ライフサイエンスコーパス: synthetic

1 en cells and biointerfaces, both natural and synthetic.

2 reening examinations performed with DBT plus synthetic 2D imaging (38.5 screens per hour) than with F

3 invasive assessment was higher for DBT plus synthetic 2D imaging than for FFDM (RR, 1.93; 95% CI: 1.

4 ctical and scalable method provides one-step synthetic access to primary anilines and phenols at low

5 For efficient synthetic access, we developed a practical mixed solid-

6 en little explored due to a lack of reliable synthetic access.

7 DMET risk filter for drug like features, and synthetic accessibility for chemical synthesis, out of 5

8 h bacterial lipopolysaccharide (LPS) and the synthetic acylated lipopeptide Pam3CSK4.

9 ecko behaviour, as well as towards designing synthetic adhesive mimics.

10 These standards, produced with whole air or synthetic air covered the mole fraction range of (378-42

11 Finally, we demonstrate that the synthetic alkylated piperazine-azole hybrids do not func

12 eoretical and experimental approaches with a synthetic anaerobic coculture pairing fermentative Esche

13 Dehaloperophoramidine is a dehalogenated synthetic analogue of perophoramidine.

14 erile insect technique (SIT) and cue-lure (a synthetic analogue of raspberry ketone (RK))-based male

15 The synthetic analogues modified within the NEP degradation

16 studies pave the way for the examination of synthetic analogues rationally designed to not only over

17 isocryptolepine alkaloid and a series of its synthetic analogues with demonstrated cancer cell antipr

18 ) (control group, no surgical anatomy); (2) "synthetic anatomy for surgical tasks" mannequin (medium-

19 We applied ECC to 110 synthetic and 48 real datasets, including 35 cancer gene

20 further advance, we anticipate that chemical synthetic and biosynthetic studies will become increasin

21 In this study we use both synthetic and experimental data to demonstrate that the

22 100 nm Au ENM were spiked into DI H2O and synthetic and natural leachates.

23 the thirteen biclustering algorithms on both synthetic and real gene expression datasets.

24 We validate our method using synthetic and real microbiome sequences.

25 tives) and a rewarding collaboration between synthetic and theoretical chemists (cf. the cerocene pro

26 also tries to exemplarily show how difficult synthetic and theoretical problems can eventually be sol

27 wed in addition to advances in the design of synthetic anion channels.

28 ts on dehydrating serpentinized peridotites (synthetic antigorite-olivine aggregates, minerals repres

29 Moreover, the effect of the addition of the synthetic antioxidant 2,6-di-tert-butyl-hydroxytoluene (

30 nder accelerated shelf-life, compared to the synthetic antioxidant, butylated hydroxytoluene (BHT).

31 The synthetic application of this method is showcased by the

32 n pursuit of these goals, we developed a new synthetic approach that enables facile manipulation of t

33 A modular synthetic approach was used to explore the chemical spac

34 we highlight the key contributions of these synthetic approaches and how the development of novel Ub

35 y toward redox active species and help guide synthetic approaches for the design of alternative devic

36 the first part of the review, the different synthetic approaches to synthesize propargylamines, such

37 red to related C horizontal lineN functions, synthetic aspects of oxime ligation and methodologies fo

38 ng the natural indole-3-acetic acid, and the synthetic auxin 2,4-dichlorophenoxyacetic acid.

39 c hindrance of these couplings restricts the synthetic availability of more substituted diarylamines.

40 pic data are not identical with those of the synthetic baulamycin A.

41 f the bacteriophage lambda cI TF against two synthetic bidirectional promoters.

42 entially very advantageous for biotechnology/synthetic biology applications.

43 hampering the design of engineered genes for synthetic biology applications.

44 es will eventually succeed, I suggest that a synthetic biology approach - moving free-living nematode

45 hanisms of filament assembly, we have used a synthetic biology approach to reconstitute, in a nonnati

46 istance with Isomap and Laplacian Eigenmaps, synthetic biology biobircks are successfully visualized

47 r aryl O-demethylation and as a component of synthetic biology efforts to valorize previously underus

48 Modern synthetic biology has been reinvented as an engineering

49 One fundamental challenge in synthetic biology is the lack of quantitative tools that

50 We cite specific examples from the synthetic biology literature that illustrate these princ

51 ization, and, with examples, demonstrate how synthetic biology may maximize CO2 uptake within and abo

52 ent very promising opportunities for further synthetic biology modification and for a variety of biot

53 Synthetic biology offers the potential to expand communi

54 cations in basic research, biotechnology and synthetic biology that involve the multistep engineering

55 approach will be a valuable addition to the synthetic biology toolkit, facilitating the understandin

56 This study offers new synthetic biology tools to program spatial structures.

57 Synthetic biology was founded as a biophysical disciplin

58 The combination of cell-free synthetic biology, nanodisc-technology and non-covalent

59 f Saccharomyces cerevisiae as a platform for synthetic biology, strain engineering remains slow and l

60 ene and genome transfer in biotechnology and synthetic biology.

61 h that is the nexus of chemical genomics and synthetic biology.

62 To overcome this barrier, we developed a synthetic-biology approach based on a technique known as

63 a possible design strategy to obtain regular synthetic cages with full control over their surface pro

64 Our design comprised de novo synthetic cancer-specific promoters and, to enhance spec

65 binding protein 1 (PABPC1) modulates protein synthetic capacity of the mammalian heart.

66 ntally friendly fashion remains a formidable synthetic challenge because of the absence of suitable h

67 emical methods were subsequently replaced by synthetic chemicals, other traditional methods were impr

68 These results illustrate the power of synthetic chemistry in elucidating the fundamental mecha

69 ology for the analysis and design of complex synthetic chemistry schemes.

70 ogical complexity by exploiting the power of synthetic chemistry, in conjunction with the molecular r

71 ter has attracted significant attention from synthetic chemists due primarily to the historically syn

72 Synthetic chemists have focused on preparing such model

73 light-activated photoredox catalysts provide synthetic chemists with the unprecedented capability to

74 on is globally unaffected by the presence of synthetic chromosome(s).

75 complete Sc2.0 genome synthesis, individual synthetic chromosomes built by Sc2.0 Consortium teams ar

76 mpleting Sc2.0 specifies consolidation of 16 synthetic chromosomes into a single strain.

77 ce allocation is a key control parameter for synthetic circuit design.

78 implications of our findings for engineering synthetic circuits are: (i) sRNAs can potentially bind n

79 Synthetic circuits embedded in host cells compete with c

80 edible coatings have various advantages over synthetic coatings such as being edible and generally be

81 However, their implementation into synthetic collagen is difficult and requires the replace

82 n attractive strategy for the development of synthetic collagen-based biocompatible materials.

83 compared with that from untreated leaves and synthetic colorant.

84 f extracts from untreated/steamed leaves and synthetic colorant.

85 ing of a 50000-member library of natural and synthetic compounds for sensitizers of RCC cells to TRAI

86 sense a broad spectrum of ligands, including synthetic compounds, chemokines, mitogens, fatty acids,

87 l groups comprise a large set of natural and synthetic compounds, often with potent biological activi

88 herry-picked from all commercially available synthetic compounds.

89 The harsh synthetic conditions and associated limited structural d

90 s of defined clusterfullerenes under typical synthetic conditions.

91 Through synthetic control of the kinetic reaction pathway, a lay

92 However, synthetic control of the structural ordering in such a c

93 ves on future developments in the context of synthetic control, structure-property relationships, and

94 tary time series and spatiotemporal methods (synthetic controls and hierarchical Bayesian spatial reg

95 These favourable characteristics, along with synthetic convenience, indicate that these agents have p

96 eactivation from latency is initiated by the synthetic corticosteroid dexamethasone.

97 sms of catalysis within the context of their synthetic counterparts and to discuss the mechanistic hy

98 Synthetic curcumin analogs that undergo oxidative transf

99 Analysis of the cytokinin response using the synthetic cytokinin sensor, TCSn, showed that this respo

100 We demonstrate the utility of AD-LIBS with synthetic data.

101 ed biological activity, or intermediates for synthetic derivatization.

102 We describe our synthetic design toward a concise and enantiospecific to

103 tructures, but their usage is limited due to synthetic difficulties, process complexities and prohibi

104 ucocorticoid in combination with bDMARDs and synthetic disease-modifying antirheumatic drugs (sDMARDs

105 e, we develop a method to quantify errors in synthetic DNA by next-generation sequencing.

106 Our findings enable rational design of synthetic donor DNAs for efficient genome editing.

107 ith implications for microbiome research and synthetic ecology.

108 a phase-transfer catalyst, greatly enhances synthetic effectiveness.

109 an incorrect diastereomer or due to lack of synthetic efficiency.

110 then provides a comprehensive review of the synthetic efforts toward each member of the natural prod

111 g the accessible chemical space and reducing synthetic efforts.

112 ated in a selective way and used for further synthetic elaboration to produce, for example, a CF3-sub

113 in by using protein trans-splicing to ligate synthetic elements to a nuclease-deficient Cas9 (dCas9)

114 res, as well as to offer guidance for future synthetic endeavors.

115 s of 2-AG deficiency by deleting its primary synthetic enzyme, diacylglycerol lipase alpha (DGLalpha)

116 assist scientists in advancing the field of synthetic epigenetics.

117 tailed description of the parameters of such synthetic epigenome remodellers is still lacking.

118 This method utilizes alkenes as synthetic equivalents of alkynes by coupling homoallylic

119 licase DNA-binding factor CHD1 as a putative synthetic-essential gene in PTEN-deficient cancers.

120 rsely, the BACHD transgene carries a floxed, synthetic exon 1 sequence.

121 ttack of C-based and N-based nucleophiles on synthetic ferric-NO hemes.

122 Here we demonstrate that a synthetic G4 ligand, Y2H2-6M(4)-oxazole telomestatin der

123 titatively by single-cell data analysis of a synthetic gene circuit integrated in human kidney cells.

124 Synthetic gene circuits that combine DNA, protein, and R

125 Lpl1 shows a synthetic genetic interaction with Hac1, the master regu

126 (HSV-1), which has a large DNA genome, using synthetic genomics tools.

127 The synthetic glucocorticoids (GCs) dexamethasone, mometason

128 ate-protein interactions on arrays of simple synthetic glycans, more complex natural glycosaminoglyca

129 r Presentation" standard-dose mammograms and synthetic images were analyzed by using a fully automate

130 in which gene expression is controlled by a synthetic inducer.

131 The latter class of synthetic inhibitors, very recently approved as antihype

132 ave access to tetracyclic derivatives of the synthetic inhibitors.

133 on then enabled the synthesis of an advanced synthetic intermediate containing the EF and G rings of

134 ccess several natural products from a common synthetic intermediate readily prepared from geranyl ace

135 tures of closely related pharmaceuticals and synthetic intermediates, including chiral and achiral dr

136 rovides the first experimental evidence that synthetic ion transporters can disrupt both autophagy an

137 The synthetic iridocytes are composed of silica nanoparticle

138 AT-deficient cell lines reconstituted with a synthetic LAT gene bearing this severe combined immunode

139 evaporation performance of a nature-inspired synthetic leaf made of graphene oxide (GO) thin film mat

140 y pooled dual-knockout libraries to identify synthetic lethal and buffering gene pairs across multipl

141 We found a synthetic lethal interaction between cytidine deaminase

142 ed to the identification of new, deleterious synthetic lethal interactions.

143 Here, we use a genome-wide RNAi-synthetic lethal screen and transcriptomic profiling to

144 In addition to known synthetic-lethal interactions, this approach uncovered t

145 The strategy could be used to search for synthetic lethality and optimise combination protocol de

146 ndidate for topoisomerase 1 (TOP1) inhibitor synthetic lethality and showed that ATR inhibition sensi

147 Conceptually, synthetic lethality holds the promise of identifying non

148 leads to increased micronuclei formation and synthetic lethality in ALT cells.

149 s to widespread DNA double-strand breaks and synthetic lethality.

150 cid and carnosic acid were the cause for the synthetic lethality.

151 as compared to conventional immunization or synthetic library selection strategies.

152 Subtle sequence variation in the modular synthetic ligand dictates assembly morphology.

153 Dexamethasone (DEX), a synthetic ligand for glucocorticoid receptor (GR), is ro

154 onformation of the receptor as assessed with synthetic ligands and GR mutants with impaired transcrip

155 used on a putative binding site in GPR39 for synthetic ligands and knowledge of ligand binding to oth

156 Surprisingly, these synthetic ligands modulated signaling of a GPR56 mutant

157 covalent linking of exogenously supplemented synthetic ligands.

158 Isolated or synthetic lipopeptides are potent vaccine adjuvants, int

159 Furthermore, studies with synthetic LtnA2 analogues containing either desmethyl- o

160 chiral resolution of 27c followed by further synthetic manipulations involving the carbamate formatio

161 fit of mimicking nature's Murray networks in synthetic materials due to the challenges in fabricating

162 In an effort to develop synthetic materials that transduce mechanical force into

163 First validated with standard synthetic membranes and then demonstrated in living epit

164 anoscale barrels that puncture biological or synthetic membranes-have become powerful tools in chemic

165 on over 2 years in women actually exposed to synthetic mesh was 51 (12%) of 434.

166 A wide variety of synthetic metalloporphyrinoid complexes have been synthe

167 Herein, we report a novel synthetic method which has the potential to produce larg

168 This review focuses on the synthetic methodologies available for the preparation of

169 Although several synthetic methodologies have been developed for introduc

170 R antagonists through succinct and efficient synthetic methodologies.

171 The synthetic methodology developed here operates at low 1 m

172 Our synthetic methodology may pave an avenue for constructin

173 The present review describes various synthetic methods and modifying concepts of 1D-photoanod

174 The synthetic methods available in the literature allow one

175 btain clinically useful drugs and to provide synthetic methods to install a gem-dimethyl group.

176 Known synthetic methods toward these structures are multistep

177 been impossible to access through classical synthetic methods.

178 ue to the availability of easy and efficient synthetic methods.

179 eet-helix architectures, are Nature-inspired synthetic mimics that expose alpha/beta and alpha+beta p

180 ol (HCA), in tandem with transformation of a synthetic, Mn(III)-rich delta-MnO2.

181 on a complex 50-species 210-genome 96-sample synthetic mock data set and then applied it to the Tara

182 Results over synthetic models and models generated from Genomics of D

183 nt enzyme will facilitate the development of synthetic molecular catalysts for hydrogen conversion.

184 g biological functions with the ones driving synthetic molecular systems.

185 y of these tools, locus-specific delivery of synthetic molecules remains limited by a lack of adequat

186 Here, the authors use synthetic momentum-space lattices to engineer spatially

187 able over a broad range of reconstructed and synthetic morphologies.

188 o tremendous progress in autonomously moving synthetic nano/micromotors with diverse functionalities

189 Thus, it supports the need to develop new synthetic network models able to replicate controllabili

190 rom one ordered state to another in real and synthetic networks.

191 We show that As adsorbed onto natural and synthetic nontronites forms identical adsorption complex

192 The resulting synthetic nucleocapsids package one full-length RNA geno

193 oli) the gene is not located within a biotin synthetic operon and its transcription is not coregulate

194 t biosynthesis as well as the parallels with synthetic organic chemistry.

195 mino acids (ncAAs) and genetically isolating synthetic organisms from natural organisms and viruses.

196 This work identifies simple synthetic parameters, such as stirring rate, that may be

197 notyped for functional variants on vitamin D synthetic pathway including GC (rs4588, rs7041, rs22020,

198 Biotin synthetic pathways are readily separated into two stages

199 Engineering synthetic pathways for production of alpha-methyl acids

200 Consistent with this, a synthetic peptide corresponding to the HAP2 fusion loop

201 (KLK7) have previously been delineated using synthetic peptide libraries of fixed length, or single p

202 A synthetic peptide spanning this sequence forms amyloid-l

203 H) insensitive CtBP, and are replicated by a synthetic peptide that inhibits CtBP dimerization.

204 oteins and a variety of complexes with short synthetic peptides.

205 From a synthetic perspective, this protocol offers an efficient

206 n a number of bioactive natural products and synthetic pharmaceuticals.

207 We show that tan1 air9 double mutants have a synthetic phenotype consisting of short, twisted roots w

208 esponses, whereas CXCR4 deficiency favored a synthetic phenotype, the occurrence of macrophage-like S

209 The spacing between two synthetic plants, a design consideration introduced by t

210 these clinical shortcomings, we developed a synthetic polycation, Universal Heparin Reversal Agent (

211 ESI-IMS-TOF-MS) was used for the analysis of synthetic polymers and fibers.

212 These results show that sequence control in synthetic polymers can have a dramatic impact on polymer

213 is somewhat problematic in the formation of synthetic polymers.

214 Synthetic porogens provide an easy way to create porous

215 An analysis of their synthetic potential and the possible unexplored directio

216 In recent years, great synthetic potential of the photorearrangement of diaryle

217 rated by the gram-scale synthesis of the key synthetic precursor of botulinum toxin inhibitors.

218 he trifluorotoluene complex is shown to be a synthetic precursor to functionalized cyclohexadienes: I

219 The synthetic procedure involved two key steps: (1) the reac

220 twork of yeast to enhance compatibility with synthetic protein and metabolite production.

221 sensitivity into a series of multi-component synthetic protein complexes.

222 achieve these goals, we demonstrate a single synthetic protocol to obtain uniform palladium-based bim

223 also known by the trade name Captagon, is a synthetic psychoactive stimulant that has recently been

224 Results in both synthetic random graphs and real networks show that the

225 easured in Arabidopsis and rice treated with synthetic RaxX peptides.

226 The MIP synthetic receptor was deposited by potentiodynamic elec

227 Synthetic receptors that are likewise capable of multi-s

228 These CAR T cells are engineered to express synthetic receptors that redirect polyclonal T cells to

229 CARs are synthetic receptors that reprogram immune cells for ther

230 QC data and experiments with 14 synthetic reference peptides indicated that reliable qua

231 ak, which impedes the construction of larger synthetic regulatory networks as leak propagation can in

232 The efficacy of the developed, fully synthetic reporters was demonstrated by the identificati

233 ll serogroups except serogroup E which has a synthetic requirement for UDP-GalNAc.

234 owever, been severely limited by challenging synthetic requirements that incorporate unstable interme

235 HIGH PRO) on the postprandial muscle protein synthetic response.

236 The synthetic route features iodine-catalyzed tandem isomeri

237 rspective, this protocol offers an efficient synthetic route for the preparation of pharmaceutical dr

238 e nanoparticles (MNPs) through a single-step synthetic route involving the simultaneous nanoparticle

239 A highly enantioselective synthetic route to hexahydropyrrolo[2,3-b]indoles via Le

240 The first synthetic route to obtain salt-free intrinsic plutonium

241 , structural analogs and provide a practical synthetic route to these important bioactive agents.

242 The first synthetic route to yndiamides, a novel class of double a

243 The new synthetic route was effective for the total synthesis of

244 New convenient wet-chemistry synthetic routes have made it possible to explore cataly

245 Importantly, the mild synthetic routes to halide perovskites and the templatin

246 l as the energy density extracted from small synthetic samples allows planning potential uses of this

247 etermine colorant concentrations in real and synthetic samples.

248 their biocatalytic use in preparing complex synthetic scaffolds.

249 n of the substitution scheme can enhance the synthetic scope of alpha-methylisoserine-derived sulfami

250 obtain an X-ray co-crystal structure of the synthetic secondary metabolite with the eukaryotic 80S r

251 Quantum defects are an emerging class of synthetic single-photon emitters that hold vast potentia

252 In conclusion, CMMPs act as 'synthetic stem cells' which mimic the paracrine and bioi

253 An easily accessible (minimal synthetic steps) and structurally planar selenophene-bas

254 udy combines these models with a database of synthetic storms in Ocean County and estimates a 16% ave

255 ry functions of natural exosomes, biomimetic synthetic strategies are exploited to prepare biofunctio

256 lored, mainly because of the lack of general synthetic strategies leading to sophisticated molecular

257 The synthetic strategies toward YSNs are divided into four c

258 uding biomimetic, semisynthetic, and de novo synthetic strategies.

259 However, a robust and versatile synthetic strategy for these materials remains one of th

260 Our synthetic strategy is inspired by nature's carbon-carbon

261 hoton output of these molecules, we report a synthetic strategy that blocks the major deactivation pa

262 We report here a general and scalable synthetic strategy to embed 2,2'-bipyridine units into t

263 A unified synthetic strategy toward the oridamycin and xiamycin fa

264 Finally, the developed synthetic strategy was successfully applied to the catal

265 Our overall synthetic strategy, which also resulted in a second-gene

266 This synthetic study disclosed that the reported structure of

267 his ostensibly dead general base mutant by a synthetic substrate, 3beta-hydroperoxycholestane (3HPC)

268 We used an mAb and/or a multimeric synthetic sulfated sialoglycan ligand recognizing Siglec

269 Synthetic supramolecular molecules and materials are cre

270 lutaraldehyde (COH) groups functionalized on synthetic surfaces.

271 The results demonstrated the promise of a synthetic surfactant- and cross-linker-free technique to

272 egradability, are potential replacements for synthetic surfactants.

273 This synthetic system will enable detailed, mechanistic disse

274 Many biological and synthetic systems exploit self-assembly to generate high

275 In contrast to the synthetic systems, LDL particles are intrinsically bioco

276 ovide insight into a range of biological and synthetic systems.

277 g visual search, item-based approaches using synthetic targets and distractors limit the real-world a

278 signed and synthesized through the developed synthetic technologies and tested against drug-resistant

279 issues or to stimulate subsets of cells when synthetic tissues are interfaced with living tissues.

280 tial to power subsets of compartments within synthetic tissues or to stimulate subsets of cells when

281 hiol-Michael "click" reactions are essential synthetic tools in the preparation of various materials

282 to assess local changes in complexity during synthetic transformations is described.

283 transition state-are among the most powerful synthetic transformations used to make multiple regiosel

284 Peptide-directed binding uses few synthetic transformations, requires the production of a

285 Covalent attachment of a synthetic triantennary N-acetylagalactosamine (GalNAc) l

286 storm surges are derived from large sets of synthetic tropical cyclones, downscaled from RCP8.5 simu

287 applicability, glucose could be detected in synthetic urine samples down to 1 mM using merely a 188

288 Furthermore, the synthetic utility of the protocol is demonstrated by per

289 We have produced synthetic vaccines that induce strong peptide-specific C

290 high preference for the (S)-substrate is of synthetic value.

291 hereby improving anti-neointimal activity of synthetic vascular grafts.

292 In addition, we suggest developing synthetic vesicles as a new delivery vehicle and adjuvan

293 eral motif variant peptides translocate into synthetic vesicles with rates that are similar to TP2.

294 rophils using biocompatible, nanometer-sized synthetic vesicles, or polymersomes, which are internali

295 pe, distribution, and physical properties of synthetic vesicles, with potential applications in vesic

296 carbon-nanotube fibers, ceramic fibers, and synthetic vitreous fibers.

297 In this study, synthetic water samples containing dissolved organic mat

298 oncentration (10 mg/L) Na humate solution in synthetic water significantly improved the mobility of P

299 Here, we report on wholly synthetic, water-soluble, and chiral tubules that incorp

300 nectar, pollen, or propolis, as well as five synthetic xenobiotics that frequently contaminate hives-