ライフサイエンスコーパス: tRNA aminoacylation

1 distinct active site structures to catalyze tRNA aminoacylation.

2 ases had the same two complementary modes of tRNA aminoacylation.

3 stem and is directly responsible for proper tRNA aminoacylation.

4 tural mechanisms ensuring the selectivity of tRNA aminoacylation.

5 the tRNA during amino acid activation and/or tRNA aminoacylation.

6 the peptide is not important for the kcat of tRNA aminoacylation.

7 the catalytic efficiency and specificity of tRNA aminoacylation.

8 synthetic and native tRNA and in inhibiting tRNA aminoacylation.

9 acids is highly sensitive to the kinetics of tRNA aminoacylation.

10 o each other in playing an important role in tRNA aminoacylation.

11 ucines in the leucine heptad repeats reduced tRNA aminoacylation.

12 nylate synthesis and the transition state of tRNA aminoacylation.

13 ative to tyrosine, and significantly reduces tRNA aminoacylation.

14 ll function, requires accurate transfer RNA (tRNA) aminoacylation.

15 t motif 2 loop residues are not critical for tRNA aminoacylation activity of the human enzyme.

16 Herein, it is documented that tRNA aminoacylation also occurs in yeast nuclei and is i

17 catalyzing aminoacyl-adenylate formation and tRNA aminoacylation and a second editing or proofreading

18 N-acylphosphoramidates, are useful probes of tRNA aminoacylation and enzyme mechanism, and have poten

19 lar ATP is utilized in protein synthesis via tRNA aminoacylation and guanosine triphosphate regenerat

20 Reports of nuclear tRNA aminoacylation and its role in tRNA nuclear export

21 os1p, is also unessential, we tested whether tRNA aminoacylation and Los1p operate in alternative tRN

22 rd a platform for the synthesis by enzymatic tRNA aminoacylation and ribosomal translation of cyclic

23 Thus, association in a MARS complex enhances tRNA-aminoacylation and contributes to parasite fitness.

24 these two sites lead to rigorous accuracy in tRNA aminoacylation, and both activities are essential t

25 ty of both CysRS and tRNA(Cys) for efficient tRNA aminoacylation, and highlight the energetic costs o

26 onsible for amino acid supply, transfer RNA (tRNA) aminoacylation, and protein folding.

27 Recognition strategies for tRNA aminoacylation are ancient and highly conserved, ha

28 term evolution of amino acid specificity and tRNA aminoacylation, both essential for expanding the ge

29 ginine residue (R144) that was essential for tRNA aminoacylation but played no role in amino acid act

30 h LeuRS improves the catalytic efficiency of tRNA aminoacylation by both LysRS and ProRS.

31 ssion of the genetic code depends on precise tRNA aminoacylation by cognate aminoacyl-tRNA synthetase

32 tion of the genetic code depends on accurate tRNA aminoacylation by cognate aminoacyl-tRNA synthetase

33 butes to translational fidelity by enhancing tRNA aminoacylation by ProRS.

34 Accurate transfer RNA (tRNA) aminoacylation by aminoacyl-tRNA synthetases contr

35 hat association in the MARS complex enhances tRNA-aminoacylation efficiency, which is in part depende

36 Assays of tRNA aminoacylation established the specific attachment

37 ases to improve the anticodon specificity of tRNA aminoacylation from bacteria to humans, possibly to

38 indicating the evolution of determinants for tRNA aminoacylation from E. coli to yeast to human and t

39 We propose that tRNA aminoacylation functions in one of at least two par

40 he availability of nutrients to cells and by tRNA aminoacylation in the nucleus.

41 The accuracy of tRNA aminoacylation in vivo is uncertain, however, and m

42 These results indicate that suppression of tRNA aminoacylation is able to inhibit p70(s6k) activity

43 Because tRNA aminoacylation is fundamental to cell growth, these

44 d by deacylated tRNA, which accumulates when tRNA aminoacylation is limited by lack of substrates or

45 he cells are viable, indicating that nuclear tRNA aminoacylation is not required for all tRNA nuclear

46 rming that the rate of the chemical step for tRNA aminoacylation (k(chem)) exceeds the steady-state r

47 ts global translation in this organism; that tRNA aminoacylation levels exert, at most, weak control

48 During the first chemical step of tRNA aminoacylation, noncognate amino acids that are sma

49 ion of the unnatural base pair into mRNA and tRNA, aminoacylation of the tRNA with a non-canonical am

50 emonstrate a potential role for the indirect tRNA aminoacylation pathway in regulating translational

51 The limited selectivity in the tRNA aminoacylation reaction appears to be due to ineffi

52 thetic aminoacyl-adenylates as substrates in tRNA aminoacylation reaction may provide a way for incor

53 the transition states for both steps of the tRNA aminoacylation reaction.

54 Most mutants are less attenuated in tRNA aminoacylation than in adenylate synthesis, suggest

55 onformation transitions in various stages of tRNA aminoacylation that are associated with catalysis.

56 erminal domain for amino acid activation and tRNA aminoacylation through a domain-domain interaction.

57 diol contribution affects steps ranging from tRNA aminoacylation to peptide bond formation.

58 A highly sensitive assay of tRNA aminoacylation was developed that directly measures

59 Nuclear tRNA aminoacylation was proposed to provide a proofreadi

60 A synthetic active site catalyzes tRNA aminoacylation, while an editing active site hydrol