1 Systemic administration of 1.4 mg kg(-1) of mRNA into mi
2 Both natural fluctuations and
systemic administration of 17beta-estradiol (E2) alter s
3 ffects of alcohol was confirmed, as both the
systemic administration of 3-Cyano-N-(1,3-diphenyl-1H-py
4 non-transgenic littermate controls received
systemic administration of 7,8-DHF (5 mg/kg, i.p.) once
5 Moreover,
systemic administration of a 5-HT6 receptor inverse agon
6 Here, delayed
systemic administration of a blood-brain barrier-permeab
7 Altogether, our data show that
systemic administration of a brain-penetrant TrkB antago
8 Our study provides first-time evidence that
systemic administration of a brain-penetrant TrkB antago
9 Whether repeated
systemic administration of a CB2-preferring agonist enga
10 e development of integrated models that link
systemic administration of a drug to the probability of
11 Previously, we showed that,
systemic administration of a GABA reuptake blocker in ME
12 Subsequent experiments showed that
systemic administration of a GABA(B)R antagonist, CGP558
13 Repeated
systemic administration of a ghrelin receptor agonist en
14 tion correlated with FOS induction following
systemic administration of a GLP-1 receptor agonist, exe
15 Moreover, we have demonstrated that
systemic administration of a GLP-1R agonist (liraglutide
16 Systemic administration of a HIF-prolyl hydroxylase inhi
17 of sustained weight reduction in response to
systemic administration of a long-acting analog of the g
18 the circulation during EAE induction through
systemic administration of a mAb against PC/activated PC
19 After
systemic administration of a MET kinase inhibitor, we pr
20 l spermine followed by a seeking test, or 3)
systemic administration of a mGluR1 positive allosteric
21 Furthermore,
systemic administration of a PKD inhibitor protects d-ga
22 e results of these studies clearly show that
systemic administration of a selective NR2B NAM can caus
23 We further show that
systemic administration of a single dose of dendrimer-N-
24 udy was to determine the skeletal effects of
systemic administration of a soluble BMPR1A fusion prote
25 Systemic administration of a TGF-beta-specific neutraliz
26 The combination of ACT with
systemic administration of a vesicular stomatitis virus
27 Our data suggest that
systemic administration of AAT can be a promising therap
28 D from the cardiac troponin-T promoter after
systemic administration of AAV9 provides significant pro
29 Systemic administration of AAV92YF-RdCVF improved cone f
30 Moreover, one-time
systemic administration of Ac2-26 Col IV NPs accelerated
31 Systemic administration of additional plg not only accel
32 sed adrenal size and elevated CORT following
systemic administration of adrenocorticotropic hormone.
33 Although chronic
systemic administration of aducanumab in 22-month-old mi
34 This can be achieved by
systemic administration of Ag-specific Treg cells, which
35 No safety concerns were identified after
systemic administration of AKB-9778 for 4 weeks in patie
36 Specifically, acute (15 min)
systemic administration of alcohol (2.5 g/kg) leads to t
37 or D2R MSNs, we show that repeated cycles of
systemic administration of alcohol or alcohol consumptio
38 We show that intranasal but not
systemic administration of alpha-GalCer to piglets infec
39 Antiallodynic efficacy of
systemic administration of AM1710 was absent in CB2KO mi
40 hat these deficits are restored by repeated,
systemic administration of AMPH (1.78 mg/kg, every other
41 Systemic administration of amphetamine (AMPH) induces ph
42 Furthermore, we show that
systemic administration of an agonist Notch3 antibody pr
43 he work described herein was to test whether
systemic administration of an antagonist of miR-467 woul
44 Neutrophil depletion by
systemic administration of an anti-Gr1 antibody improved
45 are abrogated in a dose-dependent manner by
systemic administration of an antibody targeting the C t
46 Here, we show in rats that
systemic administration of an aromatase (estrogen syntha
47 Notably,
systemic administration of an EGFL6-neutralizing antibod
48 determinant of these barriers and show that
systemic administration of an enzymatic agent can ablate
49 Systemic administration of an HDAC inhibitor rescues the
50 Also,
systemic administration of an MAP kinase kinase inhibito
51 cue-induced craving are high, we found that
systemic administration of an mGluR1 PAM attenuated the
52 First, we studied the effects of
systemic administration of an OT receptor (OTR) antagoni
53 Systemic administration of anti-C5- or anti-C5a-blocking
54 This article will focus on the
systemic administration of anti-cancer agents and their
55 These data indicate that
systemic administration of anti-CD40Ab may be particular
56 As we expected,
systemic administration of anti-DC-STAMP-mAb downregulat
57 nsection (L5SNT; modified Chung's model) and
systemic administration of anti-ganglioside Abs.
58 d that blocking of interleukin 11 (IL-11) by
systemic administration of anti-IL-11 antibodies attenua
59 r than 20% intratumoral accumulation and (b)
systemic administration of anti-MG1 HNPs can enlarge a t
60 ts in intestinal mucosal wound repair, while
systemic administration of ANXA1 promoted wound recovery
61 of dopamine receptor signaling in vivo with
systemic administration of apomorphine, amphetamine, and
62 Here we show that
systemic administration of apoptotic cells to mice induc
63 In Nrf2 wild-type mice,
systemic administration of artemisitene strongly inhibit
64 In a transgenic mouse model of DM1,
systemic administration of ASOs caused a rapid knockdown
65 nsection (to remove sympathetic influences),
systemic administration of atropine increased left ventr
66 e agonist NMDA) or inflammation in vivo (via
systemic administration of bacterial lipopolysaccharides
67 The
systemic administration of BB-94 alone at the same dose
68 In most patients,
systemic administration of biological therapies with cyt
69 notable recovery in function observed after
systemic administration of BMSCs to MCAO rats is likely
70 n the release of inflammatory mediators; the
systemic administration of Boc2, a formylated peptide re
71 Local and
systemic administration of both dexamethasone and cedira
72 e of Duchenne muscular dystrophy patients by
systemic administration of both phosphorodiamidate morph
73 We found that the
systemic administration of brain lipid rafts induced a m
74 Either intrarenal or
systemic administration of C-21 prevented Ang II-mediate
75 tes TrkB upon infusion into the hippocampus;
systemic administration of C4-3 potentiates kainic acid-
76 We have investigated whether the
systemic administration of cardiotrophin-1 (CT-1) is abl
77 type directly and specifically responding to
systemic administration of CBLB502 but not to that of th
78 s with periodontitis compared to serum after
systemic administration of clarithromycin.
79 al suppression of macrophage infiltration by
systemic administration of clodronate-incorporated lipos
80 e glutamate levels following intracranial or
systemic administration of clozapine N-oxide (CNO) and t
81 Systemic administration of CNO inhibited cue-induced rei
82 Systemic administration of CNO suppresses focal seizures
83 Systemic administration of cocaine is thought to decreas
84 confirmed VTA DA neurons that is excited by
systemic administration of cocaine.
85 mporally imaged by bioluminescence following
systemic administration of coelenterazine.
86 Moreover,
systemic administration of collagen IV targeted Ac2-26 N
87 Systemic administration of compounds that block the acti
88 at are notoriously difficult to eliminate by
systemic administration of conventional antifungal agent
89 licitation route, other routes, amongst them
systemic administration of corticosteroids may exception
90 resented with allergic manifestations due to
systemic administration of corticosteroids.
91 Systemic administration of corticosterone (0.3-3 mg/kg)
92 tricular leptin infusion was not impacted by
systemic administration of corticosterone at a dose that
93 A drug delivery system suitable for
systemic administration of CPA is needed before CPA can
94 used for the treatment of psoriasis; however
systemic administration of CsA is potentially life threa
95 Systemic administration of CTDP-32476 alone produced a s
96 Both local and
systemic administration of CTLA4(apt)-STAT3 siRNA dramat
97 Accordingly,
systemic administration of Cxcl9 led to a strong attenua
98 Notably,
systemic administration of CYM51010 induced antinocicept
99 Systemic administration of DAR decreases hepatic ischemi
100 Either
systemic administration of DCs loaded with allogeneic-Ig
101 omal gene signatures as a direct function of
systemic administration of decorin protein core and reve
102 Strikingly,
systemic administration of Del-1-Fc ameliorated clinical
103 Whereas
systemic administration of dexamethasone during the deli
104 We hypothesized that
systemic administration of DHA-derived SPMs [resolvin D2
105 After
systemic administration of diaCEST liposomes to mice bea
106 repopulating HSCs and progenitor cells, and
systemic administration of Dkk1 to irradiated mice incre
107 , while inactivating the VTA or the combined
systemic administration of dopamine D1 and D2 antagonist
108 Systemic administration of drugs that improve respirator
109 reason for functional impairment of BSEP is
systemic administration of drugs, which as a side effect
110 xpressed functional EGF receptor (EGFR), and
systemic administration of EGF promoted the recovery of
111 We demonstrated that
systemic administration of endogenous nitric oxide donor
112 In rodents,
systemic administration of endogenous or synthetic neuro
113 Moreover,
systemic administration of ephrinB2-blocking Abs caused
114 Weekly
systemic administration of ESTA-MSV/STAT3 siRNA signific
115 Systemic administration of Etanercept inhibited MHC-I(hi
116 We also report that repeated
systemic administration of ethanol causes an NR2B-NMDAR-
117 ynaptic membrane, and we found that repeated
systemic administration of ethanol, as well as cycles of
118 In vivo
systemic administration of F. major sphingolipids change
119 rge-scale clinical studies investigating the
systemic administration of fenofibrate, this ligand for
120 In this study, we showed that
systemic administration of FK506 (1.5 mg kg(-1) day(-1))
121 Systemic administration of flagellin, a bacterial protei
122 ansgene into the hippocampus and reversed by
systemic administration of fluoxetine.
123 Importantly,
systemic administration of FTY720 induced complete remis
124 Further, we show that either intra-LA or
systemic administration of garcinol within a narrow wind
125 ipulation, when tested pharmacologically via
systemic administration of group III mGluR antagonists,
126 To determine whether the
systemic administration of HER2-specific chimeric antige
127 Current treatment strategies are based on
systemic administration of high doses of antibiotics, wh
128 Following
systemic administration of HPPH liposomes, near infrared
129 These findings suggest that high-dose
systemic administration of human cultured MSCs can resto
130 t while local infusion of HSA or saline, and
systemic administration of human PRP lysate, compared to
131 We discovered that
systemic administration of human recombinant CSF1 amelio
132 In vivo,
systemic administration of human umbilical cord blood ce
133 MRI of the TNBC xenograft tumor after
systemic administration of ICAM-IONPs, coupled with iron
134 weights, both transgenic overexpression and
systemic administration of IGF-1 combined with Bax-inhib
135 Treatment of tumor bearing mice with
systemic administration of IL-12 in combination with int
136 potentially lethal toxicity associated with
systemic administration of IL-12 precludes its clinical
137 Systemic administration of IL-12p70 has demonstrated cli
138 ph nodes, both of which could be reversed by
systemic administration of IL-1R antagonist (anakinra).
139 However,
systemic administration of IL-2 induces organ pathology
140 Systemic administration of insulin delays the death of c
141 Interestingly,
systemic administration of insulin has been shown to del
142 al phenotypes of ASD, to test the effects of
systemic administration of insulin-like growth factor II
143 In a murine periodontitis model,
systemic administration of JQ1 significantly inhibited i
144 Systemic administration of JWH133 attenuated these marke
145 Systemic administration of JWH133, a highly selective CB
146 mottled-brindled (mo-br), we tested whether
systemic administration of L-threo-dihydroxyphenylserine
147 Interestingly,
systemic administration of LiCl in a critical time windo
148 In vivo,
systemic administration of lipopolysaccharide (LPS) resu
149 atty liver is partially recapitulated by the
systemic administration of low-dose carboxyatractyloside
150 Additional
systemic administration of low-dose PMO25 at 2-week inte
151 revent symptoms and suggests that subsequent
systemic administration of low-dose PMO25 in SMA mice ca
152 Systemic administration of macrophages transfected ex vi
153 A single
systemic administration of MDSC markedly prolonged survi
154 rathecal injection of an NMDAR antagonist or
systemic administration of memantine effectively reverse
155 itulated the neuronal damage produced by the
systemic administration of METH.
156 Systemic administration of methylxantines improves respi
157 Systemic administration of micelles carrying paclitaxel
158 Both
systemic administration of miR-124 or adoptive miR-124-t
159 Rescue of miR-181b levels by
systemic administration of miR-181b "mimics" reduced dow
160 r knowledge, this is the first report of the
systemic administration of mRNA for delivery to the lung
161 We find that
systemic administration of MS0021570_1 attenuates anxiet
162 target dormant breast cancer cells based on
systemic administration of MSC loaded with antagomiR-222
163 in counteracts the behavioral effects of the
systemic administration of mu-opioid receptor (MOR) agon
164 Behavioral studies show that
systemic administration of muscarinic acetylcholine rece
165 rindole into the dorsal striatum or multiple
systemic administration of naltrindole reduces ethanol c
166 Using
systemic administration of nanoparticle-formulated miRNA
167 Systemic administration of neutralizing Abs to either TN
168 The
systemic administration of neutralizing antibodies again
169 Systemic administration of nicotine increases dopaminerg
170 ease of B cells in the spleen in response to
systemic administration of Nod1 agonists in a TNF-alpha-
171 Systemic administration of NRG demonstrated efficacy in
172 Furthermore,
systemic administration of oAd/DCN/LRP-PEG-NT significan
173 luate the adjunctive clinical effects of the
systemic administration of ornidazole (ORN) in the full-
174 Allergen sensitization by either
systemic administration of OVA with aluminum hydroxide o
175 After
systemic administration of oxotremorine, an unselective
176 animals reduces muscle regeneration, whereas
systemic administration of oxytocin rapidly improves mus
177 duced epilepsy: intrahippocampal kainate and
systemic administration of paraoxon.
178 Systemic administration of pazopanib by osmotic pump wit
179 The chosen
systemic administration of PEA stabilized the amplitude
180 In rats,
systemic administration of PF-04859989 dose-dependently
181 In the context of inflammatory disorders,
systemic administration of pharmacological doses of synt
182 This study examined if
systemic administration of Piribedil, a dopamine agonist
183 Here, we found that
systemic administration of pleiotrophin (PTN), a protein
184 sulted in activities similar to those of the
systemic administration of poly I:C on lung tumor burden
185 o be available for ponezumab binding because
systemic administration of ponezumab greatly elevates pl
186 We tested the hypothesis that
systemic administration of porphyrin precursors to zebra
187 Acute
systemic administration of pregabalin in vivo also selec
188 I (DW-MRI) in wild-type (WT) mice, the acute
systemic administration of pregabalin increased the thre
189 ced changes in mPFC firing were mitigated by
systemic administration of propranolol (10 mg/kg, i.p.),
190 Systemic administration of PTH(1-34) augmented bone volu
191 t migration and mineralization in vitro, and
systemic administration of PTHrP1-17 augments ectopic bo
192 was noticed over periods of months after the
systemic administration of QDs.
193 In rats,
systemic administration of R-MOD alone (10-30 mg/kg i.p.
194 Systemic administration of recombinant EPO protected EPO
195 Importantly, we found that
systemic administration of recombinant FGF2 (rFGF2) in m
196 7 was more effective than either LL-IL-10 or
systemic administration of recombinant IL-27 in reducing
197 Finally,
systemic administration of recombinant IL-27 in Treg-spe
198 Systemic administration of recombinant MK completely res
199 inergic neurons and either local infusion or
systemic administration of retigabine normalized neurona
200 The effects of
systemic administration of rimonabant on anxiety-like be
201 Systemic administration of rimonabant precipitated anxie
202 Systemic administration of rolipram also increased cAMP
203 Systemic administration of RT53 inhibited the growth of
204 a within-subjects design, of male rats given
systemic administration of saline or lipopolysaccharide
205 We found
systemic administration of SB-334867 (0, 7.5, 15, 30 mg/
206 th other anti-TGF-beta strategies, including
systemic administration of SD208, a small-molecule inhib
207 Performance was assessed following
systemic administration of selective D(2), D(3), and D(4
208 We show that
systemic administration of siMGMT-SNAs via single tail v
209 atform may afford the specificity lacking in
systemic administration of small-molecule inhibitors.
210 Systemic administration of sodium 4-phenylbutyrate (PBA)
211 We examined the effects of local and
systemic administration of sodium nitrite on the radial
212 l microenvironment of Thbd-expressing cells,
systemic administration of soluble Thbd or aPC could rep
213 m load, which was significantly decreased by
systemic administration of specific blockers of the angi
214 immunosuppressive signals can be achieved by
systemic administration of supporting adjuvant drugs suc
215 Additional
systemic administration of T-bodies 8 weeks after the in
216 Previous research showed that
systemic administration of TAAR1 agonists could attenuat
217 Our recent studies showed that
systemic administration of TAAR1 agonists decreased abus
218 motor hyperactivity was attenuated following
systemic administration of TAT-C24WT but not TAT-C24Scr.
219 ilocarpine model of status epilepticus (SE),
systemic administration of TG6-10-1 completely recapitul
220 We found that
systemic administration of the 4-1BB aptamer-raptor siRN
221 exibility on this task is improved following
systemic administration of the 5-HT reuptake inhibitor c
222 f unfavorable outcomes were tested following
systemic administration of the 5-HT1A receptor agonist,
223 Systemic administration of the alpha2-AR agonists dexmed
224 Systemic administration of the anandamide hydrolysis inh
225 The
systemic administration of the anti-Kras nanobeacons res
226 Systemic administration of the AROM inhibitor letrozole
227 d female monkeys were severely attenuated by
systemic administration of the aromatase inhibitor, letr
228 Simultaneous
systemic administration of the bioorthogonal IONPs in tu
229 Systemic administration of the bispecific DVD-Ig or the
230 asthma in C57BL/6 mice, we demonstrate that
systemic administration of the BK channel agonist rottle
231 Systemic administration of the BMP antagonist LDN-193189
232 Importantly,
systemic administration of the CaMKII inhibitor tatCN21
233 Systemic administration of the CB2 receptor agonist JWH1
234 Systemic administration of the CCKA receptor antagonist
235 Systemic administration of the CCR3 antagonists GW766994
236 onists, we examined the cognitive effects of
systemic administration of the CRF1 receptor selective a
237 Finally, we show that
systemic administration of the CRMP-2 inhibitor lacosami
238 Following
systemic administration of the Cy5-labeled dendrimer (D-
239 and that this disruption was reversed by the
systemic administration of the dopamine D2/D3 receptor a
240 Consistent with the above,
systemic administration of the dopamine receptor blocker
241 to the dose-limiting side effects following
systemic administration of the drugs.
242 the neuroinflammatory response produced by a
systemic administration of the Escherichia coli lipopoly
243 Systemic administration of the general dopamine receptor
244 reinstated cocaine seeking was prevented by
systemic administration of the group II metabotropic glu
245 Systemic administration of the Group II metabotropic glu
246 Systemic administration of the growth factor FLT3L follo
247 Systemic administration of the Hcrtr-1 antagonist SB3348
248 In conclusion,
systemic administration of the heme precursors PP-IX or
249 Systemic administration of the high-affinity Sig1R ligan
250 Systemic administration of the KOR agonist U69,593 inhib
251 mouse intranasal virus challenge study, and
systemic administration of the mAb markedly reduced vira
252 esses rapid eye movement sleep (REM) whereas
systemic administration of the mGlu II receptor antagoni
253 Finally,
systemic administration of the mGlu2/3 agonist LY379268
254 Systemic administration of the MIF inhibitor ISO-1 signi
255 The data show that
systemic administration of the miR-467 antagonist could
256 ed on rats bearing melanoma xenografts after
systemic administration of the N-cadherin antagonist, AD
257 Systemic administration of the N/OFQ receptor (NOP) anta
258 Systemic administration of the nAChRa7 agonist PNU-28298
259 The current study contrasted the effects of
systemic administration of the nonspecific dopamine rece
260 We now report that
systemic administration of the novel mGlu5 positive allo
261 Systemic administration of the opiate antagonist, naloxo
262 ng PC, with these effects being abrogated by
systemic administration of the opioid receptor agonist m
263 Systemic administration of the orexin-1 receptor (OX1R)
264 in the DLS, as well as intra-DLS infusion or
systemic administration of the p75NTR modulator, LM11A-3
265 Finally, acute
systemic administration of the partial alpha7 nicotinic
266 pha4beta2* nicotinic ACh receptors (nAChRs),
systemic administration of the partial nAChR agonist ABT
267 Further,
systemic administration of the PCAF activator SPV106 enh
268 , and repetitive behaviors, we report that a
systemic administration of the polypeptide insulin-like
269 ntravesical cytisine (100 muM) is blocked by
systemic administration of the purinergic antagonist PPA
270 RNAs against HuR with FA-3DNA and found that
systemic administration of the resultant FA-3DNA-siHuR c
271 Noteworthy,
systemic administration of the S1PR1 modulator FTY720 (F
272 DOX and TMZ microcapsules are compared with
systemic administration of the same treatments in a rode
273 Systemic administration of the selective cyclin-dependen
274 Systemic administration of the selective eNOS inhibitor
275 gnal mediator Smoothened (Smo) as well as by
systemic administration of the Smo inhibitor vismodegib,
276 sion of follistatin in skeletal muscle or by
systemic administration of the soluble form of the activ
277 We show that topical or
systemic administration of the Src kinase inhibitor (TG1
278 Acute
systemic administration of the TAT-4BB reversed M3G-indu
279 2-specific antibody (REGN910) is reversed by
systemic administration of the Tie2 agonist Ang1.
280 We have shown previously that
systemic administration of the TLR4 ligand LPS or the TL
281 refrontal cortex of the Met68BDNF mice or by
systemic administration of the tropomyosin receptor kina
282 Furthermore,
systemic administration of the vectors results in widesp
283 Third, the
systemic administration of the water-soluble CoQ10 analo
284 Notably,
systemic administration of these agents selectively coun
285 Systemic administration of these agonists to monkeys per
286 Systemic administration of this probe to mice bearing S.
287 Knockdown of vascular DHCR24 and HO-1 and
systemic administration of tin-protoporphyrin-IX, an HO
288 Systemic administration of TNF antagonists for radiculop
289 Systemic administration of TP-10 (3.2 mg/kg) robustly in
290 Systemic administration of TRAILPEG after disease onset
291 present a tumor-detection strategy based on
systemic administration of tumor-activatable minicircles
292 Here we find that the
systemic administration of typhoid toxin, a unique virul
293 al enhancement of endocannabinoid levels via
systemic administration of URB597, an inhibitor of endoc
294 716A prevented the play-enhancing effects of
systemic administration of URB597.
295 was applied on the back of mice, followed by
systemic administration of vehicle or ARA290 at 1, 12, a
296 Systemic administration of vitamin D during regeneration
297 earing metastatic colon tumors compared with
systemic administration of wild-type VSV alone.
298 Systemic administration of Y4 effectively inhibits growt
299 At the cognitive level,
systemic administration of young blood plasma into aged
300 ns were made selectively zolpidem-sensitive,
systemic administration of zolpidem shortened sleep late