ライフサイエンスコーパス: synthetically

1 is more stable and therefore more accessible synthetically.

2 rdless of whether they arise geologically or synthetically.

3 oughness, but have proven difficult to mimic synthetically.

4 atterned biosilica that cannot be replicated synthetically.

5 eged unit, which remains highly sought after synthetically.

6 as long been proposed but was never realized synthetically.

7 he unligated (boryl)iminomethane BIM is also synthetically accessible and functions as a Frustrated L

8 Unusual, short, synthetically accessible C20 prenols (nerylnerol 1d and

9 The CB[8]-based supramolecular networks are synthetically accessible in large scale and exhibit outs

10 hypothesis-driven discovery opens novel yet synthetically accessible mitosene structural space for d

11 for a seemingly infinite variety of possible synthetically accessible polymer sequences.

12 cates and interlocked molecules that are not synthetically accessible through the use of other common

13 The dithiolodithiole (C4S4) motif is readily synthetically accessible using catalytic processes, and

14 aminocyclohex-2-enes, compounds that are not synthetically accessible using existing dearomatization

15 sely substituted cyclopentane structures not synthetically accessible using other catalytic methods.

16 efficient and rapid discovery of novel, yet synthetically accessible, bioactive chemotypes.

17 ) ), a species that has only recently become synthetically accessible.

18 to generate nanoparticle superlattices with synthetically adjustable lattice parameters and crystal

19 een used as catalyst for the construction of synthetically and biologically important [4 + 2] cycload

20 rylamino acids, a motif found in a number of synthetically and biologically interesting compounds.

21 ent approach provides a convenient access to synthetically and biologically useful 3,4-disubstituted

22 ophosphonates could be easily transformed to synthetically and biologically useful quaternary alpha-a

23 and facilitate access to a diverse range of synthetically and medicinally important carbocyclic and

24 eering criteria we build these four networks synthetically and show that they indeed operate with fou

25 Ring1B/RNF2 further induced these genes and synthetically arrested cell proliferation.

26 The reaction has led to the formation of synthetically as well as biologically important 3,4-disu

27 d fluorescent dye, Cy7, and doxorubicin were synthetically attached to polyfluorinated aryl azide to

28 The inability to synthetically attain the diversity enabled by these modi

29 nome presumed to be intergenic, or generated synthetically by 'shuffling' real sequences.

30 Switch sequencing, which combines capture of synthetically capped 5' mRNA fragments with template-swi

31 ple and also represent a facile entry to the synthetically challenging 1,2,3-substituted pyrroles.

32 Because of both their synthetically challenging and stereochemically complex s

33 ies of caffeic acid that feature an array of synthetically challenging and structurally interesting d

34 rovides direct and ortho-selective access to synthetically challenging anilines, and addresses long-s

35 Glycopeptides containing this synthetically challenging bis-N-glycosylated motif were

36 c chemists due primarily to the historically synthetically challenging C(8)-C(12) all-anti stereopent

37 5-c]pyridine P2X7 antagonists that contain a synthetically challenging chiral center.

38 ctor shows that the large-scale synthesis of synthetically challenging compounds using photochemical

39 thus constituting an attractive approach to synthetically challenging cyclobutane frameworks under m

40 ion sequence enabled the construction of the synthetically challenging dioxatricyclic framework.

41 es were constructed and elaborated to access synthetically challenging glycans of biological relevanc

42 facilitate the chemical and semisynthesis of synthetically challenging proteins from multiple fragmen

43 could effectively catalyze the formation of synthetically challenging spiro/glycoquinazolinones unde

44 (1) analogues, achieved by removal of three synthetically challenging structural units, as well as b

45 ent counter anions, including those that are synthetically challenging to install.

46 ource that leads to structurally complex and synthetically challenging tri- and tetrasubstituted alke

47 provide access to complex products that are synthetically challenging using traditional hot-injectio

48 ochemistry and functional group tolerance is synthetically challenging.

49 ternary stereocenters render these alkaloids synthetically challenging.

50 nd Snd3 (for SRP-independent targeting), can synthetically compensate for the loss of both the SRP an

51 The method presented herein is much less synthetically complex and utilizes pristine fullerene, p

52 be significantly enhanced through the use of synthetically conjugated cationic cell penetrating pepti

53 To validate our model, we predicted and synthetically constructed an optimal secretion signal wh

54 the duration of its competence events than a synthetically constructed analog that performs the same

55 s crystalline, and its facet position can be synthetically controlled in situ.

56 significantly from batch to batch and can be synthetically controlled.

57 Using triplex-forming oligonucleotides to synthetically create altered helical distortions, we hav

58 us and variants in vitro and in vivo using a synthetically created wild-type virus (rAnhui-WT) and tw

59 scale objects, whether of biologic origin or synthetically created, are being developed into devices

60 t this hypothesis, the C3-hydroxyl group was synthetically deleted, and the resulting derivative, C3d

61 Inasmuch as the neurohormone melatonin is synthetically derived from serotonin (5-HT), a close int

62 rs to provide a new platform for functional, synthetically derived polydeoxyribonucleotide-analogue m

63 A thermocline-based storage system, synthetically derived salts, and natural gas auxiliary p

64 Single crystal X-ray analyses of the synthetically derived samples of compounds 1 and 2 are r

65 Herein, we report synthetically derived, structurally more complex vinblas

66 Aptamers are short strands of synthetically designed DNA or RNA oligonucleotides that

67 Directed knockdown of matR expression via synthetically designed ribozymes altered the processing

68 nternal loops and bulges were mutated and of synthetically designed RNAs demonstrated that the distin

69 hich we monitored Psi levels at thousands of synthetically designed sequence variants comprising eith

70 An initial distribution of synthetically distorted helices having an unnatural brid

71 ocol is further demonstrated via a number of synthetically diverse product transformations.

72 tum are in a slow-growing, metabolically and synthetically downregulated state.

73 The concept can be extended to the synthetically easier to access postsynthetic 2'-modifica

74 Synthetically easily accessible (18)F-labeled silicon-fl

75 ived lactols is required in order to achieve synthetically efficient yields.

76 ndergo a McMurry coupling to form previously synthetically elusive cycloheptanone-fused indoles.

77 calculations while simultaneously leveraging synthetically enabled chemistry and structure-based drug

78 t materials, however, where conflicts can be synthetically encoded in the molecular structure, stagin

79 These mass differences are synthetically encoded into amino acids and incorporated

80 After synthetically encoding lysine-acetylation at natural mod

81 Synthetically engineered biological components ("BioBric

82 Synthetically engineered genetic circuits can perform a

83 find that Ccr4-Not and TFIIS mutations show synthetically enhanced phenotypes, and biochemical analy

84 on starting compound 8 has been proved to be synthetically equivalent to a cyclopent-2-en-1-one synth

85 show that the 26-residue peptide "MelP5", a synthetically evolved gain-of-function variant of the be

86 To facilitate synthetically feasible derivatives, an alternative core

87 e nanoporous carbon material MSC-30 was post-synthetically functionalized by oxidation.

88 erimental, empirical calibration curve and a synthetically generated one, on the basis of a reliable

89 on microsphere transport dynamics through a synthetically grown hepatic arterial tree.

90 New insight into the synthetically important aldol reaction and state-of-the-

91 A wide range of synthetically important and advanced indoline analogues

92 amidophosphite ligands L2 and L3, generating synthetically important chiral building blocks in good y

93 he primary acetamide can be manipulated into synthetically important derivatives such as nitriles and

94 in allow for easy isolation of product 3 and synthetically important derivatives, a key advantage of

95 These insights delineate the synthetically important distinctions between Munchnones

96 of alkynes using the DMPU/HF complex yields synthetically important fluoroalkenes and gem-difluorome

97 precatalyst is highly active and can couple synthetically important heterocyclic substrates.

98 he selective construction of medicinally and synthetically important indole-based unsymmetrical triar

99 The reaction to form the synthetically important lactol, 6-hydroxy-2H-pyran-3(6H)

100 cope, allowing even the most challenging and synthetically important methylations to be accomplished

101 adapt existing enzymes for the catalysis of synthetically important reactions not previously observe

102 g allows electron densities to be tuned post-synthetically in ITO nanocrystals, independent of their

103 y that sex ratio distortion can be generated synthetically in the main human malaria vector Anopheles

104 nanowire field-effect transistor detector is synthetically integrated with a nanotube cellular probe.

105 phagy/mitophagy genes ATG8, ATG18, and ATG32 synthetically interact with CL synthase mutant crd1Delta

106 itionally, alpha-functionalized ketones gave synthetically interesting amido-, alkoxy-, aryloxy-, and

107 o broaden the scope of the transformation in synthetically interesting directions.

108 ve subsequently used this reactivity to post-synthetically introduce modifications including azides a

109 Two genes are synthetically lethal (SL) when defects in both are letha

110 oad-coverage applications such as extracting synthetically lethal genes from the cancer literature.

111 ilitating for instance the identification of synthetically lethal genes from the literature.

112 al studies show that arginine deprivation is synthetically lethal in argininosuccinate synthetase 1 (

113 ADI-PEG20 was synthetically lethal in ASS1-methylated bladder cells an

114 YHC1-R21A was synthetically lethal in the absence of Mud2 and syntheti

115 -(4-morpholinyl)-4H-1-benzopyran-4-one] were synthetically lethal in XRCC1-deficient compared with pr

116 Combined YAP and RAF or MEK inhibition was synthetically lethal not only in several BRAF-mutant tum

117 Multiple clinical trials targeting synthetically lethal partners and/or downstream signalin

118 we investigated ATR pathway inhibition as a synthetically lethal strategy for targeting CLL cells wi

119 hibitor, we investigated ATR inhibition as a synthetically lethal strategy to target CLL cells with T

120 y starving cells of glucose, EA proves to be synthetically lethal to highly glycolytic tumors.

121 To find genes whose inactivation is synthetically lethal to MYCN, we implemented a genome-wi

122 manner, we determined that PTEN and ATM were synthetically lethal when jointly inhibited.

123 east purine salvage pathway mutants that are synthetically lethal with AICAR accumulation.

124 Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation.

125 r laboratory has shown that loss of RAD52 is synthetically lethal with BRCA2 deficiency, while exhibi

126 Depletion of RAD52 is synthetically lethal with defects in tumor suppressors B

127 Moreover, DeltagpsB mutations are synthetically lethal with Deltapbp1a, but not Deltapbp2a

128 s that drugs decreasing LptD assembly may be synthetically lethal with inhibitors of the Dsb pathway,

129 The results indicated that crd1Delta is synthetically lethal with mutants in pyruvate dehydrogen

130 ion in the Spt5 CTD-binding site of GTase is synthetically lethal with mutations in the Pol2 CTD-bind

131 YHC1-(1-170) was synthetically lethal with mutations of all components in

132 Pol epsilon proofreading deficiency) and is synthetically lethal with pol2-M644G (encoding altered P

133 Both complexes are epistatic with BRCA2 and synthetically lethal with Rad52.

134 gle therapeutic agent has been identified as synthetically lethal with SMARCA4/BRG1 loss.

135 in lipopolysaccharide assembly, lptD4213, is synthetically lethal with the deletion of dsbB as well a

136 was to identify chemical compounds that are synthetically lethal with VHL deficiency in CC-RCC.

137 e stressed UPR seen intrappc11mutants and is synthetically lethal withtrappc11mutation.

138 found that rdi1Delta bem2Delta mutants were synthetically lethal, suggesting that they also act in p

139 Although LTAs and WTAs are synthetically lethal, we report that they do not have th

140 Carbohydrates are especially difficult to synthetically manipulate because of the similar reactivi

141 The post-synthetically metalated BINAP-MOFs provide a versatile f

142 linker, BINAP-MOF, was synthesized and post-synthetically metalated with Ru and Rh complexes to affo

143 By using synthetically methylated DNA, we were able to train a hi

144 uester polyadenine-containing nucleotides to synthetically mimic RNA granules.

145 Numerous natural nucleosides and their synthetically modified analogues have been reported to h

146 s of unmodified and posttranscriptionally or synthetically modified RNA.

147 Here, we synthetically modified several moieties of the KCNQ2-5 c

148 omprising the so-called A/B ring system, was synthetically modified to provide antibacterially active

149 Proteins synthetically modified with a simple aromatic boronate m

150 Instead of synthetically modifying the internal surface structure o

151 late-stage transformations conducted on the synthetically more accessible C-terminus hydroxymethyl a

152 zation of LNA uridines as an alternative and synthetically more straightforward approach to improve t

153 tutorial review is limited to the simplest, synthetically most accessible self-assembling minidendro

154 Here we synthetically optimize the retrotransposon Ty1 to enable

155 and (Ph4P)2[VO(C9H6S8)2] (4), we are able to synthetically place a spin-laden propyl moiety at well-d

156 egard to their ability to detect variants in synthetically pooled Illumina sequencing data, by creati

157 characterized the fragmentation pattern of a synthetically prepared dityrosine cross-linked dimer of

158 Our data comparing a series of synthetically prepared HS block copolymers support a pre

159 s) interactions with its client proteins use synthetically produced heparin mimetics with defined str

160 Developing a synthetically produced stabilized virus-like particle (s

161 ndamental advantages of viruses, compared to synthetically programmed materials, include the highly p

162 On the basis of these findings, we synthetically re-derived an infectious full-length SHC01

163 utes to design in silico a large database of synthetically realistic PPN materials.

164 se results show that iPOLYMER can be used to synthetically reconstitute the nucleation of biologicall

165 s from a chronically infected individual, we synthetically reconstructed virus-like particles (VLPs)

166 We used tiled CRISPR activation (CRISPRa) to synthetically recruit a transcriptional activator to sit

167 roducts being suitable precursors to prepare synthetically relevant chiral nonfunctionalized alcohols

168 athesis polymerization (ROMP) catalyst under synthetically relevant conditions (e.g. unmodified indus

169 This review covers catalytic and synthetically relevant methods for direct condensation o

170 Synthetically relevant polycyclic building blocks featur

171 all with conventional halenium donors under synthetically relevant reaction conditions.

172 ty through transient enamine formation, this synthetically relevant transformation is easy to perform

173 ocycloaddition chemistry with an emphasis on synthetically relevant, regio-, and stereoselective reac

174 which a hydrogen bond in the NBD peptide is synthetically replaced by a non-labile bond, shows an ab

175 ty and tunable physicochemical properties of synthetically robust polymeric systems to facilitate tar

176 thetically lethal in the absence of Mud2 and synthetically sick in the absence of Nam8, Mud1 and Tgs1

177 re of TMA is to interrogate mutants that are synthetically sick when two other genes are deleted but

178 n the absence or in the presence of the most synthetically significant donor solvents tetrahydrofuran

179 Synthetically simple and selectively antibacterial, thes

180 Access to synthetically simple monomers will accelerate the use of

181 riggers the self-assembly of nanolasers in a synthetically simple process.

182 e morphology unlike any other spider silk or synthetically spun polymer fiber.

183 In this study, we report the production of synthetically stabilized PV VLPs in plants.

184 ionalization of pyrimidines is a general and synthetically straightforward approach to modulate bioph

185 fied several new hypothetical MOFs which are synthetically targetable.

186 Accordingly, synthetically tethering hnRNPK to Xist RNA lacking XR-PI

187 hallenge remains in replicating the strategy synthetically, that is at will, and differentially, that

188 etworks and explore both computationally and synthetically the design space of possible dynamical mec

189 ices and are often extensively modified post-synthetically to suit local requirements and development

190 Here we report the structure-based design of synthetically tractable, potent, and extremely selective

191 degrees of freedom, respectively, and their synthetically tuned and modulated properties have led to

192 al) and, thereby, emission properties can be synthetically tuned by either withholding or including t

193 ereotype, and provide dendrimers that can be synthetically tuned to be used in applications such as s

194 ve proposition because it allows chemists to synthetically tweak various kinetic and thermodynamic fa

195 ne primary products can be protected to form synthetically ubiquitous pinacol boronate esters or used

196 tions of 1,3-dienes represent a powerful yet synthetically underutilized class of reactions.

197 Herein, we demonstrate that synthetically unexplored but readily accessible benzothi

198 Synthetically useful (E)-alkenyl-CF3 building blocks and

199 opening coupled with SO2 extrusion provided synthetically useful 1,2-diamines.

200 to aldehyde substrates, providing a range of synthetically useful 1,3-dicarbonyl products in excellen

201 dioxane to provide the adducts possessing a synthetically useful 1-bis-sulfonyl-3-nitroalkene moiety

202 talyst from decomposition while preserving a synthetically useful 13 mus excited state and produces s

203 ightforward approach to pharmaceutically and synthetically useful 2-aminobenzoxazole and 4-aminoquina

204 A convenient method for the preparation of synthetically useful 3-iodoindene derivatives has been d

205 emote hydrocarbofunctionalization of several synthetically useful alkene-containing substrate classes

206 s, isatins, and imines to deliver a range of synthetically useful allylic alcohols and amines in high

207 es with aliphatic alcohols allows to produce synthetically useful alpha,beta- and beta,gamma-unsatura

208 strates undergo fragment coupling to produce synthetically useful alpha-amino-substituted motifs.

209 cient intramolecular process readily affords synthetically useful amino alcohols with excellent selec

210 Synthetically useful aminodioximes are prepared via a no

211 ing a Cu(II) catalyst and provides access to synthetically useful and pharmaceutically relevant alpha

212 d conditions, and tolerates a broad range of synthetically useful aromatic functionality.

213 anipulated in a variety of ways to result in synthetically useful bond constructions.

214 e highly diverse one-step transformations to synthetically useful building blocks, such as flavones,

215 of relatively inert C-H bonds with the more synthetically useful C-OH group.

216 Friedel-Crafts acylation reaction to produce synthetically useful carboxylic acid derivatives.

217 des, allowing for high-yielding formation of synthetically useful chiral [3.1.0]-bicyclic aziridines

218 s with beta-trifluoromethyl enones generates synthetically useful dihydropyranones containing a stere

219 not readily achieved when more reactive and synthetically useful electron-deficient quinones are use

220 We describe the synthetically useful enantioselective addition of Br-CX3

221 up tolerance, and operational simplicity are synthetically useful features.

222 The derivatives of 7-amino indole are synthetically useful for accessing a variety of natural

223 f hindered terminal alkenes to various other synthetically useful functional groups, resulting in for

224 Synthetically useful hydrocarbon oxidations are catalyse

225 cific ring contractions, providing access to synthetically useful hydroxymethyl cyclopropanes.

226 lylic alcohols and allylic silyl ethers is a synthetically useful isomerization process that occurs v

227 We describe herein a synthetically useful method for the enantioselective int

228 Here we report a robust and synthetically useful method that overcomes the complicat

229 everal important common pathways involved in synthetically useful organic reactions catalyzed by phot

230 otocol allows easy access to a wide range of synthetically useful ortho-OCF3 aniline derivatives.

231 tive DoL protocols; this thus represents the synthetically useful protocol for the DoL of dman in a o

232 A synthetically useful protocol has been developed for the

233 own since the late 1960s, the development of synthetically useful protocols that allow for a high lev

234 ods based on N-carbamoyl imines, focusing on synthetically useful protocols.

235 modynamic preference of an olefin, providing synthetically useful quantities of a kinetically favored

236 Synthetically useful radical thiol-ene reactions can be

237 nds (C-H) is important in the development of synthetically useful reactions, owing to the proximity-i

238 for creating tailored biocatalysts for many synthetically useful reactions.

239 on of alkynes into versatile 1,3-dienes with synthetically useful scope under mild reaction condition

240 ge of heteroaryl and aryl systems as well as synthetically useful secondary and tertiary amide, urea,

241 resolution of select trans-epoxides to give synthetically useful selectivity factors of 17-23 for be

242 The synthetically useful selectivity observed with cobalt wa

243 )R(5)SiH, R(4), R(5) = H or R(3)) to produce synthetically useful silylphosphines (R(1)R(2)P-SiR(3)R(

244 N-sulfamoylaziridines have proved to be more synthetically useful synthons that afford crystalline po

245 through cross-coupling reactions to generate synthetically useful tetrasubstituted alkenes.

246 protocol can be applied to the synthesis of synthetically useful thioynol ethers.

247 orresponding beta-amino derivative discloses synthetically useful transformations, exploitable to gen

248 idyl radicals, which are involved in various synthetically useful transformations, including olefin a

249 These intermediates undergo a variety of synthetically useful transformations, which include tran

250 lectronic effects and stereoselectivity with synthetically useful transformations.

251 ptane at ambient temperature in a variety of synthetically useful ways.

252 was developed in order to obtain products in synthetically useful yield and enantioselectivity.

253 oxidant and a palladium catalyst results in synthetically useful yields of alpha,beta-unsaturated es

254 directing group on the substrate, and gives synthetically useful yields with only 1 equiv of arene.

255 The method shows broad scope, proceeds in synthetically useful yields, and provides a rare means t

256 and provides access to complex structures in synthetically useful yields, hereby offering a viable al

257 ctionalized non-C2-symmetric naphthalenes in synthetically useful yields.

258 h nitrones to give isoxazolidine products in synthetically useful yields.

259 cally enriched chiral gamma-amino ketones in synthetically useful yields.

260 imple, noncyclic tertiary alkyl amines under synthetically useful, mild conditions through a biologic

261 rnative radical processes, thereby providing synthetically useful, temperature-controlled reaction ou

262 ions of isoelectronic CO, and they may prove synthetically useful.

263 product could be further oxidized to yield a synthetically valuable 1,2-diketo building block.

264 Organoboranes are some of the most synthetically valuable and widely used intermediates in

265 thods and increases the accessibility of the synthetically valuable aryl halide compounds.

266 conversion of readily available amines into synthetically valuable aziridines in high enantiomeric r

267 he Troger's base compounds resolved are four synthetically valuable bromo and iodo derivatives.

268 iants of sperm whale myoglobin catalyze this synthetically valuable C-C bond-forming transformation w

269 hyde olefination and extends the spectrum of synthetically valuable chemical transformations accessib

270 r the first time to allylic ethers, yielding synthetically valuable enantioenriched (up to 97% ee) en

271 the development of new breakthroughs in the synthetically valuable field of diazo chemistry.

272 This reaction generates synthetically valuable N-heterocyclic organoboron compou

273 to vicinal primary diamines as well as other synthetically valuable nitrogen-containing building bloc

274 ilbenes to phenanthrenes is a well-known and synthetically valuable reaction.

275 metal complexes to catalyze a broad range of synthetically valuable reactions.

276 ion via inductive effect can result notable, synthetically valuable regioselectivity.

277 ation of readily available silyl ethers into synthetically valuable silyl enols.

278 an intermediates provide efficient access to synthetically valuable substituted alpha-benzyloxyvinyl

279 This method tolerates a range of synthetically valuable substrates that have been all inc

280 ate) with high yield and (Z)-selectivity for synthetically valuable vinylboronate esters is described

281 s which provide a broad range of epoxides in synthetically valuable yields and short reaction times.

282 ylene sites, providing oxidation products in synthetically valuable yields.

283 Synthetically versatile 3,3-disubstituted fluorooxindole

284 thered alkenes and external imines, yielding synthetically versatile bicyclic cyclobutanones and beta

285 These synthetically versatile bicyclic isoxazolidines allowed

286 regioselectively form polycycles containing synthetically versatile C(sp(2) )boronate esters.

287 These studies not only provide access to synthetically versatile cyclobutanones that cannot be pr

288 enerally good to excellent efficiencies, and synthetically versatile cyclopentanones including spiro-

289 kanes as the alkylating agents, and delivers synthetically versatile five-membered carbocycles contai

290 cyclization of alpha-boryl enamides leads to synthetically versatile isoindolones.

291 The imine partner bears the synthetically versatile N-Cbz group, avoiding the use of

292 ent to an unprotected secondary amine into a synthetically versatile nitrogen heterocycle.

293 , this method is demonstrated to provide the synthetically versatile photosensitizer [Ir(ppy)2(dtbbpy

294 llow for the formation of a diverse range of synthetically versatile products from simple precursors.

295 ild conditions, providing a direct access to synthetically versatile silylated compounds.

296 ines, to address challenges posed by several synthetically versatile substrate classes.

297 nd the feedstock gas carbon monoxide to form synthetically versatile value-added amide products.

298 development of a tight-binding, orthogonal, synthetically versatile, and informationally interfaced

299 lylation of few products is shown to furnish synthetically viable enantioenriched 2-oxindoles with C-

300 One of these models, featuring the synthetically viable indanylidenepyrroline framework, ha