ライフサイエンスコーパス: systolic function

1 me less than $30,000, and 23% with preserved systolic function).

2 , larger right ventricular size, and reduced systolic function.

3 he number of patients with severely impaired systolic function.

4 ificantly reduced infarct sizes and improved systolic function.

5 ntricular volumes and mass and normal global systolic function.

6 GGF2 treatment was associated with improved systolic function.

7 ntrol in heart failure patients with reduced systolic function.

8 fibrosis and improvement of left ventricular systolic function.

9 h HF across the spectrum of left ventricular systolic function.

10 rom 2004 to 2009 and had normal preoperative systolic function.

11 significant improvement in LV diastolic and systolic function.

12 alpha1AMPK, without any further decrease in systolic function.

13 e of passive stiffening rather than enhanced systolic function.

14 icantly related to level of left ventricular systolic function.

15 nfarcted rats preserves cardiac geometry and systolic function.

16 ediatric cancer survivors with normal global systolic function.

17 significant impairment in right ventricular systolic function.

18 GGF2 induced improvement in left ventricular systolic function.

19 with left ventricular dysfunction, improves systolic function.

20 gh global afterload and reduced longitudinal systolic function.

21 y that attenuates LV remodeling or preserves systolic function.

22 ongestive heart failure (HF) and with normal systolic function.

23 ion in LV myofibre stress and more efficient systolic function.

24 g adults before any significant reduction in systolic function.

25 the regenerated ventricular apex had normal systolic function.

26 n accurate and reproducible assessment of RV systolic function.

27 crease in fractional shortening and improved systolic function.

28 n patients with HF and preserved or impaired systolic function.

29 es from L29Q-CTnC may preserve diastolic and systolic function.

30 evidence of increased LV mass and reduced LV systolic function.

31 ic dysfunction, in the absence of changes in systolic function.

32 s with HF, long-term CCM therapy improves LV systolic function.

33 using progressive LV dilation and diminished systolic function.

34 ality in patients with reduced and preserved systolic function.

35 d myocyte size, and reduced left ventricular systolic function.

36 in patients with depressed left ventricular systolic function.

37 study is to ascertain left ventricular (LV) systolic function.

38 patients with reduced left ventricular (LV) systolic function.

39 to be female and black and to have preserved systolic function.

40 utcome of patients with CAD and preserved LV systolic function.

41 2) and tau (rs=-0.59; P=0.002), but not with systolic function.

42 ion and improved both membrane integrity and systolic function.

43 sis severity, and status of left ventricular systolic function.

44 naling and improves cardiac left ventricular systolic function.

45 global longitudinal strain, a measure of LV systolic function.

46 ent and diastolic dysfunction with preserved systolic function.

47 post-PPCM women with apparent recovery of LV systolic function.

48 and 10 days proved superior toward improving systolic function.

49 the progressive decline in left ventricular systolic function.

50 damage precedes decline in left ventricular systolic function.

51 largement, and hyperdynamic left ventricular systolic function.

52 of lifelong exercise, with little change in systolic function.

53 reduced peak right ventricular longitudinal systolic function.

54 tients with nonobstructive HCM and preserved systolic function.

55 cular origin about biventricular volumes and systolic function.

56 ongestive heart failure (HF) and with normal systolic function.

57 l contractility than traditional measures of systolic functions.

58 tes mellitus and normal stress perfusion and systolic function (0.3%/y versus 0.5%/y; P=0.65).

59 I, 6.9 to 198.3; hazard ratio for borderline systolic function, 3.5; 95% CI, 1.2 to 10.2).

60 on average, later (hazard ratio for abnormal systolic function, 36.9; 95% CI, 6.9 to 198.3; hazard ra

61 years), intermediate for HF but preserved LV systolic function (5.32; 7.24), and lowest in patients w

62 twice as likely to die as those with normal systolic function, adjusted for risk factors including d

63 for cardiac PGD comprising severely impaired systolic function affecting one or both ventricles accom

64 ients with LVEF <50%, 6 had normalization of systolic function after a median of 20 days.

65 he adult heart and improves left ventricular systolic function after adult MI.

66 ardiac function; however, they display lower systolic function after I/R compared to wild-type animal

67 d with a better left ventricular filling and systolic function after surgery.

68 ulmonary resuscitation, and left ventricular systolic function after weaning.

69 eart failure, regardless of left ventricular systolic function, age, gender, or prior CHD, conferred

70 ection fraction showed a similar decrease in systolic function (all P<0.05).

71 imaging, usually with rapid return to normal systolic function, although delayed >2 months in 5%.

72 o pressure overload, LNA-antimiR-34 improved systolic function and attenuated lung congestion, associ

73 in patients with poor left ventricular (LV) systolic function and broad QRS complex in the surface e

74 termed dyssynchrony, this further decreases systolic function and chamber efficiency and worsens mor

75 trophy while attenuating deterioration in LV systolic function and contractility.

76 ion, further worsen myocardial diastolic and systolic function and contribute to the major remodeling

77 complications, most patients maintain normal systolic function and exercise capacity.

78 Recent guidelines recommend assessment of systolic function and filling pressures to augment angio

79 Measures of ventricular systolic function and functional health status, although

80 heart failure with reduced left ventricular systolic function and heart failure with preserved left

81 ndices to characterize left ventricular (LV) systolic function and its relationship to activation of

82 c arch angle, left ventricular (LV) mass, LV systolic function and left atrial (LA) volumes, and LA p

83 associated with reduced global and septal LV systolic function and LV fibrosis at the RV-LV hinge poi

84 tricular apex+LV and LV-only pacing enhanced systolic function and LV synchrony at individually optim

85 in patients with preserved left ventricular systolic function and management techniques to prevent i

86 ite measure of left ventricular longitudinal systolic function and maximum left atrium volume before

87 mon form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy

88 me catheterization studies revealed impaired systolic function and prolonged diastolic relaxation com

89 autologous CSCs is effective in improving LV systolic function and reducing infarct size in patients

90 er HT with most significant impairment in RV systolic function and RV and LV early-diastolic filling.

91 mbled the ARVC phenotype (impaired global RV systolic function and RV regional wall motion abnormalit

92 eltasg(S151A) developed marked impairment of systolic function and significantly enlarged cardiac cha

93 diastolic performance, subtle reductions of systolic function and the clinical syndrome of heart fai

94 ocardiography revealed transiently increased systolic function and unaltered diastolic function 1 day

95 By echocardiography, it was found that systolic function and ventricular geometry were maintain

96 would be a reliable method for assessing RV systolic function and whether strain values were associa

97 th acutely and chronically increases cardiac systolic function and work, yet it also reduces long-ter

98 odeling or fibrosis, normal left ventricular systolic function, and aorta stiffness).

99 lnesses, laboratory values, left ventricular systolic function, and characteristics of the index admi

100 ar (LV) volume, mass, left atrial (LA) size, systolic function, and diastolic function were made at b

101 ith pericardial edema, decreased ventricular systolic function, and embryonic mortality.

102 nd points included mean SVRI, cardiac index, systolic function, and lactate levels.

103 ith AS have impaired diastolic, longitudinal systolic function, and left atrial dilatation compared w

104 pathological cardiac hypertrophy, depressed systolic function, and lung congestion.

105 nary artery disease, better left ventricular systolic function, and similar processes and quality of

106 luble ST2 prevents eosinophilia and improves systolic function, and that IL-33 independently adversel

107 hypertrophy, worse LV and right ventricular systolic function, and worse LV diastolic function.

108 contrast, impaired relaxation and preserved systolic function appear to be the predominant early man

109 on patients with heart failure and preserved systolic function are another group in whom maintenance

110 maladaptive cardiac remodeling and decreased systolic function are common clinical consequences, begg

111 LV diastolic and systolic function are depressed after TOF repair.

112 eart failure with preserved left ventricular systolic function are partially distinct entities, with

113 Subtle abnormalities in systolic function are present in subclinical DCM mutatio

114 with subclinical alterations in LV size and systolic function as detected by cardiac MRI.

115 oorer than men in terms of right ventricular systolic function as tested by cardiac magnetic resonanc

116 Depressed systolic function, as assessed on a study echocardiogram

117 splay a marked reduction in left ventricular systolic function, as evidenced by decreases in ejection

118 dings have implications for left ventricular systolic function ascertainment in patients with HF and

119 early and delayed gadolinium enhancement and systolic function assessment.

120 In patients with reduced systolic function, AVNA demonstrates small but significa

121 Abnormal LV structure, systolic function (based on LV ejection fraction and lon

122 Right ventricular (RV) size and systolic function between baseline and last follow-up we

123 pared with patients with HF but preserved LV systolic function; both had a greater risk than patients

124 All patients had normal systolic function, but impaired diastolic function.

125 Cpt) reduced LV hypertrophy and protected LV systolic function, but we had not evaluated the clinical

126 mm Hg (left ventricular [LV] DD) with normal systolic function by echocardiogram and without severe m

127 lantation, two patients had normalization of systolic function by hospital discharge, while the systo

128 e myocardial segments, despite normal global systolic function by transthoracic echocardiography and

129 k rivaled traditional factors such as BP and systolic function; by 10 yr, creatinine clearance surpas

130 Thus, reduced systolic function cannot account for worse outcomes in p

131 tions show markedly reduced left ventricular systolic function, cardiac output, and functional work c

132 118C corrected the significant depression of systolic function caused by cTnT exon 7 deletion, and th

133 d matrix remodeling can impair diastolic and systolic function caused by excess deposition of interst

134 cally relevant differences in LV volumes and systolic function changes among the quintiles of trabecu

135 heart rate with unaffected left ventricular systolic function compared with 36 degrees C.

136 restored contractile synchrony and improved systolic function compared with DHF.

137 from TgRR mice had elevated left ventricular systolic function compared with wild-type (WT) mice, bot

138 Quantification of diastolic and systolic function continues to be a major focus in echoc

139 After transplantation, systolic function continues to improve and may reach nor

140 treated with bortezomib with improvement in systolic function, conversion of biopsy to C4d negative

141 Impaired right, left, or biventricular systolic function derived from baseline CMR and resting

142 Strain imaging detects impaired systolic function despite preserved global LVEF in HFpEF

143 iated with reduced regional left ventricular systolic function detected by tagged magnetic resonance

144 Indices of systolic function did not differ between groups.

145 Left ventricular systolic function did not differ between the 2 groups.

146 al hypertension and is closely related to RV systolic function during exercise, maximal exercise capa

147 tween echocardiographic left ventricular(LV) systolic function (E-function) and pulmonary artery cath

148 Systolic function (EF, end-systolic and end-diastolic vo

149 r, no significant change was observed in the systolic function (EF-weighted mean difference, 1.26; 95

150 r heart transplant, including 20 with normal systolic function (ejection fraction >/=50%).

151 s; male, 59%) and preserved left ventricular systolic function (ejection fraction >/=55%) were prospe

152 There was also no effect of oxygen on systolic function (ejection fraction pre oxygen, 34+/-1%

153 size and normal conventional measures of LV systolic function (end-diastolic dimension, 42 +/- 6 mm;

154 rally accepted load-independent parameter of systolic function, end systolic elastance (Ees), require

155 3,623 patients with stable CAD and preserved systolic function enrolled in the PEACE (Prevention of E

156 stable coronary artery disease and preserved systolic function enrolled in the Prevention of Events w

157 pontin and NOX4 gene expression), and normal systolic function, filling pressures, and diastolic stif

158 heart failure, in the presence of preserved systolic function, for whom heart transplant is the sole

159 Preload, contractility, systolic function (global and focal), and assessment of

160 Patients with preserved systolic function had poor outcomes, and beta-blockers d

161 Impairment in left ventricular systolic function has been described in heart failure (H

162 ure who have reduced or relatively preserved systolic function has not been well studied.

163 rval: 2.44 to 12.0; p < 0.0001) and impaired systolic function (hazard ratio: 2.37; 95% confidence in

164 comes of patients with preserved and reduced systolic function heart failure (HF).

165 xime in Pts With Worsening HF and Reduced LV Systolic Function [HORIZON-HF]; NCT00616161).

166 The present study showed that impaired RV systolic function, hypertrophy, and dilation were presen

167 in patients with heart failure and preserved systolic function (I-Preserve) trial.

168 LV systolic function improved as early as 30 days, the grea

169 y in patients with impaired left ventricular systolic function improves when performed early in the n

170 rtantly, ACCT exerted the greatest effect on systolic function, improving the end-systolic pressure-v

171 Systolic function in 32 patients with isolated moderate-

172 sed the relation of SDB to LV morphology and systolic function in a community-based sample of middle-

173 prognostic value of GLS as a new index of LV systolic function in a large cohort of patients with chr

174 et of symptoms, despite frequently preserved systolic function in about one quarter of the patients.

175 days) there was recovery of left ventricular systolic function in all patients (median ejection fract

176 hy and diastolic dysfunction, with preserved systolic function in Ang II- and PE-treated mice.

177 d diastolic dysfunction with preservation of systolic function in association with myocyte hypertroph

178 eart failure treatment that improves chamber systolic function in both the short-term and long-term y

179 Reduced dobutamine augmentation of systolic function in cMyBP-C(t3SA) hearts during echocar

180 sonance imaging was able to detect preserved systolic function in EHM-treated animals compared with c

181 contributed to the observed preservation of systolic function in HDAC inhibitor-treated hearts.

182 ity, dimerisation, and its relationship with systolic function in ICM.

183 onary load is an important determinant of RV systolic function in PAH, there remains a significant va

184 We aimed to study RV systolic function in patients with Chagas disease using

185 erload stress induces a deeper impairment of systolic function in patients with more advanced degrees

186 eometric confounders, strain better reflects systolic function in patients with preserved EF.

187 e-dependent augmentation of left ventricular systolic function in response to omecamtiv mecarbil and

188 These data provide an explanation for slowed systolic function in the intact heart in response to RLC

189 ferential strain predicts the recovery of LV systolic function in the longer term.

190 is the unexplained loss of maternal cardiac systolic function in the period surrounding parturition.

191 ased on measurements of the left ventricular systolic function in treated mice.

192 Omecamtiv mecarbil (OM) enhances systolic function in vivo by directly binding the myosin

193 on to detect differences in left ventricular systolic function in women with and without preeclampsia

194 coronary artery disease (CAD) and preserved systolic function in women, which contrasts with greater

195 d with adverse LV remodeling and impaired LV systolic function in women.

196 failure is commonly associated with impaired systolic function, in up to one half of cases, heart fai

197 Prevalence of impaired right ventricular systolic function increased from 1% in 2001 to 17% in 20

198 re treatment that enhances acute and chronic systolic function, increases cardiac work, and reduces m

199 pensated HF with either reduced or preserved systolic function, independent of other clinical and lab

200 n the midrange LVEF HF population, recovered systolic function is a marker of more favorable prognosi

201 Impaired left ventricular systolic function is a powerful predictor of HF hospital

202 Decreased systolic function is central to the pathogenesis of hear

203 LV systolic function is enhanced in cirrhosis due to augmen

204 e presence of diastolic dysfunction, even if systolic function is normal.

205 the impact of AVNA in patients with reduced systolic function is of growing interest.

206 Complete recovery of left ventricular systolic function is often delayed to more than 1 year f

207 ns for which assessment of right ventricular systolic function is particularly important, and review

208 In contrast, LV systolic function is preserved in RA patients, indicatin

209 ure, particularly when left ventricular (LV) systolic function is preserved.

210 infarct size and preserving left ventricular systolic function is primary percutaneous coronary inter

211 The ability to dynamically alter systolic function is significantly diminished, while the

212 ntain left ventricular and right ventricular systolic function, isolation from electromagnetic interf

213 itative assessment of right ventricular (RV) systolic function largely depends on right ventricular e

214 mary outcome measures: left ventricular (LV) systolic function (left ventricular ejection fraction),

215 Left ventricular (LV) systolic function, LV mass, left atrial volumes, and blo

216 s, 86+/-41 [46-195] g/m(2)) was progressive, systolic function mainly preserved (cardiac index 2.8+/-

217 AAS users demonstrated relatively reduced LV systolic function (mean+/-SD left ventricular ejection f

218 tors with left ventricular (LV) geometry and systolic function measured by cardiac magnetic resonance

219 cantly lower survival than those with higher systolic function (median 49 +/- 3.1 versus 72 +/- 4.0 m

220 Among patients with preserved systolic function (n = 4,153), beta-blockers were associ

221 include classic and novel agents to improve systolic function, neurohormonal modulators, heart rhyth

222 g-term therapy with elamipretide improves LV systolic function, normalizes plasma biomarkers, and rev

223 to providing a reliable determination of RV systolic function, nuclear-imaging techniques are emergi

224 ed by elevated filling pressures with normal systolic function, occurring in the first year after tra

225 Improvement of LV systolic function occurs early after initiating therapy.

226 rresponded to a fitness value from improving systolic function of the heart.

227 ic function by hospital discharge, while the systolic function of the remaining four patients normali

228 When the systolic functions of the NE/Ang II-treated cells were m

229 F of 40% to 55%, and the impact of recovered systolic function on the clinical features, functional c

230 in LV diastolic function but no effect on LV systolic function or LV mass.

231 nylephrine was inversely related to baseline systolic function (P < 0.05) and associated with markers

232 on, and subtle reduction in left ventricular systolic function (P</=0.01 for all).

233 bout the association of risk factors with LV systolic function, particularly in populations without c

234 ardiomyopathy with LV dilation and depressed systolic function (percent fractional shortening, 39+/-4

235 the role of nuclear imaging in assessing RV systolic function, perfusion, and metabolism.

236 1-9) gene therapy preserved left ventricular systolic function post-MI, restoring cardiac function.

237 diated intracoronary gene transfer preserved systolic function, potentially prevented diastolic dysfu

238 enic mice exhibited reduced left ventricular systolic function (predoxorubicin fractional shortening

239 C-CB7 mice exhibited normal left ventricular systolic function (predoxorubicin FS 63+/-2%, postdoxoru

240 Left ventricular systolic function (predoxorubicin FS 64+/-2%, postdoxoru

241 Heart failure with preserved systolic function (PSF) is common but not well understoo

242 ompensated heart failure (HF) with preserved systolic function (PSF).

243 erate heart failure and reduced or preserved systolic function, randomized from the Chicago metropoli

244 r afterload, and may be because of intrinsic systolic function rather than enhanced pulmonary vascula

245 Consecutive patients with preserved systolic function referred for CMR were eligible.

246 d RV function normalize in 6 to 9 months, RV systolic function remains abnormal 1 year-post-transplan

247 Left ventricular diastolic and systolic function returned to baseline level at 72 hrs p

248 diastolic volume=101+/-26 mL/m(2)) with good systolic function (right ventricular ejection fraction=5

249 However, RV systolic function (RV S' z score -1.2+/-1.1) remained im

250 = 0.33, p < 0.0001), right ventricular (RV) systolic function (RV s': r = -0.30, p < 0.0001), and RV

251 unction with most prominent impairment in RV systolic function (S' z score -2.7+/-0.8), RV early-dias

252 LV systolic function (S' z score) and late-diastolic fillin

253 n seems to be influenced by left ventricular systolic function, stress-induced myocardial ischemia, a

254 ameters traditionally considered to describe systolic function, such as ejection fraction and longitu

255 ough thapsigargin decreased left ventricular systolic function sufficient to reduce cardiac output by

256 ey often present at an older age with better systolic function than men.

257 ar size reduction and restores diastolic and systolic function toward normal after MI.

258 lysis included 21 cohorts for structural and systolic function traits (n = 32,212) and 17 cohorts for

259 e Irbesartan in Heart Failure with Preserved systolic function trial (I-Preserve), the Candesartan in

260 (Irbesartan in Heart Failure with Preserved Systolic Function Trial), with patients of similar age,

261 In patients with normal systolic function undergoing bovine pericardial aortic v

262 either reduced or preserved left ventricular systolic function, underweight or low BMI was associated

263 inants of right ventricular (RV) volumes and systolic function using a modern imaging sequence in a c

264 l as preserved (n = 18,164) left ventricular systolic function using chi-square and logistic regressi

265 with placebo in patients with HF and reduced systolic function, using quantitative radionuclide ventr

266 V and right ventricular pressure curves, and systolic function was assessed as LV dP/dtmax.

267 LV systolic function was assessed by LV ejection fraction a

268 Systolic function was assessed by transthoracic echocard

269 Left ventricular systolic function was impaired but stable in 21% of pati

270 7%+/-5.1% vs. 23.6%+/-6.2%); however, normal systolic function was not achieved before transplantatio

271 Systolic function was preserved in both cases and contro

272 eration, and isovolumic relaxation times; LV systolic function was preserved.

273 Longitudinal systolic function was reduced in affected males (radial

274 alities with reduced diastolic but preserved systolic function was seen in subclinical HCM.

275 Systolic function was significantly decreased in HIV-inf

276 Systolic function was similar when compared with patient

277 Right ventricular (RV) systolic function was worse in patients with significant

278 ents with CKD and preserved left ventricular systolic function, we report a high prevalence of PH.

279 cardiographic assessment of left ventricular systolic function were addressed at follow-up.

280 dimension, and RV and left ventricular (LV) systolic function were determined by RV fractional area

281 ociations with left ventricular structure or systolic function were identified.

282 twenty patients admitted with HF and reduced systolic function were instrumented with a pulmonary art

283 hronic stable coronary disease and preserved systolic function were randomized to trandolapril or pla

284 anthracycline dose >/=200 mg/m(2) and normal systolic function were studied 2.5 to 26.9 years after a

285 A reduced infarct size and partially rescued systolic function when administered either before surger

286 ns, mild diastolic dysfunction, and enhanced systolic function, whereas KI-TnC-A8V(+/-) mice displaye

287 ressive and reversible depression of cardiac systolic function, which is readily distinguished from o

288 and LV diastolic dysfunction with preserved systolic function, which subsequently led to elevated LV

289 be able to minimize effects on fibrosis and systolic function while improving the diastolic function

290 ng tool in ambulatory patients with impaired systolic function who are referred for cardiopulmonary e

291 atients with preserved left ventricular (LV) systolic function who may also require consideration for

292 There was a significant improvement of systolic function with CRT in all LV pacing configuratio

293 stablished cardiac hypertrophy and preserved systolic function with N-acetylcysteine or a placebo for

294 : 1.06 to 1.41) and in patients with reduced systolic function with no insurance.

295 All survivors regained normal systolic function within 6 months of surgery.

296 Variation of left ventricular systolic function within the normal range was not associ

297 These mice have compensated systolic function without evidence of fibrosis and reduc

298 OM dosing is critical for eliciting enhanced systolic function without excessive prolongation of syst

299 otropic reinforcement significantly improved systolic function without impairing diastolic function,

300 This was most apparent for systolic function; young adults born preterm had signifi