ライフサイエンスコーパス: synthetic lethality

1 cid and carnosic acid were the cause for the synthetic lethality.

2 asmic chaperone in E. coli, SurA, results in synthetic lethality.

3 loit oncogene and non-oncogene addiction and synthetic lethality.

4 s in cases where mutual exclusivity reflects synthetic lethality.

5 ly, simultaneous ATM and HUS1 defects caused synthetic lethality.

6 ess nonstop proteins may not be the cause of synthetic lethality.

7 (PARP-1) inhibition based on the concept of synthetic lethality.

8 h cellular proliferation, a concept known as synthetic lethality.

9 ) polymerase (PARP) inhibitor ABT-888 due to synthetic lethality.

10 ombination (HR) genes BRCA1 or BRCA2 through synthetic lethality.

11 cells, confirming the proposed mechanism of synthetic lethality.

12 of cdc28(CST) and cak1 mutations results in synthetic lethality.

13 r novel cancer treatment strategies based on synthetic lethality.

14 that confirmed the redundancy explanation of synthetic lethality.

15 ting the "compensation" explanation for this synthetic lethality.

16 findings provide insights into the causes of synthetic lethality.

17 behind chemosensitization and the concept of synthetic lethality.

18 athway genes PSD2 and DPL1 did not result in synthetic lethality.

19 g a case of synthetic inhibition rather than synthetic lethality.

20 ctf7 double mutant cells exhibit conditional synthetic lethality.

21 stinct complementation groups that conferred synthetic lethality.

22 on of CRM1 confers dosage suppression of the synthetic lethality.

23 in Nhp6, including multicopy suppression and synthetic lethality.

24 NA export defects of the rae1-167 Deltamex67 synthetic lethality.

25 acuolar and Golgi Ca2+ transport resulted in synthetic lethality.

26 s to widespread DNA double-strand breaks and synthetic lethality.

27 omimetic ABT737, through non-BCL-2-dependent synthetic lethality.

28 rsensitive to PARPi through the mechanism of synthetic lethality.

29 leta, polzeta and pold3 mutations results in synthetic lethality.

30 may be informed by a deeper understanding of synthetic lethality.

31 iding the first anti-cancer therapy based on synthetic lethality.

32 th oncogenic Raf or Ras induces acidosis and synthetic lethality.

33 eutic approaches that exploit the concept of synthetic lethality.

34 ting these compensatory pathways may produce synthetic lethality.

35 ame as a top candidate gene for camptothecin synthetic lethality.

36 linically approved drugs designed to exploit synthetic lethality, a genetic concept proposed nearly a

37 This synthetic lethality, along with transcriptional analyses

38 onditionally accumulate stalled forks caused synthetic lethality, an effect indistinguishable from E.

39 Diploid synthetic lethality analysis by microarray (dSLAM) using

40 We describe a new synthetic lethality analysis by microarray (SLAM) techni

41 ollectively referred as dSLAM (diploid-based synthetic lethality analysis on microarrays), to probe g

42 mple, both synthetic genetic array (SGA) and synthetic-lethality analysis by microarray (SLAM) method

43 The combination of global synthetic-lethality analysis, together with global prote

44 e-wide synthetic lethality screens, known as synthetic lethality analyzed by microarray (SLAM).

45 Such addictions, synthetic lethalities and other tumor vulnerabilities ha

46 Both the synthetic lethality and chromosomal fragmentation of dut

47 Synthetic lethality and collateral lethality are two wel

48 helicase genes RAD3 and SSL2 (RAD25) confer synthetic lethality and destabilize the Saccharomyces ce

49 er cells to a DNA repair pathway is based on synthetic lethality and has wide applicability to the tr

50 ssion of hyper-recombination, suppression of synthetic lethality and heteroduplex rejection.

51 Delineation of the mechanisms underlying synthetic lethality and identification of treatment resp

52 econd-site suppressor of sgs1Delta slx5Delta synthetic lethality and identified it as an allele of th

53 anscriptional Mediator complex, resulting in synthetic lethality and loss of male sensory neurons.

54 Synthetic lethality and multicopy suppression analyses a

55 GrxD to uncover the molecular basis of this synthetic lethality and observed that GrxD can form FeS-

56 n pathways, is a multicopy suppressor of the synthetic lethality and of the specific depletion of box

57 ecular basis of cancer--from the genetics of synthetic lethality and oncogene-dependent cellular addi

58 The strategy could be used to search for synthetic lethality and optimise combination protocol de

59 synthesis, suppress the dun1Delta pol2-M644G synthetic lethality and restore the mutator phenotype of

60 ndidate for topoisomerase 1 (TOP1) inhibitor synthetic lethality and showed that ATR inhibition sensi

61 lls to PARPi, indicating this pathway drives synthetic lethality and that in its absence alternative

62 a multicopy suppressor of rae1-167 nup184-1 synthetic lethality and the rae1-167 ts mutation.

63 rtheless, the preclinical discovery of PARPi synthetic lethality and the route to clinical approval p

64 -SUMO chains, suppressed sgs1Delta slx5Delta synthetic lethality and the slx5Delta sporulation defect

65 taxia telangiectasia mutated (ATM) result in synthetic lethality and, in the mouse, early embryonic d

66 i, inactivation of RNase H2 and RAD52 led to synthetic lethality, and combined loss of RNase H2 and R

67 ne particular type of gene-gene interaction, synthetic lethality, and find that the accuracy rate is

68 This review discusses recent developments in synthetic lethality anticancer therapeutics, including p

69 omarkers will be critical for the success of synthetic lethality anticancer therapy.

70 t Chinese hamster and human cancer cells for synthetic lethality application using double-strand brea

71 ficiency could also be exploited for a novel synthetic lethality application using DSB repair inhibit

72 gregation, represents a novel target for the synthetic lethality approach.

73 Using synthetic lethality approaches, we identified molecular

74 mics and functional genomic screens (such as synthetic lethality) are providing mechanisms to rapidly

75 Finally, we identify synthetic lethality arising from gene overactivation and

76 Accordingly, validation was achieved through synthetic lethality assays in which RNAi-mediated silenc

77 utants lacking both Ptp4E and Ptp10D display synthetic lethality at hatching owing to respiratory fai

78 Both point and deletion mutations show synthetic lethality at room temperature with temperature

79 ivation of Fancd2 and Mlh1 did not result in synthetic lethality at the cellular level.

80 ed that altered genome integrity might allow synthetic lethality-based options for targeted therapeut

81 The synthetic lethality between a group A mutant, pol30-104,

82 f prostate cancer cells and we demonstrate a synthetic lethality between ADT and PARP inhibition in v

83 Further analysis identified synthetic lethality between an elf1Delta mutation and mu

84 this is a conserved function underlying the synthetic lethality between ARID1A and ARID1B.

85 this is the first data set to demonstrate a synthetic lethality between ARID1A mutation and EZH2 inh

86 insight into the molecular mechanisms of the synthetic lethality between BRCA2 and PARP1.

87 Overall, we conclude that the synthetic lethality between clb5 and bub1 or bub3 is lik

88 This reveals synthetic lethality between mutations in Atm and DNA-PK

89 lso, there is evidence for a relationship of synthetic lethality between NRAS and BRAF oncogenes that

90 taining complexes may be responsible for the synthetic lethality between ppr2Delta and taf14Delta, we

91 edundant functions between priB and priC and synthetic lethality between priA2::kan and rep3 mutation

92 These results suggest that synthetic lethality between ROCK inhibition and VHL defi

93 The synthetic lethality between spo7Delta and mps3 mutants w

94 ic genetic array (SGA) analysis, testing for synthetic lethality between the clb5 deletion and a sele

95 Synthetic lethality between xrn1 and cdc33 was not relie

96 suppressed by an xrn1 mutation, we observed synthetic lethality between xrn1 and either cdc33 or ceg

97 on led to a partial rescue of apn1 apn2 rad1 synthetic lethality by converting lesions into Tpp1-clea

98 2 inhibition and contributed to the observed synthetic lethality by inhibiting PI3K-AKT signaling.

99 The exploitation of synthetic lethality by small-molecule targeting of pathw

100 Several of these synthetic lethalities can be suppressed by overexpressio

101 Synthetic lethality can also be achieved "chemically" by

102 igh-frequency X-linked alleles, and dominant synthetic lethality can result in high-frequency autosom

103 Recessive synthetic lethality can result in high-frequency X-linke

104 Thus, sgs1Delta slx5Delta synthetic lethality cannot be due simply to high levels

105 ranscription factor mutations, including the synthetic lethality caused by combining an spt16 mutatio

106 or E. coli genetic interactions reported the synthetic lethality (combination of mutations leading to

107 These synthetic lethalities could be suppressed by overexpress

108 cient status predisposing to RAD52-dependent synthetic lethality could be predicted by genetic abnorm

109 In most cases, synthetic lethality depends upon hyperacetylation of H3

110 Furthermore, analysis of synthetic lethality effects and examination of the activ

111 SLAM detects synthetic lethality efficiently and ranks candidate gene

112 On the basis of synthetic lethality, five genes in Caenorhabditis elegan

113 Notably, elevated genomic instability and synthetic lethality following suppression of ATR were no

114 bnormalities in multiple signaling pathways, synthetic lethality for a specific tumor suppressor gene

115 escribe a potential utility of PARPi-induced synthetic lethality for leukemia treatment and reveal a

116 53 and PIP4K2B were not viable, indicating a synthetic lethality for loss of these two genes.

117 Importantly, the synthetic lethality for some of the TBP mutations is sup

118 the budding yeast Saccharomyces cerevisiae, synthetic lethality has been extensively used both to ch

119 Conceptually, synthetic lethality holds the promise of identifying non

120 scuss the biological rationale for BRCA-PARP synthetic lethality, how the synthetic lethal approach i

121 inability of each to complement scp160/eap1 synthetic lethality in a tester strain.

122 terioration of the intestinal epithelium and synthetic lethality in adult mice.

123 leads to increased micronuclei formation and synthetic lethality in ALT cells.

124 Overexpression of PTA1 causes synthetic lethality in an ssu72-3 mutant.

125 ribose) polymerase (PARP) inhibitor, induced synthetic lethality in BRCA-deficient cells.

126 lanine 79 [F79]) as a valid target to induce synthetic lethality in BRCA1- and/or BRCA2-deficient leu

127 DP-ribose) polymerase inhibitor that induces synthetic lethality in BRCA1- or BRCA2-deficient cells,

128 , rosemary extract is hypothesized to induce synthetic lethality in BRCA2 deficient cells by PARP inh

129 e) polymerase (PARP) inhibitors can generate synthetic lethality in cancer cells defective in homolog

130 The first clinical exemplification of synthetic lethality in cancer has been the exploitation

131 n-of-function (GOF) alleles that exhibit (1) synthetic lethality in combination with mutations in BMP

132 the tpp1 apn1 apn2 triple mutation displayed synthetic lethality in combination with rad52, possibly

133 ion of tinA alone is not lethal but displays synthetic lethality in combination with the anaphase-pro

134 olate strains bearing mutations that lead to synthetic lethality in combination with the stt3-1 mutat

135 a generally applicable screening method for synthetic lethality in E. coli, and used it to select fo

136 se) polymerase (PARP) inhibitor that induces synthetic lethality in homozygous BRCA-deficient cells.

137 hese findings can be exploited for eliciting synthetic lethality in metabolically stressed cancer cel

138 e inhibitors were developed with the idea of synthetic lethality in mind, a concept from classical ge

139 Combining MYC blockade with PARPi yielded synthetic lethality in MYC-driven TNBC cells.

140 trant small molecule idasanutlin resulted in synthetic lethality in orthotopic glioblastoma xenograft

141 ATR and conventional therapies might promote synthetic lethality in p53-deficient tumors, and thus mi

142 ive PARP-1 and PARP-2 inhibitor that induces synthetic lethality in preclinical tumour models with lo

143 targeting of PARP1 resulted in dual cellular synthetic lethality in quiescent and proliferating immat

144 We validate SINaTRA by predicting synthetic lethality in S. pombe using S. cerevisiae data

145 omosome loss, chromosome missegregation, and synthetic lethality in srs2Delta.

146 Overexpression of PTC2 or PTC3 results in synthetic lethality in strains temperature-sensitive for

147 ry path amongst targeted genes or to analyse synthetic lethality in the context of anticancer therapy

148 he critical missing function that causes the synthetic lethality in the rep-priA double mutant.

149 based methodology that discovers genome-wide synthetic lethality in translation between species.

150 n and PARP-mediated DNA repair yields potent synthetic lethality in triple-negative breast tumors and

151 2, Bcl-xL, and Mcl-1 is sufficient to elicit synthetic lethality in tumors recalcitrant to therapy.

152 selective targeting of HSPA1B could produce synthetic lethality in tumors that display HSPA1A promot

153 utations of ISW1, ISW2, and CHD1 genes cause synthetic lethality in various stress conditions in yeas

154 he combined loss of Ikzf1 and Gata1 leads to synthetic lethality in vivo associated with prominent de

155 y, our results suggest a molecular basis for synthetic lethality in which hlh-1 and unc-120 mutant ph

156 Inhibition of such a pathway could cause "synthetic lethality" in adapted cells while not markedly

157 The genetic concept of synthetic lethality, in which the combination or synthes

158 High copy suppressors of this synthetic lethality included three mannosyltransferases,

159 Synthetic lethality induced by both PME-1 and HDAC4 inhi

160 Finally, we found that synthetic lethality induced by TXNRD1 and AKT inhibitors

161 Furthermore, we found that the synthetic lethality interaction between the TXNRD1 and A

162 Consistently, hst3 hst4 cells display synthetic lethality interactions with mutations that cri

163 Finally, synthetic lethality involving sec14 and UPR mutations su

164 therapeutic strategy of metabolically driven synthetic lethality involving targeting glutamine metabo

165 Synthetic lethality is a genetic concept in which cell d

166 Synthetic lethality is a genetic interaction wherein two

167 Synthetic lethality is a powerful approach to study sele

168 Synthetic lethality is an approach to study selective ce

169 Synthetic lethality is associated with high levels of ap

170 d SLX8, and by demonstrating that rmi1 mus81 synthetic lethality is dependent on homologous recombina

171 Genetic suppression revealed that this synthetic lethality is in part due to low expression of

172 We provide evidence that this synthetic lethality is independent of MRN cell cycle che

173 Synthetic lethality is inviability of a double-mutant co

174 bility to utilize different nutrients, while synthetic lethality is significantly less conserved.

175 Accordingly, this synthetic lethality is suppressed by increasing RRM2 exp

176 We show that this synthetic lethality is the result of defective crossover

177 tion, fulfilling the classical definition of synthetic lethality; loss of p53, SGK2, or PAK3 alone ha

178 The synthetic lethality map parallels observations made in y

179 f the mSWI/SNF complex, we propose that such synthetic lethality may be explained by paralog insuffic

180 Rational therapeutic approaches based on synthetic lethality may improve cancer management.

181 to bolster our understanding of fundamental synthetic lethality mechanisms and advance these finding

182 ic interactions in human cells, we created a synthetic lethality network focused on the secretory pat

183 results presented here, including extensive synthetic lethality observed between slx5delta and slx8d

184 Together, our data explain the synthetic lethality observed between topoisomerase-induc

185 Synthetic lethality occurs when the inhibition of two ge

186 Synthetic lethalities of caf1Delta, but not that of ccr4

187 Synthetic lethality of APC/C inhibition and cohesion def

188 HDR in this background, loss of ATM leads to synthetic lethality of Brca1(S1598F) mice.

189 We found that the synthetic lethality of cells lacking both Rqh1 and Eme1

190 The findings unveil the synthetic lethality of combined suppression of YAP and R

191 Synthetic lethality of double-alanine mutations highligh

192 eta interface may account for the finding of synthetic lethality of five viable tub1 alleles with the

193 aploid Saccharomyces cerevisiae, we observed synthetic lethality of pol2-4 with alleles that complete

194 Accordingly, synthetic lethality of PopZ and TipN is caused by severe

195 in is not dependent on DNA damage, since the synthetic lethality of smc6 hypomorphs with a topoisomer

196 These results, along with the synthetic lethality of the bamDR197L DeltabamE double mu

197 sphatidylpropanolamine, failed to rescue the synthetic lethality of the crd1delta psd1delta cells.

198 gtr1 and pib2 mutants and also prevented the synthetic lethality of the double mutants.

199 ot helD null or lexA3, partially rescued the synthetic lethality of the double topoisomerase III/IV m

200 ining mutant alleles of CPL1 and CPL2 causes synthetic lethality of the male but not the female gamet

201 he administration of PARP inhibitors induces synthetic lethality of tumour cells of patients with bre

202 using the keywords "RAS," "KRAS," "NSCLC," "synthetic lethality," "oncogenic driver mutations," "cli

203 sm for their antineoplastic activity, making synthetic lethality one of the most important new concep

204 t lattice assembly exhibited growth defects, synthetic lethality or both, supporting the function of

205 swm1Delta mutants exhibit synthetic lethality or conditional synthetic lethality w

206 ose disruption in a rat8-2 background causes synthetic lethality or dramatically reduced growth.

207 t and DNA repair, creating opportunities for synthetic lethality or synergistic cytotoxicity.

208 This synthetic-lethality phenotype was as pronounced as that

209 DprE1, killing also occurs through chemical synthetic lethality, presumably through the lack of deca

210 Global analysis of synthetic lethality promises to identify cellular pathwa

211 Synthetic lethality provides a potential mechanistic fra

212 In addition to the known cdc7-rad53 synthetic lethality, rad53 mutations suppress mcm5-bob1,

213 ower frequency of essential genes and higher synthetic lethality rate, but instead diverge more in ex

214 nce of CLB5, suggesting that the bub1/3 clb5 synthetic lethality reflected some function other than t

215 er, the molecular mechanisms that drive this synthetic lethality remain unclear.

216 Further, mus81 sgs1 synthetic lethality requires homologous recombination, a

217 Furthermore, the synthetic lethality resulting from combining a gcn5 muta

218 herapeutics that takes advantage of clinical synthetic lethality, resulting in selective tumor cell k

219 we present the results of a high-throughput synthetic lethality screen for genes that interact with

220 We deployed a synthetic lethality screen to investigate if knockdown o

221 A genome-wide, conditional synthetic lethality screen was performed using the yeast

222 combinatorial gene-network analysis, in vivo synthetic lethality screening and chromosome engineering

223 By synthetic lethality screening, we identified a small com

224 tion of TAG arrays is to perform genome-wide synthetic lethality screens, known as synthetic lethalit

225 , the identification of GLUT1 inhibitors via synthetic lethality screens, novel engagement of the ins

226 chanisms that have thus far been unveiled by synthetic lethality screens.

227 microarray (SLAM) methods have been used for synthetic-lethality screens.

228 peutic targeting of oncogenes is to perform "synthetic lethality" screens for genes that are essentia

229 reased uracil incorporation in DNA and known synthetic lethalities [SL(dut) mutations].

230 olecular inhibitor BIBF 1120 (BIBF) promoted synthetic lethality specifically in cells with the loss-

231 ic optimization, rational drug combinations, synthetic lethality strategies, novel biguanides, and th

232 ponse caused by mutp53 can be exploited in a synthetic lethality strategy, as depletion of another AT

233 ecretory pathway function and the utility of synthetic lethality studies and their interpretation.

234 Genome-wide synthetic lethality studies confirmed that elf1Delta spe

235 t, combining these two mutations resulted in synthetic lethality, suggesting that Mcm2 and Mcm4 play

236 Synthetic lethality suggests that Bni1p and Myo1p belong

237 Loss of cep-1 and him-5 results in synthetic lethality that is dependent on the upstream DN

238 late DNA was investigated using an assay for synthetic lethality that provides a visual readout of ce

239 The concept of synthetic lethality (the creation of a lethal phenotype

240 This study proposes a synthetic-lethality therapy for treating cancers deficie

241 e/ATPase domain to deliver on the promise of synthetic-lethality therapy.

242 tivity to promote tumor survival and confers synthetic lethality, thereby revealing a unique therapeu

243 Our objective was to engender synthetic lethality to paclitaxel (PTX), the frontline t

244 PARP inhibitors exploit synthetic lethality to target DNA repair defects in here

245 ression of anaplerotic Q utilization created synthetic lethality to the cell cycle phase-specific cyt

246 ts form a computational basis for exploiting synthetic lethality to uncover cancer-specific susceptib

247 DSB repair pathways sensitized MPN cells to synthetic lethality triggered by PARP inhibitors.

248 deletion from the plastid genome results in synthetic lethality under autotrophic conditions.

249 can produce 2 distinct biological outcomes: synthetic lethality upon significant suppression of ATR

250 Synthetic lethality was observed between null alleles of

251 Synthetic lethality was observed for these mutants when

252 oadly activated in response to A3A activity, synthetic lethality was specific to ATR signaling via Ch

253 get HRR in tumor cells, a phenomenon called "synthetic lethality" was applied, which relies on the ad

254 Ultimately, the synthetic lethality we have identified between MYC overe

255 To reconfirm scp160/eap1 synthetic lethality, we constructed a strain null for bo

256 Using a screen for synthetic lethality, we found that the V. cholerae PBP1a

257 In particular, we observed synthetic lethality when both sphingolipid and PI4P synt

258 f Gcn5-targeted histone H3 residues leads to synthetic lethality when combined with deletion of the g

259 cking the centromere binding factor Cbf1 and synthetic lethality when combined with mutations in comp

260 mage response defect of sonB1 mutants causes synthetic lethality when combined with mutations in scaA

261 t mRNA accumulation that could contribute to synthetic lethality when combined with other genetic alt

262 gets, the blockade of which showed selective synthetic lethality when combined with PI3K inhibitors.

263 hic mutations of Mre11 (Mre11(ATLD1)) led to synthetic lethality when juxtaposed with DNA-PKcs defici

264 Herein, it is shown that priA2::kan causes synthetic lethality when placed in combination with eith

265 the absence of both ShyA and ShyC results in synthetic lethality, while the absence of ShyA and ShyB

266 es a strong nuclear accumulation of mRNA and synthetic lethality with a number of mRNA export mutants

267 N-tail mutants exhibited synthetic lethality with an altered centromeric DNA sequ

268 , an altered outer membrane protein profile, synthetic lethality with both surA::Cm and deltafkpA::Cm

269 ding a septin, were isolated in a screen for synthetic lethality with CHS3, which encodes the chitin

270 sential function with Cla4p, it did not show synthetic lethality with Chs3p.

271 pindle checkpoint genes BUB1 and BUB3 caused synthetic lethality with clb5.

272 ect or suppression of defects, including the synthetic lethality with ctf4.

273 the glycosylation inhibitor tunicamycin, and synthetic lethality with deletion of the unfolded protei

274 established human cancer cell lines induced synthetic lethality with genotoxic chemotherapeutics, in

275 ge, intolerance to moderate over-expression, synthetic lethality with low Deltapsi(m) conditions, hyp

276 not essential but when deleted, it leads to synthetic lethality with many secretory mutations, defec

277 The map65-4 mutation caused synthetic lethality with map65-3 although map65-4 alone

278 oloenzyme in vivo and ppm1 mutations exhibit synthetic lethality with mutations in genes encoding the

279 uxotrophy, impaired telomeric silencing, and synthetic lethality with mutations in SPT10, a gene that

280 protein misfolding, and they do not display synthetic lethality with mutations in UPR(ER) genes, whi

281 type, sensitivity to DNA damaging agents and synthetic lethality with mutations that affect DNA metab

282 tive to genotoxic agents, and they exhibit a synthetic lethality with mutations that compromise DNA r

283 Loss of SAE1/2 enzymatic activity drives synthetic lethality with Myc.

284 s exhibit synthetic lethality or conditional synthetic lethality with other APC/C subunits and regula

285 dentified a cohort of proteins which display synthetic lethality with paclitaxel in non-small-cell lu

286 s sporadic EOC are profoundly susceptible to synthetic lethality with PARP inhibition, it is imperati

287 indicated that the rfc1::Tn3 allele displays synthetic lethality with pol30, pol3, and rad27 mutation

288 These mutations (designated mec1-srf for synthetic lethality with rad-fifty-two) simultaneously c

289 We isolated 10 mec1 mutations that display synthetic lethality with rad52.

290 Synthetic lethality with reduced H(+) efflux and activat

291 We screened for mutations that show synthetic lethality with sft2 and found one that affects

292 tion of these transitions, mutations causing synthetic lethality with sic1 Delta were isolated.

293 late synthase (ADE3) was required to achieve synthetic lethality with srp40Delta.

294 NPC clustering, nuclear import defects, and synthetic lethality with the additional absence of Pom34

295 ominant lethality, fluoride sensitivity, and synthetic lethality with the arf2 null mutation.

296 pbn1-1, a nonlethal allele of PBN1, displays synthetic lethality with the ero1-1 allele (ERO1 is requ

297 Deletion of the RPB9 gene shows synthetic lethality with the low fidelity rpb1-E1103G mu

298 n to identify genes that when silenced cause synthetic lethality with the PARP inhibitor AZD2281.

299 onferred a conditional growth defect, showed synthetic lethality with tpm1Delta, and simultaneously b

300 t eIF4E (cdc33-1(ts)) engendered conditional synthetic lethality, with extreme sensitivity to hydroxy