ライフサイエンスコーパス: tRNA(Glu

1 ; one likely to involve the transcription of tRNA(Glu) .

2 verlapping codon positions for tRNA(Asn) and tRNA(Glu).

3 hetase activates glutamate by ligating it to tRNA(Glu).

4 mutation did not introduce activity towards tRNA(Glu).

5 His-tRNA(His) and, as also seen in vivo, Glu-tRNA(Glu).

6 and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu).

7 ntified an HIV-1 with a PBS complementary to tRNA(Glu).

8 ary role is to generate Glu-tRNAGln, not Glu-tRNAGlu.

9 RlmN contacts the entire length of tRNA(Glu), accessing A37 by using an induced-fit strateg

10 ize tRNA(Met), tRNA(1,2)(Lys), tRNA(His), or tRNA(Glu), although these viruses replicate poorly.

11 H. pylori contains one tRNAGlu and one tRNAGln species, whereas A. ferrooxidans

12 of substrates and use either tRNAGlu or both tRNAGlu and tRNAGln.

13 a bacterial glutamyl-tRNA synthetase (GluRS):tRNA(Glu) and an archaeal leucyl-tRNA synthetase (LeuRS)

14 ting GluRS (D-GluRS) that biosynthesizes Glu-tRNA(Glu) and cannot make Glu-tRNA(Gln).

15 tRNA specificity capable of forming both Glu-tRNA(Glu) and Glu-tRNA(Gln).

16 was incubated with Escherichia coli glutamyl-tRNA(Glu) and purified recombinant Chlamydomonas reinhar

17 er thermautotrophicus GluRS is active toward tRNA(Glu) and the two tRNA(Gln) isoacceptors the organis

18 ting because it glutamylates both apicoplast tRNA(Glu) and tRNA(Gln), determined its kinetic paramete

19 that represent the anticodon stem loops for tRNA(Glu) and tRNA(Lys) are substrates of comparable act

20 ble position of the anticodons of tRNA(Lys), tRNA(Glu), and tRNA(1)(Gln).

21 5) or s(2) modification at U34 of tRNA(Lys), tRNA(Glu), and tRNA(Gln) causes ribosome pausing at the

22 role of modifications at U(34) of tRNA(Lys), tRNA(Glu), and tRNA(Gln) in maintenance of mitochondrial

23 le levels of nine tRNAs including tRNA(Lys), tRNA(Glu), and tRNA(Gln) in mto2/mss1, mto2/mto1, and mt

24 bolished modification at U(34) of tRNA(Lys), tRNA(Glu), and tRNA(Gln), caused by the combination of e

25 mnm)(5)s(2)U(34) in mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln).

26 NA synthetase from Thermus thermophilus (Glu-tRNA(Glu)) are considered.

27 osynthesis of s(2)U using unmodified E. coli tRNA(Glu) as a substrate.

28 HipA only phosphorylates tRNA(Glu)-bound GltX, which is consistent with the earli

29 GatDE reducing the affinity of ND-GluRS for tRNA(Glu) by at least 13-fold.

30 tructure of the Thermus thermophilus D-GluRS:tRNA(Glu) complex, a divergent pattern of conservation i

31 ehydration is catalyzed by two proteins in a tRNA(Glu)-dependent manner.

32 d in the T loop of tRNALys from Didymium and tRNAGlu from Physarum.

33 ned to use tRNA(Glu), the virus had selected tRNA(Glu) from the intracellular pool of tRNA for use in

34 One key feature that distinguishes tRNA(Glu) from tRNA(Gln) is the third position in the an

35 Modification of mt-tRNA(Glu) is a possible functional link between these tw

36 ly, A. ferrooxidans GluRS1 glutamylated both tRNAGlu isoacceptors and the tRNA(CUG)(Gln) species.

37 tRNA(Gln) while rejecting the two H. pylori tRNA(Glu) isoacceptors.

38 hat tissue-specific mechanisms downstream of tRNA(Glu) may explain the spontaneous recovery.

39 Further characterization of HIV-1 that uses tRNA(Glu) may provide new insights into the preference f

40 nic acid (ALA), from glutamate by means of a tRNAGlu-mediated pathway.

41 e P cleavage occurred upstream of an ectopic tRNA(Glu) moiety, thereby exposing A(28), U(25)A(3), [A+

42 U is responsible for 2-thiouridylation of mt-tRNA(Glu), mt-tRNA(Lys) and mt-tRNA(Gln).

43 ylation and exacerbates the effect of the mt-tRNA(Glu) mutation by triggering a mitochondrial transla

44 ernally inherited, homoplasmic m.14674T>C mt-tRNA(Glu) mutation in 17 patients from 12 families.

45 deficiency (RIRCD), due to a homoplasmic mt-tRNA(Glu) mutation, and reversible infantile hepatopathy

46 Neither tRNA(Glu) nor tRNA(Gln) were substrates.

47 in their choice of substrates and use either tRNAGlu or both tRNAGlu and tRNAGln.

48 With a single exception (tRNA(Phe)-tRNA(Glu) pair), the parallelism is especially impressiv

49 Corroborating this, tRNA(Glu) protected MnmA from tryptic digestion.

50 Eukaryotic tRNA(Gln) and tRNA(Glu) recognition determinants are found in equivale

51 ides in U5 complementary to the anticodon of tRNA(Glu) remained stable when grown in SupT1 cells or P

52 ms in these bacteria; for example, a site in tRNA(Glu) sequences was found to covary with tRNA(His) a

53 om a multiple sequence alignment of archaeal tRNA(Glu) sequences.

54 A and acceptor activity of the tRNA(His) and tRNA(Glu) species predicted in silico.

55 variant of the protein is cross-linked to a tRNA(Glu)substrate through the terminal methylene carbon

56 the virus was not initially designed to use tRNA(Glu), the virus had selected tRNA(Glu) from the int

57 ties that varied from -11.7 kcal/mol for Val-tRNA(Glu) to -8.1 kcal/mol for Val-tRNA(Tyr), clearly es

58 we show that this process involves glutamyl-tRNA(Glu) to activate Ser/Thr residues.

59 i, is responsible for modifying uridine13 in tRNA(Glu) to pseudouridine.

60 identify a novel class of tRFs derived from tRNA(Glu), tRNA(Asp), tRNA(Gly), and tRNA(Tyr) that, upo

61 ctify a break at the modified wobble base of tRNA(Glu(UUC)).

62 the uridine wobble base of tRNAARG(UCU) and tRNAGLU(UUC).

63 nt with the observation that the geranylated tRNA(Glu) UUC recognizes GAG more efficiently than GAA.

64 of conservation in enzymes that aminoacylate tRNA(Glu)versus those specific for tRNA(Gln) emerged and

65 -1 constructed with the PBS complementary to tRNA(Glu) was more stable than HIV-1 with the PBS comple

66 The H. pylori GluRS1 acylated only tRNAGlu, whereas GluRS2 was specific solely for tRNAGln.

67 GluRS) that aminoacylates both tRNA(Gln) and tRNA(Glu) with glutamate.