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1 nfidence interval [CI], 8.6-15.2; P < 0.001; systemic: 9.0 points; 95% CI, 5.6-12.3; P < 0.001; P = 0
2   3-Acetonyl-3-hydroxyoxindole (AHO) induces systemic acquired resistance (SAR) in Nicotiana.
3 no acid pipecolic acid (Pip) regulates plant systemic acquired resistance and basal immunity to bacte
4                                We found that systemic acquired resistance induction in female inflore
5                                              Systemic administration in mice followed by local light-
6 of sustained weight reduction in response to systemic administration of a long-acting analog of the g
7                              As we expected, systemic administration of anti-DC-STAMP-mAb downregulat
8                                              Systemic administration of CTDP-32476 alone produced a s
9 al phenotypes of ASD, to test the effects of systemic administration of insulin-like growth factor II
10                                 We find that systemic administration of MS0021570_1 attenuates anxiet
11 in counteracts the behavioral effects of the systemic administration of mu-opioid receptor (MOR) agon
12                                              Systemic administration of the MIF inhibitor ISO-1 signi
13                                         Upon systemic administration, exogenous Mn exhibited varying
14 ebo groups, and only grade 1 (mild) local or systemic adverse events occurred in both groups.
15 ected no significant differences in local or systemic adverse events or laboratory abnormalities betw
16 th ECD enabled treatment with a new-targeted systemic agent.
17 assess patterns of use and relative risks of systemic agents for moderate to severe psoriasis in chil
18 ucidate how skin barrier defects can lead to systemic allergen sensitization.
19 bination therapy using unmodified myxoma and systemic alphaPD1 antibodies.
20 able region (IGVL) genes among patients with systemic (ALS) and localized (ALL) amyloidosis and to as
21                   These results suggest that systemic alterations in enterohepatic circulation, as we
22 kg 6c either simultaneously or 18 h prior to systemic AMPH administration reduced both AMPH-stimulate
23                                    The human systemic amyloid precursor protein transthyretin (TTR) i
24  diseases, type II diabetes, and a number of systemic amyloidoses.
25 cognized as one of the most common causes of systemic amyloidosis in North America.
26 tic use of this antibody in the treatment of systemic amyloidosis.
27 discuss recent progress in understanding the systemic and cellular mechanisms that underlie the regul
28 ation of nitroglycerin causes changes in the systemic and coronary circulation that combine to reduce
29       Severe Perkinsea infections (SPI) were systemic and led to multiorganic failure and death.
30 e specificities, avidities, and functions of systemic and mucosal immune responses elicited by a vacc
31        These include fibrils associated with systemic and neurodegenerative diseases and cancer, func
32                                              Systemic and ocular treatment with the TR antagonists NH
33 tance to Plasmodium infections as well as to systemic and oral bacterial infections.
34 ated cirrhosis is characterized by disturbed systemic and splanchnic hemodynamics.
35    This study investigates accuracy of oral, systemic, and socioeconomic data on estimating periodont
36            Combination therapy of ISF35 with systemic anti-PD-1 generates greater antitumor activity
37   Both groups received a course of empirical systemic antibiotics (amoxicillin and clavulanic acid, 3
38                                  Exposure to systemic antibiotics destabilized the wound microbiota,
39  These results provide a proof of concept of systemic antitumor activity after intratumoral CD40 trig
40                Finally, we demonstrated that systemic application of antibiotics significantly improv
41 ssociation between post-TAVR blood pressure, systemic arterial load, and mortality.
42 enome editing could be applied to many other systemic as well as liver-restricted disorders which are
43 on renders this neutrophil functional defect systemic, associated with an increase in arterial LPS an
44 sease is considered to be a manifestation of systemic atherosclerosis with associated adverse cardiov
45 ith LAR, the potential conversion to AR with systemic atopy and the development of asthma during 10 y
46             Systemic sclerosis is an orphan, systemic autoimmune disease with no FDA-approved treatme
47 A as a novel type I IFN-independent model of systemic autoimmunity and implicate TLR-mediated NF-kapp
48 ines by eliciting local mucosal immunity and systemic B cell- and T cell-mediated memory responses.
49                                     However, systemic blockade of HCN channels produces cardiac effec
50 a coli cells both ex vivo and in vivo During systemic candidiasis, the absence of alphaXbeta2 resulte
51                                              Systemic capillary-leak syndrome is a very rare cause of
52 maternal body mass index (BMI) and offspring systemic cardio-metabolic profile are causal, via intrau
53 data suggest that exposure to PAHs may cause systemic changes during pregnancy that could lead to adv
54 erative responses in heart muscle induced by systemic chemical suppression of Wnt signaling.
55 ciation was independent of the use of modern systemic chemotherapy and remained in propensity score a
56 fin photodynamic therapy in combination with systemic chemotherapy therapies and oral corticosteroids
57 atment that includes surgery, radiation, and systemic chemotherapy.
58  to inform decisions on withholding adjuvant systemic chemotherapy.
59 to higher proportions of unconjugated BPA in systemic circulation.
60 mpanied by debilitating neuropsychiatric and systemic comorbidities; and carry a grave risk of mortal
61 ded that SSGA and MSGA, which performed more systemic comparisons and analyses of edge weights and ne
62  1029] vs 23.7% [278 of 1174], P < .001) and systemic complications (24.2% [249 of 1029] vs 31.2% [36
63 he complexity of hepatic responses and their systemic consequences in other organs.
64                                              Systemic corticosteroid therapy was not significantly as
65    An exacerbation was defined as a burst of systemic corticosteroids lasting 3 days or more.
66  severity does not influence the response to systemic corticosteroids.
67 o inhaled corticosteroids, but responsive to systemic corticosteroids.
68 sthma exacerbations requiring treatment with systemic corticosteroids.
69                                              Systemic cytokine responses may differentiate ECs from s
70                                              Systemic defence responses depend on the spread of signa
71                                     Finally, systemic deletion of Cldn14 completely rescued the hyper
72                                     Overall, systemic delivery of a bispecific molecule targeting an
73           Here we show that locoregional and systemic delivery of a rAAV2/8 vector expressing a canin
74     In this study, we sought to characterize systemic delivery of a rAAV2/9 vector as a non-invasive
75                                              Systemic delivery of anti-miR-181b in angiotensin II-inf
76 overexpression in colorectal cancer cells or systemic delivery of the conditioned medium from LOX-ove
77 : reducing acute toxicities that result from systemic diffusion of many soluble adjuvants, and delive
78 e investigated the role of PLA2 in local and systemic disease during S. pneumoniae infection.
79 his chemotherapy agent and allow for reduced systemic doses.
80 ist compound (SC-51322) to AGN 197727 in the systemic dosing regimen.
81 te an in vivo response, specifically whether systemic drug exposure is crucial for in vivo efficacy.
82 ment in a horned beetle species by combining systemic dsx knockdown, high-throughput sequencing of di
83      Interventions that attenuate or reverse systemic dysfunction associated with age therefore have
84            Pharmacodynamic assessment of the systemic effect of inhaled corticosteroids (ICSs) is oft
85 h the role of hepatocyte NAD levels from any systemic effects of NR, we generated mice overexpressing
86  expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in
87 f variable severity with little or no direct systemic effects.
88 reduce the risk of radiation-related adverse systemic effects.
89 k and severity, supporting the hypothesis of systemic elemental dysregulation in ASD.
90              We compared the rates of stroke/systemic embolism at 1 year according to diabetes status
91 ulation therapy for the prevention of stroke/systemic embolism in patients with atrial fibrillation.
92 l effectiveness end point of ischemic stroke/systemic embolism, no significant differences of the NOA
93 e of SCAF in those with a history of stroke, systemic embolism, or transient ischemic attack was 39.4
94 s: in vivo response of neutrophils evoked by systemic endotoxin challenge, the clonal response of leu
95 rates multiple metabolic pathways to warrant systemic energy homeostasis.
96 corticoids (GCs) are important regulators of systemic energy metabolism, and aberrant GC action is li
97 rt here that in rats at 24 h withdrawal from systemic ethanol administration (either by intraperitone
98                                              Systemic evolution of ligands by exponential enrichment
99                                          The systemic exposure of the free drug was much lower than t
100       To describe associations of ocular and systemic factors with retinal pigment epithelium (RPE)-B
101 ibited as water was ingested, suggesting pre-systemic feedback gating of drinking.
102 sk of adverse effects, including nephrogenic systemic fibrosis (NSF), the untreatable condition recen
103   None of the neonates developed nephrogenic systemic fibrosis.
104 ctious agents, such as acid-fast bacilli and systemic fungi, were revealed.
105 o investigate the contribution of chymase to systemic GBS infection and rates of preterm birth.
106 ling pathways in skeletal muscle to maintain systemic glucose homeostasis remains largely unexplored.
107 ts hepatic gluconeogenesis without affecting systemic glucose tolerance.
108                                              Systemic hemodynamics improved after SVR.
109 , rendering them competent to respond to the systemic hormone ecdysone.
110                                   Currently, systemic hormone replacement for cisgender adults requir
111 ce, displaying an unexpected increase in the systemic IgA responses.
112  esophagitis), suggesting both cutaneous and systemic immune activation.
113 oorer cognitive function, HIV infection, and systemic immune activation.
114 sponse of IL-1R1(-/-) mice did not reflect a systemic immune deficiency, because immunized IL-1R1(-/-
115 e studies demonstrate the critical impact of systemic immune responses that drive tumor rejection.
116 d breaks (DSB), apoptosis, and the local and systemic immune responses.
117 induce pathogen-specific SIgA in addition to systemic immunity achieved by injected vaccines.
118  commensal enteric fungi safeguard local and systemic immunity by providing tonic microbial stimulati
119 ecific immunity, enhance previously existing systemic immunity or re-target responses to the mucosae.
120 ized and nonrandomized studies on therapies (systemic immunomodulating therapies or supportive care)
121  the present study is to examine presence of systemic immunoreactivity to A. actionmycetemcomitans Lt
122 ant-associated materials have a local and/or systemic impact on the peri-implant soft and hard tissue
123 rhagic Events by Transradial Access Site and Systemic Implementation of Angiox) trial.
124                                 However, its systemic inactivation in adult mice induces T-cell acute
125 ), promotes acute pulmonary inflammation and systemic infection after lung challenge with S. pneumoni
126                             Intrauterine and systemic infection and inflammation cause 30-40% of spon
127   C57BL/6J mice are extremely susceptible to systemic infection by Salmonella Typhimurium because of
128    Reasons for isolated enterectomy included systemic infection in 11, gastrointestinal bleeding in 1
129                                During murine systemic infection, LipA suppresses pro-inflammatory mac
130 g allow us to use the eye as a window to the systemic infection.
131 issue damage in clinical scenarios of severe systemic infection.
132                                              Systemic infections are mainly with Pneumocystis jirovec
133 hat dietary Mn levels dictate the outcome of systemic infections caused by Staphylococcus aureus, a l
134 lbicans may spread to cause life-threatening systemic infections.
135 rols (n = 50), we measured parasite biomass, systemic inflammation (interleukin 6 [IL-6]), endothelia
136                                              Systemic inflammation and sarcopenia are easily evaluate
137 tand the effects of psoriasis medications on systemic inflammation associated with cardiovascular ris
138 cyte ratio (NLR) was used as an indicator of systemic inflammation before and after surgery.
139      Links between microbial alterations and systemic inflammation have been demonstrated in chronic
140 d support to a hypothesis implicating global systemic inflammation in HF with preserved ejection frac
141 nously, or per rectum; were on biomarkers of systemic inflammation in humans; and performed meta-anal
142 that plasmodial DNA is the primary driver of systemic inflammation in malaria, both within the phagol
143 hritis model and in IL-1beta- or LPS-induced systemic inflammation in vivo, IL-1R2(-/-) mice were cre
144                                              Systemic inflammation is increased in patients who devel
145 ecent findings suggest that an overexuberant systemic inflammation plays a primary role in ACLF progr
146                                              Systemic inflammation through persistent monocyte activa
147 d prior to Il1b detection in the brain, when systemic inflammation was minimal.
148                  We statistically link early systemic inflammation with later local increases in infl
149 ng left ventricular and pulmonary pathology, systemic inflammation, and neurohormonal activation.
150                          All four had marked systemic inflammation, fever and fluctuating radiologic
151  evidence supports the active involvement of systemic inflammation, in addition to local brain inflam
152                               In addition to systemic inflammation, local arterial inflammation, driv
153 on in the early phase after fracture reduced systemic inflammation, the recruitment of immune cells,
154 rate that deregulated necroptosis results in systemic inflammation, tissue fibrosis, and autoimmunity
155 ease in exercise performance observed during systemic inflammation.
156 infection-positive versus infection-negative systemic inflammation.
157 g the effect of prebiotics and synbiotics on systemic inflammation.
158 ficiencies in immune responses and increased systemic inflammation.
159 e actions of these statins on both joint and systemic inflammation.
160  in Apoe (-/-) mice by regulating lesion and systemic inflammation.
161 ted a significant decrease in >/=1 marker of systemic inflammation.
162                                Concurrently, systemic inflammatory biomarkers, ex vivo blood tests on
163  contrast, afferent cVN activation amplifies systemic inflammatory processes, leading to activation o
164                           Surgery launches a systemic inflammatory reaction that reaches the brain an
165 riteria, score discrimination was lowest for systemic inflammatory response syndrome (median area und
166  prospective identification of patients with systemic inflammatory response syndrome (SIRS) and sepsi
167 troduced quick SOFA (qSOFA), and removed the systemic inflammatory response syndrome (SIRS) criteria
168       The primary outcome was a composite of systemic inflammatory response syndrome and dysfunction
169                                              Systemic Inflammatory Response Syndrome and quick Sequen
170 psis-related Organ Failure Assessment score, systemic inflammatory response syndrome criteria, the Na
171 der the receiver operating characteristic of Systemic Inflammatory Response Syndrome for critical car
172 ic shock patients (defined: infection, >/= 2 systemic inflammatory response syndrome, and hypoperfusi
173 rotection from mortality in a mouse model of systemic inflammatory response syndrome.
174    Diagnosis is difficult due to the ongoing systemic inflammatory response.
175 ndependently involved in the pathogenesis of systemic inflammatory rheumatoid arthritis (RA) and AD.
176      The data support the emerging idea of a systemic influence to neurological disorders and point t
177 e role of specific cell types in the eye vs. systemic influences (e.g., serum) on the disease patholo
178 lsed focused ultrasound (pFUS) combined with systemic infusion of ultrasound contrast agent microbubb
179 bese dog model, suggesting the importance of systemic inhibition of DGAT1 for body weight control.
180 e of dietary exposure (e.g., via leaves) for systemic insecticides.
181 podocyte-selective injury but more likely by systemic insults, a humanized xenograft model of FSGS re
182                                              Systemic isotretinoin therapy has achieved nearly comple
183 h, or immediately following the cessation of systemic isotretinoin therapy.
184  laser are not recommended in the setting of systemic isotretinoin treatment.
185                              When applied to systemic juvenile idiopathic arthritis (sJIA), an autoin
186 ow that in nitrate-fed mice there is reduced systemic leukocyte rolling and adherence, circulating ne
187 also significantly associated with increased systemic levels of A. actinomycetemcomitans-specific imm
188  with the IgA responses 30-fold greater than systemic levels.
189                                              Systemic lipopolysaccharide (LPS) is implicated in incre
190                                              Systemic lupus erythematosus (SLE) is a known risk facto
191 e population-based studies have been done on systemic lupus erythematosus (SLE) mortality trends in t
192 a with greater coagulant effects compared to systemic lupus erythematosus (SLE) non APS IgG.
193  with several autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren's syndrome,
194 d patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE).
195 ic variants are associated with the risk for systemic lupus erythematosus (SLE); however, it is uncle
196                 Basophils from patients with systemic lupus erythematosus show an activated phenotype
197                                           In systemic lupus erythematosus, deposits of IgG-immune com
198  also in a diverse array of diseases such as systemic lupus erythematosus, diabetes, and cancer.
199 re associated with type I diabetes mellitus, systemic lupus erythematosus, RA, and celiac disease, th
200 uss the current and future impact of AMDs on systemic lupus erythematosus, rheumatoid arthritis, and
201 ular involvement, orbital lymphoma, or other systemic lymphoma.
202  deficiency, exhibit a small eye defect, and systemic malformations including hydrocephaly and cardia
203                                Patients with systemic mastocytosis (SM) may suffer from mast cell (MC
204 ular understanding of the pathophysiology of systemic mastocytosis have provided new therapeutic cons
205 by a range of modifications to the local and systemic maternal immune system.
206 ysteine therapy, delivered using a targeted, systemic, maternal, dendrimer nanoparticle (DNAC), in a
207 ed understanding of the associations between systemic medication use and intraocular pressure (IOP) i
208                                      Several systemic medications for low back pain are associated wi
209 ls that reported pain, function, or harms of systemic medications versus placebo or another intervent
210  TLR trafficking and signaling in xenobiotic systemic mercury-induced autoimmunity (HgIA).
211 nnate type 2 immunity, and also to integrate systemic metabolic and thermogenic responses.
212 onship between loss of CB1 in adipocytes and systemic metabolic changes.
213 oluntary) adipose tissue loss as well as its systemic metabolic consequences are far less understood.
214 t takes up and burns lipids and is linked to systemic metabolic homeostasis, we hypothesized that the
215                                 Therapy with systemic methotrexate did not suffice, as all the patien
216 iRNAs than the wild type and showed enhanced systemic movement of PTGS to grafted shoots.
217                                              Systemic muscimol or baclofen are antipruritic against b
218 is was considered the most prevalent endemic systemic mycosis in the Americas, but this situation mig
219                                              Systemic neutrophil depletion was found to render wild-t
220 taneous monitoring of anti-tumor potency and systemic off-tumor toxicity, micromolar affinity CAR T c
221                               The effects of systemic or centrally administered orexin receptor (OXR)
222 ion of the epitope specificities, locations (systemic or mucosal), and effector functions of antibodi
223    The aim of this study was to establish if systemic oxidative status in POAG patients was elevated
224 ed energy metabolism, which further leads to systemic oxidative stress and inflammation.
225  bacterial dissemination, and intestinal and systemic pathology of wild-type and CCR7-/- mice were as
226                                   The use of systemic prednisolone in eyes with vasculitis was associ
227  Furthermore, while both cultivars developed systemic priming of chitosan-induced callose after singl
228  vulnerable populations is representative of systemic problems plaguing the regulation of chemicals i
229                                     However, systemic processes such as inflammation, as well as cell
230 form of meat allergy characterized by severe systemic reactions 3-7 h after consumption of red meat.
231 at the injection site, and the most frequent systemic reactogenic events were fatigue (29 [43%]), hea
232                                    Local and systemic reactogenicity was transient and self-limiting.
233 inin (HA) protein substantially affected the systemic replication and pathogenicity of these H5N1 inf
234  This raises the question of the ecosystem's systemic resilience and its ability to rebound after lar
235 creasing current knowledge regarding induced systemic resistance (ISR) to pathogens and pests in whit
236 r iron with soil-borne pathogens or induce a systemic resistance that shares early signaling componen
237                                         This systemic response was coordinated across tissues and req
238 iew, the long-distance signals implicated in systemic responses to various environmental cues are dis
239                                    Worsening systemic RV function and tricuspid regurgitation may dev
240      To evaluate the efficacy and ocular and systemic safety of netarsudil 0.02% ophthalmic solution,
241                                 No ocular or systemic safety signals were observed during the long-te
242          The primary endpoint was ocular and systemic safety, but exploratory data including BCVA, re
243     Here, we review the clinical features of systemic sclerosis and describe the best practice approa
244                                              Systemic sclerosis is an autoimmune disease characterize
245                                              Systemic sclerosis is an orphan, systemic autoimmune dis
246       Skin biopsy-derived RNAs from 14 early systemic sclerosis patients and six healthy individuals
247 oding RNAs are deregulated in skin tissue of systemic sclerosis patients suggesting a novel class of
248 y of proteins not previously associated with systemic sclerosis that provide insight into pathogenesi
249 l class of genes involved in pathogenesis of systemic sclerosis.
250 ethylome in primary T cells of patients with systemic sclerosis.
251  the absence of large differences in risk of systemic serious adverse events between these two anti-V
252 the blood-brain-barrier (BBB) and eliminates systemic side effects.
253 e model and that A-SAA could be an important systemic signal of O3 exposure to the CNS.
254 rates, and amino acids, as well as governing systemic signaling networks.
255 typically ambulatory on presentation without systemic signs of infection.
256                                              Systemic small molecule Gbetagamma-GRK2 inhibition initi
257  and cerebrospinal fluid without evidence of systemic spread.
258  index, smoking, hypertension, diabetes, and systemic steroid use.
259 ory symptoms requiring either antibiotics or systemic steroids, and severe events by the need for hos
260 T is effective in reducing severe subsequent systemic sting reactions and in improving disease-specif
261 -effective in those at high risk of repeated systemic sting reactions and/or impaired quality of life
262  and local treatment or by a therapeutic and systemic strategy, abolished IL-1beta- and GLAST-depende
263                               The ability of systemic stress-level corticosterone treatment to potent
264  VHL-related juxtapapillary RCH treated with systemic sunitinib malate.
265 s followed routinely every 4 months while on systemic sunitinib prescribed by her oncologist for meta
266 n and improved muscle strength, suggesting a systemic supply of FKRP protein acting as glycosyltransf
267                                    Available systemic therapies for CTCL may variably decrease tumor
268                                       Use of systemic therapies for moderate to severe psoriasis in c
269                                           As systemic therapies improve, patients with lung cancer li
270 parison with a cohort receiving non-biologic systemic therapies in a propensity score-weighted Cox pr
271    The pipeline of more targeted topical and systemic therapies is expanding based on our growing und
272 linicians when choosing between non-biologic systemic therapies, etanercept, adalimumab, and ustekinu
273 vival, particularly in patients treated with systemic therapies.
274  assessment of tumor response to neoadjuvant systemic therapy (NST) in patients with breast cancer an
275 wed by adjuvant systemic therapy relative to systemic therapy alone for patients with breast cancer l
276 nd stratified according to duration of prior systemic therapy and presence of liver metastases.
277                                      Purpose Systemic Therapy for Advanced or Metastatic Prostate Can
278                     Twenty patients received systemic therapy for widely disseminated disease.
279 ness of liver resection followed by adjuvant systemic therapy relative to systemic therapy alone for
280 ans for treatment (surgery, radiotherapy, or systemic therapy) within 90 d for lung and 180 d for pro
281 estrogen-receptor status, type and timing of systemic therapy, menopausal status, statin use, and tre
282 uable disease, who had not received previous systemic therapy.
283 e NSCLC tumors that had been resected before systemic therapy.
284 teen patients were using a self-administered systemic therapy; 22.4% were classified as "non-adherent
285 clinical studies have in part described this systemic-to-brain signaling pathway, we lack information
286               The safety profile and risk of systemic toxic effects when brimonidine is used topicall
287 ut its use to treat GBM is limited by severe systemic toxicity and inefficient penetration of brain t
288                                           No systemic toxicity was noted with the expanders and histo
289 ic syndrome and dyslipidemia, while avoiding systemic toxicity.
290                                              Systemic treatment of rats with 6 mg/kg 6c either simult
291      INTERPRETATION: Regorafenib is the only systemic treatment shown to provide survival benefit in
292                In a proof-of-concept setting systemic treatment with ustekinumab diminished imiquimod
293 e current era, with long-term survival after systemic treatment, there is a need for a timely diagnos
294 mors highlight the need to develop effective systemic treatments for this disease.
295 has changed due to the introduction of novel systemic treatments that can result in long-term surviva
296 l for priming of CD8(+) T cells that mediate systemic tumour rejection (abscopal effect) in the conte
297 may be a surrogate biomarker of cerebral and systemic vascular risk in patients with OSA requiring fu
298 e of clinical complications of pulmonary and systemic vasculopathy, including pulmonary hypertension,
299 sm that controls osmotic water transport and systemic water balance in mammals.
300 so the ability of prosystemin to trigger the systemic wound response in vivo.

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