ライフサイエンスコーパス: synthetic compound

1 herry-picked from all commercially available synthetic compounds.

2 ably with experimental results found for the synthetic compounds.

3 on in response to a diversity of natural and synthetic compounds.

4 ne the allosteric regulation of myosins with synthetic compounds.

5 fied by screening our in-house collection of synthetic compounds.

6 ermine the absolution configurations of such synthetic compounds.

7 resent in a broad range of other natural and synthetic compounds.

8 of the substrates used to assay cytGSTs are synthetic compounds.

9 ely used building blocks in both natural and synthetic compounds.

10 , validated, and used to screen a library of synthetic compounds.

11 , mandelalides E-L (5-12), and the supply of synthetic compounds 1 and 12, as well as seco-mandelalid

12 thocholic acid, oleanolic acid [OA], and two synthetic compounds), (2) a novel TGR5 antagonist (m-tol

13 Here we describe a synthetic compound, 2-fluoro-1-methoxy-4-pentafluorophen

14 We report that EF24, a synthetic compound 3,5-bis(2-flurobenzylidene)piperidin-

15 y for new anticancer agents and identified a synthetic compound, 5-(2,4-dihydroxybenzylidene)-2-(phen

16 te MAIT cells but compete with bacterial and synthetic compounds activating MAIT cells, providing the

17 rived natural product, ikarugamycin; and the synthetic compound, alexidine dihydrochloride, which is

18 Retinoic acid and its synthetic compound AM80 play roles in immunoregulation b

19 s) of the various cytokines showed that each synthetic compound and E. coli 055:B5 LPS induced simila

20 this simple infection system to screen 6,000 synthetic compounds and 1,136 natural product extracts.

21 of biologically active natural products and synthetic compounds and can be accessed using mild react

22 particular molecular properties compared to synthetic compounds and drugs.

23 Mouse macrophages were exposed to the synthetic compounds and E. coli 055:B5 LPS, and the resu

24 These modulators include both synthetic compounds and endogenous modulators, such as c

25 date this technique, we prepared mixtures of synthetic compounds and extracts from Arabidopsis thalia

26 Biological evaluation of the synthetic compounds and intermediates against a panel of

27 creening of substantially greater numbers of synthetic compounds and natural products, we are not rou

28 were compared with several other natural and synthetic compounds and related to glutathione and ascor

29 Phthalates are ubiquitous synthetic compounds and therefore difficult to measure i

30 SHU9119 (a synthetic compound) and AGRP (an endogenous peptide) are

31 The physical properties of the synthetic compound are somewhat different from those rep

32 m this laboratory indicates that a number of synthetic compounds are high affinity transport inhibito

33 re, we examined the ability of TFA-12, a new synthetic compound belonging to tocopherol long-chain fa

34 and designed DNA fragments indicate that the synthetic compounds bind at AT sequences in the minor gr

35 We have shown previously that EM011, a synthetic compound, binds tubulin with a higher affinity

36 the sigma-1 receptor binds a vast number of synthetic compounds but does not bind opioid peptides; i

37 d synthase (FAS) inhibitors (cerulenin and a synthetic compound C75) led to inhibition of feeding and

38 the natural product cerulenin and the novel synthetic compound c75, are selective inhibitors of tumo

39 However, some synthetic compounds can fall outside the upper boundary

40 We have found that the synthetic compound CC-5079 potently inhibits cancer cell

41 sense a broad spectrum of ligands, including synthetic compounds, chemokines, mitogens, fatty acids,

42 gineered G-protein coupled receptor with the synthetic compound clozapine-N-oxide (CNO) evoked a shor

43 These synthetic compounds contain sequences that are active si

44 The synthetic compounds contained pentyl, hexyl, or hexanoyl

45 on of 7 and 8 along with several related key synthetic compounds containing the core residue 4 amidin

46 Nine structurally related synthetic compounds, containing aromatic or other hydrop

47 The NMR data of the synthetic compound did not conform to the reported natur

48 actions could be efficiently disrupted using synthetic compounds either mimicking or masking this car

49 A racemic blend of the synthetic compound elicited behavioral and electrophysio

50 mer therefore represents an innovative fully synthetic compound for the treatment of lung inflammator

51 was proposed for use in screening natural or synthetic compounds for cell cycle-dependent (particular

52 ing of a 50000-member library of natural and synthetic compounds for sensitizers of RCC cells to TRAI

53 tionship (QSAR) of a group of endogenous and synthetic compounds for the androgen receptor (AR) using

54 talline materials has prompted the design of synthetic compounds for the regulation of crystal growth

55 In addition, a number of synthetic compounds have been developed that also target

56 Many categories of both natural and synthetic compounds have been reported to have neuroprot

57 A number of synthetic compounds have been shown to block the process

58 way-specific screens of natural products and synthetic compounds have recently provided a number of s

59 The new synthetic compounds have two aromatic-amidine groups for

60 Carba-NAD is a synthetic compound identical to NAD except for one subst

61 The synthetic compounds identified in these assays should se

62 me may have evolved the ability to hydrolyze synthetic compounds in bacteria under selective pressure

63 the mechanism of stimulation mediated by the synthetic compounds in comparison with natural lipoprote

64 here the efficacies of several of these new synthetic compounds in regulating two types of protein d

65 unctional analyses using highly purified and synthetic compounds indicate that the core structure rec

66 , and further examination revealed that this synthetic compound induced expression of an AP-1 target

67 Remediation of these synthetic compounds is difficult and an enormous logisti

68 A series of chiral synthetic compounds is reported that shows intricate but

69 SU5416, a novel synthetic compound, is a potent and selective inhibitor

70 PPARs are the targets for the hypolipidemic synthetic compounds known as peroxisome proliferators, a

71 ocessing of compound lesions by human cells, synthetic compound lesions containing UV photoproducts o

72 ural products for drug discovery in favor of synthetic compound libraries.

73 search for inhibitors in natural product and synthetic compound libraries.

74 These synthetic compounds made it possible to establish relati

75 gands include a diverse array of natural and synthetic compounds, many of which are toxins.

76 The synthetic compounds matched the physical and biological

77 These synthetic compounds model peptide-nucleic acid heterocon

78 Our synthetic compounds modulated significantly both platele

79 In this report, we describe a synthetic compound of the pyrido[2,3-d]pyrimidine class,

80 oiety found in a large number of natural and synthetic compounds of medicinal significance.

81 l groups comprise a large set of natural and synthetic compounds, often with potent biological activi

82 These agents are synthetic compounds or natural products and their analog

83 Retinoids are a large family of natural and synthetic compounds related to vitamin A that have pleio

84 The degradation of synthetic compounds requires bacteria to recruit and ada

85 Analysis of synthetic compounds revealed stereoselectivity of the DA

86 , as well as the use of purified natural and synthetic compounds, showed that this process involved p

87 f the family of flavones and isoflavones and synthetic compounds such as the tyrphostins.

88 , and erysolin) and one of which was a novel synthetic compound termed MARPIN.

89 vated receptor (PPAR) gamma, we identified a synthetic compound that binds to this receptor.

90 or an estradiol-dendrimer conjugate, each a synthetic compound that stimulates kinase-mediated ER ac

91 Perfluoroalkyl substances (PFASs) are synthetic compounds that are widely used in industry and

92 and exciting target for the design of novel synthetic compounds that can act as anti-proliferative a

93 We have identified two classes of synthetic compounds that differentially modulate BAR act

94 Here we describe novel synthetic compounds that have a unique mode of binding t

95 Lack of efficient access to collections of synthetic compounds that have skeletal diversity is a ke

96 be discovered using a diverse collection of synthetic compounds that have three-dimensional features

97 r screening process was designed to identify synthetic compounds that increase the total amount of fu

98 fact, the serum of mice immunized with fully synthetic compounds that mimic cell-surface tumour antig

99 Xenoestrogens are synthetic compounds that mimic endogenous estrogens by b

100 The assays use synthetic compounds that were designed to mimic the natu

101 ttention was drawn to certain, predominantly synthetic, compounds that are responsible for disproport

102 Despite the prevalence of fluorine in synthetic compounds, the known biological scope is limit

103 c agents, and it is the first non-polyamide, synthetic compound to specifically recognize a DNA seque

104 he receptor are inferred from the ability of synthetic compounds to affect channel function without i

105 hepatocytes and are among the first totally synthetic compounds to approach the activity of adenopho

106 The work reported here uses synthetic compounds to evaluate the extent of NN weakeni

107 xidants can be used in egg powder instead of synthetic compounds to reduce malonaldehyde production d

108 mimicked reproductive cheaters by applying a synthetic compound typical of fertile individuals on non

109 e methyl siloxanes (VMS) are high-production synthetic compounds, ubiquitously found in the environme

110 h-throughput screen of approximately 200,000 synthetic compounds using Per2lucSV reporter fibroblast

111 Each synthetic compound was reacted under anaerobic condition

112 Proton, (13)C NMR, and molecular mass of the synthetic compound were identical with vesperlysine A, a

113 The synthetic compounds were employed to uncover immunodomin

114 The synthetic compounds were evaluated for antibacterial act

115 Indeed, all synthetic compounds were found to bind to the target RNA

116 Structures of the synthetic compounds were verified by NMR spectroscopy us

117 The drug is a totally synthetic compound, which lessens the likelihood of natu

118 ening of a chemical library, we identified a synthetic compound whose inducing ability significantly

119 Imiquimod is a synthetic compound with antitumor properties; a 5% cream

120 Hence, screening and identifying natural or synthetic compounds with anti-cancer activity via p53-in

121 represent a class of naturally occurring and synthetic compounds with demonstrated antitumor activity

122 f normal reproductive functions, natural and synthetic compounds with estrogen-like activities can fu

123 us antioxidant mechanisms and neutralized by synthetic compounds with peroxynitrite-scavenging capaci

124 occur as constituents of various natural and synthetic compounds with potentially useful bioactivitie

125 f cell migration data for this and two other synthetic compounds with published data on cortistatin A

126 In this case, the evaluation of just six synthetic compounds with seven riboswitch mutants led to

127 Furthermore, analyses of four of the synthetic compounds with two important purified resistan

128 of nucleic acid libraries into corresponding synthetic compounds would enable selection and amplifica

129 ion of cytochromes P4501A1/2 (CYP1A1/2) by a synthetic compound YH439 was studied in rodents as well