ライフサイエンスコーパス: synthetic peptide

1 ompeting activity of M to its finger using a synthetic peptide.

2 thout affecting the hydrolysis of gelatin or synthetic peptide.

3 trically dimethylating the N-terminus of the synthetic peptide.

4 an be applied to the characterization of any synthetic peptide.

5 rmed by comparison to spectra generated from synthetic peptides.

6 peptide can be identified by comparison with synthetic peptides.

7 tion is peptide cyclization, was tested with synthetic peptides.

8 pecificities could be studied in detail with synthetic peptides.

9 on mutants or in treatments with GLV-derived synthetic peptides.

10 d beta-Lg 40-60, was studied in detail using synthetic peptides.

11 rarchies persist even after vaccination with synthetic peptides.

12 ionship (QSAR) and confirmatory studies with synthetic peptides.

13 oteins and a variety of complexes with short synthetic peptides.

14 re designed and generated as recombinant and synthetic peptides.

15 ally acetylated and nonacetylated 15-residue synthetic peptides.

16 tacked beta-sheets found in studies of small synthetic peptides.

17 maceuticals and is particularly prevalent in synthetic peptides.

18 rom different species as well as PrP-derived synthetic peptides.

19 gamma interferon (IFN-gamma), in response to synthetic peptides.

20 tial features for binding to gH/gL by use of synthetic peptides.

21 high throughput using fluorescently labeled synthetic peptides.

22 nd standard peptides can be determined using synthetic peptides.

23 four proteins and validated by MS/MS of the synthetic peptides.

24 probed by permethylating a library of short synthetic peptides.

25 an 2000 ribosomal, 80 non-ribosomal and 5700 synthetic peptides.

26 acy being peptide-dependent for QconCATs and synthetic peptides.

27 sing statistical methods and a mixture of 14 synthetic peptides.

28 igh-throughput ELISA and ELISPOT analyses of synthetic peptides.

29 d short chain peptides were determined using synthetic peptides.

30 We found that a short synthetic peptide able to inhibit FOXP3/NFAT interaction

31 This study describes the use of a xeno-free synthetic peptide acrylate surface, the Corning(R) Synth

32 Here we describe synthetic peptide-acrylate surfaces (PAS) that support s

33 ited tethered peptide agonist-stimulated and synthetic peptide agonist-stimulated GPR56 but did not i

34 rgens, recombinant allergen derivatives, and synthetic peptides allow us to target selectively differ

35 The synthetic peptide also inhibited TCR-mediated activation

36 gh biochemical assays with seed extracts and synthetic peptides, an enzyme named oligopeptidase 1 (OL

37 oating with and without peptide 15 (P-15), a synthetic peptide analog of the cell-binding domain of c

38 tegy for the purification of the hydrophobic synthetic peptide and demonstrate the efficient ligation

39 etection of approximately 10ngmL(-1) for the synthetic peptides and 0.01microgmL(-1) for the humam se

40 to be employed to many other complexes where synthetic peptides and a suitably isotope-labeled medium

41 Using synthetic peptides and mouse immunization as a model, we

42 Using synthetic peptides and native gel electrophoresis, we co

43 d chromatographic retention time between the synthetic peptides and naturally occurring peptides.

44 cacious antagonists, the field has relied on synthetic peptides and pepducins to describe protease-ac

45 ivity using a variety of arginine-containing synthetic peptides and protein substrates, including a G

46 American patients with peanut allergy toward synthetic peptides and recombinant allergens was assesse

47 r the external binding of various His-tagged synthetic peptides and recombinant or chemically H6-modi

48 is potentially relevant for manufacturing of synthetic peptides and recombinant proteins.

49 Studies using synthetic peptides and shp gene mutants indicate that th

50 ployed as readout for receptor activation by synthetic peptides and that a new, highly sensitive, non

51 his interplay by ANT inhibitors, ANT-derived synthetic peptides, and/or function-blocking MMP14 and A

52 Synthetic peptide applications were shown to alter root

53 ikewise, large-scale libraries of quantified synthetic peptides are becoming available, enabling abso

54 applications, we devised a strategy in which synthetic peptides are built by assembling 7-residue nat

55 complexes generated by incubating cells with synthetic peptides are extensively intermingled on the c

56 ubunits (GalphaCT and GgammaCT), prepared as synthetic peptides, are likely to bind sequentially and

57 Using synthetic peptide arrays on membrane supports, we identi

58 ence independence was determined by blotting synthetic peptide arrays, and they have been tested for

59 cally recognizes pHis was obtained using the synthetic peptide as the immunogen.

60 emonstrate for the first time the utility of synthetic peptides as promising skin test antigens for b

61 d quarter fragment of type III collagen, and synthetic peptides as substrates.

62 xamined the activity of purified CCP5 toward synthetic peptides as well as soluble alpha- and beta-tu

63 opy, we have investigated the structure of a synthetic peptide assembled into a highly packed monolay

64 This includes (a) short synthetic peptides, (b) short peptides within a defined

65 effect was specific, since rclaudin-1 and a synthetic peptide based on the claudin-1 ECL-2 offered n

66 a potent adjuvant for recombinant protein or synthetic peptide-based Ags.

67 Peginesatide, a synthetic peptide-based erythropoiesis-stimulating agent

68 m treated patients, as ascertained using the synthetic peptide-based QCM assay, were typical for thos

69 The results suggested that a synthetic peptide bearing a particular functional sequen

70 Two IgE-binding synthetic peptides: beta-CN (57-68) and beta-CN (82-93),

71 An in vitro antibacterial study of synthetic peptide BF2 against the clinical isolates of v

72 trices of either laminin, recombinant L1, or synthetic peptides binding specifically to Itgb1 s or AP

73 polarizing effects could be seen with SE(+) synthetic peptides, but even more so when the SE was in

74 tro by assaying the deglutathionylation of a synthetic peptide by tryptophan fluorescence quenching a

75 is of 62 B. burgdorferi surface proteins and synthetic peptides by assessing binding of IgG and IgM t

76 onjugate the leader peptides to a variety of synthetic peptides by copper-catalyzed azide-alkyne cycl

77 ions have been the methods of choice to fold synthetic peptides by means of macrocyclization.

78 Previously, we have shown that the synthetic peptide C7H2, based on the heavy chain CDR 2 f

79 We have engineered a synthetic peptide called clavanin-MO, derived from a mar

80 entified a consensus PDZ-binding motif and a synthetic peptide capable of binding to the Tiam1 PDZ do

81 Such small synthetic peptides capable of binding phosphate could be

82 e was used to couple T4 lysozyme (T4L) and a synthetic peptide catalyst responsible for the selective

83 tion based on recombinant DNA technology and synthetic peptide chemistry.

84 As kinase substrate, we used synthetic peptide cocktails and, in the process, demonst

85 A synthetic peptide composing PAR1 residues 47-66, TR47, s

86 Moreover, a synthetic peptide comprising the last 30 amino acids of

87 um comS mutants of strain UA159 respond to a synthetic peptide comprising the seven C-terminal residu

88 Synthetic peptides comprising these stalks potently acti

89 o traditionally used recombinant proteins or synthetic peptides, concatenated peptides (QconCATs) wer

90 ibitor and an anti-root invasion, non-lethal synthetic peptide confers resistance to plantain against

91 A series of synthetic peptide constructs containing cross-linked tTG

92 native Skp1 acceptor glycoforms and a novel synthetic peptide containing GlcNAcalpha1,4-hydroxy(tran

93 combinant proteins methylate variants of the synthetic peptide containing N-terminal alanine and seri

94 A synthetic peptide containing the conserved motif can par

95 Disruption of this interaction using a synthetic peptide containing the p66(shc) polyproline do

96 -3 cells was reduced by approximately 65% by synthetic peptides containing an Arg-Gly-Asp sequence, s

97 To achieve this goal, synthetic peptides containing two disulfides were studie

98 A synthetic peptide corresponding to the cav-1 scaffolding

99 The current study evaluated whether a synthetic peptide corresponding to the claudin-4 ECL-2 s

100 CaMKIID was able to phosphorylate a synthetic peptide corresponding to the cytoplasmic domai

101 Consistent with this, a synthetic peptide corresponding to the HAP2 fusion loop

102 A synthetic peptide corresponding to the helix, but not to

103 epcidin-25 IgG, and a biomimetic-based, on a synthetic peptide corresponding to the hepcidin-binding

104 We observe that a synthetic peptide corresponding to the N-terminal 20 ami

105 A synthetic peptide corresponding to this decorin region d

106 We found that a synthetic peptide corresponding to this region inhibits

107 Synthetic peptides corresponding to a portion of the HeV

108 We raised antisera against synthetic peptides corresponding to an extracellular dom

109 The study of synthetic peptides corresponding to discrete regions of

110 Furthermore, treatment with synthetic peptides corresponding to FasL(117-126) signif

111 b to meningococci was inhibited using either synthetic peptides corresponding to H.8 or a nonblocking

112 rtens and removes side chain glutamates from synthetic peptides corresponding to the C-terminal regio

113 cH2GTP from GTP (GTP 3',8-cyclase), and that synthetic peptides corresponding to the C-terminal regio

114 tle; all four genes are transcribed, and the synthetic peptides corresponding to the core regions are

115 syndrome coronavirus) can be inhibited with synthetic peptides corresponding to the native CHR seque

116 Synthetic peptides corresponding to the released peptide

117 t protein-lipid interactions simply by using synthetic peptides, corresponding to the membrane-spanni

118 this study are significant in that low-cost synthetic peptides could be used in a QCM assay, in lieu

119 transferases (GalNAc-Ts) could glycosylate a synthetic peptide covering the IRTT sequence.

120 and age-matched controls against 141 20-mer synthetic peptides covering the entire sequence of major

121 nt of the immunosensor was conducted using a synthetic peptide, derivative from the H6PGA4 R. rickett

122 nsportan 10; the second was based on DL1a, a synthetic peptide derived from staphylococcal delta-lysi

123 HCV attachment could also be inhibited by a synthetic peptide derived from the apoE receptor-binding

124 A synthetic peptide derived from the beta(2)AR-binding dom

125 n, we examined the effects of oxidation of a synthetic peptide derived from the C-terminal 25 amino a

126 Vaccination with J8, a conserved region synthetic peptide derived from the M-protein of GAS and

127 Here we report that a synthetic peptide derived from the stem region of ZIKV e

128 A synthetic peptide derived from this region of E-cadherin

129 Using synthetic peptides derived from the active C-terminal po

130 Furthermore, synthetic peptides derived from the divergent Na(V)beta4

131 se produced in artificial lipid membranes by synthetic peptides derived from the PrP sequence because

132 Synthetic peptides derived from transmembrane (TM) domai

133 Finally, the intracellular inclusion of synthetic peptide designed to block GluA1 subunit of AMP

134 We additionally performed synthetic peptide digestions with recombinant ERAP1 vari

135 Using synthetic peptide dilution series, we show that the sens

136 (CDRs) from monoclonal antibodies tested as synthetic peptides display anti-infective and antitumor

137 Synthetic peptides duplicating these segments inhibited

138 the first genetically encoded alternative to synthetic peptide encapsulation schemes for sustained de

139 stimulation of HLA-A2(+) CD8(+) T cells with synthetic peptide encompassing the H3.3K27M mutation, co

140 novel approach for expansion of hiPSCs using synthetic peptide engineered surface as a substrate to a

141 Synthetic peptide epitopes with high affinities for nAbs

142 In addition, Hamp2 synthetic peptides exhibited a clear antimicrobial activ

143 ed molecular patterns (MAMPs), including the synthetic peptides Flg22 and Elf26 corresponding to bact

144 We utilized synthetic peptides for EA, EB, and a scrambled control t

145 ensional multiplexing workflow that utilizes synthetic peptides for each protein to prompt the simult

146 rized dendritic cells (alphaDC1) loaded with synthetic peptides for glioma-associated antigen (GAA) e

147 The fibrils are built by modifying the synthetic peptide fragment corresponding to residues 105

148 thermal titration calorimetry to investigate synthetic peptide fragments from different domains of th

149 half-life of peptide-MHC-II complexes using synthetic peptides from regions of the Factor VIII prote

150 ls of fibrin(ogen) fragment D complexed with synthetic peptides GPRP (knob 'A' mimetic) and GHRP (kno

151 eriment, rabbits preimmunized with V6 region synthetic peptides had more rapid accumulation of V6 var

152 ntegrity, and this functionality was lost in synthetic peptides harboring amino acid substitutions W8

153 erse transmembrane barrels formed from short synthetic peptides has not been demonstrated previously.

154 homotrimers of gp41, from which a number of synthetic peptides have been derived as antagonists of v

155 Synthetic peptides have been developed for therapeutic a

156 Studies of synthetic peptides have contributed substantially to our

157 These synthetic peptide hormones share the overall structure o

158 Five casein-derived synthetic peptides (Ile-Pro-Ile-Gln-Tyr, Leu-Pro-Leu-Pro

159 owth factor receptor (HER2) mimotope-derived synthetic peptide immobilized on the surface of a Au qua

160 Cat-PAD, the first in a new class of synthetic peptide immuno-regulatory epitopes (SPIREs), w

161 Synthetic peptide immunoregulatory epitopes are a new cl

162 differences in the molecular behavior of the synthetic peptide in the presence and absence of TFA at

163 als whose T cells do not recognize the short synthetic peptide in the vaccine will be able to generat

164 , which quantifies the phosphorylation of 90 synthetic peptides in a single mass spectrometry run, is

165 Using QconCAT and synthetic peptides in parallel gives a refined focus on

166 PLB species, we co-reconstituted each of the synthetic peptides in phospholipid membranes with SERCA

167 effect has not been extensively explored in synthetic peptides in the context of supramolecular self

168 A similar pattern is observed for synthetic peptides incorporated into oriented phospholip

169 sly demonstrated that cNK-lysin and cNK-2, a synthetic peptide incorporating the core alpha-helical r

170 se its displacement in tissue culture with a synthetic peptide increases cell death.

171 Domain mapping using synthetic peptides indicated that the IQ motif of Ng is

172 These synthetic peptides inhibit MMP-14-enhanced cell migratio

173 tinct sources (cultured cells, AD cortex, or synthetic peptide) inhibited LTP, and this was prevented

174 A thermal stress study of the synthetic peptide (l-)L2 showed that the isomerization a

175 al stress as evidenced by the coinjection of synthetic peptide L2 with l-Asp-12, l-isoAsp-12, d-Asp-1

176 The sensors feature a synthetic peptide layer of the major IgE-binding epitope

177 (KLK7) have previously been delineated using synthetic peptide libraries of fixed length, or single p

178 nzymatic technology was demonstrated for two synthetic peptide libraries that were used to screen and

179 optimized through screening and analysis of synthetic peptide libraries, ligand 1 has 7500-fold impr

180 we performed an external correction using a synthetic peptide library with known peptide relative ab

181 of the human memory T cell response using a synthetic peptide library.

182 Peptides and synthetic peptide-like molecules are powerful tools for

183 etry-based antimicrobial assay revealed that synthetic peptides LL-37, hBD-3, and hBD-1 had activity

184 dation or pharmacological inhibition using a synthetic peptide (LR12) dampens myocardial inflammation

185 evaluates in vitro antimicrobial activity of synthetic peptide LyeTxI and association compound LyeTxI

186 The results indicate that the synthetic peptide m1E41920 was able to inhibit the bindi

187 Dialysing a synthetic peptide mimicking the C-terminus of the alpha-

188 Similarly, a synthetic peptide mimicking the C-terminus of the fibrin

189 sordered in the reported E2 structure, but a synthetic peptide mimicking this site forms a beta-hairp

190 We designed multiple synthetic peptides mimicking the predicted cleavage site

191 utagenesis and interference experiments with synthetic peptides mimicking transmembrane helices (TMH)

192 ides was characterized by infusion of a five synthetic peptide mix with zero to four phophorylation s

193 We report that a novel synthetic peptide, modeled after the Bcl-2-interacting s

194 has been developed that uses the immobilized synthetic peptide, NFO4; which possesses a high binding

195 This was confirmed in experiments with a synthetic peptide of 24 aa, derived from the central par

196 A synthetic peptide of NS1 residues 305-311 could inhibit

197 tly reported that a cell-permeable "stapled" synthetic peptide of the Notch coactivator Mastermind is

198 atch clamp electrophysiology, we show that a synthetic peptide of the NSP4 VPD has ion channel activi

199 Synthetic peptides of each variant were tested individua

200 Importantly, synthetic peptides of FnIII(1) , FnIII(5) or FnIII(15) b

201 Conformations of synthetic peptides of representative copies of each of t

202 The oriented assembly of the synthetic peptides on electrode surfaces through an engi

203 he immobilization and orientation of NOF4, a synthetic peptide, onto 3-D porous chitosan supports usi

204 K8 Q70 cross-linking, in the context of synthetic peptides or intact proteins transfected into c

205 Synthetic peptides P2 and P4 of PvTRAg38 interfered with

206 ducing beta-actin availability or by using a synthetic peptide (P326TAT) containing a sequence corres

207 A synthetic peptide, P454, corresponding to this sequence

208 tions of MST2 SARAH domains with a series of synthetic peptides particularly designed to bind to it,

209 heart cytosol catalyze the methylation of a synthetic peptide (PPKQQLSKY) that contains the first ei

210 Similarly, the synthetic peptides presented here proceed from monomer t

211 other functional groups to the N-termini of synthetic peptides prior to cleavage and deprotection.

212 recombinant IL-2 protein, IL-2 DNA, or IL-2 synthetic peptides prior to infection with wild-type (wt

213 ee conventional internal standard platforms (synthetic peptides, QconCAT constructs, and recombinant

214 sms of internalization have focused on small synthetic peptides rather than full-length globular home

215 nt of the BCR with an epitope-bearing 17-mer synthetic peptide readily activated OB1 B cells.

216 Novel synthetic peptides represent smart molecules for antigen

217 variable (scFv, designated 2B4) to a linear synthetic peptide representing Herceptin's heavy chain C

218 GBV-C E2 protein and a synthetic peptide representing the inhibitory amino acid

219 Purified active CtsH sequentially cleaved a synthetic peptide representing the N terminus of the tal

220 Synthetic peptides representing the allelic forms of the

221 of recombinant Scribble PDZ domains and the synthetic peptides representing the C termini of these p

222 Synthetic peptides representing the last 10 amino acids

223 Antibodies to synthetic peptides representing the transcription factor

224 In this context, preliminary results using synthetic peptides reveal significant inhibition of subs

225 n on the T cells, and ex vivo analyses using synthetic peptides revealed a concurrent hierarchical lo

226 Analyses with recombinant proteins and synthetic peptides revealed that the N-terminal part of

227 ergent chemical ligation of four unprotected synthetic peptide segments.

228 Also in transfected cells, a synthetic peptide selectively disrupted MOR-Gal1R hetero

229 an oil-based medium, also includes a unique synthetic peptide sequence that acts as a traceable "cod

230 ilisin BPN' propeptide structure to generate synthetic peptide sequences with increased and tunable s

231 Data with synthetic peptides, serving as orientation probes, indic

232 The corresponding synthetic peptides showed binding to the joint-derived e

233 Inhibition experiments with synthetic peptides showed that HLA-E shares epitopes wit

234 In vitro assays using synthetic peptides showed that purified protein kinase A

235 The synthetic peptide side chain displays 10 melamine rings,

236 Furthermore, E1 ectodomain-derived synthetic peptides significantly inhibited the interacti

237 A synthetic peptide spanning this sequence forms amyloid-l

238 Overlapping synthetic peptides spanning B3B4 were then tested in fun

239 Submolecular mapping analysis by using synthetic peptides spanning BoNT serotype A (BoNT/A) and

240 Binding assays using synthetic peptides spanning L4 showed that PEDF selectiv

241 Overlapping synthetic peptides spanning the B1B2 region identified t

242 fied protein was calculated using a set of 7 synthetic peptides spiked into the samples.

243 .TAP1KO-HLA-C*06:02 cells, we identified the synthetic peptide SRGPVHHLL presented by HLA-C*06:02 tha

244 quantitative performance of both QconCAT and synthetic peptide standards.

245 sing the cell-permeable, hydrocarbon-stapled synthetic peptide stapled alpha-helical peptide derived

246 iometric measurement of phosphorylation of a synthetic peptide substrate (Ac-RRRRRRSETDDYAEIID-NH(2),

247 ng hiPSCs on a chemically defined, xeno-free synthetic peptide substrate, i.e. Corning Synthemax((R))

248 ost protease-substrate assays rely on short, synthetic peptide substrates consisting of native or mod

249 , the detection system has been validated on synthetic peptide substrates of Chk2, a key protein kina

250 g purified enzyme and fluorescently labeled, synthetic peptide substrates.

251 t it exhibits allosteric kinetics with small synthetic peptide substrates.

252 ance cleavage of the P25K protein but not of synthetic peptides, suggesting that nucleic acids augmen

253 y has successfully identified a set of novel synthetic peptides targeting the BBI, and has demonstrat

254 wavelengths of light, attached to a helical synthetic peptide that both promotes membrane insertion

255 A PrP GPI-PSS synthetic peptide that crosses the cell membrane inhibit

256 H) insensitive CtBP, and are replicated by a synthetic peptide that inhibits CtBP dimerization.

257 A synthetic peptide that mimics the main FN-binding sequen

258 Furthermore, using synthetic peptides that comprise sequences in either NLG

259 Synthetic peptides that contain backbone modifications b

260 Using synthetic peptides that cover the complete sequence of t

261 Sets of synthetic peptides that interact with the insulin recept

262 ensitized Balb/c mice upon stimulation by 18 synthetic peptides that span the full-length Met e 1.

263 Using 5 synthetic peptides that spanned the amino-terminal porti

264 Synthetic peptides that specifically bind nuclear hormon

265 residues 864 to 881 in membrane fusion, only synthetic peptides that were based on the native E2 func

266 g recombinant fragments from the HMW Bx7 and synthetic peptides thereof for testing of allergic patie

267 d by native chemical ligation of the central synthetic peptide to flanking recombinant polypeptides.

268 dministration and chronic infusion of an RGD synthetic peptide to obese C57BL/6 mice improved glucose

269 epitope of which can be mimicked using short synthetic peptides to allow antigen-specific engagement

270 ross-presentation and direct presentation of synthetic peptides to CD8(+) T cells.

271 n of the MS/MS settings was performed with a synthetic peptide (TP1) cross-linked with bis[sulfosucci

272 A synthetic peptide vaccine (J8-DT) from the conserved reg

273 We conclude that a synthetic peptide vaccine targeting the LND would be a p

274 hemagglutinin subunit 2 protein (HA2)-based synthetic peptide vaccine that provides protection in mi

275 that are well suited for the development of synthetic peptide vaccines.

276 ivery of the N-terminal domain of VDAC1 as a synthetic peptide (VDAC1-NP) abolishes the ability of BH

277 tudy compares transferrin levels obtained by synthetic peptides versus QconCAT peptides as internal s

278 Using synthetic peptides, VesB efficiently cleaved a trypsin s

279 To screen for TcdB-derived CPPs, a panel of synthetic peptides was tested for the ability to enhance

280 Using synthetic peptides, we evaluate them by targeted proteom

281 tering length and valency of epitope-bearing synthetic peptides, we examined the properties of ligand

282 Several synthetic peptides were dissolved in dilute acid contain

283 The synthetic peptides were immobilized on the gold surface

284 r peptides, IgE ELISA inhibition assays with synthetic peptides were performed.

285 The limits of detection, determined using synthetic peptides, were 1 ng/mL for unadducted BuChE an

286 -like structural architecture assumed by the synthetic peptide which makes use of unusually remote in

287 Synthetic peptides which were designed on the basis of p

288 ave studied CLN025, an optimized ten residue synthetic peptide, which adopts a compact, well-structur

289 quencing and, where required, confirmed with synthetic peptides, which were also used to determine th

290 we documented that either adiponectin or the synthetic peptide with adiponectin properties, ADP355, s

291 A small synthetic peptide with nanomolar affinity for cardiac tr

292 nd demonstrate the efficient ligation of the synthetic peptide with the recombinant peptide thioester

293 Synthetic peptides with a MeCAT label which are external

294 the MAPK level were counteracted by specific synthetic peptides with amino acid sequences correspondi

295 trongly inhibited the interactions of eEF-1A synthetic peptides with calmodulin recombinant proteins

296 ified enzyme was able to cleave proteins and synthetic peptides with greatest activity toward acidic

297 rophil elastase and proteinase-3, as well as synthetic peptides with sequences derived from these nov

298 Synthetic peptides with the sequence of transmembrane he

299 In this work, synthetic peptides with various sequence motifs were use

300 nvestigated for antibody response along with synthetic peptides within those regions, using in vivo p