ライフサイエンスコーパス: synthon

1 eld (8 steps from Evans' chiral dipropionate synthon).

2 from 2-alkynylbenzaldehydes (1) as a common synthon.

3 The quinone can function as a (CF)(4) synthon.

4 synthon, or the alpha-keto ester homoenolate synthon.

5 eactions to the latent C(7)-C(11) dialdehyde synthon.

6 currently underutilize this versatile carbon synthon.

7 he cubane core as a masked cyclooctatetraene synthon.

8 ilylmethyl)benzotriazole (1) as a one-carbon synthon.

9 ed by unequivocal synthesis from a diltiazem synthon.

10 ient use of dimethyl malonate as a methylene synthon.

11 d by a short synthesis of a (+)-peloruside A synthon.

12 talysts for amine methylation using CO2 as a synthon.

13 ely completes the coordination sphere of the synthon.

14 (1)-N:eta(1)-O)-NO2 motif, derived from this synthon.

15 ation states, can be regarded as interesting synthons.

16 ly converted into a variety of useful olefin synthons.

17 yloxy ketones produced are polyvalent chiral synthons.

18 )-5 are densely functionalized and versatile synthons.

19 derivatized peptides that serve as valuable synthons.

20 ndolyl)methane products, which may be useful synthons.

21 acid, starting from easily accessible chiral synthons.

22 the practical synthesis of important chiral synthons.

23 -1-yl)methyl]amines 3 as 1,3-biselectrophile synthons.

24 he preparation of C-13 paclitaxel side chain synthons.

25 2S leads to a range of >99:1 er difunctional synthons.

26 aryl/1-heteroaryl propargylic alcohols as C2 synthons.

27 diverse set of oxygen-functionalized chiral synthons.

28 lowed the preparation of the tetrahydrofuran synthons.

29 products are easily transformed into useful synthons.

30 ta,gamma-unsaturated alpha-keto esters as C4 synthons.

31 urans as powerful nucleophiles and versatile synthons.

32 on of the products into valuable and complex synthons.

33 In yet another strategy, the synthon 1 was condensed with nitromethane followed by el

34 lkynyl)benzene species 2 via condensation of synthon 1 with nitromethane followed by a [3 + 2] cycloa

35 tioselective and stereospecific syntheses of synthon 17 and its attachment to the five-membered ring

36 Synthons 18 and 27 reacted with Grignard reagents, allyl

37 The new synthon 18F-FBEM developed in this study will also be us

38 The synthon [2-(pivaloylamino)pyrid-3-yl]oxoacetic acid ethy

39 with DIBAL-H or LiAlH4 affords the versatile synthons, 2-alkyl-propane-1,3-diols or those 3-protected

40 Also, a homologous synthon 23 with an attached dihydropyran ring was succes

41 des of D(-)-penicillamine, prepared from the synthon 3-formyl-2,2,5,5-tetramethylthiazolidine-4S-carb

42 d widespread use as masked beta-oxo carbonyl synthons 3, the possibility that 2,5-cyclohexadienones 5

43 al synthesis of d4-iPF2alpha-VI by using two synthons, (3,3,4,4-d4)-hexylphosphonium bromide 23 prepa

44 and finally, amidation to afford the ring-D synthon 45 having the proper geometry and oxidation stat

45 -free synthesis of a versatile 1,2-azaborine synthon 5 is described.

46 of the melampomagnolide-B-triazole carbamate synthon 6 with various terminal diamino- and dihydroxyal

47 ed N-donors using Pd-catalysis from a common synthon affording access to pyridinyl triazines as the 4

48 ADO (2-azaadamantane-N-oxyl) with an iron(I) synthon affords iron(II)-nitroxido complexes ((Ar) L)Fe(

49 Direct modification of the hydrogen-bond synthon after macrocyclization proceeds smoothly to furn

50 the O-(9-fluorenemethyl)-H-phosphonothioate synthon and oxidation with elemental sulfur.

51 methyl-2,3-butadienoate acts as a 1,4-dipole synthon and undergoes [4 + 2] annulation with N-tosylimi

52 ine interaction is an interesting biological synthon and will allow for the future development of imp

53 We introduce unexplored, alpha-enaminone synthones and reveal the unusual functionalities of thes

54 n between diazooxindoles as electrophilic C1 synthons and 1,3-heterodienes for the construction of sp

55 s was devised employing allene ketones as C2 synthons and beta,gamma-unsaturated alpha-keto esters as

56 ces highlight the complementarity of organic synthons and boron clusters, and therefore the feasibili

57 was then labeled with (18)F using this novel synthon, and the resulting imaging probe was subjected t

58 ally prepared from chiral protected glycerol synthons, and the alpha-monofluoromethylene-substituted

59 interaction and can be utilized as an Fe(I) synthon ((Ar)L = 5-mesityl-1,9-(2,4,6-Ph3C6H2)dipyrrin).

60 By parallel processing, these synthons are efficiently joined into multisynthon approx

61 Synthons are then assembled into longer full-length sequ

62 The utility of metabolic synthons as the building blocks for new biomaterials is

63 teps--highly improved syntheses of many C6On synthons as well as several previously undescribed produ

64 The different synthons being put into practice by the use of lithiated

65 unique molecular features of the morpholine synthon bestows selectivity against class I PI3Ks.

66 these R(P) chiral methylphosphonate linkage synthons bind RNA with significantly higher affinity tha

67 synthon -O-CO- in lieu of the supramolecular synthon Br...Br in the precursor.

68 ic labeling was achieved using the following synthons: bromo[2-(13)C]acetic acid, [(13)C]formic acid,

69 This highly versatile class of synthons can be subjected to Suzuki cross coupling affor

70 These dimer synthons can be used to prepare (i) all-MP linked oligon

71 idines with dimethyl sulfoxide as the carbon synthon (CH2) using H2O2 as a mild oxidant under air.

72 tural products synthesis adopting the Chiral Synthon (Chiron) Approach and spanning nearly 50 years o

73 roach to asymmetric synthesis to a versatile synthon class.

74 The reactivity patterns involved and the synthons derived from alkoxyallenes are presented.

75 arbonyl fluoride 2a is a particularly useful synthon due to its high yield of preparation and easy is

76 macrocyclic lactam 4 as one of the important synthons (eight steps).

77 assium trinitromethanide as a 1,1-ambiphilic synthon equivalent for the construction of a benzofuran

78 and their reactivities as CN(+) and R-CC(+) synthons evaluated, respectively.

79 peroxo-Cu compounds, using a "naked" complex synthon, [(F8)Fe(III)-(O2(2-))-Cu(II)(MeTHF)3](+) (MeTHF

80 The other synthon (five steps) was bicyclo[6.3.0] lactam 5 contain

81 Thus, 1 is found to be a reliable synthon for [{Fe(NO)(2)}(9)](+).

82 The latter is a useful synthon for assembly of L-threo-sphingoid bases: long-ch

83 TPP was successfully employed as a versatile synthon for convenient synthesis of a wide range of beta

84 on of Meldrum's acid to generate a versatile synthon for highly fluorinated alpha-phenyl acetic acid

85 keto-ketal 2, employed a dioxenyl group as a synthon for installing a corticosteroid side chain in ke

86 ilicon fragment is promising as a convenient synthon for labeling potential PET radiotracers.

87 alpha-fluoro aldehydes, an important chiral synthon for medicinal agent synthesis.

88 To establish 1 as a synthon for n-type organic semiconductors, the compound

89 romethyl stereogenicity, an important chiral synthon for pharmaceutical, materials, and agrochemical

90 ative 4 is shown to be a potential triagonal synthon for polymers and other macromolecules.

91 C halogen bonds could provide a valuable new synthon for supramolecular chemists.

92 its reaction with dinitrogen, 4 behaves as a synthon for the 14-electron fragment [Cp*(dmpe)W]+, to g

93 Noviose is a key synthon for the construction of novobiocin, a clinically

94 Furthermore, it serves as a convenient synthon for the development of challenging higher-order

95 e (difluoroamino)silane has promise as a new synthon for the introduction of the -NF2 group into a va

96 en achieved using a newly developed 1,3-diol synthon for the introduction of two key stereogenic cent

97 building block 9 is proposed as a universal synthon for the preparation of branched and branched cyc

98 Compound I is shown to be a synthon for the preparation of trans-Mo2(T(i)PB)2(ThCCPh

99 ha-formyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.

100 ctionality as well as providing an efficient synthon for the requisite methylamino group at C9.

101 The cyclopentenone unit is a very powerful synthon for the synthesis of a variety of bioactive targ

102 utyliminoborane is found to be a very useful synthon for the synthesis of a variety of functionalized

103 xadieno-oxazolidino-quinolinols, as valuable synthons for a broad range of post-photochemical transfo

104 ificity, allylic gem-dicarboxylates serve as synthons for a double allylic transformation.

105 ns enable these silicon dienes to be used as synthons for a variety of other dienes one might prepare

106 Useful synthons for beta-polycarbonyl derivatives are branched

107 phthyl alcohols represent potentially useful synthons for chiral ligands and auxiliaries.

108 ghly selective nanoscale sensors, as well as synthons for defect-free self-assembly.

109 reagents are shown to be effective umpolung synthons for enantioselective additions to N-Boc-aldimin

110 reagents are shown to be effective umpolung synthons for enantioselective Michael addition to substi

111 tial utility of [(18)F]sulfonyl fluorides as synthons for indirect radiolabeling.

112 acid, amide, and amine derivatives as useful synthons for medicinal chemistry targets.

113 eate chiral 4-hydroxy-2-oxoacid skeletons as synthons for organic reactions.

114 were utilized as alternative to cyanohydrin synthons for preparation of the corresponding heteroaryl

115 4-Deoxypentenosides (4-DPs) are versatile synthons for rare or higher-order pyranosides, and they

116 f robust supramolecular motifs that serve as synthons for the assembly of crystal lattices.

117 bsequently, they were recognized as valuable synthons for the construction of a wide range of compoun

118 yfunctional intermediates serve as versatile synthons for the construction of various chiral compound

119 is of 2-halogenated cordycepins, also useful synthons for the development of additional novel C2-subs

120 opure 4-formyl-beta-lactams were deployed as synthons for the diastereoselective formation of chiral

121 0] bicyclic aziridines prove to be versatile synthons for the preparation of a diverse range of 1,2-

122 g the 5-hydroxy-isoxazolidines that serve as synthons for the preparation of N,O-nucleoside analogues

123 n, the potential of H-phosphinates as useful synthons for the preparation of other organophosphorus c

124 These characteristics make them attractive synthons for the production of industrially and medicall

125 The chiral beta-borylated amides are useful synthons for the synthesis of chiral beta-hydroxylated,

126 isting routes for accessing useful synthetic synthons for the synthesis of complex terpenoids.

127 (>90% ee), which are versatile chiral (18)F synthons for the synthesis of radiotracers.

128 As attractive synthons for these, N-protected (2S,4S)-4-fluoropyrrolid

129 idered inert substrates, can be harnessed as synthons for use in reactions that form C-C bonds throug

130 diarylmethylbenzaldehydes, which are useful synthons for various organic transformations.

131 [5Fe-5S] cluster is the site of Fe(CO)x(CN)y synthon formation and that the limited bonding between t

132 Although it is thought that the site of synthon formation in HydG is the "dangler" Fe of a [5Fe]

133 The use of this umpolung synthon has enabled, in enantiomerically enriched form,

134 carbonates of acetylenic aldehydes as handy synthons has allowed a facile synthesis of azaspirocyclo

135 n contaminated soil and generation of chiral synthons have been the major foci of RO research.

136 tically equivalent to a cyclopent-2-en-1-one synthon having opposite donor and acceptor properties at

137 esolved including the full ligand set of the synthon, how the dangler Fe initially binds to HydG, and

138 coupling of a bromochlorin with a one-carbon synthon (hydroxymethyl tributyltin or CO) to give a 13-,

139 e preparation of what should become a useful synthon in synthetic organic chemistry.

140 4-(trimethylsilyl)nicotinonitrile as the key synthon in the preparation of highly substituted 2-amino

141 f silyl glyoxylates as dipolar glycolic acid synthons in a controlled oligomerization reaction for th

142 Furans and pyrroles are important synthons in chemical synthesis and are commonly found in

143 d their close analogues, which are important synthons in organic synthesis and for the preparation of

144 esize 2-acyloxyacrylamides, which are useful synthons in organic synthesis.

145 eed for protecting groups, yielding powerful synthons in previously unreported mild conditions.

146 y of 2-azidofucosyl (FucN3) donors, valuable synthons in the synthesis of 2-acetamido-2-deoxyfucose (

147 ominant (regularly occurring) supramolecular synthons in these crystal structures are (1) the heterom

148 nthesized as approximately 500 bp fragments (synthons) in a two-step PCR reaction and cloned using li

149 In the new approach a preformed rotaxane synthon is attached to the end of an otherwise fully for

150 s serves as the ligand platform on which the synthon is built and plays a role in both Fe(2+) binding

151 scopic analysis of HydG before and after the synthon is formed, we conclude that Cys serves as the li

152 The oxirane synthon is obtained with an anti configuration fitting t

153 gler Fe initially binds to HydG, and how the synthon is released at the end of the reaction.

154 [1-(I)2] and [1-(II)2] in which the mercury synthon is sandwiched by two molecules of the palladium

155 ient methodology for the obtainment of these synthons is highly desirable.

156 Ready access to (18)F-labeled aryl synthons is required for preparing novel radiotracers fo

157 dition of 1-azidoadamantane to the diiron(I) synthon LRFeNNFeL R (L R = HC[C(R)N(2,6- iPr 2C 6H 3)] 2

158 was synthesized by means of the beta-lactam synthon method using 10-modified 7-(triethylsilyl)-10-de

159 are synthesized by means of the beta-lactam synthon method.

160 was synthesized by means of the beta-lactam synthon method.

161 beling RGD peptides through a thiol-reactive synthon, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide (18

162 lorobenzoate, by introduction of a molecular synthon -O-CO- in lieu of the supramolecular synthon Br.

163 the 18-nor Grundmann type alcohol (C,D-ring synthon), obtained by oxidative degradation of vitamin D

164 The utility of 1 as an enolate synthon of homoglycine (beta-alanine) is illustrated by

165 hols that are either the structural units or synthons of many important organic molecules as well as

166 tonitrile derivatives are thus umpolung-type synthons of the corresponding aryl carbonyl functionalit

167 isulfide or sulfonate ester functionalities (synthons of the eventual sulfonic acid groups) are synth

168 on by a new strategy beginning with ring-B,C synthons of type 19 (bis-iododipyrrins).

169 orphyrin architectures bearing hydrogen-bond synthons on a xanthene platform is presented.

170 glycolic acid synthon, the glyoxylate anion synthon, or the alpha-keto ester homoenolate synthon.

171 ause of incomplete cleavage, PivCN-protected synthons performed well and allowed the generation of ol

172 The reaction of TEMPO with the iron(I) synthon PhB(MesIm)(3)Fe(COE) leads to formation of the k

173 Thus, the methodology using the synthons prepared by the stereospecific double fluorinat

174 ynthesis features the use of the enantiopure synthon, prepared in a set of highly stereoselective rea

175 lationships established for three novobiocin synthons produced optimized scaffolds, which manifest mi

176 employs nitroalkenes as latent 1,2-dication synthons providing a novel access to highly useful symme

177 [PhB(tBuIm)3Fe-N(CH2CHPh)] acts as a nitride synthon, reacting with electron-poor styrenes to generat

178 This multifunctional fluorine synthon reacts with carbonyl compounds under WHE conditi

179 ane sesquiterpenes, from a chiral, tricyclic synthon, readily available via an enzymatic resolution s

180 and plays a role in both Fe(2+) binding and synthon release.

181 ch assemble via shape complementarity (shape synthons), reliably form low energy slip planes, thus fa

182 xpected since the two primary supramolecular synthons remain intact.

183 These synthons represent the core structure of the furaquinoci

184 he path to alternate monocyclic and bicyclic synthons representing the basis of a myriad of bioactive

185 vised for preparation of the required A-ring synthons, starting from the chiral compound derived from

186 -based nanopropeller 1 by using an efficient synthon strategy involving sequential intramolecular bis

187 sors for producing useful (18)F-labeled aryl synthons, such as (18)F-labeled halomethylbenzenes, benz

188 formed by fluctuations in the supramolecular synthons, suggesting a nucleation and growth mechanism i

189 as further modified with the metal-chelating synthon terpyridine.

190 orms Fe and L-tyrosine into an [Fe(CO)2(CN)] synthon that is incorporated into the H cluster.

191 und species as an organometallic Fe(CO)2(CN) synthon that is ultimately transferred to apohydrogenase

192 ng the enantiomer of the C,D-ring side-chain synthon that leads to ent-cholesterol, the A- and B-ring

193 c products form an enzyme-bound Fe(CO)x(CN)y synthon that serves as a precursor for eventual H-cluste

194 have proved to be more synthetically useful synthons that afford crystalline polycyclic structures i

195 -methyl-5H-inden-5-o ne, C,D ring-side chain synthons that can be used for the synthesis of enantiome

196 The products of these additions are useful synthons that contain termini capable of differentiation

197 nyl-, and 2-formyl-1,4-benzodioxane, are key synthons that for the most part are never described as e

198 By initially synthesizing smaller fragments (synthons), the number of clones sequenced is low compare

199 etic equivalent to the dipolar glycolic acid synthon, the glyoxylate anion synthon, or the alpha-keto

200 We have developed a new phosphoramidite synthon--the alkynyl phosphinoamidite, which is compatib

201 d HydG may facilitate transfer of the intact synthon to its cognate acceptor for subsequent H-cluster

202 nyl acetates, exploiting disubstituted silyl synthons to afford silyl acetals and Rh-catalyzed ortho-

203 ightforward chemical design of the molecular synthons to create spontaneous polarization and to adjus

204 g and applies the concepts of supramolecular synthons to molecular systems constrained to 2D by physi

205 and diformylated azaBODIPYs are very useful synthons to prepare a wide variety of new fluorescent co

206 resulting dinuclear species were utilized as synthons to prepare bimetallic trinuclear clusters.

207 s condensed with various azomycin-containing synthons to produce chemical compounds that could chelat

208 re synthesized using a novel phosphoramidite synthon, tris-2,2,2-[3-(4,4'-dimethoxytrityloxy) propylo

209 gh-yielding synthesis of the valuable U(III) synthon [U(BH4)3(THF)2] is reported.

210 This synthon undergoes effective Mitsunobu alkylation reactio

211 struction of the requisite vinyl nucleophile synthon using hydrostannylation of an alkyne was foiled

212 coli tRNA(Lys) was then assembled from these synthons using phosphoramidite coupling chemistry.

213 rylated products can be converted to various synthons via diverse transformations.

214 The preparation of a four-coordinate Co(II) synthon was achieved with the tripodal ligand, N,N',N"-[

215 A di-O-TBS protected glyceraldehyde synthon was condensed with Ellman's reagent to form a be

216 The synthon was derived from sequential use of the Noyori as

217 this synthesis was that a relatively complex synthon was obtained from simple and inexpensive startin

218 Notably, a spicifernin-like synthon was prepared with defined C22 stereochemistry in

219 first step in the preparation of appropriate synthons was condensation of bis(N,N-diisopropylamino)ph

220 a series of tri-, tetra-, and pentacarbonyl synthons was successfully synthesized.

221 Chirally pure dimer synthons were also prepared with 2'-O-methyl sugar modif

222 Subsequently, these synthons were examined in an ozonolysis/cyclization reac

223 To prepare the array, monomeric vancomycin synthons were linked through four distinct positions of

224 Synthons were sequentially added to this support using t

225 These synthons when activated with tetrazole were used with an

226 demonstrated by introducing phosphoramidite synthons where N-benzyloxycarbonyl (Z) protected amino a

227 es to generate synthetically useful a1,a3,d5-synthons which are prone to undergo multiple consecutive

228 vailable monoterpene (S)-carvone as a C-ring synthon, which is incorporated into the tetracyclic isos

229 importance and utility of the supramolecular synthon, which is one of the most important concepts in

230 efficiently transformed into a sesquiterpene synthon, which was converted into the corresponding brom

231 While these intermediates are convenient synthons, which are readily available from several commo

232 cognate structures may act as supramolecular synthons, which, given their chirality, may even be amen

233 ction of 3-alkenylpyrroles/-thiophenes as C4 synthons with 1-aryl/1-heteroaryl propargylic alcohols a

234 sis allows for the formation of novel chiral synthons with either absolute configuration.

235 gonucleotides are built into 500- to 800-bp "synthons" with low error frequency by automated PCR-base

236 with an integrated 1-nm pore as an 'aperture synthon', with manganese linkers yields a vast three-dim

237 The reactions of acyl anion equivalents (d1 synthons) with carbonyl electrophiles allow for the cons

238 striction enzymes allow seamless assembly of synthons without placing restrictions on the sequence be

239 pid composition of novel key alpha-enaminone synthones yields an assembly of oxazines, azaspirones, q