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1 d acetylcholinesterase (AChE) in relation to tacrine.
2 as markedly reduced in comparison to that of tacrine.
3 being more potent than the parent inhibitor, tacrine.
4 of training, similar to the positive control tacrine.
5 a axis in underpinning the hepatotoxicity of tacrine.
6 r's disease before they began treatment with tacrine.
7 ice develop fewer jaw tremors in response to tacrine.
8 could be facilitated with different doses of tacrine (0.0003-10 mg/kg).
9 nary metabolic profiles in rats administered tacrine (1) suggested the presence of an unidentified me
10 of Alzheimer's disease (AD), a new family of tacrine-4-oxo-4H-chromene hybrids has been designed, syn
11  nano- and picomolar concentrations, the new tacrine-4-oxo-4H-chromene hybrids inhibit human acetyl-
12                                 Therapy with tacrine, a promising new treatment for Alzheimer's disea
13      These relative changes in propidium and tacrine affinities thus provided a sensitive molecular r
14 g metoprine, and the anticholinesterase drug tacrine (an early drug for Alzheimer's disease) are surp
15 mperature to perform the synthesis of chiral tacrine analogues in good yields (up to 93%) and excelle
16                                 In contrast, tacrine and donepezil, typical AChE inhibitors, could no
17 receptor epitopes involved in the binding of tacrine and Duo3 may not be identical.
18             By analyzing the interactions of tacrine and Duo3 with other allosteric muscarinic agents
19 alidated using the reference AChE inhibitors tacrine and galanthamine.
20 A5, syn-TA2PZ6, and syn-TA2PZ5, derived from tacrine and phenylphenanthridinium azides and acetylenes
21               The cholinesterase inhibitors, tacrine and physostigmine, and the mixed muscarinic m1 a
22 e, being superior to the physical mixture of tacrine and silibinin in all these regards.
23 including the acetylcholinesterase inhibitor tacrine and the bis-pyridinium derivative 4,4'-bis-[(2,6
24          A codrug of the anti-Alzheimer drug tacrine and the natural product silibinin was synthesize
25     Coupling of two distinct pharmacophores, tacrine and trolox, endowed with different biological pr
26 eral AChE inhibitors, including huperzine A, tacrine, and 1,5-bis(4-allyldimethylammoniumphenyl)penta
27 major route of metabolism and elimination of tacrine, and also catalyzes the pathway(s) involved in t
28 nhibitory activity, less hepatotoxicity than tacrine, and the best neuroprotective capacity, being ab
29  Association of the active center inhibitor, tacrine, and the peripheral site peptide inhibitor, fasc
30               Cholinesterase inhibition with tacrine appears to reduce deterioration in cognitive per
31 ) inhibitors by incubating a selected enzyme/tacrine azide combination with a variety of acetylene re
32 (PIQ) building blocks that combined with the tacrine azide within the active center gorge to form mul
33 ws the same pro-cognitive effects in vivo as tacrine, being superior to the physical mixture of tacri
34 relation we observed between CBT results and tacrine blood levels is the first evidence supporting a
35 g during the study while they were receiving tacrine compared with placebo was 3.63 (95% CI, 2.80- 4.
36 ge scale (range, 1-7) for patients receiving tacrine compared with those receiving placebo was 1.58 (
37                          Of these compounds, tacrine-coumarin heterodimer 7c and tacrine derivative 6
38    A series of novel tacrine derivatives and tacrine-coumarin heterodimers were designed, synthesized
39 mpounds, tacrine-coumarin heterodimer 7c and tacrine derivative 6b were found to be the most potent i
40                            A series of novel tacrine derivatives and tacrine-coumarin heterodimers we
41 melatonin-like isocyanide, formaldehyde, and tacrine derivatives, according to the antioxidant additi
42  who are nonadherent, while recent trials of tacrine for Alzheimer disease and carvedilol for congest
43                        Novel multifunctional tacrines for Alzheimer's disease were obtained by Ugi-re
44                                          The tacrine fragment was selected for its inhibition of chol
45 by combining a naphthoquinone function and a tacrine fragment.
46                              We administered tacrine, galantamine or memantine to mouse cerebral cort
47 le-blind, placebo-controlled trials in which tacrine had been given for more than 1 day and that were
48 g the subset of patients most susceptible to tacrine hepatotoxicity.
49                          A family of huprine-tacrine heterodimers has been developed to simultaneousl
50                                      Huprine-tacrine heterodimers take on added value in that they di
51 iracetam-huprine and levetiracetam-(6-chloro)tacrine hybrids to hit amyloid, tau, and cholinergic pat
52 , only one of them was less hepatotoxic than tacrine in HepG2 cells.
53 ing Wistar rats, the codrug was as potent as tacrine in reversing memory dysfunction.
54 strated 3.3-fold higher systemic exposure to tacrine in strong responders that experienced transamini
55  enterohepatic recycling of deglucuronidated tacrine in this subgroup, not attributable to variation
56            In contrast, the value of KI2 for tacrine increased substantially only when ligands had lo
57 s to elucidate and validate the mechanism of tacrine-induced hepatotoxicity in Lister hooded rats.
58 ice were hypersensitive to galanthamine- and tacrine-induced seizures and Straub tails.
59 ignificantly modulated the susceptibility to tacrine-induced transaminitis in vivo.
60 in gut microbial activities that mapped onto tacrine-induced transaminitis.
61 gic acetyltransferase (ChAT) neurons reduces tacrine-induced tremor.
62 s disease such as (-) huperzine A and E2020; tacrine inhibited the monomeric form 2-3-fold more poten
63 e inhibition constants KI2 for propidium and tacrine, inhibitors specific for the P- and A-sites, res
64 ith the logarithm of the steady-state plasma tacrine level obtained in 10 patients (R(2) = .69, P = .
65 f cationic trialkylammonium, acridinium, and tacrine ligands with tethers of varying length.
66  in identifying patients most susceptible to tacrine liver toxicity.
67 range, 0-50) showed a difference in favor of tacrine of 0.58 points (95% CI, 0.17-1.00; P= .006).
68                          Fasciculin, but not tacrine, on the other hand, dramatically altered the dec
69 emorine), an acetylcholinesterase inhibitor (tacrine or E2020), or nicotine, increased the response l
70 cholinesterase (AChE) inhibitor derived from tacrine, prevented Abeta oligomers-induced inhibition of
71   Age, severity of dementia, and exposure to tacrine prior to randomization had no clear influence on
72 nfluences in modifying the hepatotoxicity of tacrine, providing insights for personalized medicine in
73 E inhibition, neuroprotective effects, lacks tacrine's hepatotoxicity in vitro and in vivo, and shows
74                                          The tacrine-silibinin codrug shows high AChE and BChE inhibi
75 inefungin, amodiaquine, diphenhydramine, and tacrine suggest differences in the active sites of these
76 nge, 0-30), was better in patients receiving tacrine than in patients receiving placebo by 0.62 point
77       For patients without prior exposure to tacrine, the odds of patients' withdrawing during the st
78  rats, in contrast to the effects seen after tacrine treatment, after administration of the codrug no
79                                     Finally, tacrine-trolox hybrids exhibited low in vivo toxicity af
80   A coumarin derivative with IC50 similar to tacrine was highlighted.
81           The structurally similar compound, tacrine, which is a known allosteric modulator of the mu
82 12 weeks, the progress of patients receiving tacrine would be expected to range between an improvemen

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