ライフサイエンスコーパス: systemic effect

1 or VMH under normoglycemic conditions had no systemic effect.

2 25 days), suggesting that topical VEGF had a systemic effect.

3 sms and evoke a host response could elicit a systemic effect.

4 ions was the best outcome variable to assess systemic effect.

5 r crypt-restricted level with no discernable systemic effect.

6 e requirement of an intact pituitary for the systemic effect.

7 on induced a local host response with little systemic effect.

8 rfactant and the lidocaine derivative, not a systemic effect.

9 f variable severity with little or no direct systemic effects.

10 ectin can exert such a variety of beneficial systemic effects.

11 ffectors outside the treatment field and has systemic effects.

12 acute inflammation and determine beneficial systemic effects.

13 O by systemic delivery is low with potential systemic effects.

14 y be useful for tissue repair and minimizing systemic effects.

15 the impact on liver parenchyma and avoiding systemic effects.

16 pressures without any adverse cardiovascular systemic effects.

17 ile minimizing the confounding influences of systemic effects.

18 f the potential for local destruction and/or systemic effects.

19 ow by 24+/-4% (n=8, P<0.001) without causing systemic effects.

20 ripheral muscular insulin resistance through systemic effects.

21 stoperatively, with no signs of tolerance or systemic effects.

22 nged use is not associated with tolerance or systemic effects.

23 Thus, catecholamines may have both local and systemic effects.

24 ioplasty in pigs without causing significant systemic effects.

25 and was well tolerated, with no evidence of systemic effects.

26 onse that differ depending upon the local or systemic effects.

27 nist can cause coronary vasodilation without systemic effects.

28 reduce the risk of radiation-related adverse systemic effects.

29 e propionate are mediated through topical or systemic effects.

30 topical effects in the lungs and not through systemic effects.

31 otent pulmonary vasodilator without apparent systemic effects.

32 tissue-specific effect rather than to other systemic effects.

33 ne the role of the cortex in mediating their systemic effects.

34 r release into the circulation may also have systemic effects.

35 to the left main coronary artery to minimize systemic effects.

36 ecessary to see more pronounced clinical and systemic effects.

37 t rejection is not long lasting and can have systemic effects.

38 er growth and progression locally or through systemic effects.

39 cells, or a heightened immune reaction with systemic effects.

40 , extracellular dsRNA induces both local and systemic effects.

41 te in the skin and require the pituitary for systemic effects.

42 ic full dose administration but with minimal systemic effects.

43 triglyceride and VAT may be because of toxic systemic effects.

44 ces can cause these effects along with other systemic effects.

45 icular (i.a.) administration, and it induces systemic effects.

46 the skin, whereas others are not, indicating systemic effects.

47 asis, which in turn translates positively to systemic effects.

48 that affect inflammation with both local and systemic effects.

49 pproach to treating obesity while minimizing systemic effects.

50 a dose (4.6 mug) that was too low to produce systemic effects.

51 efficacy as oral propranolol while reducing systemic effects.

52 cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty ac

53 Here, we present supportive evidence on systemic effects after (211)At administration.

54 e (10 mg/kg) caused lung inflammation but no systemic effects after 6 h of ventilation.

55 n the cardiovascular system result from both systemic effects and direct actions of the hormone on th

56 ponse in relation to baseline, adjusting for systemic effects and skewed data, we expressed the hyper

57 anisms of action, efficacy, adverse effects, systemic effects, and comparisons with standard treatmen

58 questions have arisen about their local and systemic effects, and their effects upon the optic nerve

59 There is increasing evidence that leptin has systemic effects apart from those related to energy home

60 Both local and systemic effects are likely to contribute to the develop

61 medications suppress arrhythmias, but their systemic effects are often poorly tolerated and their pr

62 a 3-D tissue architecture while eliminating systemic effects as can be seen with in vivo models.

63 for 2 hours is below the threshold for acute systemic effects as detected by these endpoints.

64 2D-regulating hormone FGF23, and the broader systemic effects associated with abnormalities of calciu

65 on has significant systemic effects, but the systemic effects associated with ventilator-induced lung

66 e endotoxin-exposed preterm lung resulted in systemic effects at a low endotoxin dose and without hig

67 hildren may be at a greater risk for adverse systemic effects because they can receive higher mg/kg d

68 Such agents, having negligible systemic effects but active at sites of inflammation, re

69 -activated CD4(+) T lymphocytes had positive systemic effect, but failed to improve control of tuberc

70 ssure mechanical ventilation has significant systemic effects, but the systemic effects associated wi

71 To assess whether this is a local or a systemic effect, C57BL/6 mice were infected simultaneous

72 and generalized) associated with nonspecific systemic effects, diaphoresis, and less commonly other a

73 fying mechanism of action for the beneficial systemic effects exerted by adiponectin, with sphingolip

74 d new inhalers also affect the potential for systemic effects following inhaled administration.

75 The systemic effects from the excessive use of alcohol incre

76 ce of disease and unknown adverse ocular and systemic effects have caused concern from some clinician

77 In addition to potential systemic effects, IL-17 is expressed locally in AT by le

78 dolent cells, these activated BMCs mimic the systemic effects imparted by instigating tumors.

79 ced local IFN-I responses and did not induce systemic effects, implying good tolerability and a favor

80 ogeneic islet transplantation had a positive systemic effect in diabetic rats and induced regression

81 Spider bites cause fewer systemic effects in children than adults.

82 ation settings induced pronounced persistent systemic effects in mice, which resulted from even short

83 i.a. injection of HA-sCT did not trigger any systemic effects in rats.

84 Systemic effects include transient volume expansion, nat

85 energy imbalance frequently associated with systemic effects including insulin resistance, altered h

86 e may be related to paracrine properties and systemic effects, including anti-inflammatory activities

87 nhances Ca2+ and Mg2+ excretion and leads to systemic effects, including bone loss.

88 hese local changes of IRE induce more robust systemic effects, including both tumorigenic and immunog

89 These treatments also displayed systemic effects, including reversal of the tumor-induce

90 flammatory reactions may lead to detrimental systemic effects, including septic shock and autoimmunit

91 le-specific genetic interventions can induce systemic effects indirectly, via changes in the mass and

92 ent on both dose and duration; the degree of systemic effects is dependent on pharmacokinetic propert

93 However, better understanding of systemic effects is essential in unraveling key molecula

94 However, knowledge of systemic effects is still rudimentary.

95 ce that the neuropeptide SP, among its broad systemic effects, is a potent neuroimmunoregulator that

96 New therapeutic strategies with global systemic effects may offer advances in treatment and out

97 and can cause severe skin lesions and rarely systemic effects; most bites are unremarkable.

98 In addition to its systemic effects, obesity causes subclinical white adipo

99 Adverse systemic effects occurred in 9 of 40 (23%) patients rece

100 A decrease in splenic weight (evidence of a systemic effect) occurred at all doses of budesonide.

101 ese prefrontal regions alone may mediate the systemic effect of ADHD medications on impulsive choice.

102 nt in the sexual dimorphism, we examined the systemic effect of IL-17 by genetically ablating Il-17 i

103 Pharmacodynamic assessment of the systemic effect of inhaled corticosteroids (ICSs) is oft

104 Higher circulatory HGF levels indicate a systemic effect of periodontitis.

105 To date, few studies have characterized the systemic effect of sepsis on DC populations in lymphoid

106 ion, and this appears to be unrelated to any systemic effect of the treatment regimen.

107 using several murine tumors, we examined the systemic effects of 4-1BB mAb on the growth of s.c., int

108 RPV1 to OA-related pain, we investigated the systemic effects of a selective TRPV1 receptor antagonis

109 a method to examine directly the deleterious systemic effects of absent renal clearance in ARF withou

110 However, the systemic effects of adiponectin in humans are unknown.

111 Potential systemic effects of alcohol relapse were assessed by cha

112 Systemic effects of anesthesia on the dynamics of the ap

113 The devastating systemic effects of bacterial superantigens may be expla

114 bloodstream infection at removal; local and systemic effects of catheters were assessed.

115 g in the hippocampus could contribute to the systemic effects of cholinergic drugs, we infused physos

116 blood substitutes have been appreciated, the systemic effects of chronic hemolysis on nitric oxide bi

117 rmalities on arrhythmias without the complex systemic effects of diabetes mellitus and obesity, we st

118 In Group 2 we measured the pulmonary and systemic effects of dipyridamole while the patients were

119 n shown to cause forearm vasodilatation, the systemic effects of endothelin receptor blockade in heal

120 nt glucocerebrosidase (GCase) ameliorate the systemic effects of GD, the lack of efficacy for the neu

121 acteristics of the individual drug influence systemic effects of ICS.

122 a more sensitive pharmacodynamic measure of systemic effects of ICSs than 24-hour UFC excretion and

123 The present study results link the systemic effects of induced periodontitis with changes i

124 tudy validates a new tool to study local and systemic effects of leukocytes in pancreatitis as well a

125 ral, untreated joints, indicating beneficial systemic effects of local suppression of NF-kappaB.

126 these findings were not attributable to the systemic effects of medications or the postoperative sta

127 pite recent advances in understanding of the systemic effects of methylglyoxal, the full significance

128 Gauging the systemic effects of non-synonymous single nucleotide pol

129 h the role of hepatocyte NAD levels from any systemic effects of NR, we generated mice overexpressing

130 tructure and function are independent of the systemic effects of obesity and visceral adiposity has n

131 These results suggest that the systemic effects of obesity on cardiac structure and fun

132 current knowledge regarding the deleterious systemic effects of phosphate and FGF23 excess, identifi

133 mor effects of antibodies and reduce adverse systemic effects of potent cytotoxic drugs.

134 of PPARalpha in vivo can be masked by other systemic effects of PPARalpha activators.

135 l mice, which may contribute to the observed systemic effects of PT.

136 nd prevention of CRC; and, further, that the systemic effects of resistant starch may be important fo

137 We evaluated the systemic effects of SLIT in a longitudinal analysis of h

138 3-/- phenotype may be, in part, secondary to systemic effects of Smad3 deletion.

139 inhibition had no effect on the coronary and systemic effects of SNP and adenosine.

140 he need to further investigate the potential systemic effects of specific 5-HT(2A)R agonists, such as

141 he current study, we evaluated the local and systemic effects of staphylococcal enterotoxin B (SEB) a

142 To gain more insight into the systemic effects of such cellular search precision modul

143 actions could be attributed to local and not systemic effects of the antagonists.

144 h a number of biochemical changes indicating systemic effects of the cancer.

145 ntralesional therapy is used to minimize the systemic effects of the drug.

146 Life-threatening intestinal and systemic effects of the Shiga toxins produced by enteroh

147 well investigated, little is known about the systemic effects of the stress response mechanism.

148 portunity to mechanistically investigate the systemic effects of the surgical interventions, such as

149 (MC5-R), suggested non-steroidally mediated systemic effects of these peptides.

150 To more fully assess the systemic effects of this primary virus infection, specim

151 NF-alpha synthesis and limits TNFRI-mediated systemic effects of TNF-alpha originating in the lung.

152 With respect to systemic effects of topical ocular medications, there wa

153 tudies investigating the pathophysiology and systemic effects of transient hyperglycemia in nondiabet

154 ey might provide the possibility to evaluate systemic effects of treatments.

155 Purpose To compare both periablational and systemic effects of two mechanistically different types

156 roves that CPB is a major contributor to the systemic effects of type C infections and provides new m

157 The role of Rho-kinase in the renal and systemic effects of vasopressin was investigated through

158 Here, we discuss the local and systemic effects of VEGF on tumor immunity and propose a

159 Methods of limiting visceral ischemia or the systemic effects of visceral ischemia may decrease both

160 The importance of nontargeted (systemic) effects of ionizing radiation is attracting in

161 administered CAR enhanced pulmonary, but not systemic, effects of the vasodilators, fasudil and imati

162 ects on bone resorption and only a transient systemic effect on bone formation.

163 cemia in SCHAD CHI can be uncoupled from the systemic effect on fatty acid oxidation.

164 fferences in bacterial burdens, indicating a systemic effect on host innate immunity from production

165 irectly and autonomously, in addition to its systemic effect on lifespan.

166 ulation, causing a localized response and/or systemic effect on phloem transportation.

167 al effects in the arterial wall as well as a systemic effect on plasma lipoproteins.

168 488 injections partially mimicked the drug's systemic effect on reinstatement.

169 leaves (i.e. local effects), but they had no systemic effect on rust of leaves not inoculated with en

170 indicate that tumor cells exert an aberrant systemic effect on the bone marrow microenvironment and

171 Induction of IL-2 had no systemic effect on the frequency or activational status

172 a models, suggesting that cancers, through a systemic effect on the host, can induce an increase in p

173 e potential of the skin microbiome to have a systemic effect on the human body.

174 This demonstrates long-term systemic effect on the regulatory immune system that was

175 Because this pancreatic peptide has systemic effects on bone resorption and blood ionized ca

176 dipogenesis by bone marrow stromal cells and systemic effects on bone resorption.

177 xamined whether psoriasis is associated with systemic effects on epidermal Langerhans cell (LC) funct

178 mune response to chronic viral infection has systemic effects on epithelial turnover through a myeloi

179 amine (DA) agonists were evaluated for their systemic effects on firing rates of DA neurons in rat su

180 n addition, vitamin D has been shown to have systemic effects on insulin resistance, dyslipidemia, an

181 between local effects in the artery wall and systemic effects on lipid metabolism.

182 Lebrikizumab exerted systemic effects on markers of Th2 inflammation, reducin

183 contraindicated for obesity treatment due to systemic effects on multiple organs.

184 ead to altered exposure to Notch signals and systemic effects on neurogenesis in the retina.

185 tohormone in plant-microbe interactions with systemic effects on resistance and susceptibility.

186 Systemic effects on skeletal muscle and the heart and in

187 t discovery is that food antigens have major systemic effects on T cells, similar in many ways to tho

188 ynovium, suggesting the T cells may have had systemic effects on the B cell response as well as local

189 olized EPI-2010 did not have any significant systemic effects on the cardiovascular system as determi

190 late in the bloodstream, where they can have systemic effects on the host.

191 periodontitis and damage caused through its systemic effects on the liver.

192 al or processive), rather than to any direct systemic effects (pain, blood loss, infection, etc.) of

193 hough most studies focus on the influence of systemic effects, recent studies indicate that ultrafine

194 travitreal anti-CCR3 antibody yielded strong systemic effects, reducing CNV in the untreated, contral

195 role for the immune system in both local and systemic effects resulting from HSV-tk treatment, the ca

196 lated under various conditions to illustrate systemic effects such as catabolite repression, the aero

197 ates BAT energy expenditure with fewer other systemic effects, suggesting that cold activates specifi

198 In addition to its systemic effects, TGF-beta regulates infiltration of inf

199 in human lung S9 fraction, showed much lower systemic effects than budesonide in the thymus involutio

200 lic deactivation and may have less prolonged systemic effects than other compounds with arotinoid-lik

201 of L. donovani by infected hosts, owing to a systemic effect that exposure to bites has on the parasi

202 Local radiation also triggers systemic effects that can be used in combination with im

203 expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in

204 at air pollution components reach the brain; systemic effects that impact lung and cardiovascular dis

205 mone epinephrine is known to elicit multiple systemic effects that include changes in cardiovascular

206 can causally induce long-lasting beneficial systemic effects that lead to life span extension in a v

207 lysosomes of macrophages in the lesions; (2) systemic effects that mediate the liver to reduce the he

208 Therefore, to control for these systemic effects, the current studies utilized microinje

209 icular injection of insulin led to a greater systemic effect to improve glucose tolerance and insulin

210 immunostimulatory DNA sequences likely exert systemic effects via IL-12 and IFN-gamma-dependent mecha

211 ere no significant differences in markers of systemic effects (vital signs, potassium, and blood gluc

212 Systemic effect was evaluated by hourly plasma cortisol

213 The contribution of local versus systemic effects was evaluated using hemibody (left vers

214 To overcome treatment evasion and reduce systemic effects, we developed CXCR4-targeted nanopartic

215 To model systemic effects, we used the human monocytic cell line

216 Systemic effects were also observed, including diarrhea,

217 No considerable systemic effects were observed with epinephrine treatmen

218 No serious adverse events or systemic effects were observed.

219 Systemic effects were then assessed by comparing tumor f

220 duce cancer cell apoptosis but cause adverse systemic effects when administered to mice.

221 chondria of tumor cells, or through indirect systemic effects, which remain to be identified.

222 To avoid these systemic effects while stimulating glucagon-like peptide

223 delivery of drugs to the skin for local and systemic effects without the need for hypodermic needles