ライフサイエンスコーパス: tRNA(Gly

1 cognate amino acids; GARS ligates glycine to tRNA(Gly).

2 ' region of the mRNA by binding of uncharged tRNA(Gly).

3 tion from thrombin digestion was afforded by tRNA(gly).

4 -box riboswitch in complex with an uncharged tRNAGly.

5 me and to be amplified by mutant variants of tRNA(Gly)(2) known to diminish bypassing efficiency.

6 Mutant variants of tRNA(Gly)(2) that impair bypassing mediate stop-hopping

7 ubstantially impairing the ability of mutant tRNA(Gly)(2) variants to re-pair with the mRNA by sub-op

8 Mutations affecting ribosomal protein L9 or tRNA(Gly)(2), the tRNA that decodes GGA, alter the effic

9 onal slowdown is not attributable to altered tRNA(Gly) aminoacylation, and cannot be rescued by Droso

10 d from specific tRNA loci (e.g., the nuclear tRNA(Gly) and tRNA(Leu), the mitochondrial tRNA(Val) and

11 he tRNA acceptor stem to specifically select tRNA(Gly) and tRNA(Thr).

12 s of tRFs derived from tRNA(Glu), tRNA(Asp), tRNA(Gly), and tRNA(Tyr) that, upon induction, suppress

13 ecifier Sequence of the glyQS leader RNA and tRNA(Gly) anticodon to test the effect of all possible p

14 ressed by the insertion of a structured RNA (tRNA(Gly)) between fimE and the fim switch, indicating t

15 hat CMT mutant glycyl-tRNA synthetases bound tRNA(Gly) but failed to release it, resulting in tRNA(Gl

16 We found that addition of tRNA(Gly) can promote antitermination as long as the tRN

17 tion by uncharged tRNA unless the leader RNA-tRNA(Gly) complexes contained the complete antiterminato

18 tRNA(Gly)-dependent antitermination of the Bacillus subt

19 tRNA(Gly)-dependent antitermination of the Bacillus subt

20 turase, and addition of Gly by DhpK in a Gly-tRNA(Gly)-dependent manner completes the in vitro biosyn

21 identified dynamic changes in glycine tRNA (tRNA(Gly)(GCC)) cytosine methylation, corresponding to a

22 strand exchange occurs and which overlaps a tRNAGly gene at attB.

23 lies within the 5' region of the M. xanthus tRNA(Gly) gene.

24 r to one-half as many were found upstream of tRNA(Gly) genes in a hos2delta or set3delta mutant than

25 us Ty1 elements into the upstream regions of tRNA(Gly) genes was substantially decreased.

26 ation of the six mutant mispair sites across tRNA(Gly) in many organisms points to a fundamental stru

27 Structural mapping studies revealed tRNA(Gly)-induced protection in the glyQS leader RNA at

28 A mimic of charged tRNA(Gly) inhibited antitermination by uncharged tRNA un

29 ic counterpart in charging the mitochondrial tRNA(Gly) isoacceptor, which carries a defective TpsiC h

30 levels and the ability to discriminate among tRNAGly isoacceptors, both in vitro and in vivo.

31 ion among proteinogenic and nonproteinogenic tRNAGly isoacceptors.

32 esulting in deficits in expression of 70% of tRNA(Gly) isodecoders.

33 molecular mechanism for CMT2D, and elevating tRNA(Gly) levels may thus have therapeutic potential.

34 The consequent Gly-tRNA(Gly) 'misediting paradox' is resolved by EF-Tu in t

35 ealed that MuLV prefers to select tRNA(Pro), tRNA(Gly), or tRNA(Arg).

36 uestration potentially depleted the cellular tRNA(Gly) pool, leading to insufficient glycyl-tRNA(Gly)

37 Moreover, transgenic overexpression of tRNA(Gly) rescued protein synthesis, peripheral neuropat

38 tion of a feature of the Mypoplasma mycoides tRNAGly responsible for non-discriminate decoding, a C a

39 identity elements into the Escherichia coli tRNA(Gly) scaffold endowed facile phosphoserylation acti

40 (Gly) but failed to release it, resulting in tRNA(Gly) sequestration.

41 NA(Gly) pool, leading to insufficient glycyl-tRNA(Gly) supply to the ribosome.

42 tablished conditions for specific binding of tRNA(Gly) to glyQS leader RNA generated by phage T7 RNA

43 aves a subset of tRNAs, including tRNA(Glu), tRNA(Gly), tRNA(Lys), tRNA(Val), tRNA(His), tRNA(Asp), a

44 expression of SR1 glycyl-tRNA synthetase and tRNA(Gly)UCA in Escherichia coli yields significant beta

45 SR1 encodes a divergent tRNA(Gly)UCA with an opal-decoding anticodon.

46 SR1 glycyl-tRNA synthetase acylates tRNA(Gly)UCA with glycine in vitro with similar activity

47 o with similar activity compared with normal tRNA(Gly)UCC.

48 Changes in tRNA(Gly) upon binding to glyQS leader RNA were detected

49 ant G-U and A-C mispairs in Escherichia coli tRNA(Gly) using genetic and bioinformatic tools and show

50 ated glyQS T-box in complex with its cognate tRNAGly was derived based on the molecular envelope.

51 ia coli EF-Tu, whereas Ala-tRNA(Ala) and Gly-tRNA(Gly) were unaffected.

52 ochemical evidence for direct interaction of tRNA(Gly) with full-length in vitro transcribed glyQS le

53 damental structure-function signature within tRNA(Gly) with possible analogous missions in other RNAs