181 Blast TBI increased glycogen synthase kinase (GSK)-3beta activities in ApoE4 mice, an

182 Glycogen synthase kinase 3 (GSK3) plays a central role in diverse

183 ogues which are inhibitors of human glycogen synthase kinase 3 (GSK3).

184 The BCR attenuates glycogen synthase kinase 3 beta (GSK3beta) activity to support MY

185 ta receptors and p38 MAPK increased glycogen synthase kinase 3beta (GSK3beta) phosphorylation, wherea

186 rong bias toward phosphorylation of glycogen synthase kinase 3beta (GSK3beta) via the full-length rec

187 which results in hyperactivation of glycogen synthase kinase 3beta (GSK3beta), followed by phosphoryl

188 The phosphorylation is catalyzed by glycogen synthase kinase 3beta (GSK3beta), ultimately resulting i

189 ing pathways occurs at the point of glycogen synthase kinase 3beta (GSK3beta)-TANK-binding kinase 1 (

190 signaling pathway and inhibition of glycogen synthase kinase 3beta (GSK3beta).

191 -dependent protein kinase 5 (Cdk5), glycogen synthase kinase 3beta, protein phosphatase 1, or protein

192 olecularly, ROCK inhibition induced glycogen synthase kinase 3beta-dependent phosphorylation and degr

193 togen-activated protein kinase, and glycogen synthase kinase 3beta.

194 d that the serine/threonine kinase, glycogen synthase kinase, GSK-3alpha/beta, is a central regulator

195 Glycogen synthase kinase-3 (GSK-3) is a constitutively active, ub

196 ts that result in the inhibition of glycogen synthase kinase-3 (GSK-3)beta represent an adaptive resp

197 ning fetal bovine serum (FBS) and a glycogen synthase kinase-3 (GSK3) inhibitor, and in serum-free me

198 Glycogen synthase kinase-3 (GSK3) regulates many physiological pr

199 2 and Akt, including p70 S6-kinase, glycogen synthase kinase-3, ribosomal S6 kinase, c-Jun, and cAMP

200 ate that alcohol intake also blocks glycogen synthase kinase-3beta (GSK-3beta)-phosphorylation of CRM

201 synaptic protein deficit, decreased glycogen synthase kinase-3beta (GSK3beta) activity, and increased

202 ival pathway, and the inhibition of glycogen synthase kinase-3beta and nuclear factor kappa B.

203 Aergic transmission via D2 receptor-glycogen synthase kinase-3beta signaling dramatically reduced exc

204 ed with inhibitors of inducible nitric oxide synthase (L-NAME and NCX-4016).

205 escein diacetate dye, inducible nitric oxide synthase levels determined by Western blot, 3-nitrotyros

206 d that P. palmivora encodes an active chitin synthase-like protein, and mycelial growth is impaired a

207 solic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interferon genes) pathw

208 Lipoyl synthase (LipA) catalyzes the last step in the biosynthe

209 own a large electrochemical gradient via ATP synthase located on the folded inner membrane, known as

210 covered that unlike undecaprenyl diphosphate synthase, mammalian cis-PT is a heteromer consisting of

211 s a cofactor in their specialized methionine synthase (MetH).

212 roduced the S148C mutation into a polyketide synthase module (PikAIII-TE) to impart increased substra

213 Methylphosphonate synthase (MPnS) produces methylphosphonate, a metabolic

214 Methionine synthase (MS) catalyzes methylation of homocysteine, the

215 Multiproduct sesquiterpene synthase MtTPS5 isolated from Medicago truncatula genera

216 ion (R644W) in an uncharacterized polyketide synthase (MuPKS).

217 ardiac myocytes, we identified a neuronal NO synthase (nNOS) as the most relevant source of intracell

218 de synthesizing enzyme neuronal nitric oxide synthase (nNOS) in nerve fibers of the murine vaginal wa

219 Inhibition of neuronal nitric oxide synthase (nNOS) is a promising therapeutic approach to t

220 the amino acid l-arginine, via nitric oxide synthase (NOS) enzymes, research in recent years has est

221 cts, which are inhibited by the nitric oxide synthase (NOS) inhibitor L-NIO, and genetic inhibition o

222 sarcoglycan complex delocalizes nitric oxide synthase (NOS) to alter its signaling, and augments mech

223 inase Cbeta (PKCbeta) and brain nitric oxide synthase (NOS1), both identified by proteomic analysis a

224 roteinase ADAMTS1 and inducible nitric oxide synthase (NOS2) as therapeutic targets in individuals wi

225 hesion molecule 1 (ICAM-1), and nitric oxide synthase (NOS2), developed leukostasis and capillary deg

226 esized in animals by structurally related NO synthases (NOSs), which contain NADPH/FAD- and FMN-bindi

227 ) domains from fungal nonreducing polyketide synthases (NR-PKSs) are responsible for controlling the

228 The ATP synthases of these organisms present a unique model syst

229 n ascribed to any of the individual c-di-GMP synthases or phosphodiesterases (PDEs).

230 ny Gram-negative bacteria, the peptidoglycan synthase PBP1A requires the outer membrane lipoprotein L

231 steine synthetase (gamma-ECS), phytochelatin synthase (PCS1) and phosphate effluxer (PHO1), and the h

232 sW is thought to work in concert with the PG synthases penicillin-binding proteins PBP3 and PBP1b.

233 significant interaction was at prostacyclin synthase (PGIS) rs5602 (OR = 0.34, 95% CI 0.19-0.60, p =

234 on complex localizes to phosphatidylinositol synthase (PIS)-enriched ER subdomains.

235 e natural products synthesized by polyketide synthase (PKS) enzyme complexes predominantly from aceta

236 report a differentially expressed polyketide synthase (PKS) gene candidate.

237 Here, we identified and deleted a polyketide synthase (PKS) gene PfmaE and showed that it is essentia

238 ed analysis of the modular Type I polyketide synthase (PKS) involved in the biosynthesis of the margi

239 of the iso-migrastatin (iso-MGS) polyketide synthase (PKS) were investigated by systematic inactivat

240 Modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (N

241 r, manipulation of modular type I polyketide synthases (PKSs) to make unnatural metabolites commonly

242 dition to their synthase function most F-ATP synthases possess an ATP-hydrolase activity, which is co

243 ATP synthases produce ATP by rotary catalysis, powered by th

244 te-derived innate TNF-alpha and inducible NO synthase-producing DCs dominated the antibacterial respo

245 Substrate promiscuity of terpene synthases provides organism access to novel chemical bou

246 egulation of CHO1-encoded phosphatidylserine synthase (PSS), which catalyzes the committed step for t

247 sequence or abundance of mRNAs from phytoene synthase (PSY) and chromoplast-specific lycopene beta-cy

248 by posttranscriptionally regulating phytoene synthase (PSY).

249 on mammalian mRNA, to identify the main Psi-synthases (PUSs) catalyzing Psi formation, and to unders

250 7-Carboxy-7-deazaguanine (CDG) synthase (QueE) catalyzes a key step in the biosynthesis

251 cells, pharmacologic inhibition of ceramide synthase reduced lipid accumulation by reducing PLIN2 RN

252 of the requisite pyridine/dehydropiperidine synthase remains to be elucidated.

253 n, both hly and gshF (encoding a glutathione synthase required for full PrfA activity) were missing d

254 The polyketide synthases responsible for the biosynthesis of the polyet

255 n, augmentation of translation of fatty acid synthase resulting in de novo lipogenesis, and increased

256 microalgal polyunsaturated fatty acid (PUFA) synthase revealed that small RNA (sRNA)-mediated silenci

257 GALACTINOL SYNTHASE (GOLS), RAFFINOSE SYNTHASE (RS), and STACHYOSE SYNTHASE (STS) are the enzy

258 TPSs), the ent-copalyl diphosphate (ent-CPP) synthase SdCPS1, and the clerodienyl diphosphate (CLPP)

259 CPS1, and the clerodienyl diphosphate (CLPP) synthase SdCPS2.

260 unded Sep into cysteine by Sep-tRNA:Cys-tRNA synthase (SepCysS).

261 y fluvoxamine triggered the Akt-nitric oxide synthase signaling pathway, resulting in time- and isofo

262 eonine resistant 1 [OMR1]), acetohydroxyacid synthase small subunit 2 (AHASS2), and isopropylmalate s

263 , namely, acetyl-CoA carboxylase, fatty acid synthase, SREBP1c, chREBP, glucokinase, and pyruvate kin

264 sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway.

265 by chronic activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-TANK-binding kin

266 OLS), RAFFINOSE SYNTHASE (RS), and STACHYOSE SYNTHASE (STS) are the enzymes responsible for RFO biosy

267 Sesterterpene synthase (STS)-mediated cyclization of the linear C25 is

268 (Nus1) and hCIT (dehydrodolichol diphosphate synthase) subunits, and this composition has been confir

269 t to macrophages that expressed inducible NO synthase, suggesting a potential protective role for the

270 2)) and another also expressing nitric oxide synthase (SuM(Nos1/Vglut2)).

271 tivation of the Akt-endothelial nitric oxide synthase survival pathway, and the inhibition of glycoge

272 is (Arabidopsis thaliana) trimethylguanosine synthase (TGS1), previously uncharacterized in the plant

273 n in the PTP; thus, the only subunits of ATP synthase that could participate in pore formation are e,

274 tains a pyridoxal phosphate-dependent 4-HPAA synthase that directly converts tyrosine to 4-HPAA.

275 rnesyl, decaprenyl, undecaprenyl diphosphate synthases), the large, hydrophobic side chain does not o

276 nge, we have characterized C. neoformans GMP synthase, the second enzyme in the guanylate branch of d

277 r the expression of endothelial nitric oxide synthase, the stability of atherosclerotic plaques, the

278 nation substrate for hyaluronan or heparosan synthases; the resulting 4-N3-GlcNAc-terminated hyaluron

279 Corroborated by data referring to citrate synthase, these results confirm the transitory (mTBI) or

280 ed the sensitivity of the bacterial acyl-ACP synthase to these drugs in infected human cells.

281 renyltransferase (PT) and N-terminal terpene synthase (TPS) domains.

282 nsposon-like silencing of canola-biased PUFA synthase transgenes.

283 Fadrozole (an inhibitor of aldosterone synthase) treatment significantly reduced BPs of hAS(+/-

284 on by p53 is augmented following thymidylate synthase (TS) inhibition and DPYD repression by p53 is d

285 Thymidylate synthase (TS) is the sole enzyme responsible for de novo

286 nflammatory proteins (inducible nitric oxide synthase, tumor necrosis factor-alpha, and interleukin 6

287 both ornithine decarboxylase and spermidine synthase, two enzymes of the polyamine biosynthetic path

288 9v2, or the subsequently acting miltiradiene synthase, TwTPS27v2, led to decreased production of trip

289 nterference targeting either both of the CPP synthases, TwTPS7v2 and TwTPS9v2, or the subsequently ac

290 but industrially important enzyme, taxadiene synthase (TXS).

291 form a multienzyme complex with thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR), as w

292 acid directly inhibits uridine monophosphate synthase (UMPS) and consequently reduces the sensitivity

293 isrupted BH4, which resulted in nitric oxide synthases uncoupling and augmented radiation-induced ROS

294 odel for the NiP center of acetyl coenzyme A synthase using a nickel-substituted azurin protein (NiAz

295 r, and the amount of phosphorylated glycogen synthase was 34% lower, indicating activation of the enz

296 fam57ba, encoding a ceramide synthase, was identified as interacting with the doc2a g

297 etyl-Glucosamine, as well as hyaluronic acid synthase which forms the disaccharide chain.

298 benthamiana identified SdCPS1 as an ent-CPP synthase, which is prevalent in roots and, together with

299 vely inhibits the hydrolysis activity of ATP synthase, which may render the protective role of IF1 in

300 s persisted until inhibition of nitric oxide synthase with N(omega) -nitro-l-arginine methyl ester.