ライフサイエンスコーパス: synthetic route

1 -like morphologies were obtained through the synthetic route.

2 uces additional steps and obstacles into the synthetic route.

3 ually interpenetrating rings, via an unusual synthetic route.

4 kbone, giving a straightforward and low-cost synthetic route.

5 f alpha-diazoketone 7 as the key step in the synthetic route.

6 red using a modified hot injection colloidal synthetic route.

7 actions between the reagents used in a given synthetic route.

8 uctions are staged at or near the end of the synthetic route.

9 ation of the natural product and to plan the synthetic route.

10 over 30 analogues using a novel solid-phase synthetic route.

11 vestigations, which have led to new valuable synthetic routes.

12 vironmental friendliness low cost and simple synthetic routes.

13 de clues for developing new and controllable synthetic routes.

14 azardous and costly chemicals or any complex synthetic routes.

15 SPP), into a network displays tentative (bio)synthetic routes.

16 onditions than the conventional hydrothermal synthetic routes.

17 minescence probes and the development of new synthetic routes.

18 eld, a significant improvement over previous synthetic routes.

19 s, a complete set of step reactions in their synthetic routes.

20 hat have never before been accessed by fully synthetic routes.

21 re difficult to achieve through conventional synthetic routes.

22 ompositions that are inaccessible via direct synthetic routes.

23 /macromolecules tailored through appropriate synthetic routes.

24 action times in comparison with conventional synthetic routes.

25 tified: (1) signatures that were unique to a synthetic route; (2) signatures associated with a combin

26 A newly developed synthetic route allowed synthesizing the biologically mo

27 nd 8 metals (for which a number of versatile synthetic routes already exist) to provide access to com

28 The nine-step synthetic route also features a novel desymmetrizing ena

29 oth bioactive small molecules and associated synthetic routes, analogous to the evolution of biosynth

30 This agent was prepared by a concise synthetic route and formulated for dynamic nuclear polar

31 the synthetic route or a combination of the synthetic route and reaction solvent.

32 signatures associated with a combination of synthetic route and reaction solvent; (3) signatures rel

33 The facile described synthetic route and the strategic combination of computa

34 Also presented are some interesting synthetic routes and procedures that can be used toward

35 s has been underexplored, due to the lengthy synthetic routes and the lack of structure-activity rela

36 owing repeat dosing, are prepared by a short synthetic route, and have druglike properties suitable f

37 The compact size, simple synthetic route, and molecular motions of this gyroscope

38 ance of the raw materials, the simplicity of synthetic routes, and processing versatility make MHPs i

39 was prepared through two different stepwise synthetic routes, and the complicated chemical structure

40 AlFe2B2 was prepared by two alternative synthetic routes, arc melting and synthesis from Ga flux

41 Blatter's radicals are limited, however, and synthetic routes are complex.

42 Especially simple synthetic routes are disclosed that provide access to dy

43 spects for the industrial amenability of new synthetic routes are exemplified through case studies.

44 ne (TPE) small molecule prepared by a facile synthetic route as a superior dopant-free HTL for lead-f

45 The most direct synthetic route available for their generation is heatin

46 s synthesized through a short and convenient synthetic route based on a one-pot reduction/condensatio

47 Cu2O NPs were prepared by means of a novel synthetic route based on flame spray pyrolysis.

48 This tutorial review highlights synthetic routes based on self-assembly and macrocycle-t

49 ha-position has gathered much attention as a synthetic route because of the wide biological importanc

50 y semisynthetic and to a lesser degree fully synthetic routes, but economic factors have led to a sub

51 -state compounds inaccessible by traditional synthetic routes, but there has been little development

52 The synthetic route can access >400 mg in a single batch, em

53 We show that this new synthetic route can be upscaled to a high volume yield o

54 The synthetic route comprises three steps: site-specific (ed

55 s, and hemostats, their design requirements, synthetic routes, determination of properties, and the t

56 We describe new synthetic routes developed toward a range of substituted

57 Our synthetic route effectively overcomes this limitation th

58 The ease and scalability of the synthetic route employed and the quality of the interfac

59 This synthetic route features a palladium-catalyzed alkoxycar

60 The synthetic route features iodine-catalyzed tandem isomeri

61 An efficient synthetic route for ipomoeassin F and its tiglate-modifi

62 Cation exchange is an emerging synthetic route for modifying the secondary building uni

63 s report, we describe an efficient and short synthetic route for preparation of molecular rotors with

64 A novel synthetic route for preparation of proxyphylline enantio

65 We have developed a modular practical synthetic route for preparation of turn-ON fluorophore-t

66 easing interfacial stability and as a simple synthetic route for preparing spatially controlled, mult

67 A synthetic route for producing Cu(2)ZnGeSe(4) nanocrystal

68 A new, four-step synthetic route for substituted 2,3-benzodiazepines 1, s

69 that the transformation can be an effective synthetic route for the annulation of benzene rings to v

70 A convenient synthetic route for the construction of functionalized 2

71 An analogue-oriented synthetic route for the formulation of furazan-functiona

72 This paper presents a 10-step synthetic route for the preparation of a series of new b

73 a kinetically tuned dimensional augmentation synthetic route for the preparation of highly crystallin

74 rspective, this protocol offers an efficient synthetic route for the preparation of pharmaceutical dr

75 this article, a facile two-step and one-pot synthetic route for the preparation of substituted aryl

76 Furthermore, this study provides a synthetic route for the synthesis of 1,20S(OH)2D3 using

77 A versatile and general synthetic route for the synthesis of conjugated main gro

78 Disclosed herein is an efficient synthetic route for the synthesis of functionalized 2-be

79 In this work, we developed a concise synthetic route for the synthesis of polysubstituted nap

80 address this issue, we have developed a new synthetic route for the synthesis of site-specifically p

81 pure oxides and thus enable a more targeted synthetic route for their preparation.

82 order to develop an efficient and versatile synthetic route for this molecule, a modular strategy is

83 Our novel synthetic route for ZnO wire fabrication provides new op

84 Engineering and evaluation of synthetic routes for generating valuable compounds requi

85 and amorphous MOFs, as well as providing new synthetic routes for MOF preparation.

86 y well explored owing to a lack of available synthetic routes for preparing them.

87 the use of these heteroaromatic rings, novel synthetic routes for ready access of a broad spectrum of

88 fer cheap, scalable and highly tunable green synthetic routes for the production of the latest genera

89 Facile and highly efficient synthetic routes for the synthesis of (S)- and (R)-23-hy

90 f sugars ("semi-synthetic"), and by a "fully synthetic" route from propiophenone.

91 To address this problem, an efficient synthetic route has been developed for highly polar sulf

92 the Gq subfamily of G proteins; however, no synthetic route has been reported previously for these c

93 terest of mechanochemistry as an ecofriendly synthetic route has inspired original methodologies to p

94 ained from zinc acetate/cycteine/oxalic acid synthetic route has the highest sensitivity of 64.29 muA

95 ted [2 + 2 + 2] cycloaddition reactions, two synthetic routes have been developed with different sequ

96 The different synthetic routes have been grouped according to the way

97 New convenient wet-chemistry synthetic routes have made it possible to explore cataly

98 groups to the polymer backbone, alternative synthetic routes have to be developed.

99 ey ( references) of the most promising novel synthetic routes, i.e., electrochemical, microwave, mech

100 Highlights of the synthetic route include an iridium-catalyzed hydrogenati

101 Key steps in the synthetic route include spiroacetal lactone alkylidenati

102 Key elements of the synthetic route include the use of an isopropenyl group

103 The synthetic route includes a Pd-catalyzed monoallylation s

104 hSi(Trip)][HB(C6F5)3], was prepared by a new synthetic route involving hydride abstraction from silic

105 uoro-4-hexylthiophene has been prepared by a synthetic route involving perbromination of 3-hexylthiop

106 e nanoparticles (MNPs) through a single-step synthetic route involving the simultaneous nanoparticle

107 are synthesized by a simple, easily scalable synthetic route involving thermal treatment of Co(2+) -e

108 Herein, the synthetic route is adapted to the syntheses of six addit

109 The synthetic route is based on the oxidative condensation o

110 The synthetic route is different from conventional counterpa

111 The synthetic route is general for both D- and L-sugars and

112 The synthetic route is highly efficient (13 steps), featurin

113 The synthetic route is highly stereoselective, featuring (1)

114 This synthetic route is in competition with a reaction previo

115 A facile synthetic route is presented that produces a porous Ga-I

116 The synthetic route is rapid, efficient and possible on the

117 A facile, template-free synthetic route is reported toward poly(ionic liquid) co

118 dified expanded calixphyrin, by an efficient synthetic route is reported.

119 pe compounds that is assembled by convenient synthetic routes is described as a new class of CXCR3 ag

120 lid/gas and single-crystal to single-crystal synthetic routes is reported for the synthesis and chara

121 The synthetic route leading to the trinuclear clusters invol

122 In the present review, the different synthetic routes leading to hierarchical zeolites have b

123 this purpose, such as inexpensive, scalable synthetic routes, low-toxicity and tuneable surface chem

124 hodology has been applied toward an improved synthetic route of uncialamycin and its analogs.

125 This synthetic route opens a path for exploring superconducti

126 This new synthetic route opens up the possibility of further expl

127 ol has been identified as a key point in the synthetic route, optimizing this process to avoid racemi

128 ajority of the signatures are related to the synthetic route or a combination of the synthetic route

129 s methods, all previously published fentanyl synthetic routes or hybrid versions thereof, were studie

130 ions, often hindering the development of new synthetic routes or, if chosen wisely, facilitating rout

131 antly better ligand efficiency and a shorter synthetic route over previously disclosed CYP51 inhibito

132 existing approaches to these alkaloids, our synthetic route possesses superior stereocontrol over th

133 The synthetic routes presented here could, in principle, be

134 The synthetic route proceeds in 7 steps with 47% overall yie

135 This new synthetic route provides a simple and general access to

136 This synthetic route provides new opportunities for exploring

137 This synthetic route provides practical access to 2-alkyl-2H-

138 We have established a concise synthetic route relying on a key base-promoted epimeriza

139 The key steps in both synthetic routes represent a stereoselective Heck-type p

140 Traditional synthetic routes require high metal-dye affinities and a

141 The successful execution of this synthetic route resulted in the total synthesis of all t

142 2-phenylacetaldehyde oxime, a reagent in the synthetic route, reveal existence of strong intramolecul

143 enabling high-throughput experimentation for synthetic route scouting to identify conditions for prep

144 s between particles, often influenced by the synthetic route taken to form them, lead to difficulties

145 We report here a synthetic route that allowed us to characterize and unam

146 mimic nature's biopolymers, but a practical synthetic route that enables absolute control over polym

147 We present here a facile synthetic route that yields enantiomerically pure deriva

148 In addition to reporting three new, modular synthetic routes that can be used to access these struct

149 ut these key differences, discusses possible synthetic routes, the key characterisation techniques, a

150 cribe the development of an enantioselective synthetic route to (+)-pleuromutilin (1), (+)-12-epi-mut

151 the course of this study, a highly efficient synthetic route to (+/-)-yezo'otogirin C has been establ

152 e presence of cyclohexene gives an efficient synthetic route to 1,2-substituted cyclohexyldisulfides.

153 We have developed a short, general synthetic route to 1,3,6-trisubstituted azulenes.

154 A simple and efficient synthetic route to 2,3,4,5-tetrahydrobenzoxazepines and

155 A new synthetic route to 3-(heteroaryl) tetrahydropyrazolo[3,4

156 A new synthetic route to a 3'-fluoro-3'-deoxytetrose adenine p

157 Here we developed a synthetic route to a library of compositionally defined,

158 An efficient synthetic route to an A1/A2-difunctionalized pillar[5]ar

159 We have developed a convergent synthetic route to an all-carbon, 14-membered Z,E-macroc

160 nzaldehyde was investigated as a streamlined synthetic route to an N-confused porphyrin bearing penta

161 A straightforward synthetic route to arylazoindazoles via nucleophilic aro

162 To test this hypothesis, we devised a synthetic route to assemble oligosaccharides with natura

163 of DPA, we developed a general and efficient synthetic route to beta-D-arabinofuranosyl phosphodieste

164 An efficient synthetic route to biologically relevant (-)-5-fluorocar

165 w classes of polymer semiconductors, and the synthetic route to BTzOR reported here should be adaptab

166 ver, for these applications to be realized a synthetic route to bulk C3B must be developed.

167 We report an efficient synthetic route to chiral pyrrolidine inhibitors of neur

168 A synthetic route to cis-2-methyl-4-oxo-6-alkylpiperidines

169 We have developed a modular synthetic route to combretastatin analogs based on a pyr

170 ticle products, may provide an important new synthetic route to control final metal nanoparticle comp

171 s this cyclization reaction attractive for a synthetic route to cyclohexadiene derivatives from alkyn

172 ther this chemistry has allowed the shortest synthetic route to date for manzamine A (18-step longest

173 Here, we report a synthetic route to DC-45-A2 from a differentially protec

174 by inter- or intramolecular ways provides a synthetic route to derivatives of styrene, stilbene, cha

175 monstrated the facile hydrothermal oxidative synthetic route to develop highly fluorescent boron/nitr

176 We have developed an efficient synthetic route to fluorescent BODIPY analogues, with st

177 Light without fright: a synthetic route to fluorescent primary phosphanes (RPH(2

178 provides with an atom-economical and general synthetic route to generate aryl-(hetero)aryl ketones us

179 A highly enantioselective synthetic route to hexahydropyrrolo[2,3-b]indoles via Le

180 The discovered synthetic route to introduce three different substituent

181 We report an 11-step, enantioselective synthetic route to lomaiviticin aglycon.

182 Here we present a practical, fully synthetic route to macrolide antibiotics by the converge

183 cleophilic radiofluorination is an efficient synthetic route to many positron-emission tomography (PE

184 as further extended to a novel and efficient synthetic route to methanoanthracenes employing a one-po

185 Besides these studies, we developed a synthetic route to mixed dianilides as starting material

186 To this end, we have developed a facile synthetic route to nanoporous polymer monoliths based on

187 A new synthetic route to nonracemic tetrahydropyrrolo[2,3-b]in

188 ed as an isosteric DNA base surrogate, and a synthetic route to nucleoside 1 together with the 2,4-di

189 This represents a bottom-up synthetic route to objects analogous to nanoscale pixels

190 The first synthetic route to obtain salt-free intrinsic plutonium

191 of aromatic molecules could provide a viable synthetic route to ordered carbon nanomaterials, but des

192 A synthetic route to planar P-modified polycylic aromatic

193 A palladium-catalyzed multicomponent synthetic route to polysubstituted pyrroles from aryl io

194 This convenient synthetic route to porous polymer monoliths has the pote

195 Herein we describe a flexible and convergent synthetic route to prepare advanced precolibactins and d

196 A general synthetic route to prepare all four carboline regioisome

197 A new and general synthetic route to prepare dibenzosultams is here report

198 m and progenitor cells; the development of a synthetic route to provide laboratory access to the natu

199 An efficient synthetic route to rhodol derivatives possessing five-me

200 ith dienes provide a mild and chemoselective synthetic route to seven-membered carbocycles.

201 A synthetic route to symmetrical tetraaryltetraanthra[2,3]

202 Utilizing a fully synthetic route to tetracycline analogues, the C-9 side-

203 In the present study, a facile synthetic route to the 2,3-dideoxy 1-O-glucosides of imp

204 ing an efficient and economically affordable synthetic route to the amides in excellent yields.

205 A novel synthetic route to the chemoselectively protected N,S-di

206 pression in mammalian cells and report a new synthetic route to the compound that should make obtaini

207 For this purpose, an optimized and general synthetic route to the desired compounds was developed.

208 Here we describe a fully convergent synthetic route to the ester insulin molecule from three

209 An efficient synthetic route to the hydronaphthoquinone sulfonamide s

210 We have developed a convergent synthetic route to the potent cAMP signaling agonist (-)

211 An efficient synthetic route to the resveratrol oligomers quadrangula

212 A convergent synthetic route to the sesterterpenoid framework of the

213 diynes has established a novel and efficient synthetic route to the structural framework of many biol

214 The synthetic route to the targeted molecule is simple, conc

215 (+)-irciniastatin A, we devised an improved synthetic route to the tetrahydropyran core (13 steps) c

216 calization and simultaneously simplifies the synthetic route to the voltage sensors.

217 of the parasite's life cycle, but a lengthy synthetic route to these compounds may affect the feasib

218 , structural analogs and provide a practical synthetic route to these important bioactive agents.

219 -benzoylethylpyridinium-4-oximate, the novel synthetic route to this engaging target class of compoun

220 ing from d-glucose, we developed a divergent synthetic route to three derivatives of 3,5-diamino-3,5-

221 odel studies demonstrating a stereoselective synthetic route to tricyclic analogues of the bis(piperi

222 RBF3 K is a chemist's BFF: A metal-free synthetic route to unprecedented organoboron compounds b

223 ude olefins and alkynes; this provides a new synthetic route to valuable amino-substituted phosphiran

224 The first synthetic route to yndiamides, a novel class of double a

225 The development of enantioselective synthetic routes to (-)-kinamycin F (9) and (-)-lomaivit

226 Here we describe short synthetic routes to a series of O2'-intercalator-functio

227 We cover the synthetic routes to AdoMet analogues, their stability in

228 However, the lack of synthetic routes to all but the simplest molecular knots

229 In this paper, parallel synthetic routes to benzothiadiazole derivatives, inspir

230 can facilitate better understanding of which synthetic routes to choose, an aspiration of the Dial-a-

231 multiscale biological assembly inspires new synthetic routes to complex materials.

232 Furthermore, we suggest synthetic routes to control surface terminations based o

233 ormance as heterogeneous catalysts; however, synthetic routes to control the spatial distribution of

234 to the wide number and variety of available synthetic routes to conventional linear polymers, the sy

235 lopment of renewable monomers, the versatile synthetic routes to convert these monomers to polyesters

236 mical fragments and two experimentally known synthetic routes to design in silico a large database of

237 c-inorganic dielectric materials and suggest synthetic routes to even higher capacitance materials us

238 We developed efficient synthetic routes to explore a wide variety of substituti

239 s review, we first summarize the established synthetic routes to grow high quality nanocrystals of se

240 Importantly, the mild synthetic routes to halide perovskites and the templatin

241 The development of synthetic routes to hierarchically organized porous mate

242 s highlight the importance of developing new synthetic routes to high quality oxynitrides.

243 nformation that will be helpful in designing synthetic routes to higher carbaporphyrinoid systems.

244 xidation of alkene feedstocks could simplify synthetic routes to many important molecules and solve a

245 An outline of the various synthetic routes to metal-borane (metallaboratrane) comp

246 aper, we report the development of different synthetic routes to MK-7246 (1) designed by the Process

247 We describe efficient synthetic routes to murrayamine A (mukoenine C), O-methy

248 ed systems and for the design of appropriate synthetic routes to new macrocyclic compounds.

249 Very short synthetic routes to nine cis-olefin-containing pheromone

250 nones) with alkynes offer versatile, modular synthetic routes to pyrroles.

251 A drawback of recently reported synthetic routes to RNA is the requirement for enantioen

252 Synthetic routes to salts containing uranium bis-imido t

253 The main synthetic routes to soft, hard, and hybrid soft/hard Jan

254 We focus on the development of new synthetic routes to stable and isolable radicals contain

255 Previous synthetic routes to the 1,3,2-benzodiazaborole core have

256 New synthetic routes to the 1-amino-2,5-diarylpyrrolidines w

257 Practical stereoselective synthetic routes to the antihistaminic drug olopatadine

258 Two synthetic routes to the chiral azinylferrocenes (CAFs) 5

259 ified functional group reactivity molded our synthetic routes to the hasubanan and acutumine alkaloid

260 Unfortunately, current synthetic routes to these molecules are inefficient.

261 nic semiconductors; despite their potential, synthetic routes to thionated NDIs are generally lengthy

262 and high-yielding (for macrocyclic species) synthetic routes to two novel alkynyl-conjugated multipl

263 Novel synthetic routes to various hydantoin structures, the ad

264 Successful development of synthetic routes to various triynes and the subsequent c

265 The development of reliable synthetic routes to various useful starting materials ha

266 pyridin-2-yl)-6-undecylpiperidine in a short synthetic route toward (+/-)-solenopsin A (trans diaster

267 In this paper, a new synthetic route toward 6-hydroxysphingosine and alpha-hy

268 A straightforward synthetic route toward indole-fused heteroacenes was dev

269 This work not only opens up a new synthetic route toward mixed-linker MOFs, but also provi

270 A convergent synthetic route toward orthogonally protected alphaGlcN(

271 A facile synthetic route toward pharmaceutically interesting 1-am

272 We present a simple and generalizable synthetic route toward phase-pure, monodisperse transiti

273 vaccine adjuvant, we undertook to develop a synthetic route toward single-glycoform GM-CSF.

274 To this end, we first designed a convergent synthetic route toward the diminutive analogue (+)-C(8)-

275 concepts have emerged enabling unprecedented synthetic routes toward molecules of this kind.

276 es, and furthermore, elaborate on convenient synthetic routes toward preparing borides.

277 e molecule have been recognized as effective synthetic routes toward realizing complex tricyclic mole

278 embranes and, in some cases, the only viable synthetic route towards certain membranes.

279 ein, we report a concise and stereodivergent synthetic route towards some novel carbasugar SGLT2 inhi

280 Reported herein is a short and convergent synthetic route towards some small-molecule SGLT2 inhibi

281 A new general synthetic route towards three key Maillard flavour compo

282 Reported herein is a new synthetic route utilizing the isoacyl peptide approach t

283 The efficiency of the synthetic route was demonstrated by preparing a collecti

284 ng in seven steps from dihydrofarnesal, this synthetic route was designed to circumvent macrocyclizat

285 A general and convenient synthetic route was developed by utilizing a highly subs

286 A novel synthetic route was developed for the construction of is

287 In this work, a convenient synthetic route was developed to synthesize two kinetica

288 The new synthetic route was effective for the total synthesis of

289 In this work, an efficient synthetic route was employed to construct extended benzo

290 e of polycrystalline films, depending on the synthetic route, we demonstrate the presence of both dee

291 Through this versatile synthetic route, we obtain large single crystals of 34 d

292 Initially, five synthetic routes were confirmed to successfully produce

293 Synthetic routes were developed based on N-acylpyridiniu

294 Two alternative synthetic routes were devised for preparation of the req

295 and SAR interpretation, robust and flexible synthetic routes were established.

296 Various synthetic routes were explored, and two different routes

297 -membered ring lactam intermediates in these synthetic routes were sensitive to elimination side reac

298 of the design strategy was to use a modular synthetic route with three fragments that can be readily

299 Representative synthetic routes within each class are discussed in deta

300 Exploration of multiple synthetic routes yielded an approach that has permitted