ライフサイエンスコーパス: synthetase

1 se lanthipeptides using a single lanthionine synthetase.

2 zed from selenide and ATP by selenophosphate synthetase.

3 genome encodes a single copy of tyrosyl-tRNA synthetase.

4 nonical function of L. donovani tyrosyl-tRNA synthetase.

5 the catalytic efficiency and fidelity of the synthetase.

6 rtyl-adenylate, which inhibits aspartyl-tRNA synthetase.

7 a new antimalarial target, phenylalanyl-tRNA synthetase.

8 spectively; and (iv) GLN1 encoding glutamine synthetase.

9 lian cells by S207-phosphorylated Lysyl-tRNA synthetase.

10 idyl-adenylate, which inhibits aspartyl-tRNA synthetase.

11 otide antibiotic that inhibits aspartyl-tRNA synthetase.

12 tide synthesis assay with intact bacillamide synthetase.

13 e engineering of novel non-ribosomal peptide synthetases.

14 iting of misacylated tRNAs by aminoacyl-tRNA synthetases.

15 by CylM, a member of the LanM lanthipeptide synthetases.

16 ivated by both human prolyl- and alanyl-tRNA synthetases.

17 Long-chain acyl-CoA synthetase 1 (ACSL1) plays a key role in fatty acid meta

18 ntial amino acid levels in argininosuccinate synthetase 1 (ASS1) -negative tumors by converting argin

19 ne (Arg) as the key enzyme argininosuccinate synthetase 1 (ASS1) is silenced.

20 Argininosuccinate synthetase 1 (ASS1) is the key enzyme that controls bios

21 Loss of argininosuccinate synthetase 1 (ASS1), a key enzyme for arginine synthesis

22 is synthetically lethal in argininosuccinate synthetase 1 (ASS1)-negative cancers, including mesothel

23 In mitochondria, carbamoyl-phosphate synthetase 1 activity produces carbamoyl phosphate for u

24 ty overexpressing ACSL1 (long-chain acyl-CoA synthetase 1) in cardiomyocytes, we show that modestly i

25 uires activation by very long-chain acyl-CoA synthetase-1 (ACSVL1) to modulate both targets, and that

26 ss the urea cycle enzyme carbamoyl phosphate synthetase-1 (CPS1), which produces carbamoyl phosphate

27 Human 2'-5' oligoadenylate synthetase-1 (OAS1) is central in innate immune system d

28 Phosphoribosyl pyrophosphate synthetase-1 (PRPS1) is a key enzyme in nucleotide biosy

29 elic mutations in the alanyl-transfer (t)RNA synthetase 2 (AARS2) gene were found in all 5 patients.

30 we show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) directly regulates histone acetylat

31 ed protein kinase (AMPK)-mediated acetyl-CoA synthetase 2 (ACSS2) phosphorylation at S659, which expo

32 s expression of the antiviral oligoadenylate synthetase 2, but does not affect expression of antibact

33 KEY POINTS: Long-chain acyl-CoA synthetase 6 (ACSL6) mRNA is present in human and rat sk

34 Long-chain acyl-CoA synthetase 6 (ACSL6) mRNA is present in human and rat sk

35 While aminoacyl-tRNA synthetase (AARS) editing potentially provides a mechani

36 aromyces cerevisiae, a single aminoacyl-tRNA synthetase (aaRS), MST1, aminoacylates two isoacceptor t

37 is work indicates that mutations in the tRNA synthetase AARS2 gene cause a recessive form of ALSP.

38 Aminoacyl-tRNA synthetases (AARSs) are a superfamily of enzymes respons

39 Aminoacyl-tRNA synthetases (aaRSs) are housekeeping enzymes essential f

40 Aminoacyl-tRNA synthetases (aaRSs) charge tRNAs with their cognate amin

41 The 20 aminoacyl tRNA synthetases (aaRSs) couple each amino acid to their cogn

42 y players in this process are aminoacyl-tRNA synthetases (aaRSs), which not only catalyse the attachm

43 re activated by an acyl-acyl carrier protein synthetase (AasN) and validate type II fatty acid synthe

44 e nuclear-encoded mitochondrial tyrosyl-tRNA synthetase (Aatm) and the mitochondrial-encoded tyrosyl-

45 The NDP-forming acyl-CoA synthetases (ACDs) catalyze the conversion of various Co

46 We show that the acyl-CoA synthetase ACS-7, which localizes to lysosome-related or

47 ABSTRACT: Long-chain acyl-CoA synthetases (ACSL 1 to 6) are key enzymes regulating the

48 Long-chain acyl-CoA synthetases (ACSL 1 to 6) are key enzymes regulating the

49 Long-chain acyl-CoA synthetases (ACSLs) are key host-cell enzymes that conve

50 Acetyl-CoA synthetases (ACSS1, ACSS2) are involved in this acetate-

51 ion of the substrate peptide relative to the synthetase active sites.

52 e levels resulting from decreased acetyl-CoA synthetase activity.

53 mRNA and protein levels as well as acyl-CoA synthetase activity.

54 strate specificities of nonribosomal peptide synthetase adenylation (A) domains from DNA sequences, w

55 ificity prediction for non-ribosomal peptide synthetase adenylation domains based on the new SANDPUMA

56 ed syn-BNPs inspired by nonribosomal peptide synthetases against microbial pathogens, and discovered

57 Seven synthetases, Ala-, Arg-, Asp-, Asn-, Leu-, Lys- and TyrR

58 veral transcripts, including XDH1, glutamine synthetase, alanine aminotransferase, catalase, superoxi

59 This gain was abolished by blocking Gln synthetase, an enzyme that responds to Gln and purine/py

60 d that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 mutations

61 tive protein complex composed of leucyl-tRNA-synthetase and folliculin, which regulates mTOR tetherin

62 netic analysis identified ACS-4, an acyl-CoA synthetase and its FA-CoA product, as key germline facto

63 nd double knockouts of genes relating to PEP synthetase and PTS components.

64 ally aminoacylated with serine by seryl-tRNA synthetase and the resulting seryl moiety is converted t

65 of decreased expression of argininosuccinate synthetase and/or ornithine transcarbamoylase, several t

66 ession of nearly all of the cytoplasmic tRNA synthetases and associated ARS-interacting multifunction

67 s exist in certain eukaryotic aminoacyl-tRNA synthetases and play roles in tRNA or protein binding.

68 ific substrates of eukaryotic aminoacyl-tRNA synthetases and ribosomes.

69 the bulk purification of the aminoacyl-tRNA synthetases and translation factors necessary for afford

70 cal markers (PD-1, cytokeratin 19, glutamine synthetase, and beta-catenin expression).

71 itor of the Plasmodium falciparum lysyl-tRNA synthetase, and exhibits activity against both blood- an

72 biologically active and target aspartyl-tRNA synthetase, and that the carboxymethyl group prevents re

73 Protein kinase B and pantothenate synthetase are examined in detail.

74 (AA) limitation of the entire aminoacyl-tRNA synthetase (ARS) gene family revealed that 16/20 of the

75 Mutations in several aminoacyl-tRNA synthetase (ARS) genes have been implicated in inherited

76 Aminoacyl-tRNA synthetases (ARSs) are responsible for charging amino ac

77 g Asn to tRNA(Asn) using an asparaginyl-tRNA synthetase (AsnRS) or by synthesizing Asn on the tRNA.

78 Asparagine synthetase (ASNS) converts aspartate and glutamine to as

79 Silencing of asparagine synthetase (ASNS), an amidotransferase that converts asp

80 can take up asparagine, silencing asparagine synthetase (ASNS, which converts glutamine-derived nitro

81 s in a tRNA gene, aspT, in an aminoacyl tRNA synthetase, AspRS, and in a translation factor needed fo

82 the ornithine cycle enzyme argininosuccinate synthetase (ASS) is a principle site of AMP generation i

83 equired for growth in some argininosuccinate synthetase (ASS)-deficient cancers.

84 ng of PRMT7 and identified argininosuccinate synthetase (ASS1) as a potential interaction partner of

85 The latter lack argininosuccinate synthetase (ASS1) making them auxotrophic for arginine.

86 ure of an NRPS Cy domain, Cy2 of bacillamide synthetase, at a resolution of 2.3 A.

87 ial lung disease and myositis with anti-tRNA synthetase autoantibodies.

88 Lanthionine synthetase C-like 2 (LANCL2), a novel therapeutic target

89 n by sulfur is catalyzed by tRNA thiouridine synthetases called TtuA.

90 Proteins made in cells that express the synthetase can be labeled with Anl, tagged with dyes or

91 by prokaryotic and mammalian cysteinyl-tRNA synthetases (CARSs).

92 lfide synthesizing enzyme cystathionine beta-synthetase (CBS) in sensitization of VGSCs in a previous

93 forms of Caenorhabditis elegans glycyl-tRNA synthetase (CeGlyRS) are encoded by the same gene (CeGRS

94 the recently discovered cyclic dinucleotide synthetase cGAS and the cyclic dinucleotide receptor STI

95 Cyclic GMP-AMP synthetase (cGAS) is a DNA-specific cytosolic sensor, wh

96 ed a homozygous nonsense mutation in proline synthetase co-transcribed homolog (bacterial), PROSC, wh

97 The predicted (p)ppGpp synthetase coded by the Phrann prophage defends against

98 ild-type E. coli EF-Tu and phenylalanyl-tRNA synthetase collaborate with these mutant ribosomes and o

99 The mammalian cytoplasmic multi-tRNA synthetase complex (MSC) is a depot system that regulate

100 a high-molecular-weight multi-aminoacyl-tRNA synthetase complex (MSC), restricting the pool of free L

101 rmally sequestered in a multi-aminoacyl-tRNA synthetase complex (MSC).

102 iae could play a role analogous to the multi-synthetase complex present in higher order organisms and

103 known structure (the exocyst and tRNA multi-synthetase complex) and by establishing evidence for the

104 ting Plasmodium falciparum phenylalanyl-tRNA synthetase comprise one promising new class of antimalar

105 The mechanisms by which lanthipeptide synthetases control the order in which they catalyze mul

106 The pathway builds on a nonribosomal peptide synthetase de-rived di-tyrosine piperazine intermediate.

107 tRNA synthetase deficiencies are a growing group of genetic d

108 e been clinically associated with asparagine synthetase deficiency (ASD).

109 Moderately higher folate intake and MTHFD1-synthetase deficiency in pregnant mice result in a lower

110 The combination of FASD and maternal MTHFD1-synthetase deficiency led to a greater incidence of defe

111 by acyltransferase/acyl-acyl carrier protein synthetase, demonstrating the first evidence of cardioli

112 Collectively, these results reveal a Gln synthetase-dependent increase and resilience of FOXP3(hi

113 chondrial glutaminase and carbamoylphosphate synthetase) depends on the rate of glutamine synthesis a

114 e we describe a mutant murine methionyl-tRNA synthetase (designated L274GMmMetRS) that charges the no

115 bolites synthesized by non-ribosomal peptide synthetases display diverse and complex topologies and p

116 nst the 30S subunit, presenting the (p)ppGpp-synthetase domain near the 30S spur.

117 xtend understanding of the broader impact of synthetase editing reactions on organismal homeostasis,

118 ion through evasion of one but not both tRNA synthetase editing systems.

119 n this study we demonstrate that malonyl-CoA synthetase encoded by the Arabidopsis AAE13 (AT3G16170)

120 ase AasC but inhibitors of the host acyl-CoA synthetase enymes ACSL also impaired growth of C.t.

121 correlated with high expression of glutamine synthetase, enzymes utilizing nitrite/nitrate, and those

122 Here we identify glutamyl-prolyl-tRNA synthetase (EPRS) as an mTORC1-S6K1 target that contribu

123 that the MSC component glutamyl-prolyl-tRNA synthetase (EPRS) switched its function following viral

124 Many human tRNA synthetases evolved alternative functions outside of pro

125 ide substrates, the prochlorosin lanthionine synthetase evolves under a strong purifying selection, i

126 ession of human MAT2A, which encodes the SAM synthetase expressed in most cells.

127 NO synthetase expression and NO synthesis are linked to alt

128 hology through the long-chain fatty acyl-CoA synthetase Faa1, independently of the RNA methylation co

129 ty acid export in cells lacking the acyl-CoA synthetases Faa1 and Faa4.

130 Bifunctional FAD synthetases (FADSs) fold in two independent modules; The

131 ase (HIBCH, p = 8.42 x 10(-89)) and acyl-CoA synthetase family member 3 (ACSF3, p = 3.48 x 10(-19)).

132 ble of aberrant interactions, links the tRNA synthetase family to CMT.

133 icated structural plasticity of a human tRNA synthetase for architectural reorganizations that are pr

134 ere we investigate thirty-one aminoacyl-tRNA synthetases from infectious disease organisms by co-crys

135 ied, the non-canonical non-ribosomal peptide synthetase Fub8.

136 te reductase (HAC1), gamma-glutamyl-cysteine synthetase (gamma-ECS), phytochelatin synthase (PCS1) an

137 , caused by dominant mutations in Glycl tRNA synthetase (GARS), present with progressive weakness, co

138 he primary sequence of the human glycyl-tRNA synthetase (GARS).

139 y distributed family of nonribosomal peptide synthetase gene clusters in gut bacteria.

140 Translation of the glutamyl-prolyl-tRNA synthetase gene EPRS is enhanced in response to eIF2alph

141 e transcription of the non-ribosomal peptide synthetase gene required for nidulanin A biosynthesis.

142 tors (aer and mcn gene sets) and microcystin synthetase genes (mcy), with urea enrichment yielding si

143 ft, along with expression of both acetyl-CoA synthetase genes ACS1 and ACS2 We conclude that CR maxim

144 results explain why B. subtilis with its Asn synthetase genes knocked out is still an Asn prototroph.

145 liana), one of the four S-adenosylmethionine synthetase genes, METHIONINE ADENOSYLTRANSFERASE3 (MAT3)

146 he model predicts the responses of glutamine synthetase, GlnB, and GlnK under time-varying external a

147 Cytosolic glutaminyl-tRNA synthetase (GlnRS) is the singular enzyme responsible fo

148 tein A) kinase, which inhibits glutamyl tRNA synthetase (GltX).

149 t forms a ternary complex with glutamyl-tRNA synthetase (GluRSc) and methionyl-tRNA synthetase (MetRS

150 f glial fibrillary acidic protein, glutamine synthetase, glutamate transporter 1 (GLT1), aquaporin-4,

151 g machinery, including catalase, glutathione synthetase, glutathione reductase, NADPH-cytochrome P450

152 Glycyl tRNA synthetase (GlyRS) provides a unique case among class II

153 keeping gene GARS, which encodes glycyl-tRNA synthetase (GlyRS), mediate selective peripheral nerve t

154 GDP-mannose dehydratase (GMD) and GDP-fucose synthetase (GMER) were expressed ectopically; from these

155 Herein, we identified GMP synthetase (GMPS), a key enzyme of de novo purine biosyn

156 ated by the indole-3-acetic acid (IAA)-amido synthetase Gretchen Hagen 3 (GH3).17 [10].

157 how that loss of function of VAS2 (IAA-amido synthetase Gretchen Hagen 3 (GH3).17) leads to increases

158 In Arabidopsis thaliana, the acyl acid amido synthetase Gretchen Hagen 3.5 (AtGH3.5) conjugates both

159 Glutamine synthetase (GS) catalyzes condensation of ammonia with g

160 ated with changes in expression in glutamine synthetase (GS) in astrocyte-like glia and in changes in

161 dy focuses on the mechanism of how glutamine synthetase (GS) inhibits TnrA function in response to ke

162 Here we report that glutamine synthetase (GS) is an endogenous substrate of CRL4(CRBN)

163 Glutamine synthetase (GS) plays an essential role in metabolism by

164 t p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4(CRBN) E

165 ation of beta-catenin targets like glutamine synthetase (GS), leukocyte cell-derived chemotaxin 2, Re

166 exhibited negligible expression of glutamine synthetase (GS).

167 3 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome integ

168 mportant biological function, aminoacyl-tRNA synthetases have been the focus of anti-infective drug d

169 Beauvericin and bassianolide synthetases have the same C1-A1-T1-C2-A2-MT-T2a-T2b-C3 d

170 oxylases by a biotin ligase: holocarboxylase synthetase (HCS) in mammalian cells and BirA in microbes

171 tly linked to apoproteins by holocarboxylase synthetase (HCS).

172 teins detected by iTRAQ, carbamoyl-phosphate synthetase I (CPSI, related to urea cycle and endogenous

173 an allosteric activator of carbamylphosphate synthetase I and III.

174 g, urea production via carbamoyl phosphatase synthetase I staining, and cell viability after exposure

175 In cattle, cytosolic isoleucyl-tRNA synthetase (IARS) missense mutations cause hereditary we

176 Isoleucyl-tRNA synthetase (IleRS) is an aminoacyl-tRNA synthetase whose

177 Isoleucyl-tRNA synthetase (IleRS) is unusual among aminoacyl-tRNA synth

178 Like some other aminoacyl-tRNA synthetases, IleRS can mischarge tRNA(Ile) and correct t

179 While having multiple aminoacyl-tRNA synthetases implicated in Charcot-Marie-Tooth (CMT) dise

180 a key regulator of ACS1 encoding acetyl-CoA synthetase in cells cultured in YPA.

181 viously identified to be the second (p)ppGpp synthetase in Mycobacterium smegmatis.

182 sC, illustrating its function as an acyl-ACP synthetase in vivo.

183 tase (IleRS) is unusual among aminoacyl-tRNA synthetases in having a tRNA-dependent pre-transfer edit

184 ding the role of mutations in aminoacyl-tRNA synthetases in neurological diseases.

185 y dictated by the accuracy of aminoacyl-tRNA synthetases in pairing amino acids with correct tRNAs, i

186 the potential roles for GH3 acyl acid amido synthetases in plants.

187 CMP-Kdo synthetase inhibition and competition assays showing tha

188 production with the addition of a glutamate synthetase inhibitor.

189 xide (NO) release and inducible nitric oxide synthetase (iNOS) expression.

190 Cytosolic GS1 (Gln synthetase) is central for ammonium assimilation in plan

191 n in the specificity constant of the CMP-Kdo synthetase KdsB with Kdo-N3 compared with Kdo.

192 Through asparagine synthetase knockdown and altering of media asparagine co

193 may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium.

194 nduced expression of a mutant methionyl-tRNA synthetase (L274G) enables the cell-type-specific labeli

195 ed a central role of the long-chain acyl-CoA synthetase LCS2 in the production of triacylglycerol fro

196 The lacticin 481 synthetase (LctM) cleaves eight chemical bonds and forms

197 e twin attributes of Leishmania tyrosyl-tRNA synthetase (LdTyrRS) namely, aminoacylation, and as a mi

198 A-dependent mechanism to inhibit leucyl-tRNA synthetase (LeuRS), while the TM84-producer prevents sel

199 interaction with and inhibition of acyl CoA-synthetase ligase (ACSL) activity.

200 Interleukin 16 (IL16), 2',5'-Oligoadenylate Synthetase Like (OASL), and Adhesion G Protein Coupled R

201 them, the gene encoding 2'-5' oligoadenylate synthetase-like (OASL) underwent the greatest upregulati

202 overed an unprecedented nonribosomal peptide synthetase-like-pteridine synthase hybrid biosynthetic g

203 R)(rs2228570AG, rs1544410CT), oligoadenylate synthetases-like (OASL)(rs1169279CT) and adenosine deami

204 we determine that the bacterial lipoic acid synthetase LipA suppresses macrophage activation.

205 cancer-associated MTOR mutations.Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1 pathw

206 Leucyl-tRNA synthetase (LRS) is known to function as leucine sensor

207 primer via an interaction between lysyl-tRNA synthetase (LysRS) and the HIV-1 Gag polyprotein.

208 identification of its cognate aminoacyl-tRNA synthetase makes it possible to map transient protein-pr

209 and suggests that editing by aminoacyl-tRNA synthetases may be important for survival under starvati

210 -tRNA synthetase (GluRSc) and methionyl-tRNA synthetase (MetRS) in the cytoplasm to regulate their ca

211 A(Leu) with methionine by the methionyl-tRNA synthetase (MetRS).

212 d antibiotic exposure via the methionyl-tRNA synthetase (MetRS).

213 of two different holo-non-ribosomal peptide synthetase modules, each revealing a distinct step in th

214 e aminoacylated by Class I mt-aminoacyl-tRNA synthetases (mt-aaRSs).

215 folate cyclohydrolase-formyltetrahydrofolate synthetase (MTHFD1) R653Q, may modulate the effects of e

216 folate cyclohydrolase-formyltetrahydrofolate synthetase (MTHFD1) rs2236225, influenced choline dynami

217 raction of the supplemented diet with MTHFD1-synthetase (Mthfd1S) deficiency in mice, which is a mode

218 The mitochondrial tyrosyl-tRNA synthetases (mtTyrRSs) of Pezizomycotina fungi, a subphy

219 pathway, a non-discriminating aspartyl-tRNA synthetase (ND-AspRS) attaches Asp to tRNA(Asn) and the

220 ermediates bound to the nonribosomal peptide synthetase (NRPS) assembly line.

221 lyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) enzymes EpoA-F.

222 tabolites derived from non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS).

223 domain communication in nonribosomal peptide synthetases (NRPSs) and lay the groundwork for the ratio

224 Nonribosomal peptide synthetases (NRPSs) are a family of multidomain, multimo

225 The nonribosomal peptide synthetases (NRPSs) are one of the most promising resour

226 Nonribosomal peptide synthetases (NRPSs) assemble a large group of structural

227 de synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) comprise giant multidomain enzymes r

228 Nonribosomal peptide synthetases (NRPSs) produce a wide variety of peptide na

229 roduced by multidomain non-ribosomal peptide synthetases (NRPSs).

230 myxovirus resistance 1 (Mx1), oligoadenylate synthetase (OAS) and viperin in unstimulated sputum cell

231 The 2'-5' oligoadenylate synthetase (OAS) locus encodes for three OAS enzymes (OA

232 virus uses to block the 2',5'-oligoadenylate synthetase (OAS)-RNase L (RNase L) antiviral pathway.

233 The oligoadenylate synthetase (OAS)-RNase L pathway is a potent antiviral a

234 The oligoadenylate synthetase (OAS)-RNase L pathway is a potent interferon

235 stance protein 2 (Mx2), 2',5'-oligoadenylate synthetase (OAS-1), Virus inhibitory protein (viperin),

236 by acyltransferase/acyl-acyl carrier protein synthetase on the inner leaflet of the membrane.

237 crt, pfmdr, pfdhfr, cytoplasmic prolyl t-RNA synthetase or hsp90.

238 onal nonsense suppressor tRNA/aminoacyl-tRNA synthetase pair in Escherichia coli.

239 equires a functional gamma-glutamylpolyamine synthetase PauA2.

240 Phenylalanyl-tRNA synthetase (PheRS) maintains specificity via an editing

241 For example phenylalanyl-tRNA synthetase (PheRS) proofreads the non-protein hydroxylat

242 ated with the outcome obtained by polyketide synthetase (pks) coding genes established that seaweed-a

243 roteins due to misrecognition by prolyl-tRNA synthetase (ProRS).

244 is the first report to implicate a (p)ppGpp synthetase protein in R-loop-induced stress response.

245 of the Methanosarcina mazei pyrrolysyl-tRNA synthetase (PylRS)/tRNA(Pyl)CUA pair (and its derivative

246 Here, two (p)ppGpp synthetases RelA and RelQ are identified in Streptococcu

247 minal domain (Cterm) of human mt-leucyl tRNA synthetase rescues the pathologic phenotype associated e

248 A putative lysyl-tRNA synthetase resistance gene was identified in the cladosp

249 ubstrates, including multiple aminoacyl tRNA synthetases, ribosomal proteins, protein chaperones, and

250 ed H3K4me3 caused by knockdown of either SAM synthetase (Sam-S) or the histone methyltransferase Set1

251 We show that the tetrameric small alarmone synthetase (SAS) RelQ from the Gram-positive pathogen En

252 Succinyl Coenzyme A synthetase (SCS) is a key mitochondrial enzyme.

253 tic step typically performed by succinyl-CoA synthetase (SCS), has arisen in diverse bacterial groups

254 indirect pathway, where O-phosphoseryl-tRNA synthetase (SepRS) catalyzes the ligation of a mismatchi

255 itochondria-derived citrate or by acetyl-CoA synthetase short-chain family member 2 (ACSS2) from acet

256 tem components, in particular aminoacyl-tRNA synthetases, shows that, at a stage of evolution when th

257 the central role of the nonribosomal peptide synthetase Sln9 in constructing and installing the disti

258 rosin peptide substrates and the lanthionine synthetase suggests that structure diversification, rath

259 BioW is a pimeloyl-CoA synthetase that converts pimelic acid to pimeloyl-CoA.

260 We evolved a pyrrolysyl-tRNA synthetase that incorporates site-specifically PheK and

261 tion into selD, encoding the selenophosphate synthetase that is essential for the specific incorporat

262 onjointly modulate the activity of glutamine synthetase, the key enzyme for nitrogen assimilation, is

263 cientific community requested aminoacyl-tRNA synthetases to be targeted in the Seattle Structural Gen

264 Using this strategy, we evolved new synthetases to genetically encode N(epsilon)-fluoroacety

265 de AsnRS for Asn-tRNA(Asn) formation and Asn synthetases to synthesize Asn and GatCAB for Gln-tRNA(Gl

266 er activated amino acids from aminoacyl-tRNA synthetases to the ribosome, where they are used for the

267 oach for directly discovering aminoacyl-tRNA synthetase-tRNA pairs that selectively incorporate non-n

268 direct, scalable discovery of aminoacyl-tRNA synthetase-tRNA pairs with mutually orthogonal substrate

269 n coordination with a mutant pyrrolysyl-tRNA synthetase-tRNA(Pyl) pair, azidonorleucine is geneticall

270 ng the recently evolved M. jannaschii Y-tRNA synthetase/tRNA pair.

271 g orthogonal amber suppressor aminoacyl-tRNA synthetase/tRNA pairs into a thiocillin producer strain

272 approach, we discover a phosphothreonyl-tRNA synthetase-tRNACUA pair and create an entirely biosynthe

273 E. coli containing a mutated orthogonal tRNA synthetase/tRNACUA pair enabling site-specific insertion

274 l amino acid using a pyrrolysyl transfer RNA synthetase/tRNACUA pair in mammalian cells enables the s

275 expression of an orthogonal pyrrolysyl-tRNA synthetase-tRNAXXX pair in a cell type of interest and p

276 tryptophan for binding to tryptophanyl-tRNA synthetase (TrpRS) enzymes.

277 57Arg), in the cytoplasmic tryptophanyl-tRNA synthetase (TrpRS) gene (WARS) that co-segregates with t

278 g carboxylate-amine ligases of the glutamine synthetase type.

279 nction of amacrine cells (brain nitric oxide synthetase/tyrosine hydroxylase expression) and ganglion

280 three CMT-causing mutations in tyrosyl-tRNA synthetase (TyrRS or YARS).

281 leted, SVs of homodimeric human tyrosyl-tRNA synthetase (TyrRS).

282 ption factor Gln3 or inactivation of the CTP synthetase Ura7 both resulted in the activation of the D

283 erexpression of editing-defective valyl-tRNA synthetase (ValRS(ED)) activated DNA break-responsive H2

284 Mitochondrial tryptophanyl-tRNA synthetase (Wars2), encoding an L53F protein variant wit

285 With recent data on another CMT-linked tRNA synthetase, we suggest that an inherent plasticity, enge

286 [TDO], arginase [ARG] 1, ARG2, inducible NO synthetase) were evaluated in PBMCs.

287 ic exclusion system and a predicted (p)ppGpp synthetase, which blocks lytic phage growth, promotes ba

288 RS2 gene encoding mitochondrial tyrosyl-tRNA synthetase, which interacts with m.11778G>A mutation to

289 rial GlyRS is closely related to alanyl tRNA synthetase, which led us to define a new subclassificati

290 ncestor related to glutaminyl aminoacyl-tRNA synthetases, which may have been one of the key factors

291 ed by editing defects of transfer RNA (tRNA) synthetases, which preserve genetic code fidelity by rem

292 cylated tRNAs is catalyzed by aminoacyl-tRNA synthetases, which use quality control pathways to maint

293 tRNA synthetase (IleRS) is an aminoacyl-tRNA synthetase whose essential function is to aminoacylate t

294 sis for catalysis with non-ribosomal peptide synthetases will facilitate bioengineering to create nov

295 We identify a nonribosomal peptide synthetase with an unusual domain architecture and an L-

296 dy, we identified two class-I aminoacyl-tRNA synthetases with high similarities to consensus amino ac

297 machinery, including aminoacyl transfer RNA synthetases with specificities for all 20 amino acids.

298 icate that inhibition of long-chain acyl-CoA synthetases with triacsin C, a fatty acid analogue, impa

299 lyketide synthases and non-ribosomal peptide synthetases with unusual domain structures, including se

300 a unique case among class II aminoacyl tRNA synthetases, with two clearly widespread types of enzyme