ライフサイエンスコーパス: syntheses

1 n the basis of the catalysts employed in the syntheses.

2 to identify strategies for shape-controlled syntheses.

3 ropane motif in a collection of recent total syntheses.

4 e mechanisms of Fischer-Tropsch and methanol syntheses.

5 aordinary reactions and led to some landmark syntheses.

6 ew compounds relies primarily on exploratory syntheses.

7 s, as evidenced by common abiotic laboratory syntheses.

8 y be underestimated by this and other global syntheses.

9 y half the steps required in two prior total syntheses.

10 c labeling, have not been considered in past syntheses.

11 tandard ( 6: ) were synthesized in multistep syntheses.

12 oposed as a crucial step in many heterocycle syntheses.

13 based catalysts for a broad range of organic syntheses.

14 on and avoids steatosis by diminishing lipid syntheses.

15 hniques, in contrast to medium-sized peptide syntheses.

16 g syntheses as well as improved and scale-up syntheses.

17 successful application in preparative solar syntheses.

18 carbocycle, heterocycle, and natural product syntheses.

19 an be generalized in other metallic nanowire syntheses.

20 allenging, requiring regional or global data syntheses.

21 eaction rates and yields for multigram-scale syntheses.

22 surrogate for other well-established alkyne syntheses.

23 ents in mechanical properties, and difficult syntheses.

24 number of trityl-based reactions in organic syntheses.

25 equire rather long, laborious, and expensive syntheses.

26 In 4 previously reported total syntheses, 17-28 steps were required.

27 In eight prior syntheses, 22-32 steps were required.

28 In contrast to many transition-metal-based syntheses, a direct C-H arylation of nitrogen-containing

29 e development of more highly step-economical syntheses, a synthesis that combines high levels of step

30 ress has been made, but to date all proposed syntheses account separately for the pyrimidine and puri

31 Here we present the syntheses, activities, and crystal structures of the p53

32 The syntheses and antiplasmodial activities of various subst

33 view covering several aspects related to the syntheses and applications of aminooxylated carbohydrate

34 Both, highly stereoselective syntheses and asymmetric procedures leading to the stere

35 ineral weathering, glass alteration, zeolite syntheses and cement hydration.

36 In this Review, we introduce innovative syntheses and characterization techniques for SACs, with

37 We also briefly mention the syntheses and charaterization of the so far reported sta

38 s and surveys published since 2000 about the syntheses and diverse bioactivities of C-glycopyranosyl

39 ic uses of these metals to realize efficient syntheses and highlight the future potential of these re

40 Syntheses and optical properties of mono- and bis-chrome

41 The syntheses and optical, electronic, and structural proper

42 Herein, we report the syntheses and pharmacokinetic evaluation of phosphate pr

43 This work describes the syntheses and preliminary mechanistic research of unprec

44 rrently require laborious and time-consuming syntheses and purification.

45 Herein, we disclose the syntheses and reactivity of three Ntau-imidazole bonded

46 This review focuses on the syntheses and structures of Ni(i) complexes and shows th

47 nsive account is given of long-chain monomer syntheses and the preparation and physical properties, m

48 The results show that mechanochemical syntheses and transformations of ZIFs are consistent wit

49 cesses such as energy production, metabolite syntheses, and programmed cell death.

50 alysts face relatively high cost and complex syntheses, and their activation mechanisms have not been

51 he C1 carbon of isoquinoline core along with syntheses applying various biocatalytic techniques have

52 The key features of these syntheses are 1) the organocatalytic, enantioselective c

53 Currently 2D COF syntheses are developed empirically, and most materials

54 f these skeletons for which enantioselective syntheses are still very limited.

55 Because nonenzymatic aqueous oligosaccharide syntheses are underdeveloped, mechanistic studies were c

56 In these syntheses, aryl ynol ethers were employed as the key bui

57 Furthermore, we explore analog syntheses as well as improved and scale-up syntheses.

58 s provided, including the six reported total syntheses, as well as a comparative analysis of the appr

59 can inform optimization efforts and library syntheses by illuminating trends relating to biological

60 lymerization of two variable monomers, their syntheses can be controlled by discrete metal complexes,

61 le by combining whole-cell catalyzed on-chip syntheses, chiral microchip electrophoresis, and label-f

62 actions--failed or unsuccessful hydrothermal syntheses--collected from archived laboratory notebooks

63 tays practically constant at 3 nm in all the syntheses conducted at short-to-long ligands volumetric

64 t were used in some of the original II-VI QD syntheses decades ago, i.e., hydrogen chalcogenide gas a

65 Since the syntheses do not rely on natural product extraction, our

66 eses with a particular emphasis on the first syntheses, enantiomeric versions, and syntheses that led

67 erns are discussed, but also (semi)automated syntheses, enzymatic approaches, and functionalizations

68 pacts on ecosystem services, no quantitative syntheses exist.

69 The syntheses feature enantioselective vinylogous Mukaiyama-

70 hod development and diversity-oriented total syntheses for structure verification, structure-function

71 chemical transformations in vitro, chemical syntheses guided by these principles have not been fully

72 Both solution-phase and solid-support syntheses have been developed and are reported here.

73 con-containing amino acids is necessary: new syntheses have been developed, and work in this area is

74 Single-source precursor syntheses have been devised for the preparation of struc

75 hydrothermal and (non-aqueous) solvothermal syntheses have produced thousands of new materials that

76 The pragmatic evidence syntheses identified few studies that addressed the clin

77 eal that Ag NPs inhibit secondary metabolite syntheses in several mycotoxin producing filamentous fun

78 iotemporal pattern whereby low and high POMC syntheses in tanycytes occur periodically in each brain,

79 iles by consecutive four- and five-component syntheses in the sense of an activation-alkynylation-cyc

80 ndmark successes in simple and elegant total syntheses in virtually every natural product class: terp

81 We herein present the chiral pool syntheses, in vitro evaluation, and SAR studies of a ser

82 ylic oxidations have featured in hundreds of syntheses, including some natural product syntheses rega

83 The syntheses involved the development of highly enantiosele

84 On the basis of quantitative and qualitative syntheses involving 17 observational studies, metformin

85 a result, it important to understand why MOF syntheses involving different metals arrive at or fail t

86 The key step of all syntheses is a perfluoroalkyl lithium-mediated C-C bond

87 e of 4,4'-bipyridinium (BIPY(2+) ) units, in syntheses is not only a convenient but also an attractiv

88 and key reactions in their total or partial syntheses is provided in the Supporting Information.

89 The syntheses, isolation, and characterization of the first

90 e of the most versatile large-scale chemical syntheses leading to variable chemical feedstock.

91 Syntheses monitoring experiments show that seeding accel

92 The concise, enantioselective total syntheses of (+)-asperazine (1), (+)-iso-pestalazine A (

93 (-)-goniomitine, along with divergent formal syntheses of (+)-aspidospermidine and (-)-quebrachamine,

94 We report the first total syntheses of (+)-haplocidine and its N1-amide congener (

95 , respectively, en route to highly efficient syntheses of (+)-limaspermidine and (+)-kopsihainanine A

96 Efficient de novo asymmetric syntheses of (+)-preussin B, the C(2)-epimer of (-)-preu

97 Formal stereocontrolled syntheses of (+/-)- and (+)-C9-deoxyomuralide is reporte

98 A new approach for the divergent total syntheses of (+/-)-vincaminorine, (+/-)-N-methylquebrach

99 Highly stereoselective six-step syntheses of (-)-1-deoxyaltronojirimycin (altro-DNJ) and

100 ids, which has culminated in the first total syntheses of (-)-2(S)-cathafoline and the long-standing

101 cationic oxycyclizations enabled asymmetric syntheses of (-)-6-epi-6 and (+)-30-epi-6.

102 The asymmetric syntheses of (-)-ADMJ and (+)-ADANJ, the 2-deoxy-2-amino

103 of this methodology were demonstrated by the syntheses of (-)-hyacinthacine B4 and of two epimers of

104 e describe concise enantioselective chemical syntheses of (-)-viridin and (-)-viridiol.

105 Lewis basic components, with the three-step syntheses of 10 new intermolecular transition metal FLPs

106 The total syntheses of 12-epoxyobtusallene IV, 12-epoxyobtusallene

107 The first syntheses of 13,14-didehydroxyisogarcinol (6) and garcim

108 luoromethylsulfonyl)imide (PyTFSI)-templated syntheses of 2,6-pyridyl cryptands of cis(4,4')-dibenzo-

109 In this paper, the syntheses of 24 known PET probes are adapted to this sys

110 Rapid syntheses of 5-HT2C agonist, (-)-enduracididine and azid

111 The asymmetric syntheses of a range of N- and O-protected 3-deoxy-3-ami

112 ep continuous-flow systems have improved the syntheses of active pharmaceutical ingredients (APIs), n

113 Approaches toward the syntheses of alkaloids belonging to the 2,6-disubstitute

114 applications as well as the stereoselective syntheses of all classes of phosphorus compounds has not

115 The asymmetric syntheses of all eight tetraponerine alkaloids (T1-T8) w

116 Thus, syntheses of alpha-ketoamides proceeding via C(2)-oxidat

117 The total syntheses of aminocyclitols, (-)-conduramine F-4, and po

118 With [Rh]-H, catalytic syntheses of ammonia, silylamine and N,N-dimethylhydrazi

119 This strategy has enabled the syntheses of an array of analogous 3-nitro sugars.

120 Syntheses of analytical standards, including deuterium-l

121 Application of these reactions to the formal syntheses of baclofen and (+)-monomorine was demonstrate

122 This process is superior to previous syntheses of benzobicyclo[3.1.1]heptanones, which are re

123 mistry approach to one-pot reactions for the syntheses of benzoxazoles and quinazolines.

124 demonstrated by the concise stereoselective syntheses of biologically active compounds, such as the

125 We report the first chemical syntheses of both (-)-majucin and (-)-jiadifenoxolane A

126 Short gram-scale syntheses of both enantiomers of 2-amino-3-hydroxycyclob

127 The syntheses of both N-aryl-2H-indazoles and furans have be

128 ment of trioxacacin C was deciphered via the syntheses of both of its C7'' epimers.

129 The syntheses of carboxylates from petroleum feedstock requi

130 Syntheses of certain di- and mono-oxygenated derivatives

131 The method enables enantioselective syntheses of challenging alpha-tri- and tetrasubstituted

132 mmon dichloroalcohol building blocks used in syntheses of chlorosulfolipid natural products.

133 of this methodology toward the concise total syntheses of classical indole alkaloids (-)-aspidospermi

134 The syntheses of CMPF and analogues are described.

135 We report the syntheses of combretastatins D-2 and D-4 as well as a fo

136 es them invaluable as starting materials for syntheses of complex molecules, highly diverse elements

137 ssible and the development of more efficient syntheses of complex molecules.

138 eat interest for greener and step-economical syntheses of complex organic targets.

139 A straightforward strategy for the syntheses of curcumene and ar-himachalene is reported.

140 sual endo-attack employed in the few radical syntheses of cyclooctanes.

141 methods for enantioselective and asymmetric syntheses of cyclopentenones, including chemical and enz

142 noid analogue to classical Pauson-Khand-type syntheses of cyclopentenones.

143 Design criteria are outlined and the syntheses of cytidine and uridine azo dye analogues deri

144 well on average in this context, some recent syntheses of deglacial climate history have underestimat

145 ir role in crystallization will guide future syntheses of designed functional coordination polymers.

146 Although the syntheses of DFCs were successfully achieved, the synthe

147 pled with our previously developed templated syntheses of dibenzo crown ethers, this protocol makes p

148 hesis of dictyodendrin F and the first total syntheses of dictyodendrins H and I in six steps.

149 cope of this methodology to the formal total syntheses of dimeric cyclotyrptamine alkaloids (+/-)-chi

150 nsively exploited as a building block in the syntheses of efficient organic semiconducting materials

151 ncise, scalable, and enantioselective formal syntheses of eight dimeric and three monomeric nuphar al

152 The method is demonstrated in the successful syntheses of eighty-eight otherwise difficult to access

153 ly applied to the catalytic enantioselective syntheses of enantiopure (S)-econazole and (R)-mirabegro

154 Total syntheses of ent-penicillones A (ent-1) and B (ent-2) fr

155 Recently, the chemical syntheses of eudesmanes, germacrenes, taxanes and ingena

156 Total syntheses of five naturally occurring polyacetylenes fro

157 d, followed by reactions directed toward the syntheses of five-membered rings, other carbocycles and,

158 In this work, we report the syntheses of fluorescently labeled MIF inhibitors and th

159 We describe efficient asymmetric syntheses of four photoswitchable Delta(9)-tetrahydrocan

160 the potential for larger-scale, higher-yield syntheses of freestanding, higher surface area materials

161 Syntheses of functionally and stereochemically diversifi

162 s Review summarizes the progress of chemical syntheses of GAGs over the last 10 years.

163 odology has been successfully applied to the syntheses of hitherto unreported imidazo-fused benzimida

164 We herein summarize the asymmetric syntheses of indanes with a particular focus on asymmetr

165 l space-time yields are demonstrated for the syntheses of industrial precursors to valsartan and bosc

166 les metal-ligand interactions play in modern syntheses of interlocked molecules and materials, with a

167 nd part of this review, we also describe the syntheses of isocorroles and heteroanalogs of corroles s

168 The syntheses of isomeric helical viologens that have potent

169 Syntheses of large polycyclic aromatic hydrocarbons (PAH

170 We focus on the organic phase syntheses of magnetic NPs with precise control over thei

171 A unified approach for the asymmetric syntheses of medicinally important isoindolinones (S)-PD

172 The first total syntheses of members of these natural product families a

173 ation of vinyl acetohydroxamates facilitated syntheses of monocyclic beta-lactams suitable for incorp

174 n 1925, resulting in a large number of total syntheses of morphine alkaloids.

175 two-fold C-N bond formation protocol for the syntheses of N-aryl benzimidazoquinazolinones is being r

176 Successful syntheses of nanohoop targets containing benzo[k]tetraph

177 ears a particular attention has been paid to syntheses of nanostructured MIP films and MIP nanopartic

178 iene moiety and demonstrate this strategy by syntheses of natural products methyl carlactonoate and c

179 a result linking new and existing laboratory syntheses of natural products with findings of the compo

180 Described herein are the first total syntheses of naturally occurring antitumor agents disora

181 s has been investigated and found to provide syntheses of new classes of thorium hydride compounds.

182 ible outlook is projected for the design and syntheses of next generation multifunctional gel-nanocom

183 However, the photoinduced syntheses of non-metallic nanocrystalline products (such

184 is a versatile reaction that has enabled the syntheses of numerous polycyclic aromatic hydrocarbons (

185 evoted to detailed summaries of the chemical syntheses of oligosaccharide fragments of cellulose, hem

186 overage of modern transition metal-catalyzed syntheses of organohalides via a diverse array of mechan

187 Total syntheses of oridamycin A, triptoquinones B and C, and i

188 satile cross-coupling reagents, enabling the syntheses of other enantiomerically pure, stereodefined

189 diverse in nature and have been employed for syntheses of oxime-based metal complexes and cage-compou

190 These features enable syntheses of popular nucleophilic, radical, and electrop

191 dwide as a serious problem, yet quantitative syntheses of prevalence studies are rare.

192 The first syntheses of privileged [5,6]-bicyclic heterocycles, wit

193 omponent coupling-coupling-cyclocondensation syntheses of pyrazoles and pyrimidines were developed by

194 Moreover, the prebiotic syntheses of pyrimidine and purine nucleotides that have

195 troacetophenone, and aldehyde for high yield syntheses of quinazolines.

196 Total syntheses of racemic gamma-indomycinone and kidamycinone

197 and utility of our methodology by the total syntheses of seven carbasugars viz.

198 The syntheses of seven novel amido nicotine derivatives 12-1

199 pplications to efficient and stereoselective syntheses of several biologically active molecules.

200 The total syntheses of several iconic type I polyketide natural pr

201 strategic approach has now made possible the syntheses of several natural products, including malbran

202 Over the last five decades, the syntheses of several stable radicals have been reported.

203 Syntheses of strained cyclic dienes were accomplished vi

204 ghly substituted acyclic ketones used in the syntheses of tetrasubstituted olefin-based anticancer ag

205 Here, we describe the first chemical syntheses of the "higher" dendralenes, [9]dendralene thr

206 Concise syntheses of the acidic pentasaccharide, related to the

207 Syntheses of the alkyne-functionalized endogenous reacti

208 Efficient bioinspired syntheses of the biologically active pyridoacridine mari

209 nt alpha-amino carbonyls all complicated the syntheses of the dihydro-4-pyranone and dihydro-4-pyrido

210 The syntheses of the first C3 P3 tricyclic compounds are rep

211 Asymmetric syntheses of the flavonoid Diels-Alder natural products

212 The versatile syntheses of the fragments, their stereocontrolled assem

213 Unified, efficient, and scalable syntheses of the halichondrin natural products are repor

214 d potent activity, and thus stereocontrolled syntheses of the individual isomers have been developed.

215 We describe herein formal syntheses of the indole alkaloids cis-trikentrin A and h

216 Total syntheses of the monoterpenoid indole alkaloids (+/-)-al

217 Here we report concise asymmetric syntheses of the natural (-) and non-natural (+) antipod

218 Using this methodology, total syntheses of the natural products (+/-)-foveoglin A and

219 Described herein are syntheses of the naturally occurring polyketides (-)-tet

220 Chemoenzymatic and stereoselective total syntheses of the non-natural enantiomeric forms of the r

221 Total syntheses of the reported structures of the rhamnofolane

222 e quaternary carbon stereocenters, including syntheses of the same natural product by different group

223 Short and highly stereoselective total syntheses of the sesquilignan natural product tatanan A

224 was demonstrated in highly enantioselective syntheses of the sesquiterpenoids (-)-gossoronol and (-)

225 The syntheses of the targeted pentasaccharide have been perf

226 w method were highlighted in expedient total syntheses of the Turkish tobacco natural products alpha-

227 Enantioselective syntheses of the two fragments were developed, with high

228 ompelling mandate to develop practical total syntheses of these agents.

229 To complete the syntheses of these base- and nucleophile-sensitive natur

230 Unfortunately, all current methods for the syntheses of these compounds only work for a hand full o

231 A new method was thus developed for the syntheses of these compounds with high efficiency and di

232 safe and useful alternatives to the chemical syntheses of these compounds.

233 al starting materials as opposed to previous syntheses of these ligands, which have confronted long a

234 However, quantitative syntheses of these patterns and processes across studies

235 The syntheses of these two isomers involved symmetrical disu

236 from the proposed biosynthesis1 and previous syntheses of this family of alkaloids,2,3 all of which e

237 Total syntheses of three different lamellarins have been accom

238 Herein, we disclose the first total syntheses of three members, scaparvins B, C, and D, thro

239 Enantioselective total syntheses of title natural products from a common cycloh

240 Syntheses of TMF behavior relative to chemical traits an

241 Syntheses of two 14-membered macrolides Sch-725674 and G

242 data obtained in the course of the attempted syntheses of two additional bicyclic guanidinium salts.

243 ition reactions that result in the efficient syntheses of two catenanes and one rotaxane, assisted by

244 esis reaction is demonstrated by the concise syntheses of two insect pheromones.

245 The first total syntheses of two possible diastereomers of gliomasolide

246 gand-free Cu(II) catalytic strategy for easy syntheses of unsymmetrical indolotriarylmethanes and new

247 istry is continually evolving to improve the syntheses of value added and bioactive compounds.

248 A review of efforts that have provided total syntheses of vancomycin and related glycopeptide antibio

249 Photoinduced syntheses offer significant advantages over conventional

250 sufficiently fast to render these expensive syntheses pointless.

251 The review highlights the hydantoin syntheses presented from the point of view of the prepar

252 The syntheses proceed by a direct reaction between Ca metal

253 Both syntheses proceed with complete diastereocontrol and all

254 Herein, we review syntheses, properties, and applications of various gel-n

255 cent advances in semiconductor nanostructure syntheses provide unprecedented control over electronic

256 nthetic intermediates from our irciniastatin syntheses, provides an additional five analogues (7-11).

257 of syntheses, including some natural product syntheses regarded as "classics".

258 pared using both chemical and chemoenzymatic syntheses relying on N-acetylglucosamine-1-phosphate uri

259 The syntheses reported herein complete the realization of a

260 emonstrating that time-specific (time-slice) syntheses represent the next logical step in exploring c

261 bimetallic catalysis for sustainable organic syntheses (SOS), highlighting key advances and represent

262 In this review, aspects of the syntheses, structures and magnetic properties of giant 3

263 of the s-block amidoborane compounds - their syntheses, structures and reactivity.

264 s a nitrogen source for prebiotic amino acid syntheses such as the Strecker reaction.

265 Our syntheses suggest that structural revisions of curcusone

266 These syntheses take advantage of a common intermediate (8) th

267 Successful syntheses that allow a delicate structural design of bui

268 ophanes and derivatives has been hindered by syntheses that are traditionally low-yielding, requiring

269 tion of the cell designs is illustrated with syntheses that have been reported.

270 first syntheses, enantiomeric versions, and syntheses that led to the revision of structures or ster

271 cal II-VI materials because of their complex syntheses that require hazardous precursors.

272 itors of Gln-dependent pyrimidine and purine syntheses that together closely mimicked declining cell

273 es the stereochemically modified traditional syntheses (the Pictet-Spengler, the Bischler-Napieralski

274 In chemical syntheses, the activation of carbon-hydrogen (C-H) bonds

275 In contrast to traditional alkene syntheses, the eliminative cross-coupling of carbenoids

276 ports the best stereoselective or asymmetric syntheses, the most efficient P*-building blocks and fun

277 ike Zn/Pd- and Fe/Cu-mediated one-pot ketone syntheses, the new method is effective for nucleophiles

278 neral summary of the different isoxazolidine syntheses, their use as starting building blocks for the

279 sults highlight the ability of high-pressure syntheses to allow for inroads into heretofore-undiscove

280 h a silicone cap and Teflon septum and allow syntheses to be performed on a 2-6 mL scale.

281 Two methodologists performed evidence syntheses to summarize available evidence relevant to ke

282 rn, facilitates the development of efficient syntheses toward oxepane terpenoids, such as aplysistati

283 w benzyne precursors enable inventive biaryl syntheses under mild conditions.

284 robust and safe laboratory scale reactor for syntheses under sealed-vessel conditions at 250 degrees

285 The modular motif affords efficient syntheses using building blocks optimized for interactio

286 The syntheses were achieved through convergent strategies em

287 Three aggregated mixed methods syntheses were developed: 1) Mealtimes should be viewed

288 The evidence syntheses were used to inform the formulation and gradin

289 r, in the oligo(pyrrolidinone-piperidine)s H syntheses were vulnerable to epimerization.

290 We also present hybrid syntheses which combine several of the previously descri

291 th proteins induced various granular protein syntheses which led to enhanced glucose-stimulated insul

292 review highlights 21st century terpene total syntheses which themselves use small, terpene-derived ma

293 f the committee conducted pragmatic evidence syntheses, which followed the Grading of Recommendations

294 a continual growing demand for new chemical syntheses, which suffice the high claim to stereoselecti

295 kes on added importance, and the most useful syntheses will combine high levels of step-economy with

296 Their total syntheses with a particular emphasis on the first synthe

297 low cell design that make possible selective syntheses with high conversion of reactant to product wi

298 ve intermediates, leading to more controlled syntheses with improved reproducibility.

299 New syntheses with very short-lived intermediates have been

300 the icosahedral phase and facilitate routine syntheses without extraordinary precision in preparation