ライフサイエンスコーパス: tRNA(Thr)

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1 Thr and to lack editing activity against Ser-tRNAThr.

2 nt to 3' end, at conventional position 71 of tRNA(Thr).

3 ectively editing the misacylated species Ser-tRNA(Thr).

4 activity that also generates mischarged Ser-tRNA(Thr).

5 onor to methylate t(6)A to form m(6)t(6)A in tRNA(Thr).

6 (C182 in Escherichia coli) to hydrolyze Ser-tRNA(Thr).

7 These imply that the tRNA(Thr) A15951G mutation may have a potential modifier

8 -mediated repression, and focused on TRT2, a tRNA(Thr) adjacent to the STE6 alpha2 operator.

9 ting at position 32 of the anticodon loop of tRNA(Thr)(AGU) stimulates, but is not required for, the

10 We have shown that cytoplasmic tRNA(Thr)(AGU) undergoes two distinct editing events in

11 In ThrRS, however, the 2'-OH of A76 of tRNA(Thr) and a conserved active-site histidine (His-309

12 s ThrRS-cat was shown to synthesize both Thr-tRNAThr and Ser-tRNAThr and to lack editing activity aga

13 shown to synthesize both Thr-tRNAThr and Ser-tRNAThr and to lack editing activity against Ser-tRNAThr

14 charged at >80% levels, whereas tRNASer and tRNAThr are charged at lower levels.

15 residue critical for editing, leading to Ser-tRNA(Thr) formation and protein mistranslation that impa

16 Finally, we discovered that a tRNA(Thr) gene near HMR-I helped maintain silenced chrom

17 of auxiliary elements, such as HMR-I and the tRNA(Thr) gene, in enhancing the association of Sir sile

18 ond and final site of termination beyond the tRNAThr gene remains unclear.

19 content of Escherichia coli tRNASer(VGA) and tRNAThr(GGU) as controls were measured as 2.03 and 2.84

20 analyses of E. coli tRNASer(VGA) and E. coli tRNAThr(GGU), unfractionated tRNA from E. coli and 23S r

21 f missense suppression by Cys-tRNA(Pro), Ser-tRNA(Thr), Glu-tRNA(Gln), and Asp-tRNA(Asn).

22 The adenine (A71) at this position of tRNA(Thr), highly conserved from bacteria to human mitoc

23 In vivo, every inosine-containing tRNA(Thr) is also C to U edited at position 32.

24 in the anticodon loop of Trypanosoma brucei tRNA(Thr) is methylated to 3-methylcytosine (m(3)C) as a

25 Here we show that archaeal editing of Ser-tRNAThr is catalyzed by a domain unrelated to, and absen

26 showed that air oxidation increased the Ser-tRNA(Thr) level in the presence of elongation factor Tu.

27 otein in trans to hydrolyze specifically Ser-tRNAThr, or it can be fused to ThrRS-cat to provide the

28 rogen peroxide oxidizes C182, leading to Ser-tRNA(Thr) production and mistranslation of threonine cod

29 le for the N(6)-methyl group of m(6)t(6)A in tRNA(Thr) specific for ACY codons.

30 reonyl-tRNA synthetases, responsible for Thr-tRNA(Thr) synthesis: one accurate and constitutively exp

31 an A3G mutation in Saccharomyces cerevisiae tRNA(Thr)UAG confers tRNA recognition by AgAlaRS.

32 r the expression and processing of the genes tRNA(Thr)(UGU), tRNA(Leu)(UAA), and tRNA(Phe) (GAA) ther

33 e, early hypoxia increases wobble cmo(5)U in tRNA(Thr(UGU)), which parallels translation of transcrip

34 cant reduction of the steady-state levels in tRNA(Thr) was observed in cells carrying both the A15951

35 cine to threonine, which requires an unusual tRNA(Thr) with an enlarged 8-nt anticodon loop ( ).

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