ライフサイエンスコーパス: systemic disease

1 infection, and the host (age, presence of a systemic disease).

2 ogic, oncologic, mechanical instability, and systemic disease).

3 ir for bacteria implicated in both local and systemic disease.

4 eria developed moderate to severe additional systemic disease.

5 contributed to suppression and prevention of systemic disease.

6 an influenza virus causes a rapid and lethal systemic disease.

7 for furthering understanding of cancer as a systemic disease.

8 acerbate intestinal inflammation or manifest systemic disease.

9 a risk in inherited and acquired cardiac and systemic disease.

10 fection to severe manifestations of focal or systemic disease.

11 ven if they do, most patients will have mild systemic disease.

12 g a causal link between oral pathobionts and systemic disease.

13 patients and to differentiate localized from systemic disease.

14 in cases of aggressive clinical behavior or systemic disease.

15 c measures but does not treat the underlying systemic disease.

16 doses of L. monocytogenes without developing systemic disease.

17 ermine the future pathways and timescales of systemic disease.

18 dings or have CLE associated with underlying systemic disease.

19 percentage of B lymphocytes and no signs of systemic disease.

20 during intramacrophage replication promoting systemic disease.

21 lf-limiting gastroenteritis that may lead to systemic disease.

22 clinical course, and risk for progression to systemic disease.

23 ement is rare and associated especially with systemic disease.

24 liferations improved in association with the systemic disease.

25 or both, suggesting that celiac disease is a systemic disease.

26 ations of host epithelium that contribute to systemic disease.

27 elium, causing vascular damage that leads to systemic disease.

28 olated aortitis in patients with unexplained systemic disease.

29 of disease, from mild diarrhea to fulminant systemic disease.

30 inoculation of HPAIV H5N1 resulted in fatal systemic disease.

31 ges is an important biomarker of retinal and systemic disease.

32 levels of DENV replication and show signs of systemic disease.

33 between male reproductive failure and future systemic disease.

34 leria mellonella (greater wax worm) model of systemic disease.

35 ation or more commonly as a manifestation of systemic disease.

36 ns causing typhoid fever, a life-threatening systemic disease.

37 critical for the treatment of patients with systemic disease.

38 disease called immunoglobulin G4-associated systemic disease.

39 ibrosis cases are all caused by IgG4-related systemic disease.

40 n be idiopathic or associated with ocular or systemic disease.

41 nt for IFN-alpha/beta signaling in combating systemic disease.

42 y recognized condition known as IgG4-related systemic disease.

43 s well as its transformation from a local to systemic disease.

44 of the relationship between periodontal and systemic disease.

45 nditions, these organisms may cause local or systemic disease.

46 y remains the gold standard for treatment of systemic disease.

47 uction agent for those with limited or early systemic disease.

48 che and, in some cases, disseminate to cause systemic disease.

49 g conditions in patients with a debilitating systemic disease.

50 eatment of ocular conditions associated with systemic disease.

51 eoformans in the environment whilst avoiding systemic disease.

52 teritis, typhoid fever is a life-threatening systemic disease.

53 dings were correlated with the course of the systemic disease.

54 rocess by which a localized cancer becomes a systemic disease.

55 microbiome due to its links with health and systemic disease.

56 n preceding any other organ manifestation or systemic disease.

57 required for early surveillance that limits systemic disease.

58 Organomegaly was a strong indicator of systemic disease.

59 distress syndrome probably mirroring severe systemic disease.

60 c disease, and none without organomegaly had systemic disease.

61 cial mucosal infections and life-threatening systemic disease.

62 ined treatment, and survival was extended in systemic disease.

63 o address the potentially serious associated systemic disease.

64 ement can be seen in patients with extensive systemic disease.

65 are described in 3 patients with aggressive systemic disease.

66 interrelationship between periodontitis and systemic diseases.

67 brosis and that can occur in isolation or in systemic diseases.

68 orly understood symptom in numerous skin and systemic diseases.

69 pretations of studies of the relationship to systemic diseases.

70 scriminatory biomarkers in saliva and distal systemic diseases.

71 future studies of putative associations with systemic diseases.

72 A minority developed other systemic diseases.

73 secondary to a wide range of neurological or systemic diseases.

74 l deformities, global airway dysfunction and systemic diseases.

75 ciation with periodontitis, as well as other systemic diseases.

76 been implicated as a contributing factor in systemic diseases.

77 has similar treatment challenges to chronic systemic diseases.

78 d image analysis, to detect risk factors for systemic diseases.

79 of a number of chronic gastrointestinal and systemic diseases.

80 disease are linked with various sequelae of systemic diseases.

81 rapid POC chairside diagnostics for oral and systemic diseases.

82 uorides-first to dental diseases and then to systemic diseases.

83 affect preventive approaches for dental and systemic diseases.

84 r treating ocular conditions associated with systemic diseases.

85 : that excessive dietary lipid intake caused systemic diseases.

86 nger considered as a common cause for dental-systemic diseases.

87 nts, is a central mechanism linking oral and systemic diseases.

88 arbohydrate intake prevented both dental and systemic diseases.

89 the role of nucleic acid sensors in various systemic diseases.

90 g may potentially be a link between oral and systemic diseases.

91 (PdD) has been shown to be related to other systemic diseases.

92 es the etiopathologic basis of many oral and systemic diseases.

93 es for treating or preventing both local and systemic diseases.

94 picting fundus pathologic features of common systemic diseases.

95 nd points included complete renal remission, systemic disease activity and damage, and safety.

96 whether sociodemographic factors and certain systemic diseases affected the odds of KCN.

97 e for future studies investigating local and systemic diseases affecting human health.

98 s study was to determine whether the risk of systemic disease after esophagectomy could be predicted

99 We report the associations with systemic disease and describe 3 stages of a CRF-related

100 ed with an H3N2 influenza virus succumbed to systemic disease and encephalitis after H5N1 virus chall

101 Treating systemic disease and identifying patients with early dis

102 natural progression of these malignancies to systemic disease and indicates a cell autonomous leukemo

103 nderlying genetic defect to those related to systemic disease and malnutrition.

104 shes that gingipains are crucially linked to systemic disease and potentially contribute to CVD.

105 s increasing with the improved management of systemic disease and prolongation of survival.

106 volvement occurs in patients with aggressive systemic disease and usually portends a poor prognosis f

107 tients in whom uveitis was associated with a systemic disease and was not influenced by concomitant i

108 Subjects with no known systemic disease and without retinal pathology were incl

109 r the remaining patients have submicroscopic systemic disease and, if so, what is the clinical signif

110 ive to Argentina and is associated with both systemic disease and, in some patients, neurological sym

111 o examine their relationship with ocular and systemic disease and, in some studies, to calculate the

112 ught to be associated with increased risk of systemic diseases and adverse pregnancy outcomes, includ

113 nto how its dysfunction contributes to multi-systemic diseases and cancer.

114 ht the complex relationship between CRVE and systemic diseases and conditions and the difficulty in d

115 The effect of periodontal infection on systemic diseases and conditions has been the subject of

116 associations between periodontal disease and systemic diseases and conditions specifically respirator

117 sociations between periodontitis and various systemic diseases and conditions, including chronic obst

118 sociations between periodontitis and various systemic diseases and conditions.

119 events, which variously manifest within the systemic diseases and disorders discussed.

120 d diabetes mellitus, and 3 had no associated systemic diseases and exhibited no evidence of immune de

121 Various systemic diseases and medications have been associated w

122 mation in the oral cavity is associated with systemic diseases and that oral microbial DNA is isolate

123 cal levels to the development of a number of systemic diseases and to the development of oral and gas

124 ogic changes associated with functional use, systemic disease, and aging.

125 sence of hypertension, proteinuria (>1 g/d), systemic disease, and CKD stage (at referral) were asses

126 charts included gender, age at presentation, systemic disease, and clinical presentation in each eye.

127 mediator symptoms, all with organomegaly had systemic disease, and none without organomegaly had syst

128 r disease in AAV can occur in the absence of systemic disease, and that in limited eye disease the AN

129 merican participants aged 5 to 21 y, free of systemic diseases, and diagnosed with LAP.

130 es were regarded as an alarm bell for future systemic diseases, and restricting carbohydrate intake p

131 children with diverse cardiac, pulmonary, or systemic diseases, and therapeutic options are currently

132 were clinical features, associated ocular or systemic diseases, approach towards its management, and

133 le localized hypersensitivity reactions from systemic disease are areas of active investigation.

134 and 1 (SPI-1), while macrophage survival and systemic disease are mediated by the T3SS encoded in SPI

135 This review will focus on IgG4-related systemic disease as a cause of thoracic aortitis, inflam

136 lack functional FasL, results in diminished systemic disease as well as pulmonary eosinophilia.

137 ss likely to seek care for this multifaceted systemic disease as well as to be aware of reasons for n

138 rahepatic metastases, the notion of HCC as a systemic disease, as detected by imaging, may be reconsi

139 ivity loss due to ocular, neurologic, and/or systemic disease, as well as injury and physiological st

140 Systemic diseases associated with NAION included hyperte

141 st the involvement of periodontopathogens in systemic diseases associated with periodontal inflammati

142 us uveitic diseases are idiopathic, and most systemic diseases associated with uveitis also are idiop

143 elay in presentation, and follow-up period), systemic disease association (associated disease, potent

144 al inheritance pattern can be masked and the systemic disease associations can be variable or even ab

145 Uveal melanoma appears to be a systemic disease at presentation.

146 t may also be involved in the development of systemic diseases (atherosclerosis, rheumatoid arthritis

147 95% CI, 0.32-0.86), patients with a moderate systemic disease burden (HR, 0.71; 95% CI, 0.69-0.72), a

148 es and within strata of age, gender, region, systemic disease burden, and in patients with versus wit

149 eterogeneous disorder that usually occurs in systemic diseases, but less commonly appears as nonsyste

150 Gut microbiota profoundly affect gut and systemic diseases, but the mechanism whereby microbiota

151 wed that gut microbiota remotely regulated a systemic disease by driving the induction and egress of

152 Recognition that IgG4-related systemic disease can involve the ascending as well as th

153 c diseases such as inflammation and of other systemic diseases can also be envisioned.

154 ent cataract surgery without other ocular or systemic disease comprised the controls.

155 ociated with several cardiac, pulmonary, and systemic diseases contributing to morbidity and mortalit

156 Systemic diseases, dental use, or smoking were not expla

157 excluded people with a history of ocular or systemic disease (diabetes or neurodegenerative diseases

158 Scleritis preceded systemic disease diagnosis in 38.7% of patients.

159 ortant biological process, especially in the systemic disease diagnostics and therapeutics, yet the p

160 accommodative esotropia, concurrent onset of systemic disease, disruption of central fusion, and mono

161 -cell lymphomas (ALCLs) encompass at least 2 systemic diseases distinguished by the presence or absen

162 da in the early 1990s, an epidemic of severe systemic disease due to PCV2 spread worldwide in the ens

163 Systemic disease due to shigellae is associated with hum

164 onset, putative trigger factors, coexisting systemic diseases, duration of symptoms and diagnoses gi

165 e investigated the role of PLA2 in local and systemic disease during S. pneumoniae infection.

166 e majority developed none to mild additional systemic disease during the study period.

167 disease and any associated often-undiagnosed systemic disease (e.g., Sjogren syndrome).

168 on health history, including the presence of systemic diseases (e.g., hypertension, cancer, or immuno

169 lly selected patients without extrapulmonary systemic disease experience similar survival after lung

170 It contrasts with the pathogenesis of systemic disease from the same virus following entry via

171 s with idiopathic dry eye and no evidence of systemic diseases from a dry eye practice have these aut

172 of salivary biomarkers for the detection of systemic diseases has been undermined due to the absence

173 unately, the targeted therapies that control systemic disease have diminished efficacy against brain

174 rious clinical presentations of IgG4-related systemic disease (IgG4-RSD) and to review the evolving l

175 The spectrum of IgG4-related systemic disease (IgG4-RSD) continues to widen.

176 Patients with IgG4-related systemic disease (IgG4-RSD) frequently show an incomplet

177 sorders collectively defined as IgG4-related systemic disease (IgG4-RSD) have prompted this review of

178 IgG4-related systemic disease (IgG4-RSD) is a systemic fibroinflammat

179 ch cognitive abnormalities are a function of systemic disease, impaired hepatic function, or virus in

180 eal findings were the first manifestation of systemic disease in 4 patients, and the diagnosis was no

181 gangrenosum is associated with a concomitant systemic disease in 50 to 70 % of cases, including infla

182 ) pathway markedly improves neurological and systemic disease in a mouse model of GD.

183 Ebola virus (EBOV) causes severe systemic disease in humans and non-human primates charac

184 Head smut is a systemic disease in maize caused by the soil-borne fungu

185 ainst both toxins blocked the development of systemic disease in mice.

186 gastroenteritis in humans and a typhoid-like systemic disease in mice.

187 lbicans is a commensal fungus that can cause systemic disease in patients with breaches in mucosal in

188 cherichia coli (APEC) causes respiratory and systemic disease in poultry.

189 ogen Listeria monocytogenes causes foodborne systemic disease in pregnant women, which can lead to pr

190 radation correlates with host adaptation and systemic disease in Salmonella.

191 lla enterica cause both gastrointestinal and systemic diseases in a broad range of mammalian hosts, i

192 ease complex and can also cause a variety of systemic diseases in cattle and sheep.

193 ociated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older childr

194 , has been implicated in various enteric and systemic diseases in normal and immunocompromised patien

195 In contrast, systemic disease, in the form of unrestrained lymphoprol

196 eatment of ocular conditions associated with systemic diseases including diabetic retinopathy, retina

197 d-borne illness and can cause intestinal and systemic disease, including severe renal damage.

198 The association between periodontitis and systemic diseases, including cardiovascular diseases and

199 Oral streptococci have been associated with systemic diseases, including infective endocarditis and

200 Several systemic diseases, including thrombotic thrombocytopenic

201 stically the sophisticated interplay between systemic disease 'initiators' and joint-specific 'locali

202 IgG4-related systemic disease is a newly recognized disorder that may

203 IgG4-related systemic disease is an autoimmune disease that was first

204 ough IL-1R, instigates skin inflammation and systemic disease is not known.

205 onella enterica to cause both intestinal and systemic disease is the direct injection of effector pro

206 but the mechanism whereby microbiota affect systemic diseases is unclear.

207 nying many dermatological, neurological, and systemic diseases is unresponsive to antihistamines.

208 IgG4-related systemic disease (ISD) is a recently recognized syndrome

209 lthough this supports the notion of AMD as a systemic disease, it also suggests that the adaptive imm

210 Although atherosclerosis is a systemic disease, its burden varies considerably across

211 In patients with progressive systemic disease, limited treatment options, and poor pe

212 cending aorta in the setting of IgG4-related systemic disease, linking IgG4-related systemic disease

213 (A/Vietnam/1203/04 virus) resulted in lethal systemic disease mainly affecting the intestine, liver,

214 l visual loss or rapid progression of latent systemic disease, making early diagnosis important.

215 diffuse or nodular scleritis with associated systemic disease may respond to IMT or BRMs.

216 the eye; none of the patients developed new systemic disease (median follow-up, 30.3 months).

217 utic treatments as well as several ocular or systemic diseases might induce changes in the mechanical

218 Systemic disease occurred more commonly in older patient

219 es (demographic and environmental variables, systemic diseases, ocular traits, and medications).

220 the causative agent of Glasser's disease, a systemic disease of pigs, and is also associated with pn

221 Viruses that cause systemic disease often spread through the bloodstream to

222 mework in which AD may be viewed either as a systemic disease or as a metastatic disorder leading to

223 small-cell lung cancer excluded) with stable systemic disease or asymptomatic primary tumors and WHO

224 cularly when inflammation is associated with systemic disease or when bilateral ocular disease is pre

225 diffuse or nodular scleritis with associated systemic disease (OR = 1.57, P = 0.047), mainly potentia

226 diffuse or nodular scleritis with associated systemic disease (OR = 3.15, P < 0.001).

227 thout baseline hypertension, proteinuria, or systemic disease (OR, 1.88; 95% CI, 1.27 to 2.79).

228 confidence interval [95% CI], 1.87 to 6.21), systemic disease (OR, 3.13; 95% CI, 1.51 to 6.50), and p

229 Epidemiologic factors, systemic diseases, other ocular pathologic characteristi

230 etween the gut and systemic sites alters the systemic disease outcome.

231 ting with solely orbital GPA developed later systemic disease over a median follow-up of 2.7 years.

232 nited States and that causes respiratory and systemic disease, particularly in individuals with impai

233 (MCI), and MBL and 2) to assess how various systemic diseases, periodontitis, and placement of impla

234 The frequency of hospital admission with systemic disease preinjury and postinjury was higher in

235 s cause CRS, are promoted by CRS, or share a systemic disease process with CRS.

236 Shared risk factors and/or common systemic disease processes might underlie this associati

237 at include genetic factors, association with systemic disease processes, and inflammatory or fibrotic

238 nset of other diseases or is an indicator of systemic disease processes.

239 metastasis form HCC has been considered as a systemic disease, prognosis after resection of them rema

240 follow-up time of 33 months, locoregional or systemic disease progression was observed in six patient

241 D patients affected by glomerulonephritis or systemic diseases ("progressive CKD") are compared with

242 these infections in the aetiology of several systemic diseases, ranging from arthritis to neurodegene

243 o this in the context of cancer as a complex systemic disease, rather than as a simple linearly progr

244 Two of these patients had systemic disease recurrence involving the primary malign

245 tive care, the mortality associated with the systemic disease remains high.

246 Under this hypothesis, dental and systemic diseases shared-as a common cause-a diet of exc

247 IgG4-related systemic disease should be considered in all patients wi

248 IgG4-related systemic disease should be considered in any patient fou

249 whether an association exists between common systemic diseases, sociodemographic factors, and keratoc

250 ted sialadenitis belongs to the IgG4-related systemic disease spectrum and shows a swift response to

251 d is seen in hepatitis C virus infection and systemic diseases such as B-cell lineage hematologic mal

252 Bone fracture healing impairment related to systemic diseases such as diabetes can be addressed by g

253 sideration the aging population and emerging systemic diseases such as diabetes mellitus and hyperten

254 be readily detected upon the development of systemic diseases such as pancreatic cancer, breast canc

255 In addition, all patients showed signs of systemic disease, such as arthritis, lymphopenia, or ant

256 ransposons to liver for treatment of various systemic diseases, such as hemophilia and mucopolysaccha

257 f a gingipain inhibitor (KYT) on Pg-mediated systemic disease, suggesting its potential use therapeut

258 al GPA involvement at presentation developed systemic disease, suggesting that orbital GPA can remain

259 reduce risks for a variety of age-associated systemic diseases, suggesting that such drugs might also

260 lation between toxemia and the occurrence of systemic disease, supporting the hypothesis that systemi

261 responses during early infection, and causes systemic disease symptoms.

262 Although systemic diseases take the biggest toll on human health

263 phoidal Salmonella serovars causes a febrile systemic disease, termed enteric fever.

264 (i.b.) exposure of NHPs to MPXV results in a systemic disease that better resembles the progression o

265 Diabetes mellitus is a systemic disease that increases the risk of infections.

266 ry responses in Gram-positive toxic shock, a systemic disease that is a significant cause of morbidit

267 aortic stenosis is a complex, multifaceted, systemic disease that is not solely limited to the aorti

268 An emerging view is that breast cancer is a systemic disease that utilizes intrinsic and extrinsic t

269 an infection (which will alter therapy) or a systemic disease that will affect the patient's health.

270 al process (the "high-risk plaque") and as a systemic disease (the "high-risk patient").

271 ed IL10 microparticles ameliorates local and systemic disease to enhance survival.

272 f the frequent good response of IgG4-related systemic disease to glucocorticoid treatment without add

273 may prevent progression of the IgG4-related systemic disease to involvement of other organs.

274 matic mosaicism are at risk for transmitting systemic disease to their offspring, and all individuals

275 Salmonella enterica serovar Typhi causes the systemic disease typhoid fever.

276 Salmonella enterica causes systemic diseases (typhoid and paratyphoid fever), nonty

277 Severity of ocular surface and systemic disease was graded.

278 Underlying systemic disease was identified in 34 (32.7%) patients.

279 The severity of SS ocular and systemic disease was inversely correlated with microbial

280 The incidence of systemic disease was reduced in coinfected animals, comp

281 Lymph-node involvement, as a marker of systemic disease, was also significant on univariate ana

282 s relevant to cutaneous lupus as compared to systemic disease, we generated genome-wide expression da

283 gle test definitively diagnoses IgG4-related systemic disease, we rely on a combination of histologic

284 associated uveitis, keratitis, glaucoma, or systemic disease were documented over the follow-up peri

285 Subjects with any ocular or systemic disease were excluded.

286 onic periodontitis (CP) (n = 15) without any systemic disease were included in the study.

287 Systemic diseases were common (diabetes: 5.8%; cardiovas

288 ata, clinical manifestations, and associated systemic diseases were recorded.

289 tor [RF]-negative polyarthritis, and 21 with systemic disease) were isolated from whole blood.

290 vealed features consistent with IgG4-related systemic disease, which had not been recognized at the t

291 coccus agalactiae, are an important cause of systemic disease, which is facilitated in part by the pr

292 dry eye disease and rheumatoid arthritis, a systemic disease with a known association with dry eye,

293 These findings suggest that VEDS is a systemic disease with a major inflammatory component.

294 lated systemic disease, linking IgG4-related systemic disease with a newly-recognized subset of nonin

295 FMD allowed us to demonstrate that FMD is a systemic disease with alterations in common with the spe

296 y-four hours before death, animals developed systemic disease with an apparent delayed inflammatory r

297 genus, Iridoviridae family, causing a severe systemic disease with high mortality in mandarin fish (S

298 rbidities, atopic dermatitis (AD) emerges as systemic disease with increased cardiovascular risk.

299 tered only anti-TcdA developed severe GI and systemic disease, with 67%-83% fatality, faring worse th

300 Glucocorticoid therapy for the IgG4-related systemic disease yielded a prompt response.