ライフサイエンスコーパス: tRNA synthetase

1 ibit a new antimalarial target, phenylalanyl-tRNA synthetase.

2 mammalian cells by S207-phosphorylated Lysyl-tRNA synthetase.

3 yl-thioribosyl pyrimidine that targets seryl-tRNA synthetase.

4 aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase.

5 artamidyl-adenylate, which inhibits aspartyl-tRNA synthetase.

6 amino acid mutagenesis using a Cnf-specific tRNA synthetase.

7 ity of some synthetic inhibitors of threonyl-tRNA synthetase.

8 g an engineered pair of yeast tRNA/aminoacyl tRNA synthetase.

9 nucleotide antibiotic that inhibits aspartyl-tRNA synthetase.

10 Its genome encodes a single copy of tyrosyl-tRNA synthetase.

11 on-canonical function of L. donovani tyrosyl-tRNA synthetase.

12 aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase.

13 on with other class I and class II aminoacyl-tRNA synthetases.

14 ccus jannaschii and Escherichia coli tyrosyl-tRNA synthetases.

15 ability to be aminoacylated onto tRNAs by aa-tRNA synthetases.

16 lected amino acid transporters and aminoacyl-tRNA synthetases.

17 s activated by both human prolyl- and alanyl-tRNA synthetases.

18 tRNA interaction network, such as aminoacyl-tRNA synthetases.

19 ants for aminoacylation by cognate aminoacyl-tRNA synthetases.

20 is editing of misacylated tRNAs by aminoacyl-tRNA synthetases.

21 and p.Arg403Trp disrupted QARS-RARS (arginyl-tRNA synthetase 1) interaction.

22 identified as the binding partner of arginyl-tRNA synthetase, a polypeptide of the multi-aminoacyl tR

23 While aminoacyl-tRNA synthetase (AARS) editing potentially provides a me

24 fied mutations in the nuclear-encoded alanyl-tRNA synthetase (AARS) in these two unrelated families:

25 n orthogonal amber suppressor tRNA/aminoacyl-tRNA synthetase (aaRS) pair.

26 Saccharomyces cerevisiae, a single aminoacyl-tRNA synthetase (aaRS), MST1, aminoacylates two isoaccep

27 Aminoacyl-tRNA synthetases (aaRS) catalyze both chemical steps tha

28 e: This work indicates that mutations in the tRNA synthetase AARS2 gene cause a recessive form of ALS

29 adynamics simulations on a class I aminoacyl-tRNA synthetase (aaRSs), the largest group in the superf

30 derived from Class I and Class II aminoacyl-tRNA synthetases (aaRSs) acylate tRNA far faster than th

31 acid:transfer RNA (tRNA) pairs by aminoacyl-tRNA synthetases (aaRSs) and inaccurate selection of ami

32 Aminoacyl-tRNA synthetases (AARSs) are a superfamily of enzymes re

33 Aminoacyl-tRNA synthetases (aaRSs) are housekeeping enzymes essent

34 Aminoacyl-tRNA synthetases (AARSs) catalyze an early step in prote

35 Aminoacyl-tRNA synthetases (aaRSs) charge tRNAs with their cognate

36 The 20 aminoacyl tRNA synthetases (aaRSs) couple each amino acid to their

37 To ensure translational fidelity, aminoacyl-tRNA synthetases (aaRSs) employ pre-transfer and post-tr

38 Aminoacyl-tRNA synthetases (aaRSs) play a key role in deciphering

39 and potentially all mitochondrial aminoacyl-tRNA synthetases (aaRSs) were identified, and all those

40 We evolved chromosomal aminoacyl-tRNA synthetases (aaRSs) with up to 25-fold increased pr

41 Key players in this process are aminoacyl-tRNA synthetases (aaRSs), which not only catalyse the at

42 ion for an enzyme family, we chose aminoacyl tRNA synthetases (AARSs).

43 of the nuclear-encoded mitochondrial tyrosyl-tRNA synthetase (Aatm) and the mitochondrial-encoded tyr

44 Here, we examine an N(epsilon)-acetyl-lysyl-tRNA synthetase (AcKRS), which is polyspecific (i.e., ac

45 haracterized PylRS variants (N()-acetyllysyl-tRNA synthetase [AcKRS], 3-iodo-phenylalanyl-tRNA synthe

46 SR1 glycyl-tRNA synthetase acylates tRNA(Gly)UCA with glycine in vi

47 mplex contains a non-discriminating aspartyl-tRNA synthetase, AdT, and Hp0100 but does not require tR

48 cognized by A. gossypii mitochondrial alanyl-tRNA synthetase (AgAlaRS).

49 out evolution, tRNA(Ala) selection by alanyl-tRNA synthetase (AlaRS) has depended predominantly on a

50 ery provides MurM, quality control by alanyl-tRNA synthetase (AlaRS) was investigated.

51 hic mutation in the editing domain of alanyl-tRNA synthetase (AlaRS), resulted in accumulation of mis

52 Expression of CMT-mutant tyrosyl-tRNA synthetase also impairs translation, suggesting a c

53 RARS encodes the cytoplasmic arginyl-tRNA synthetase, an enzyme essential for RNA translation

54 e find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 muta

55 enes encoding asparaginyl- and/or glutaminyl-tRNA synthetase and consequently rely on an indirect pat

56 ncoding truncated homologs of class II lysyl-tRNA synthetase and of lysine-2,3-aminomutase, respectiv

57 molecules that inhibit recombinant isoleucyl-tRNA synthetase and that are lethal to the parasites in

58 initially aminoacylated with serine by seryl-tRNA synthetase and the resulting seryl moiety is conver

59 Coexpression of SR1 glycyl-tRNA synthetase and tRNA(Gly)UCA in Escherichia coli yie

60 Together with prior analyses of isoleucyl-tRNA synthetase and valyl-tRNA synthetase, these experim

61 rexpression of nearly all of the cytoplasmic tRNA synthetases and associated ARS-interacting multifun

62 This role is specific to SerRS among all tRNA synthetases and is independent of its well-known am

63 Several aminoacyl-tRNA synthetases and Mcm2-7 proteins were identified by

64 al-type but not by eukaryotic-type isoleucyl-tRNA synthetases and might also be a determinant for the

65 r, when CP1 domains from different aminoacyl-tRNA synthetases and origins were fused to this common L

66 witches regulate the expression of aminoacyl-tRNA synthetases and other proteins in response to fluct

67 omains exist in certain eukaryotic aminoacyl-tRNA synthetases and play roles in tRNA or protein bindi

68 specific substrates of eukaryotic aminoacyl-tRNA synthetases and ribosomes.

69 selections do not produce optimally specific tRNA synthetases and suggest that translation fidelity w

70 ables the bulk purification of the aminoacyl-tRNA synthetases and translation factors necessary for a

71 stitutive protein complex composed of leucyl-tRNA-synthetase and folliculin, which regulates mTOR tet

72 eins (e.g. ribosomal proteins and amino-acyl tRNA synthetases) and moderate preference for metabolic

73 inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, and exhibits activity against both bloo

74 are biologically active and target aspartyl-tRNA synthetase, and that the carboxymethyl group preven

75 factor for the development of anti-histidyl tRNA synthetase antibodies, and HLA-DRB1*11:01 and stati

76 In animal cells, nine aminoacyl-tRNA synthetases are associated with the three auxiliary

77 Although tRNA synthetases are enzymes that catalyze the first ste

78 Mutations in genes encoding aminoacyl-tRNA synthetases are known to cause leukodystrophies and

79 re we explore the potential of the aminoacyl-tRNA synthetase (ARS) family as a source of antimalarial

80 acid (AA) limitation of the entire aminoacyl-tRNA synthetase (ARS) gene family revealed that 16/20 of

81 Mutations in several aminoacyl-tRNA synthetase (ARS) genes have been implicated in inhe

82 Aminoacyl-tRNA synthetases (ARSs) are responsible for charging ami

83 Aminoacyl-tRNA synthetases (ARSs) catalyze the attachment of speci

84 also comprise the identification of aspartyl-tRNA synthetase as a receptor of the priming activator b

85 gating Asn to tRNA(Asn) using an asparaginyl-tRNA synthetase (AsnRS) or by synthesizing Asn on the tR

86 ations in a tRNA gene, aspT, in an aminoacyl tRNA synthetase, AspRS, and in a translation factor need

87 rstitial lung disease and myositis with anti-tRNA synthetase autoantibodies.

88 oacylation, a unique example of an aminoacyl-tRNA synthetase being inhibited by a toxin encoded by a

89 Aminoacyl-tRNA synthetase binding is RNase A sensitive, whereas in

90 the ribosome, or proteins such as aminoacyl-tRNA synthetases, but is unprecedented for a compact mRN

91 Here we show that mRNAs for most tRNA synthetases can be detected in exosomes.

92 neered a Caenorhabditis elegans phenylalanyl-tRNA synthetase capable of tagging proteins with the rea

93 lyzed by prokaryotic and mammalian cysteinyl-tRNA synthetases (CARSs).

94 In contrast to functionally diverse tRNA synthetase catalytic nulls created by alternative s

95 Aminoacyl-tRNA synthetases catalyze ATP-dependent covalent couplin

96 Dominant mutations in five tRNA synthetases cause Charcot-Marie-Tooth (CMT) neuropa

97 drial forms of Caenorhabditis elegans glycyl-tRNA synthetase (CeGlyRS) are encoded by the same gene (

98 ytosolic complex (AME) made of two aminoacyl-tRNA synthetases (cERS and cMRS) attached to an anchor p

99 rates included ribosomal proteins, aminoacyl-tRNA synthetases, chaperones, catalases, peroxidases, an

100 Urzymes from both aminoacyl-tRNA synthetase classes possess sophisticated catalytic

101 Aminoacyl-tRNA synthetases classically regulate protein synthesis

102 hat wild-type E. coli EF-Tu and phenylalanyl-tRNA synthetase collaborate with these mutant ribosomes

103 a stable and conserved large multi-aminoacyl-tRNA synthetase complex (MARS), whose molecular mass has

104 The mammalian cytoplasmic multi-tRNA synthetase complex (MSC) is a depot system that reg

105 d in a high-molecular-weight multi-aminoacyl-tRNA synthetase complex (MSC), restricting the pool of f

106 is normally sequestered in a multi-aminoacyl-tRNA synthetase complex (MSC).

107 rexpression of a parkin substrate, aminoacyl-tRNA synthetase complex interacting multifunctional prot

108 orm is a component of the multiple aminoacyl-tRNA synthetase complex, and the other is an N-terminal

109 AP II), one component of the multi-aminoacyl tRNA synthetase complex, plays multiple roles in physiol

110 s, in the case of a heterotrimeric aminoacyl-tRNA synthetase complex, the aggregated proteins remain

111 hetase, a polypeptide of the multi-aminoacyl tRNA synthetase complex.

112 analogous interactions in a closely related tRNA/synthetase complex.

113 targeting Plasmodium falciparum phenylalanyl-tRNA synthetase comprise one promising new class of anti

114 tRNA synthetase deficiencies are a growing group of gene

115 Thus, a broad and diverse regulated pool of tRNA synthetase-derived mRNAs is packaged for genetic ex

116 Here we present a pyrrolysyl-tRNA synthetase-derived, engineered enzyme BtaRS that en

117 Here we describe a mutant murine methionyl-tRNA synthetase (designated L274GMmMetRS) that charges t

118 ich are activated by an engineered methionyl-tRNA synthetase (designated NLL-MetRS), are excluded fro

119 ally severe in comparison to other aminoacyl-tRNA synthetase disorders.

120 s releasing asynchronously the two aminoacyl-tRNA synthetases display aberrant expression of nuclear

121 the pathological consequences of diminished tRNA synthetase editing activity, and thus translational

122 nslation through evasion of one but not both tRNA synthetase editing systems.

123 Here we identify glutamyl-prolyl-tRNA synthetase (EPRS) as an mTORC1-S6K1 target that con

124 found that the MSC component glutamyl-prolyl-tRNA synthetase (EPRS) switched its function following v

125 tly, the EN1-iPeps bound the glutamyl-prolyl tRNA synthetase (EPRS) target, which has been associated

126 with their cognate amino acids, by aminoacyl-tRNA synthetases, establishes the genetic code.

127 Many human tRNA synthetases evolved alternative functions outside o

128 capable of aberrant interactions, links the tRNA synthetase family to CMT.

129 that requires a mutant form of the methionyl-tRNA synthetase for activation.

130 phisticated structural plasticity of a human tRNA synthetase for architectural reorganizations that a

131 eterologous expression of a mutant methionyl-tRNA synthetase from Escherichia coli permits incorporat

132 Here we investigate thirty-one aminoacyl-tRNA synthetases from infectious disease organisms by co

133 MT2D), caused by dominant mutations in Glycl tRNA synthetase (GARS), present with progressive weaknes

134 phila model for CMT with mutations in glycyl-tRNA synthetase (GARS).

135 out the primary sequence of the human glycyl-tRNA synthetase (GARS).

136 In this study, a novel group of isoleucyl-tRNA synthetase gene (ileS) T box leader sequences found

137 Translation of the glutamyl-prolyl-tRNA synthetase gene EPRS is enhanced in response to eIF

138 sion of amino acid transporter and aminoacyl-tRNA synthetase genes downstream of the stress-induced A

139 The crystal structure of E. coli glutaminyl-tRNA synthetase (GlnRS) bound to native tRNA1(Gln) and A

140 o acid specificities of TrpRS and glutaminyl-tRNA synthetase (GlnRS) by mutagenesis without extensive

141 Eukaryotic glutaminyl-tRNA synthetase (GlnRS) contains an appended N-terminal

142 The glutaminyl-tRNA synthetase (GlnRS) enzyme, which pairs glutamine wi

143 Cytosolic glutaminyl-tRNA synthetase (GlnRS) is the singular enzyme responsib

144 reveals that the overexpression of glutamyl-tRNA synthetase (GltX) suppresses the toxicity of HipA.

145 r protein A) kinase, which inhibits glutamyl tRNA synthetase (GltX).

146 eukaryotes from a nondiscriminating glutamyl-tRNA synthetase (GluRS) that aminoacylates both tRNA(Gln

147 yme in this pathway, the apicoplast glutamyl-tRNA synthetase (GluRS).

148 n that forms a ternary complex with glutamyl-tRNA synthetase (GluRSc) and methionyl-tRNA synthetase (

149 Glycyl tRNA synthetase (GlyRS) provides a unique case among cla

150 GARS, encoding the ubiquitous enzyme, glycyl-tRNA synthetase (GlyRS), cause peripheral nerve degenera

151 housekeeping gene GARS, which encodes glycyl-tRNA synthetase (GlyRS), mediate selective peripheral ne

152 tously expressed enzyme glycyl-transfer RNA (tRNA) synthetase (GlyRS).

153 Recently, a mutation in histidyl-tRNA synthetase (HARS) was identified in a single patien

154 of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome

155 Many eukaryotic tRNA synthetases have acquired appended domains, whose o

156 Mutations in genes encoding aminoacyl-tRNA synthetases have been implicated in peripheral neur

157 his important biological function, aminoacyl-tRNA synthetases have been the focus of anti-infective d

158 here are two isoforms of cytoplasmic arginyl-tRNA synthetase (hcArgRS) in human cells.

159 ions in LARS2, encoding mitochondrial leucyl-tRNA synthetase: homozygous c.1565C>A (p.Thr522Asn) in a

160 ion of bacterially expressed murine histidyl-tRNA synthetase (HRS) triggers florid muscle inflammatio

161 In cattle, cytosolic isoleucyl-tRNA synthetase (IARS) missense mutations cause heredita

162 RS and in a PylRS variant [iodo-phenylalanyl-tRNA synthetase (IFRS)] that displays both enhanced acti

163 tRNA synthetase [AcKRS], 3-iodo-phenylalanyl-tRNA synthetase [IFRS], a broad specific PylRS variant [

164 Escherichia coli isoleucyl-tRNA synthetase (IleRS) exploits both the tRNA-dependent

165 Isoleucyl-tRNA synthetase (IleRS) is an aminoacyl-tRNA synthetase

166 Isoleucyl-tRNA synthetase (IleRS) is unusual among aminoacyl-tRNA

167 Like some other aminoacyl-tRNA synthetases, IleRS can mischarge tRNA(Ile) and corr

168 While having multiple aminoacyl-tRNA synthetases implicated in Charcot-Marie-Tooth (CMT)

169 Moreover, the cytosolic histidyl-tRNA synthetase in A. castellanii exhibits an unusual tR

170 nthesis and must be cleared by phenylalanine-tRNA synthetase in order to prevent cellular toxicity ca

171 synthetase (PylRS), a polyspecific aminoacyl-tRNA synthetase in wide use, has facilitated incorporati

172 ynthetase (IleRS) is unusual among aminoacyl-tRNA synthetases in having a tRNA-dependent pre-transfer

173 rstanding the role of mutations in aminoacyl-tRNA synthetases in neurological diseases.

174 nately dictated by the accuracy of aminoacyl-tRNA synthetases in pairing amino acids with correct tRN

175 a comprehensive model of editing by class I tRNA synthetases, in which kinetic partitioning plays an

176 The prolyl-tRNA synthetase inhibitor halofuginone blocks IL-23-indu

177 The bacterial tryptophanyl-tRNA synthetase inhibitor indolmycin features a unique o

178 ells of leucine or treating them with leucyl-tRNA synthetase inhibitors did not elicit nuclear Gln3-M

179 ice variants, suggest a far broader reach of tRNA synthetases into cell biology than previously recog

180 d by RNAi knockdown that T. brucei isoleucyl-tRNA synthetase is essential for the parasites in vitro

181 tified at highly conserved residues of lysyl-tRNA synthetase (KARS): the c.1129G>A (p.Asp377Asn) vari

182 cases may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium.

183 ase-induced expression of a mutant methionyl-tRNA synthetase (L274G) enables the cell-type-specific l

184 es the twin attributes of Leishmania tyrosyl-tRNA synthetase (LdTyrRS) namely, aminoacylation, and as

185 e tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase (LeuRS), while the TM84-producer prevent

186 Leucyl-tRNA synthetases (LeuRSs) have an essential role in tran

187 Mycoplasma leucyl-tRNA synthetases (LeuRSs) have been identified in which

188 ans pQTL relationship between the KARS lysyl-tRNA synthetase locus and levels of the DIDO1 protein.

189 from cancer-associated MTOR mutations.Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1

190 Leucyl-tRNA synthetase (LRS) is known to function as leucine se

191 tion primer via an interaction between lysyl-tRNA synthetase (LysRS) and the HIV-1 Gag polyprotein.

192 Aminoacyl-tRNA synthetases maintain the fidelity during protein sy

193 the identification of its cognate aminoacyl-tRNA synthetase makes it possible to map transient prote

194 The multiple aminoacyl-tRNA synthetase (MARS) complex contained at least six aa

195 ation and suggests that editing by aminoacyl-tRNA synthetases may be important for survival under sta

196 tamyl-tRNA synthetase (GluRSc) and methionyl-tRNA synthetase (MetRS) in the cytoplasm to regulate the

197 iece of the AND gate is a bisected methionyl-tRNA synthetase (MetRS) that charges the Met surrogate a

198 is and antibiotic exposure via the methionyl-tRNA synthetase (MetRS).

199 f tRNA(Leu) with methionine by the methionyl-tRNA synthetase (MetRS).

200 lysidine to prevent recognition by methionyl-tRNA synthetase (MRS) and production of a chimeric Met-t

201 ch are aminoacylated by Class I mt-aminoacyl-tRNA synthetases (mt-aaRSs).

202 The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (mtTyrRS; CYT-18 protein) evolved a new

203 The mitochondrial tyrosyl-tRNA synthetases (mtTyrRSs) of Pezizomycotina fungi, a s

204 ns in HARS2, encoding mitochondrial histidyl-tRNA synthetase, mutations in CLPP expose dysfunction of

205 irect pathway, a non-discriminating aspartyl-tRNA synthetase (ND-AspRS) attaches Asp to tRNA(Asn) and

206 the catalytic capacities of the asparaginyl-tRNA synthetase of the parasite in vitro.

207 These include the engineered tRNA/aminoacyl-tRNA synthetase pair and the nonsense mutant of the targ

208 rthogonal nonsense suppressor tRNA/aminoacyl-tRNA synthetase pair in Escherichia coli.

209 Methanocaldococcus jannaschii tRNA:aminoacyl-tRNA synthetase pair into the chromosome of a GRO derive

210 E. coli cells with a special tRNA/aminoacyl-tRNA synthetase pair, two PPARalpha variants were prepar

211 By using an orthogonal tRNA-synthetase pair, the fluorescent unnatural amino ac

212 Two polyspecific tRNA/aminoacyl-tRNA synthetase pairs were inserted into this expression

213 een much more challenging to create tRNA and tRNA-Synthetase pairs that enable UAAs incorporation, fo

214 Orthogonal tRNA/synthetase pairs were evolved to incorporate these

215 hown that Leishmania spp. possess asparagine-tRNA synthetase paralog asparagine synthetase A (LdASNA)

216 dification with (R)-beta-lysine by the lysyl-tRNA synthetase paralog PoxA.

217 d binding and recognition step, phenylalanyl-tRNA synthetase (PheRS) faces the challenge of discrimin

218 Phenylalanyl-tRNA synthetase (PheRS) maintains specificity via an edi

219 For example phenylalanyl-tRNA synthetase (PheRS) proofreads the non-protein hydro

220 vergence of tyrosine editing by phenylalanyl-tRNA synthetase (PheRS) was used as a model.

221 r stem that prevents editing by phenylalanyl-tRNA synthetase (PheRS), leading to the accumulation of

222 nto proteins due to misrecognition by prolyl-tRNA synthetase (ProRS).

223 diting domain (INS) of most bacterial prolyl-tRNA synthetases (ProRSs) and an autonomous single-domai

224 For example, prolyl-tRNA synthetases (ProRSs) mischarge alanine and cysteine

225 Pyrrolysyl-tRNA synthetase (PylRS) and its cognate tRNA(Pyl) have e

226 Pyrrolysyl-tRNA synthetase (PylRS) attaches pyrrolysine to the ambe

227 Pyrrolysyl-tRNA synthetase (PylRS), a polyspecific aminoacyl-tRNA s

228 ation of the Methanosarcina mazei pyrrolysyl-tRNA synthetase (PylRS)/tRNA(Pyl)CUA pair (and its deriv

229 on of mutations in QARS (encoding glutaminyl-tRNA synthetase [QARS]) as the causative variants in two

230 Aminoacyl-tRNA synthetases recognize tRNA anticodon and 3' accepto

231 e genetic and clinical spectrum of aminoacyl-tRNA synthetase-related human disease.

232 f tRNA recognition from the parent aminoacyl-tRNA synthetase, relaxed tRNA specificity leading to sem

233 y-terminal domain (Cterm) of human mt-leucyl tRNA synthetase rescues the pathologic phenotype associa

234 A putative lysyl-tRNA synthetase resistance gene was identified in the cl

235 ganism that expresses two different threonyl-tRNA synthetases, responsible for Thr-tRNA(Thr) synthesi

236 kinetic analyses of CHO cytoplasmic tyrosyl-tRNA synthetase revealed a 25-fold lower specificity for

237 mparisons of mammalian and bacterial tyrosyl-tRNA synthetase revealed key differences at residues res

238 lso substrates, including multiple aminoacyl tRNA synthetases, ribosomal proteins, protein chaperones

239 ense codon, and an orthogonal tRNA/aminoacyl-tRNA synthetase (RS) pair is used to generate amber supp

240 Aminoacyl-transfer RNA (tRNA) synthetases (RS) are essential components of the c

241 -step indirect pathway, where O-phosphoseryl-tRNA synthetase (SepRS) catalyzes the ligation of a mism

242 tudies suggested an essential role for seryl-tRNA synthetase (SerRS) in vascular development.

243 specific tRNA (tRNA(Sec)) catalyzed by seryl-tRNA synthetase (SerRS)-is unclear.

244 n system components, in particular aminoacyl-tRNA synthetases, shows that, at a stage of evolution wh

245 promoter and to reengineer the tryptophanyl tRNA-synthetase:suppressor tRNA pair from Saccharomyces

246 mmalian cells using an engineered pyrrolysyl-tRNA synthetase system.

247 Threonyl-tRNA synthetase (TARS) is an autoantigen in the autoimmu

248 ese include angiogenesis, and human threonyl-tRNA synthetase (TARS) represents a potent pro-angiogeni

249 cid and the generation of a mutant aminoacyl tRNA synthetase that can selectively charge the amino ac

250 We evolved a pyrrolysyl-tRNA synthetase that incorporates site-specifically PheK

251 e models of muscle inflammation suggest that tRNA synthetases themselves may act to trigger an initia

252 lyses of isoleucyl-tRNA synthetase and valyl-tRNA synthetase, these experiments provide the basis for

253 es of potent and bacteria-selective threonyl-tRNA synthetase (ThrRS) inhibitors have been identified

254 Threonyl-tRNA synthetase (ThrRS) misactivates serine and utilizes

255 Borrelidin, a natural inhibitor of threonyl-tRNA synthetase (ThrRS), stands out for its potent antim

256 through the selective inhibition of threonyl-tRNA synthetase (ThrRS).

257 NA(Asn) from the non-discriminating aspartyl-tRNA synthetase to AdT, where it is converted into Asn-t

258 S2 is the second gene encoding mitochondrial tRNA synthetase to be found to harbor mutations leading

259 thway utilizes a non-discriminating glutamyl-tRNA synthetase to synthesize Glu-tRNA(Gln) and a glutam

260 the scientific community requested aminoacyl-tRNA synthetases to be targeted in the Seattle Structura

261 ransfer activated amino acids from aminoacyl-tRNA synthetases to the ribosome, where they are used fo

262 SelA converts Ser-tRNA(Sec), formed by seryl-tRNA synthetase, to Sec-tRNA(Sec).

263 approach for directly discovering aminoacyl-tRNA synthetase-tRNA pairs that selectively incorporate

264 the direct, scalable discovery of aminoacyl-tRNA synthetase-tRNA pairs with mutually orthogonal subs

265 ion in coordination with a mutant pyrrolysyl-tRNA synthetase-tRNA(Pyl) pair, azidonorleucine is genet

266 ing cells to express an orthogonal aminoacyl-tRNA synthetase/tRNA pair to enable the incorporation of

267 ) using the recently evolved M. jannaschii Y-tRNA synthetase/tRNA pair.

268 ducing orthogonal amber suppressor aminoacyl-tRNA synthetase/tRNA pairs into a thiocillin producer st

269 teins using established orthogonal aminoacyl-tRNA synthetase/tRNA systems.

270 y encoded Tet-v2.0 with an evolved aminoacyl-tRNA synthetase/tRNA(CUA) pair.

271 n suppression using the wild-type pyrrolysyl-tRNA synthetase/tRNA(CUA) pair.

272 application of the pyrrolysyl-transfer RNA (tRNA) synthetase/tRNA pair for unnatural amino acid inco

273 tion approach, we discover a phosphothreonyl-tRNA synthetase-tRNACUA pair and create an entirely bios

274 By combining the optimized pyrrolysyl-tRNA synthetase/tRNACUA expression system and an enginee

275 ency, and we develop an optimized pyrrolysyl-tRNA synthetase/tRNACUA expression system, with optimize

276 from E. coli containing a mutated orthogonal tRNA synthetase/tRNACUA pair enabling site-specific inse

277 ng an evolved orthogonal nitro-Tyr-aminoacyl-tRNA synthetase/tRNACUA pair for functional studies.

278 We have evolved orthogonal aminoacyl-tRNA synthetase/tRNACUA pairs that genetically encode th

279 iated expression of an orthogonal pyrrolysyl-tRNA synthetase-tRNAXXX pair in a cell type of interest

280 with tryptophan for binding to tryptophanyl-tRNA synthetase (TrpRS) enzymes.

281 .His257Arg), in the cytoplasmic tryptophanyl-tRNA synthetase (TrpRS) gene (WARS) that co-segregates w

282 ary Bacillus stearothermophilus tryptophanyl-tRNA synthetase (TrpRS) over that of TrpRS Urzyme result

283 Tryptophanyl-tRNA Synthetase (TrpRS) Urzyme (fragments A and C), a 13

284 ct of three CMT-causing mutations in tyrosyl-tRNA synthetase (TyrRS or YARS).

285 Tyrosyl-tRNA synthetase (TyrRS) is known for its essential amino

286 ly deleted, SVs of homodimeric human tyrosyl-tRNA synthetase (TyrRS).

287 Because human tyrosyl transfer-RNA (tRNA) synthetase (TyrRS) translocates to the nucleus und

288 Aminoacyl-tRNA synthetases use a variety of mechanisms to ensure f

289 nt overexpression of editing-defective valyl-tRNA synthetase (ValRS(ED)) activated DNA break-responsi

290 Mitochondrial tryptophanyl-tRNA synthetase (Wars2), encoding an L53F protein varian

291 of tRNA(Tyr) with noncognate Phe by tyrosyl-tRNA synthetase was responsible for mistranslation.

292 With recent data on another CMT-linked tRNA synthetase, we suggest that an inherent plasticity,

293 A evolved from tRNA recognition by aminoacyl-tRNA synthetases, we compared the roles of EF-P/PoxA pol

294 Orthogonal tRNA-synthetases were evolved to genetically encode PSCa

295 in YARS2 gene encoding mitochondrial tyrosyl-tRNA synthetase, which interacts with m.11778G>A mutatio

296 bacterial GlyRS is closely related to alanyl tRNA synthetase, which led us to define a new subclassif

297 mon ancestor related to glutaminyl aminoacyl-tRNA synthetases, which may have been one of the key fac

298 d deacylated tRNAs is catalyzed by aminoacyl-tRNA synthetases, which use quality control pathways to

299 e caused by editing defects of transfer RNA (tRNA) synthetases, which preserve genetic code fidelity

300 ucyl-tRNA synthetase (IleRS) is an aminoacyl-tRNA synthetase whose essential function is to aminoacyl

301 s study, we identified two class-I aminoacyl-tRNA synthetases with high similarities to consensus ami

302 vides a unique case among class II aminoacyl tRNA synthetases, with two clearly widespread types of e