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1 nfidence interval [CI], 8.6-15.2; P < 0.001; systemic: 9.0 points; 95% CI, 5.6-12.3; P < 0.001; P = 0
3 no acid pipecolic acid (Pip) regulates plant systemic acquired resistance and basal immunity to bacte
6 of sustained weight reduction in response to systemic administration of a long-acting analog of the g
9 al phenotypes of ASD, to test the effects of systemic administration of insulin-like growth factor II
11 in counteracts the behavioral effects of the systemic administration of mu-opioid receptor (MOR) agon
15 ected no significant differences in local or systemic adverse events or laboratory abnormalities betw
17 assess patterns of use and relative risks of systemic agents for moderate to severe psoriasis in chil
20 able region (IGVL) genes among patients with systemic (ALS) and localized (ALL) amyloidosis and to as
22 kg 6c either simultaneously or 18 h prior to systemic AMPH administration reduced both AMPH-stimulate
27 discuss recent progress in understanding the systemic and cellular mechanisms that underlie the regul
28 ation of nitroglycerin causes changes in the systemic and coronary circulation that combine to reduce
30 e specificities, avidities, and functions of systemic and mucosal immune responses elicited by a vacc
35 This study investigates accuracy of oral, systemic, and socioeconomic data on estimating periodont
37 Both groups received a course of empirical systemic antibiotics (amoxicillin and clavulanic acid, 3
39 These results provide a proof of concept of systemic antitumor activity after intratumoral CD40 trig
42 enome editing could be applied to many other systemic as well as liver-restricted disorders which are
43 on renders this neutrophil functional defect systemic, associated with an increase in arterial LPS an
44 sease is considered to be a manifestation of systemic atherosclerosis with associated adverse cardiov
45 ith LAR, the potential conversion to AR with systemic atopy and the development of asthma during 10 y
47 A as a novel type I IFN-independent model of systemic autoimmunity and implicate TLR-mediated NF-kapp
48 ines by eliciting local mucosal immunity and systemic B cell- and T cell-mediated memory responses.
50 a coli cells both ex vivo and in vivo During systemic candidiasis, the absence of alphaXbeta2 resulte
52 maternal body mass index (BMI) and offspring systemic cardio-metabolic profile are causal, via intrau
53 data suggest that exposure to PAHs may cause systemic changes during pregnancy that could lead to adv
55 ciation was independent of the use of modern systemic chemotherapy and remained in propensity score a
56 fin photodynamic therapy in combination with systemic chemotherapy therapies and oral corticosteroids
60 mpanied by debilitating neuropsychiatric and systemic comorbidities; and carry a grave risk of mortal
61 ded that SSGA and MSGA, which performed more systemic comparisons and analyses of edge weights and ne
62 1029] vs 23.7% [278 of 1174], P < .001) and systemic complications (24.2% [249 of 1029] vs 31.2% [36
76 overexpression in colorectal cancer cells or systemic delivery of the conditioned medium from LOX-ove
77 : reducing acute toxicities that result from systemic diffusion of many soluble adjuvants, and delive
81 te an in vivo response, specifically whether systemic drug exposure is crucial for in vivo efficacy.
82 ment in a horned beetle species by combining systemic dsx knockdown, high-throughput sequencing of di
85 h the role of hepatocyte NAD levels from any systemic effects of NR, we generated mice overexpressing
86 expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in
91 ulation therapy for the prevention of stroke/systemic embolism in patients with atrial fibrillation.
92 l effectiveness end point of ischemic stroke/systemic embolism, no significant differences of the NOA
93 e of SCAF in those with a history of stroke, systemic embolism, or transient ischemic attack was 39.4
94 s: in vivo response of neutrophils evoked by systemic endotoxin challenge, the clonal response of leu
96 corticoids (GCs) are important regulators of systemic energy metabolism, and aberrant GC action is li
97 rt here that in rats at 24 h withdrawal from systemic ethanol administration (either by intraperitone
102 sk of adverse effects, including nephrogenic systemic fibrosis (NSF), the untreatable condition recen
106 ling pathways in skeletal muscle to maintain systemic glucose homeostasis remains largely unexplored.
114 sponse of IL-1R1(-/-) mice did not reflect a systemic immune deficiency, because immunized IL-1R1(-/-
115 e studies demonstrate the critical impact of systemic immune responses that drive tumor rejection.
118 commensal enteric fungi safeguard local and systemic immunity by providing tonic microbial stimulati
119 ecific immunity, enhance previously existing systemic immunity or re-target responses to the mucosae.
120 ized and nonrandomized studies on therapies (systemic immunomodulating therapies or supportive care)
121 the present study is to examine presence of systemic immunoreactivity to A. actionmycetemcomitans Lt
122 ant-associated materials have a local and/or systemic impact on the peri-implant soft and hard tissue
125 ), promotes acute pulmonary inflammation and systemic infection after lung challenge with S. pneumoni
127 C57BL/6J mice are extremely susceptible to systemic infection by Salmonella Typhimurium because of
128 Reasons for isolated enterectomy included systemic infection in 11, gastrointestinal bleeding in 1
133 hat dietary Mn levels dictate the outcome of systemic infections caused by Staphylococcus aureus, a l
135 rols (n = 50), we measured parasite biomass, systemic inflammation (interleukin 6 [IL-6]), endothelia
137 tand the effects of psoriasis medications on systemic inflammation associated with cardiovascular ris
140 d support to a hypothesis implicating global systemic inflammation in HF with preserved ejection frac
141 nously, or per rectum; were on biomarkers of systemic inflammation in humans; and performed meta-anal
142 that plasmodial DNA is the primary driver of systemic inflammation in malaria, both within the phagol
143 hritis model and in IL-1beta- or LPS-induced systemic inflammation in vivo, IL-1R2(-/-) mice were cre
145 ecent findings suggest that an overexuberant systemic inflammation plays a primary role in ACLF progr
149 ng left ventricular and pulmonary pathology, systemic inflammation, and neurohormonal activation.
151 evidence supports the active involvement of systemic inflammation, in addition to local brain inflam
153 on in the early phase after fracture reduced systemic inflammation, the recruitment of immune cells,
154 rate that deregulated necroptosis results in systemic inflammation, tissue fibrosis, and autoimmunity
163 contrast, afferent cVN activation amplifies systemic inflammatory processes, leading to activation o
165 riteria, score discrimination was lowest for systemic inflammatory response syndrome (median area und
166 prospective identification of patients with systemic inflammatory response syndrome (SIRS) and sepsi
167 troduced quick SOFA (qSOFA), and removed the systemic inflammatory response syndrome (SIRS) criteria
170 psis-related Organ Failure Assessment score, systemic inflammatory response syndrome criteria, the Na
171 der the receiver operating characteristic of Systemic Inflammatory Response Syndrome for critical car
172 ic shock patients (defined: infection, >/= 2 systemic inflammatory response syndrome, and hypoperfusi
175 ndependently involved in the pathogenesis of systemic inflammatory rheumatoid arthritis (RA) and AD.
176 The data support the emerging idea of a systemic influence to neurological disorders and point t
177 e role of specific cell types in the eye vs. systemic influences (e.g., serum) on the disease patholo
178 lsed focused ultrasound (pFUS) combined with systemic infusion of ultrasound contrast agent microbubb
179 bese dog model, suggesting the importance of systemic inhibition of DGAT1 for body weight control.
181 podocyte-selective injury but more likely by systemic insults, a humanized xenograft model of FSGS re
186 ow that in nitrate-fed mice there is reduced systemic leukocyte rolling and adherence, circulating ne
187 also significantly associated with increased systemic levels of A. actinomycetemcomitans-specific imm
191 e population-based studies have been done on systemic lupus erythematosus (SLE) mortality trends in t
193 with several autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren's syndrome,
195 ic variants are associated with the risk for systemic lupus erythematosus (SLE); however, it is uncle
199 re associated with type I diabetes mellitus, systemic lupus erythematosus, RA, and celiac disease, th
200 uss the current and future impact of AMDs on systemic lupus erythematosus, rheumatoid arthritis, and
202 deficiency, exhibit a small eye defect, and systemic malformations including hydrocephaly and cardia
204 ular understanding of the pathophysiology of systemic mastocytosis have provided new therapeutic cons
206 ysteine therapy, delivered using a targeted, systemic, maternal, dendrimer nanoparticle (DNAC), in a
207 ed understanding of the associations between systemic medication use and intraocular pressure (IOP) i
209 ls that reported pain, function, or harms of systemic medications versus placebo or another intervent
213 oluntary) adipose tissue loss as well as its systemic metabolic consequences are far less understood.
214 t takes up and burns lipids and is linked to systemic metabolic homeostasis, we hypothesized that the
218 is was considered the most prevalent endemic systemic mycosis in the Americas, but this situation mig
220 taneous monitoring of anti-tumor potency and systemic off-tumor toxicity, micromolar affinity CAR T c
222 ion of the epitope specificities, locations (systemic or mucosal), and effector functions of antibodi
223 The aim of this study was to establish if systemic oxidative status in POAG patients was elevated
225 bacterial dissemination, and intestinal and systemic pathology of wild-type and CCR7-/- mice were as
227 Furthermore, while both cultivars developed systemic priming of chitosan-induced callose after singl
228 vulnerable populations is representative of systemic problems plaguing the regulation of chemicals i
230 form of meat allergy characterized by severe systemic reactions 3-7 h after consumption of red meat.
231 at the injection site, and the most frequent systemic reactogenic events were fatigue (29 [43%]), hea
233 inin (HA) protein substantially affected the systemic replication and pathogenicity of these H5N1 inf
234 This raises the question of the ecosystem's systemic resilience and its ability to rebound after lar
235 creasing current knowledge regarding induced systemic resistance (ISR) to pathogens and pests in whit
236 r iron with soil-borne pathogens or induce a systemic resistance that shares early signaling componen
238 iew, the long-distance signals implicated in systemic responses to various environmental cues are dis
240 To evaluate the efficacy and ocular and systemic safety of netarsudil 0.02% ophthalmic solution,
243 Here, we review the clinical features of systemic sclerosis and describe the best practice approa
247 oding RNAs are deregulated in skin tissue of systemic sclerosis patients suggesting a novel class of
248 y of proteins not previously associated with systemic sclerosis that provide insight into pathogenesi
251 the absence of large differences in risk of systemic serious adverse events between these two anti-V
259 ory symptoms requiring either antibiotics or systemic steroids, and severe events by the need for hos
260 T is effective in reducing severe subsequent systemic sting reactions and in improving disease-specif
261 -effective in those at high risk of repeated systemic sting reactions and/or impaired quality of life
262 and local treatment or by a therapeutic and systemic strategy, abolished IL-1beta- and GLAST-depende
265 s followed routinely every 4 months while on systemic sunitinib prescribed by her oncologist for meta
266 n and improved muscle strength, suggesting a systemic supply of FKRP protein acting as glycosyltransf
270 parison with a cohort receiving non-biologic systemic therapies in a propensity score-weighted Cox pr
271 The pipeline of more targeted topical and systemic therapies is expanding based on our growing und
272 linicians when choosing between non-biologic systemic therapies, etanercept, adalimumab, and ustekinu
274 assessment of tumor response to neoadjuvant systemic therapy (NST) in patients with breast cancer an
275 wed by adjuvant systemic therapy relative to systemic therapy alone for patients with breast cancer l
279 ness of liver resection followed by adjuvant systemic therapy relative to systemic therapy alone for
280 ans for treatment (surgery, radiotherapy, or systemic therapy) within 90 d for lung and 180 d for pro
281 estrogen-receptor status, type and timing of systemic therapy, menopausal status, statin use, and tre
284 teen patients were using a self-administered systemic therapy; 22.4% were classified as "non-adherent
285 clinical studies have in part described this systemic-to-brain signaling pathway, we lack information
287 ut its use to treat GBM is limited by severe systemic toxicity and inefficient penetration of brain t
293 e current era, with long-term survival after systemic treatment, there is a need for a timely diagnos
295 has changed due to the introduction of novel systemic treatments that can result in long-term surviva
296 l for priming of CD8(+) T cells that mediate systemic tumour rejection (abscopal effect) in the conte
297 may be a surrogate biomarker of cerebral and systemic vascular risk in patients with OSA requiring fu
298 e of clinical complications of pulmonary and systemic vasculopathy, including pulmonary hypertension,
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