ライフサイエンスコーパス: tachykinin

1 ortant role in the inactivation of mammalian tachykinins.

2 arge diameter nonnociceptive neurons express tachykinins.

3 arily conserved family of neuropeptides, the tachykinins.

4 okinin, corticotropin-releasing hormone, and tachykinin 1) label sleep-promoting neurons.

5 peptide Y, neurotensin, preproenkephalin and tachykinin 1; this involved a critical period at the com

6 sing hormone, and substance P encoded by the Tachykinin-1 (Tac1) gene.

7 ses, 88%) and the substance P precursor gene tachykinin-1 (TAC1; 16 of 34 cases, 47%).

8 lthough NK1R immunoreactivity was increased, tachykinin-1 receptor (Tacr1) mRNA was not increased in

9 ecently we determined that activation of the tachykinin 2 (Tac2) pathway in the central amygdala (CeA

10 s been mounting for peripheral functions for tachykinins, a family of neuropeptides including substan

11 motor neurons that release acetylcholine and tachykinins acting on muscarinic and NK1 receptors, resp

12 tion in response to superfusion of different tachykinin agonists (neurokinins A (NKA) and B (NKB), SP

13 revealed a similar profile of sensitivity to tachykinin agonists and antagonists for both receptors;

14 ed actions of several peptide neurohormones, tachykinin among them.

15 controls on central neurons, and blockade of tachykinin and glutamate receptors.

16 okinin receptor are homologous to vertebrate tachykinin and its receptor, and injection of tachykinin

17 These results indicate that tachykinin and opioid neuropeptides contained in NA proj

18 d genetic mutant analyses revealed that both Tachykinin and Tachykinin-like receptor (DTKR99D) are re

19 However, such relationship between tachykinins and kisspeptins has not been demonstrated in

20 sin C-terminal motifs to those of vertebrate tachykinins and of tachykinin-related peptides in arthro

21 The neuropeptide tachykinins and their receptors have been implicated in

22 Furthermore, we examined the coexpression of tachykinins and two kisspeptin genes in the brain of zeb

23 Glycine treatment during tachykinin- and acetylcholine-induced contractions signi

24 Tachykinins are a family of neuropeptides that inhibit s

25 The tachykinins are a family of neuropeptides that share a c

26 The tachykinins are a family of neuropeptides, including sub

27 Tachykinins are widely distributed in the central nervou

28 refore suitable pharmacological tools in the tachykinin area to elucidate further the pathophysiologi

29 duce this effect (termed sub-threshold), the tachykinin attenuated AMG stimulation-evoked glutamaterg

30 ive regulatory role of serotonin on striatal tachykinin biosynthesis, PPT and PPE gene regulation in

31 receptors) on microglia and shown that this tachykinin can significantly elevate bacterially induced

32 g the receptors were closely associated with tachykinin-containing nerve fibers.

33 nnervation of the airways by sympathetic and tachykinin-containing sensory nerve fibers.

34 tomy is mediated by sequential activation of tachykinin-containing spinal afferent and sympathetic ef

35 Tachykinin-containing, capsaicin-sensitive C-fibres also

36 Tachykinins contribute to the control of gastrointestina

37 Since reduced synthesis of tachykinins could not account for increased appetite, we

38 Tachykinins depolarize guinea pig intracardiac neurons b

39 histamine, prostaglandins, leukotrienes and tachykinins do not appear to be essential.

40 lobe glomerulus wired for attraction, while tachykinin (DTK) suppresses activity of a glomerulus wir

41 eness to inhaled CS, and that the endogenous tachykinins evoked by CS-induced activation of lung C fi

42 es trsn function to neurons that produce the tachykinin family neuropeptide Leucokinin.

43 Substance P (SP) belongs to the tachykinin family of bioactive peptides and exerts its m

44 Substance P (SP) belongs to the tachykinin family of molecules.

45 The tachykinin family of neuropeptides, which includes subst

46 ted by neurokinin-3 receptors (NK3Rs) of the tachykinin family of neuropeptides.

47 ructure of substance P (SP), a member of the tachykinin family of neuropeptides.

48 Substance P (SP), a member of the tachykinin family of neurotransmitters and neuromodulato

49 for peripherally distributed members of the tachykinin family of peptides, namely substance P and th

50 an 11-amino acid peptide that belongs to the tachykinin family of peptides.

51 Tac1 gene encodes peptides belonging to the tachykinin family with substance P being the predominant

52 Proinflammatory neuropeptides of the tachykinin family, including substance P (SP) and hemoki

53 ance P (SP), a neuropeptide belonging to the tachykinin family, is expressed in gastrointestinal trac

54 Substance P (SP), a member of the tachykinin family, is widely distributed in the central

55 We conclude that the release of tachykinins from primary afferent pain-sensing receptors

56 dure which results in permanent depletion of tachykinins from the lungs and airways as well as degene

57 These findings indicate that tachykinin gene expression is inducible within slice cul

58 (arcuate) nucleus, accompanied by increased tachykinin gene expression.

59 tion of the location of neurons that express tachykinin gene transcripts in the human hypothalamus.

60 Two distinct but functionally overlapping tachykinins govern inflammation through NK-1R at sites o

61 Because tachykinins have been identified as neurotransmitters in

62 eripherally, adds support to the notion that tachykinins have physiologic/endocrine roles in the peri

63 Protease-activated receptors (PARs) and tachykinin-immunoreactive fibers are located in the lung

64 alysis has shown that during the first week, tachykinin-immunoreactive profiles appeared as round or

65 hypotension-induced release of an endogenous tachykinin in SON and evidence suggesting a role for NK3

66 NKB was the predominant tachykinin in the rostral hypothalamus, whereas SP mRNA

67 ublications have demonstrated a key role for tachykinins in the positive feedback regulation of plate

68 udy we report a fundamental new function for tachykinins in the regulation of platelet function.

69 To determine the involvement of tachykinins in the reproduction in teleosts, we identifi

70 igh affinities for other naturally occurring tachykinins including neurokinin A, neuropeptide K, neur

71 Tachykinins including substance P and cytokines includin

72 whether an increase in endogenously released tachykinins is involved.

73 he pattern of distribution and appearance of tachykinin-labelled fibers in the dorsal lateral genicul

74 ypothesis, the binding affinities of natural tachykinin ligands may be largely determined by their co

75 A set of novel tachykinin-like peptides has been isolated from bullfrog

76 t analyses revealed that both Tachykinin and Tachykinin-like receptor (DTKR99D) are required for dama

77 heart failure - has shown that serotonin and tachykinins may be the key mediators.

78 Tachykinins may be the main excitatory neurotransmitters

79 These data suggest that tachykinins mediate their pressor activity by increasing

80 minor peripheral nervous system component to tachykinin-mediated vomiting.

81 These results validate the least shrew as a tachykinin model at the molecular level.

82 These targets include receptors for tachykinins, motilin, ghrelin, corticotropin-releasing f

83 situ hybridization showed no coexpression of tachykinins mRNA with kisspeptins mRNA in hypothalamic n

84 Although decreased tachykinin-mRNA levels are observed in natriorexic sodiu

85 ng existing agents that have such properties-tachykinin neurokinin 3 receptor antagonists-is proposed

86 The tachykinin neurokinin B (NKB) has been implicated in the

87 senktide analogue, but not significantly by tachykinin neurokinin-1 or neurokinin-2 receptor-selecti

88 ndogenous tachykinins or exogenous selective tachykinin neurokinin-3 receptor activation with senktid

89 ide analogue were inhibited by the selective tachykinin neurokinin-3 receptor antagonists, SB 223412

90 is of lung disease, although the role of the tachykinin neurokinin-3 receptor has not been elucidated

91 response was mimicked by exogenously applied tachykinin neurokinin-3 receptor-selective agonist, senk

92 Using confocal microscopy, we identified tachykinin neurokinin-3 receptors on human bronchial par

93 We provide the first evidence that tachykinin neurokinin-3 receptors regulate human bronchi

94 -A), which encodes substance P and a related tachykinin, neurokinin A.

95 Substance P (SP), a tachykinin neuropeptide, has been associated with neurog

96 removal of extracellular calcium, but not by tachykinin neuropeptide, voltage-sensitive calcium chann

97 members respond specifically to a Drosophila tachykinin neuropeptide.

98 ated peptides, including somatostatin (SST), tachykinin, neuropeptide Y (NPY) and cortistatin, in a p

99 The tachykinin neuropeptides, substance P and substance K, a

100 -AbetaP antibody, zinc, and Tris, but not by tachykinin neuropeptides.

101 sly injected (125)I-albumin in wild-type and tachykinin NK(1) receptor knockout mice.

102 ve radioligand for in vivo quantification of tachykinin NK(1) receptors with PET.

103 ated with apoptosis, 2) decreased macrophage tachykinin NK(1)-dependent phagocytosis, 3) substantiall

104 urokinin-1 receptor and selectivity over the tachykinin NK(2) and NK(3) receptor subtypes.

105 The tachykinin NK1 receptor antagonist, GR205171 (100 microg

106 Muscarinic M3 receptor antagonists and tachykinin NK1 receptor antagonists inhibit neurogenic s

107 penetration and the antiemetic potential of tachykinin NK1 receptor antagonists.

108 the neuropeptide substance P (SP) acting via tachykinin NK1 receptor inhibition of GABA(A) currents.

109 e P release and activity because blockade of tachykinin NK1 receptors (66.3+/-13.7% inhibition, n=6;

110 role in emesis via the activation of central tachykinin NK1 receptors during the delayed phase of vom

111 Phe8]-substance P (SENK; 25, 100, 200 ng), a tachykinin NK3 receptor agonist, and [Sar9, Met(O2)11]-s

112 , and NK1-R and NK2-R mediate the effects of tachykinins on interstitial and smooth muscle cells, res

113 The pro-thrombotic effects of tachykinins on platelets are mediated through the neurok

114 Responses to endogenous tachykinins or exogenous selective tachykinin neurokinin

115 Tachykinin, PBAN, and sNPF were among the peptides with

116 Substance P is the prototype tachykinin peptide and triggers a variety of biological

117 Substance P (SP), a member of the tachykinin peptide family, has been found in high concen

118 ), an 11-residue peptide that belongs to the tachykinin peptide family.

119 Rana catesbeiana, and their homology to the tachykinin peptide family.

120 The tachykinin peptide innervation of the developing dorsal

121 rimary effector of this pathway, co-released tachykinin peptides and their respective nigral tachykin

122 The rank order of tachykinin peptides competing for [3H]senktide binding a

123 esent and previous findings, we suggest that tachykinin peptides not only play a role as putative neu

124 Tachykinin peptides stimulated both inositol phospholipi

125 and the structure of two naturally occurring tachykinin peptides, substance P (SP, RPKPQQFFGLM-NH2) a

126 e piscine Tac3 gene encodes for two putative tachykinin peptides, the mammalian ortholog encodes for

127 directed to the C-terminal of the mammalian tachykinin peptides.

128 mice lacking SP signaling by deletion of the tachykinin precursor 1 (Tac1) gene or coadministration o

129 Tachykinin production also has been implicated in RSV pa

130 areas of the brain normally associated with tachykinin production.

131 d analysis of sialyltransferase 4A (SIAT4A), tachykinin receptor 1 (TACR1), and gamma-aminobutyric ac

132 rotein-coupled receptor, previously known as tachykinin receptor 86C (also known as the neurokinin K

133 ulphonic acid (PPADS; 10 microM) or an NK(3) tachykinin receptor antagonist (Neurokinin A 4-10; 100 n

134 To this end, we used the tachykinin receptor antagonist Spantide I to eliminate t

135 tamate receptor antagonist; L733,060, an NK1 tachykinin receptor antagonist, and chelerythrine, a pro

136 The use of the selective tachykinin receptor antagonists SR 140333, SR 48986, and

137 By contrast, tachykinin receptor antagonists, which abolished capsaic

138 There have been proposals that the tachykinin receptor classification should be extended to

139 hought to be premature to extend the current tachykinin receptor classification.

140 15 and CG7887 by showing these two suspected tachykinin receptor family members respond specifically

141 The NK(3) subtype of tachykinin receptor is a G protein-coupled receptor that

142 rpolarization or current was mimicked by the tachykinin receptor NK1 agonist Ac-[Arg6, Sar9, Met(O2)1

143 ith DOCA once daily for 11 days and analyzed tachykinin receptor subtype, neurokinin 3 (NK3r)-immunor

144 ent studies determined to what extent nigral tachykinin receptor subtypes contribute to striatal D1-m

145 lammatory response is altered by alternative tachykinin receptor usage.

146 we have attempted to: (1) define the type of tachykinin receptor which mediates the negative chronotr

147 n C3aR, whereas C3a levels were unchanged in tachykinin receptor-null animals.

148 been implicated in RSV pathophysiology, and tachykinin receptor-null mice were similarly protected f

149 antigen challenge appears to unmask an NK-2 tachykinin receptor.

150 reference to the existence of a novel human tachykinin receptor.

151 GIR shares 31-34% amino acid identity to the tachykinin receptors (substance P receptor, neurokinin A

152 human ileum, we examined a possible role of tachykinin receptors and neurokinin (NK) A in neurally i

153 hykinin peptides and their respective nigral tachykinin receptors are also in position to influence m

154 The present results suggest that the tachykinin receptors are downregulated after subchronic

155 The down-regulation of neurokinin-tachykinin receptors is accomplished by a rapid internal

156 We demonstrate the presence of the tachykinin receptors NK1 and NK3 in platelets and presen

157 ivities of human and mouse HK-1 on the three tachykinin receptors, neurokinin-1-3 (NK1-3).

158 salt appetite was due to a downregulation of tachykinin receptors.

159 mmation were mediated by neurokinin-2 (NK-2) tachykinin receptors.

160 achykinin and its receptor, and injection of tachykinins reduces food consumption.

161 local interneurons express allatotropin and tachykinin-related neuropeptides (TKRPs).

162 olin, but only MCN1 contains Cancer borealis tachykinin-related peptide (CabTRP Ia).

163 ro(5)-Asp(6)-Asn(7)-Pro(8)-Gly(9)-NH2) and a tachykinin-related peptide (CabTRP Ia, Ala(1)-Pro(2)-Ser

164 entrating hormone (RPCH) and Cancer borealis tachykinin-related peptide (CabTRP) are colocalized in a

165 wo closely related neuropeptidergic systems, tachykinin-related peptide (TRP) and natalisin (NTL), an

166 show by immunocytochemistry that GABA and a tachykinin-related peptide (TRP) are localized in the am

167 Cancer borealis tachykinin-related peptide 1a, a peptide that does not a

168 and five additional modulators [C. borealis tachykinin-related peptide Ia (CabTRP Ia), crustacean ca

169 MCN1 also contains Cancer borealis tachykinin-related peptide Ia (CabTRP Ia).

170 of the peptide cotransmitter Cancer borealis tachykinin-related peptide Ia (CabTRP Ia).

171 neuromodulators [proctolin, Cancer borealis tachykinin-related peptide Ia, crustacean cardioactive p

172 to regions of the neuropil that also display tachykinin-related peptide immunoreactivity.

173 This endopeptidase cleaved another insect tachykinin-related peptide, CavTK-II, in a predictable m

174 in, allatostatin, serotonin, Cancer borealis tachykinin-related peptide, cholecystokinin, and crustac

175 fs to those of vertebrate tachykinins and of tachykinin-related peptides in arthropods led us to iden

176 bound NEP is involved in the inactivation of tachykinin-related peptides in the brain of the cockroac

177 onserved role for NEP in the inactivation of tachykinin-related peptides in the brain.

178 t neuropeptide F, myoinhibitory peptide, and tachykinin-related peptides were found to be expressed i

179 suggesting that the peptidase can hydrolyse tachykinin-related peptides with different structures.

180 MRFamides], crustacean cardioactive peptide, tachykinin-related peptides).

181 own to receive neuronal processes containing tachykinin-related peptides.

182 ke significant action potential discharge or tachykinin release from bronchopulmonary C-fibre termina

183 d substantial action potential discharge and tachykinin release from bronchopulmonary C-fibre termina

184 Tachykinin release was absent in mice deficient in C3aR,

185 nfection where initial C3a production causes tachykinin release, followed by activation of the IL-17A

186 Understanding the physiological role of tachykinins requires precise cellular and subcellular lo

187 lammation provokes phenotypic changes in the tachykinin responsiveness of nodose neurons.

188 ociceptive signaling pathways we examined SP/Tachykinin signaling in a Drosophila model of tissue dam

189 Our results highlight a conserved role for Tachykinin signaling in regulating nociception and the p

190 dogenous opioid endomorphin-2 (EM-2) and the tachykinin SP, respectively.

191 Together our data implicate tachykinins, specifically SP and EKA/B, in the regulatio

192 There is increasing evidence that the tachykinin substance P (SP) can augment inflammatory imm

193 The tachykinin substance P (SP) represents the prototypic sp

194 By comparison, the tachykinin substance P induced only minimal plasma extra

195 The tachykinin substance P was recovered from the commissura

196 We also demonstrate TAC1 (encoding the tachykinins substance P and neurokinin A) to be strongly

197 tion on enkephalin (Met5-enkephalin; ME) and tachykinin (substance P; SP) systems of basal ganglia of

198 The tachykinin, substance P (SP), is well known to augment i

199 Tachykinin/Substance P has been implicated in aggression

200 The results show that (a) the tachykinin subtypes are not equally involved in the cont

201 Our results suggest that the roles of the tachykinin system in regulating food intake might be evo

202 nctions of neurokinin B (NKB), we identified tachykinin (tac) and tac receptor (NKBR) genes from many

203 cells (BCCs) is caused by the enhancement of tachykinin (TAC)1 translation by cytosolic factor.

204 Hemokinin (HK) is another tachykinin that binds NK-1R.

205 Substance P is a tachykinin that enhances pathways of inflammation.

206 st that natalisin is an ancestral sibling of tachykinin that evolved only in the arthropod lineage.

207 ropin (AT), short neuropeptide F (sNPF), and tachykinin (TK) as potential candidates.

208 Tachykinin (TK) peptides influence neuronal activity in

209 ruM(+) neurons that express the neuropeptide tachykinin (Tk).

210 evertheless, the ability of pro-inflammatory tachykinins to affect the immune functions of DCs remain

211 traction since leukotriene C4, histamine and tachykinins, which all caused a similar contraction to a

212 Hemokinin is another tachykinin with homology to substance P.

213 NK1-R and NK3-R mediate neurotransmission by tachykinins within enteric nerve plexuses, and NK1-R and