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1                                              Systemic administration of 1.4 mg kg(-1) of mRNA into mi
2                Both natural fluctuations and systemic administration of 17beta-estradiol (E2) alter s
3 ffects of alcohol was confirmed, as both the systemic administration of 3-Cyano-N-(1,3-diphenyl-1H-py
4  non-transgenic littermate controls received systemic administration of 7,8-DHF (5 mg/kg, i.p.) once
5                                    Moreover, systemic administration of a 5-HT6 receptor inverse agon
6                                Here, delayed systemic administration of a blood-brain barrier-permeab
7               Altogether, our data show that systemic administration of a brain-penetrant TrkB antago
8  Our study provides first-time evidence that systemic administration of a brain-penetrant TrkB antago
9                             Whether repeated systemic administration of a CB2-preferring agonist enga
10 e development of integrated models that link systemic administration of a drug to the probability of
11                  Previously, we showed that, systemic administration of a GABA reuptake blocker in ME
12           Subsequent experiments showed that systemic administration of a GABA(B)R antagonist, CGP558
13                                     Repeated systemic administration of a ghrelin receptor agonist en
14 tion correlated with FOS induction following systemic administration of a GLP-1 receptor agonist, exe
15          Moreover, we have demonstrated that systemic administration of a GLP-1R agonist (liraglutide
16                                              Systemic administration of a HIF-prolyl hydroxylase inhi
17 of sustained weight reduction in response to systemic administration of a long-acting analog of the g
18 the circulation during EAE induction through systemic administration of a mAb against PC/activated PC
19                                        After systemic administration of a MET kinase inhibitor, we pr
20 l spermine followed by a seeking test, or 3) systemic administration of a mGluR1 positive allosteric
21                                 Furthermore, systemic administration of a PKD inhibitor protects d-ga
22 e results of these studies clearly show that systemic administration of a selective NR2B NAM can caus
23                         We further show that systemic administration of a single dose of dendrimer-N-
24 udy was to determine the skeletal effects of systemic administration of a soluble BMPR1A fusion prote
25                                              Systemic administration of a TGF-beta-specific neutraliz
26                  The combination of ACT with systemic administration of a vesicular stomatitis virus
27                        Our data suggest that systemic administration of AAT can be a promising therap
28 D from the cardiac troponin-T promoter after systemic administration of AAV9 provides significant pro
29                                              Systemic administration of AAV92YF-RdCVF improved cone f
30                           Moreover, one-time systemic administration of Ac2-26 Col IV NPs accelerated
31                                              Systemic administration of additional plg not only accel
32 sed adrenal size and elevated CORT following systemic administration of adrenocorticotropic hormone.
33                             Although chronic systemic administration of aducanumab in 22-month-old mi
34                      This can be achieved by systemic administration of Ag-specific Treg cells, which
35     No safety concerns were identified after systemic administration of AKB-9778 for 4 weeks in patie
36                 Specifically, acute (15 min) systemic administration of alcohol (2.5 g/kg) leads to t
37 or D2R MSNs, we show that repeated cycles of systemic administration of alcohol or alcohol consumptio
38              We show that intranasal but not systemic administration of alpha-GalCer to piglets infec
39                    Antiallodynic efficacy of systemic administration of AM1710 was absent in CB2KO mi
40 hat these deficits are restored by repeated, systemic administration of AMPH (1.78 mg/kg, every other
41                                              Systemic administration of amphetamine (AMPH) induces ph
42                    Furthermore, we show that systemic administration of an agonist Notch3 antibody pr
43 he work described herein was to test whether systemic administration of an antagonist of miR-467 woul
44                      Neutrophil depletion by systemic administration of an anti-Gr1 antibody improved
45  are abrogated in a dose-dependent manner by systemic administration of an antibody targeting the C t
46                   Here, we show in rats that systemic administration of an aromatase (estrogen syntha
47                                     Notably, systemic administration of an EGFL6-neutralizing antibod
48  determinant of these barriers and show that systemic administration of an enzymatic agent can ablate
49                                              Systemic administration of an HDAC inhibitor rescues the
50                                        Also, systemic administration of an MAP kinase kinase inhibito
51  cue-induced craving are high, we found that systemic administration of an mGluR1 PAM attenuated the
52             First, we studied the effects of systemic administration of an OT receptor (OTR) antagoni
53                                              Systemic administration of anti-C5- or anti-C5a-blocking
54               This article will focus on the systemic administration of anti-cancer agents and their
55                     These data indicate that systemic administration of anti-CD40Ab may be particular
56                              As we expected, systemic administration of anti-DC-STAMP-mAb downregulat
57 nsection (L5SNT; modified Chung's model) and systemic administration of anti-ganglioside Abs.
58 d that blocking of interleukin 11 (IL-11) by systemic administration of anti-IL-11 antibodies attenua
59 r than 20% intratumoral accumulation and (b) systemic administration of anti-MG1 HNPs can enlarge a t
60 ts in intestinal mucosal wound repair, while systemic administration of ANXA1 promoted wound recovery
61  of dopamine receptor signaling in vivo with systemic administration of apomorphine, amphetamine, and
62                            Here we show that systemic administration of apoptotic cells to mice induc
63                      In Nrf2 wild-type mice, systemic administration of artemisitene strongly inhibit
64          In a transgenic mouse model of DM1, systemic administration of ASOs caused a rapid knockdown
65 nsection (to remove sympathetic influences), systemic administration of atropine increased left ventr
66 e agonist NMDA) or inflammation in vivo (via systemic administration of bacterial lipopolysaccharides
67                                          The systemic administration of BB-94 alone at the same dose
68                            In most patients, systemic administration of biological therapies with cyt
69  notable recovery in function observed after systemic administration of BMSCs to MCAO rats is likely
70 n the release of inflammatory mediators; the systemic administration of Boc2, a formylated peptide re
71                                    Local and systemic administration of both dexamethasone and cedira
72 e of Duchenne muscular dystrophy patients by systemic administration of both phosphorodiamidate morph
73                            We found that the systemic administration of brain lipid rafts induced a m
74                         Either intrarenal or systemic administration of C-21 prevented Ang II-mediate
75 tes TrkB upon infusion into the hippocampus; systemic administration of C4-3 potentiates kainic acid-
76             We have investigated whether the systemic administration of cardiotrophin-1 (CT-1) is abl
77 type directly and specifically responding to systemic administration of CBLB502 but not to that of th
78 s with periodontitis compared to serum after systemic administration of clarithromycin.
79 al suppression of macrophage infiltration by systemic administration of clodronate-incorporated lipos
80 e glutamate levels following intracranial or systemic administration of clozapine N-oxide (CNO) and t
81                                              Systemic administration of CNO inhibited cue-induced rei
82                                              Systemic administration of CNO suppresses focal seizures
83                                              Systemic administration of cocaine is thought to decreas
84  confirmed VTA DA neurons that is excited by systemic administration of cocaine.
85 mporally imaged by bioluminescence following systemic administration of coelenterazine.
86                                    Moreover, systemic administration of collagen IV targeted Ac2-26 N
87                                              Systemic administration of compounds that block the acti
88 at are notoriously difficult to eliminate by systemic administration of conventional antifungal agent
89 licitation route, other routes, amongst them systemic administration of corticosteroids may exception
90 resented with allergic manifestations due to systemic administration of corticosteroids.
91                                              Systemic administration of corticosterone (0.3-3 mg/kg)
92 tricular leptin infusion was not impacted by systemic administration of corticosterone at a dose that
93          A drug delivery system suitable for systemic administration of CPA is needed before CPA can
94 used for the treatment of psoriasis; however systemic administration of CsA is potentially life threa
95                                              Systemic administration of CTDP-32476 alone produced a s
96                               Both local and systemic administration of CTLA4(apt)-STAT3 siRNA dramat
97                                 Accordingly, systemic administration of Cxcl9 led to a strong attenua
98                                     Notably, systemic administration of CYM51010 induced antinocicept
99                                              Systemic administration of DAR decreases hepatic ischemi
100                                       Either systemic administration of DCs loaded with allogeneic-Ig
101 omal gene signatures as a direct function of systemic administration of decorin protein core and reve
102                                  Strikingly, systemic administration of Del-1-Fc ameliorated clinical
103                                      Whereas systemic administration of dexamethasone during the deli
104                         We hypothesized that systemic administration of DHA-derived SPMs [resolvin D2
105                                        After systemic administration of diaCEST liposomes to mice bea
106  repopulating HSCs and progenitor cells, and systemic administration of Dkk1 to irradiated mice incre
107 , while inactivating the VTA or the combined systemic administration of dopamine D1 and D2 antagonist
108                                              Systemic administration of drugs that improve respirator
109  reason for functional impairment of BSEP is systemic administration of drugs, which as a side effect
110 xpressed functional EGF receptor (EGFR), and systemic administration of EGF promoted the recovery of
111                         We demonstrated that systemic administration of endogenous nitric oxide donor
112                                  In rodents, systemic administration of endogenous or synthetic neuro
113                                    Moreover, systemic administration of ephrinB2-blocking Abs caused
114                                       Weekly systemic administration of ESTA-MSV/STAT3 siRNA signific
115                                              Systemic administration of Etanercept inhibited MHC-I(hi
116                 We also report that repeated systemic administration of ethanol causes an NR2B-NMDAR-
117 ynaptic membrane, and we found that repeated systemic administration of ethanol, as well as cycles of
118                                      In vivo systemic administration of F. major sphingolipids change
119 rge-scale clinical studies investigating the systemic administration of fenofibrate, this ligand for
120                In this study, we showed that systemic administration of FK506 (1.5 mg kg(-1) day(-1))
121                                              Systemic administration of flagellin, a bacterial protei
122 ansgene into the hippocampus and reversed by systemic administration of fluoxetine.
123                                 Importantly, systemic administration of FTY720 induced complete remis
124     Further, we show that either intra-LA or systemic administration of garcinol within a narrow wind
125 ipulation, when tested pharmacologically via systemic administration of group III mGluR antagonists,
126                     To determine whether the systemic administration of HER2-specific chimeric antige
127    Current treatment strategies are based on systemic administration of high doses of antibiotics, wh
128                                    Following systemic administration of HPPH liposomes, near infrared
129        These findings suggest that high-dose systemic administration of human cultured MSCs can resto
130 t while local infusion of HSA or saline, and systemic administration of human PRP lysate, compared to
131                           We discovered that systemic administration of human recombinant CSF1 amelio
132                                     In vivo, systemic administration of human umbilical cord blood ce
133        MRI of the TNBC xenograft tumor after systemic administration of ICAM-IONPs, coupled with iron
134  weights, both transgenic overexpression and systemic administration of IGF-1 combined with Bax-inhib
135         Treatment of tumor bearing mice with systemic administration of IL-12 in combination with int
136  potentially lethal toxicity associated with systemic administration of IL-12 precludes its clinical
137                                              Systemic administration of IL-12p70 has demonstrated cli
138 ph nodes, both of which could be reversed by systemic administration of IL-1R antagonist (anakinra).
139                                     However, systemic administration of IL-2 induces organ pathology
140                                              Systemic administration of insulin delays the death of c
141                               Interestingly, systemic administration of insulin has been shown to del
142 al phenotypes of ASD, to test the effects of systemic administration of insulin-like growth factor II
143             In a murine periodontitis model, systemic administration of JQ1 significantly inhibited i
144                                              Systemic administration of JWH133 attenuated these marke
145                                              Systemic administration of JWH133, a highly selective CB
146  mottled-brindled (mo-br), we tested whether systemic administration of L-threo-dihydroxyphenylserine
147                               Interestingly, systemic administration of LiCl in a critical time windo
148                                     In vivo, systemic administration of lipopolysaccharide (LPS) resu
149 atty liver is partially recapitulated by the systemic administration of low-dose carboxyatractyloside
150                                   Additional systemic administration of low-dose PMO25 at 2-week inte
151 revent symptoms and suggests that subsequent systemic administration of low-dose PMO25 in SMA mice ca
152                                              Systemic administration of macrophages transfected ex vi
153                                     A single systemic administration of MDSC markedly prolonged survi
154 rathecal injection of an NMDAR antagonist or systemic administration of memantine effectively reverse
155 itulated the neuronal damage produced by the systemic administration of METH.
156                                              Systemic administration of methylxantines improves respi
157                                              Systemic administration of micelles carrying paclitaxel
158                                         Both systemic administration of miR-124 or adoptive miR-124-t
159                 Rescue of miR-181b levels by systemic administration of miR-181b "mimics" reduced dow
160 r knowledge, this is the first report of the systemic administration of mRNA for delivery to the lung
161                                 We find that systemic administration of MS0021570_1 attenuates anxiet
162  target dormant breast cancer cells based on systemic administration of MSC loaded with antagomiR-222
163 in counteracts the behavioral effects of the systemic administration of mu-opioid receptor (MOR) agon
164                 Behavioral studies show that systemic administration of muscarinic acetylcholine rece
165 rindole into the dorsal striatum or multiple systemic administration of naltrindole reduces ethanol c
166                                        Using systemic administration of nanoparticle-formulated miRNA
167                                              Systemic administration of neutralizing Abs to either TN
168                                          The systemic administration of neutralizing antibodies again
169                                              Systemic administration of nicotine increases dopaminerg
170 ease of B cells in the spleen in response to systemic administration of Nod1 agonists in a TNF-alpha-
171                                              Systemic administration of NRG demonstrated efficacy in
172                                 Furthermore, systemic administration of oAd/DCN/LRP-PEG-NT significan
173 luate the adjunctive clinical effects of the systemic administration of ornidazole (ORN) in the full-
174             Allergen sensitization by either systemic administration of OVA with aluminum hydroxide o
175                                        After systemic administration of oxotremorine, an unselective
176 animals reduces muscle regeneration, whereas systemic administration of oxytocin rapidly improves mus
177 duced epilepsy: intrahippocampal kainate and systemic administration of paraoxon.
178                                              Systemic administration of pazopanib by osmotic pump wit
179                                   The chosen systemic administration of PEA stabilized the amplitude
180                                     In rats, systemic administration of PF-04859989 dose-dependently
181    In the context of inflammatory disorders, systemic administration of pharmacological doses of synt
182                       This study examined if systemic administration of Piribedil, a dopamine agonist
183                          Here, we found that systemic administration of pleiotrophin (PTN), a protein
184 sulted in activities similar to those of the systemic administration of poly I:C on lung tumor burden
185 o be available for ponezumab binding because systemic administration of ponezumab greatly elevates pl
186                We tested the hypothesis that systemic administration of porphyrin precursors to zebra
187                                        Acute systemic administration of pregabalin in vivo also selec
188 I (DW-MRI) in wild-type (WT) mice, the acute systemic administration of pregabalin increased the thre
189 ced changes in mPFC firing were mitigated by systemic administration of propranolol (10 mg/kg, i.p.),
190                                              Systemic administration of PTH(1-34) augmented bone volu
191 t migration and mineralization in vitro, and systemic administration of PTHrP1-17 augments ectopic bo
192 was noticed over periods of months after the systemic administration of QDs.
193                                     In rats, systemic administration of R-MOD alone (10-30 mg/kg i.p.
194                                              Systemic administration of recombinant EPO protected EPO
195                   Importantly, we found that systemic administration of recombinant FGF2 (rFGF2) in m
196 7 was more effective than either LL-IL-10 or systemic administration of recombinant IL-27 in reducing
197                                     Finally, systemic administration of recombinant IL-27 in Treg-spe
198                                              Systemic administration of recombinant MK completely res
199 inergic neurons and either local infusion or systemic administration of retigabine normalized neurona
200                               The effects of systemic administration of rimonabant on anxiety-like be
201                                              Systemic administration of rimonabant precipitated anxie
202                                              Systemic administration of rolipram also increased cAMP
203                                              Systemic administration of RT53 inhibited the growth of
204 a within-subjects design, of male rats given systemic administration of saline or lipopolysaccharide
205                                     We found systemic administration of SB-334867 (0, 7.5, 15, 30 mg/
206 th other anti-TGF-beta strategies, including systemic administration of SD208, a small-molecule inhib
207           Performance was assessed following systemic administration of selective D(2), D(3), and D(4
208                                 We show that systemic administration of siMGMT-SNAs via single tail v
209 atform may afford the specificity lacking in systemic administration of small-molecule inhibitors.
210                                              Systemic administration of sodium 4-phenylbutyrate (PBA)
211         We examined the effects of local and systemic administration of sodium nitrite on the radial
212 l microenvironment of Thbd-expressing cells, systemic administration of soluble Thbd or aPC could rep
213 m load, which was significantly decreased by systemic administration of specific blockers of the angi
214 immunosuppressive signals can be achieved by systemic administration of supporting adjuvant drugs suc
215                                   Additional systemic administration of T-bodies 8 weeks after the in
216                Previous research showed that systemic administration of TAAR1 agonists could attenuat
217               Our recent studies showed that systemic administration of TAAR1 agonists decreased abus
218 motor hyperactivity was attenuated following systemic administration of TAT-C24WT but not TAT-C24Scr.
219 ilocarpine model of status epilepticus (SE), systemic administration of TG6-10-1 completely recapitul
220                                We found that systemic administration of the 4-1BB aptamer-raptor siRN
221 exibility on this task is improved following systemic administration of the 5-HT reuptake inhibitor c
222 f unfavorable outcomes were tested following systemic administration of the 5-HT1A receptor agonist,
223                                              Systemic administration of the alpha2-AR agonists dexmed
224                                              Systemic administration of the anandamide hydrolysis inh
225                                          The systemic administration of the anti-Kras nanobeacons res
226                                              Systemic administration of the AROM inhibitor letrozole
227 d female monkeys were severely attenuated by systemic administration of the aromatase inhibitor, letr
228                                 Simultaneous systemic administration of the bioorthogonal IONPs in tu
229                                              Systemic administration of the bispecific DVD-Ig or the
230  asthma in C57BL/6 mice, we demonstrate that systemic administration of the BK channel agonist rottle
231                                              Systemic administration of the BMP antagonist LDN-193189
232                                 Importantly, systemic administration of the CaMKII inhibitor tatCN21
233                                              Systemic administration of the CB2 receptor agonist JWH1
234                                              Systemic administration of the CCKA receptor antagonist
235                                              Systemic administration of the CCR3 antagonists GW766994
236 onists, we examined the cognitive effects of systemic administration of the CRF1 receptor selective a
237                        Finally, we show that systemic administration of the CRMP-2 inhibitor lacosami
238                                    Following systemic administration of the Cy5-labeled dendrimer (D-
239 and that this disruption was reversed by the systemic administration of the dopamine D2/D3 receptor a
240                   Consistent with the above, systemic administration of the dopamine receptor blocker
241  to the dose-limiting side effects following systemic administration of the drugs.
242 the neuroinflammatory response produced by a systemic administration of the Escherichia coli lipopoly
243                                              Systemic administration of the general dopamine receptor
244  reinstated cocaine seeking was prevented by systemic administration of the group II metabotropic glu
245                                              Systemic administration of the Group II metabotropic glu
246                                              Systemic administration of the growth factor FLT3L follo
247                                              Systemic administration of the Hcrtr-1 antagonist SB3348
248                               In conclusion, systemic administration of the heme precursors PP-IX or
249                                              Systemic administration of the high-affinity Sig1R ligan
250                                              Systemic administration of the KOR agonist U69,593 inhib
251  mouse intranasal virus challenge study, and systemic administration of the mAb markedly reduced vira
252 esses rapid eye movement sleep (REM) whereas systemic administration of the mGlu II receptor antagoni
253                                     Finally, systemic administration of the mGlu2/3 agonist LY379268
254                                              Systemic administration of the MIF inhibitor ISO-1 signi
255                           The data show that systemic administration of the miR-467 antagonist could
256 ed on rats bearing melanoma xenografts after systemic administration of the N-cadherin antagonist, AD
257                                              Systemic administration of the N/OFQ receptor (NOP) anta
258                                              Systemic administration of the nAChRa7 agonist PNU-28298
259  The current study contrasted the effects of systemic administration of the nonspecific dopamine rece
260                           We now report that systemic administration of the novel mGlu5 positive allo
261                                              Systemic administration of the opiate antagonist, naloxo
262 ng PC, with these effects being abrogated by systemic administration of the opioid receptor agonist m
263                                              Systemic administration of the orexin-1 receptor (OX1R)
264 in the DLS, as well as intra-DLS infusion or systemic administration of the p75NTR modulator, LM11A-3
265                               Finally, acute systemic administration of the partial alpha7 nicotinic
266 pha4beta2* nicotinic ACh receptors (nAChRs), systemic administration of the partial nAChR agonist ABT
267                                     Further, systemic administration of the PCAF activator SPV106 enh
268 , and repetitive behaviors, we report that a systemic administration of the polypeptide insulin-like
269 ntravesical cytisine (100 muM) is blocked by systemic administration of the purinergic antagonist PPA
270 RNAs against HuR with FA-3DNA and found that systemic administration of the resultant FA-3DNA-siHuR c
271                                  Noteworthy, systemic administration of the S1PR1 modulator FTY720 (F
272  DOX and TMZ microcapsules are compared with systemic administration of the same treatments in a rode
273                                              Systemic administration of the selective cyclin-dependen
274                                              Systemic administration of the selective eNOS inhibitor
275 gnal mediator Smoothened (Smo) as well as by systemic administration of the Smo inhibitor vismodegib,
276 sion of follistatin in skeletal muscle or by systemic administration of the soluble form of the activ
277                      We show that topical or systemic administration of the Src kinase inhibitor (TG1
278                                        Acute systemic administration of the TAT-4BB reversed M3G-indu
279 2-specific antibody (REGN910) is reversed by systemic administration of the Tie2 agonist Ang1.
280                We have shown previously that systemic administration of the TLR4 ligand LPS or the TL
281 refrontal cortex of the Met68BDNF mice or by systemic administration of the tropomyosin receptor kina
282                                 Furthermore, systemic administration of the vectors results in widesp
283                                   Third, the systemic administration of the water-soluble CoQ10 analo
284                                     Notably, systemic administration of these agents selectively coun
285                                              Systemic administration of these agonists to monkeys per
286                                              Systemic administration of this probe to mice bearing S.
287    Knockdown of vascular DHCR24 and HO-1 and systemic administration of tin-protoporphyrin-IX, an HO
288                                              Systemic administration of TNF antagonists for radiculop
289                                              Systemic administration of TP-10 (3.2 mg/kg) robustly in
290                                              Systemic administration of TRAILPEG after disease onset
291  present a tumor-detection strategy based on systemic administration of tumor-activatable minicircles
292                        Here we find that the systemic administration of typhoid toxin, a unique virul
293 al enhancement of endocannabinoid levels via systemic administration of URB597, an inhibitor of endoc
294 716A prevented the play-enhancing effects of systemic administration of URB597.
295 was applied on the back of mice, followed by systemic administration of vehicle or ARA290 at 1, 12, a
296                                              Systemic administration of vitamin D during regeneration
297 earing metastatic colon tumors compared with systemic administration of wild-type VSV alone.
298                                              Systemic administration of Y4 effectively inhibits growt
299                      At the cognitive level, systemic administration of young blood plasma into aged
300 ns were made selectively zolpidem-sensitive, systemic administration of zolpidem shortened sleep late

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