ライフサイエンスコーパス: tail domain

1 o its head domain and actin filaments to its tail domain.

2 -based motif localized within the receptor C-tail domain.

3 negatively charged surfaces in the upstream tail domain.

4 e shaft domain, and a penton base-attachment tail domain.

5 ongest selective pressure on the cytoplasmic tail domain.

6 t microtubule-binding site in its C-terminal tail domain.

7 lves rapidly, particularly in its N-terminal tail domain.

8 sites of phosphorylation occur within the C-tail domain.

9 etween the kinesin-1 head and its regulatory tail domain.

10 ut little is known about the function of the tail domain.

11 for post-translational export of the Cox2 C-tail domain.

12 tol 4,5-bisphosphate (PtdIns(4,5)P2)-binding tail domain.

13 age phagocytosis via a conserved collagenous tail domain.

14 tions that are distinct from those of the H3 tail domain.

15 t least in part by the collagenous collectin tail domain.

16 cleavage site and a hirudin-like C-terminal tail domain.

17 similar to that found previously for the H3 tail domain.

18 esidue region (1849-1940) of the coiled-coil tail domain.

19 ently of beta-arrestins and the receptor's C-tail domain.

20 that is predicted to completely alter the K1 tail domain.

21 with acidic phospholipids through its basic tail domain.

22 ine motifs found within the LMP2A N-terminal tail domain.

23 ned the interactions between Hat1 and the H4 tail domain.

24 d to cause MPS in this study occurred in the tail domain.

25 osphorylated on two residues at its unfolded tail domain.

26 b38 and regions of the Myosin Vc coiled-coil tail domain.

27 a C-terminal motor domain and an N-terminal tail domain.

28 n and an intrinsically disordered C-terminal tail domain.

29 is independent of either kinase function or tail domain.

30 nfluenza B virus lacking the BHA cytoplasmic tail domain.

31 culin, the actin binding site resides in the tail domain.

32 ds actin filaments similarly to the vinculin tail domain.

33 globular head, coiled-coil rod, and globular tail domains.

34 rod" domain flanked by the flexible head and tail domains.

35 is partially redundant with the core histone tail domains.

36 ical central rod domain, flanked by head and tail domains.

37 ta have been reported for either the head or tail domains.

38 main that is flanked by non-helical head and tail domains.

39 al interactions mediated by the core histone tail domains.

40 -MMP hemopexin, transmembrane, and cytosolic tail domains.

41 to the focal adhesion targeting and vinculin tail domains.

42 were not altered by removal of core histone tail domains.

43 re specifically associated with expressed H3 tail domains.

44 interarray interactions mediated by histone tail domains.

45 er in the overall orientation of the head to tail domains.

46 embedded in intrinsically disordered histone tail domains.

47 etween the C terminus helical and nonhelical tail domains.

48 d differentially on vinculin head (V(H)) and tail domains.

49 ing up the dynamically disordered N-terminal tail domains.

50 ly to Rab5-containing endosomes through its "tail" domain.

51 otif localized within the C-terminal tail (C-tail) domain.

52 ear localization signal (NLS) located in the tail domain [14].

53 contrast to their inhibition of ADP release, tail domains accelerate the rate of ADP binding to nucle

54 oes promote some translocation of the Cox2 C-tail domain across the inner membrane and causes increas

55 ass III myosins that requires both motor and tail domain actin-binding activity and show that the act

56 lt hypothesis, where the CD loop in the beta tail domain acts to restrain the I domain in the inactiv

57 organelles through their C-terminal globular tail domain, although recent studies have also suggested

58 al 207 amino acid region containing both the tail domain and a calponin homology (CH) domain.

59 prisingly, a minimal dimeric motor lacking a tail domain and associated subunits can cause MT sliding

60 Removal of the tail domain and lysine-serine-proline (KSP) repeats of N

61 ough the disordered N-terminal 80 amino acid tail domain and mitotic-checkpoint function is dependent

62 amolecular interactions between its head and tail domain and must be activated to bind talin and acti

63 itated by a large movement of the polymerase tail domain and tauc.

64 ctively associates with EBs via its specific tail domain and that this interaction is crucial for AIS

65 h an engineered peptide inserted between the tail domain and the motor head retain wild-type motor ac

66 s allowed us to construct models of both the tail domain and the pentameric complex.

67 interactions between K14's carboxy-terminal tail domain and two regions in the central alpha-helical

68 s intramolecular association with vinculin's tail domain and which differ from the alterations in Vh1

69 etylated status of brain nucleosomal histone tail domains and (ii) to regulate brain histone-RELN and

70 onal change that separates the KHC motor and tail domains and a local conformational change that move

71 uncated DKH894 which has lost the inhibitory tail domains and does not fold.

72 ever, the structures and interactions of the tail domains and the molecular mechanisms by which acety

73 Each enzyme is characterized by a dynamic 'tail' domain and a compact 'head' that contains Rvb1/Rvb

74 subunits, Med14/Rgr1 and Med16/Sin4, to its tail domain; and one subunit, Med19/Rox3, to its head do

75 The tail domain appears to bind microtubules through nonspec

76 These effects of the tail domain are likely to be mediated by the tubulin- an

77 The core histone tail domains are known to be key regulators of chromatin

78 gene mutations affecting nonhelical head and tail domains are not usually associated with prominent s

79 ion of the cytoplasmic dynein amino-terminal tail domain, as it emerges from the main mass of the mot

80 of a motor domain dimer in complex with its tail domain at 2.2 angstroms and compare it with a struc

81 the MYO7A transcript and truncates the MYO7A tail domain at the C-terminal FERM domain.

82 nd programmed to cell-autonomously enter the tail domain beginning with the 16th somite.

83 ct region between the membrane-proximal beta-tail domain (betaTD) and the ligand-binding betaA domain

84 a closed conformation, in which the head and tail domains bind to each other and mask the binding sit

85 Our data support the notion that the basic tail domains bind to nucleosomal DNA and influence the s

86 where its head domain binds to talin and its tail domain binds to filamentous actin, thus linking act

87 The cytoplasmic region of BMPRII contains a "tail" domain (BMPRII-TD) with no enzymatic activity or k

88 s very rapid, independent of calcium and the tail domain, both heads do not bind actin strongly durin

89 is trafficking requires the CXCR4 C-terminal tail domain but not the CXCR4 ubiquitination sites.

90 ependent catch bond with F-actin through its tail domain, but with lifetimes that depend strongly on

91 ifications occur, not only in the N-terminal tail domains, but also in the core domains.

92 ro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation,

93 A H3.3 tail domain-CENH3 histone-fold domain chimera rescued vi

94 tivity of a tetrameric Cin8 lacking only the tail domains (Cin8Deltatail).

95 ys-27 to block cellular modifications of the tail domains completely abolished the association of spe

96 ease is also observed when separate head and tail domain constructs are mixed at low salt concentrati

97 Tail domains contain an alternating electrostatic repeat

98 e we demonstrate that the Xenopus laevis Npm tail domain controls the binding of histones at its larg

99 deadbolt model, a hairpin loop in the beta3 tail domain could act as a deadbolt to restrain the disp

100 acking proteins required for export of the C-tail domain, Cox18 and Mss2.

101 unction of the EBV gB cytoplasmic C-terminal tail domain (CTD) in fusion, we used a previously constr

102 (+3 leucine) or by deleting the cytoplasmic tail domain (CTD) in the +1 leucine background.

103 However, when the C-terminal tail domain (CTD) is deleted, the majority of the protei

104 speculation, the divergent carboxyl-terminal tail domain (CTD) is dispensable, but serves to modulate

105 nt studies, we characterized a gB C-terminal tail domain (CTD) mutant truncated at amino acid 843 (gB

106 TDs) of the core histones and the C-terminal tail domain (CTD) of linker histones bind to many differ

107 their N-terminal FERM domain and C-terminal tail domain (CTD), and an open conformation, in which th

108 a chimeric F-MLV Env with a GaLV cytoplasmic tail domain (CTD).

109 he N terminus to S6 with the mslo3 cytosolic tail domain (CTD).

110 However, when the cytoplasmic tail domains (CTDs) in the Env constructs were deleted,

111 gate the negatively charged carboxy-terminal tail domains (CTTs) of alpha- and beta-tubulins, using a

112 -binding site of T3 sigma1 is located in the tail domain, distal to the antibody epitope.

113 nderstand the complex interactions of the H3 tail domain during chromatin condensation, we have devel

114 The histone H4 tail domain facilitates inter-array interactions by cont

115 s or the disordered N-terminal 80 amino acid tail domain fail to generate stable kinetochore-microtub

116 osin sequences provides evidence that myosin tail domain features can be maintained without strict co

117 The negatively charged tail domain floats away from the anionic MT surface whil

118 lines that constitutively express ectopic H4 tail domain for biochemical purification of proteins ass

119 mulation shows the essential role of Kif15's tail domain for load storage within the Kif15-microtubul

120 binding in cGAS as well as carboxy terminal tail domain for transducing signals in STING, only recen

121 re both the catalytic head domain as well as tail domains for function, with the tails providing dist

122 A recombinant tail domain fragment of myosin Vb attenuated the plasma

123 Remarkably, we find that removal of tail domains from a nucleosome assembled on a DNA fragme

124 ined whether the removal of the core histone tail domains from nucleosomes reconstituted with specifi

125 aches to these vesicles through its globular-tail domain (GTD) and mediates their polarized delivery

126 ed myosin Va without the C-terminal globular tail domain (GTD) is not.

127 hibition of MyoVa function with the globular tail domain (GTD) of MyoVa protein or short hairpin RNA

128 indicate that it is the C-terminal globular tail domain (GTD) that directly inhibits the motor activ

129 s of the myosin Va or the myosin Vb globular tail domain (GTD) that gives insights into how the motor

130 Its tail ends in paired globular tail domains (GTDs) thought to bind cargo.

131 In contrast, the isolated tail domain has no inhibitory effect on Dyn1/HC targetin

132 tutions and lysine acetylation within the H4 tail domain have identical effects on nucleosome array s

133 genes exhibited increased recruitment of the tail domain; however, only genes with increased occupanc

134 Our data show a role for the Capu-tail domain in assembling the actin cytoskeleton, largel

135 ing to organelles may occur via the globular tail domain in both types of motors, even though sequenc

136 the functional importance of the nonhelical tail domain in keratin molecules despite the obvious var

137 gated the role of the PTEN carboxyl-terminal tail domain in regulating its membrane targeting and cat

138 questered within a hydrophobic region in the tail domain in the absence of calcium.

139 xpression of green fluorescent protein-Myo1B tail domain in the larval gut showed that the tail domai

140 es of specific regions within the individual tail domains in model chromatin complexes.

141 le for histone modifications outside the NH2-tail domains in the processes of chromatin assembly, DNA

142 nal T1 domain and a conserved region in KIF5 tail domains, in which proper T1 tetramerization is cruc

143 The myo1e C-terminal tail domain includes a basic region that is required for

144 hat acetylation mimics within the histone H4 tail domain increased accessibility of the surrounding l

145 report here that removal of the core histone tail domains increases the exposure of the DNA backbone

146 xaminations of specific sites within the H2B tail domain indicate that this tail contains distinct st

147 runcation of the last 40 residues from the C-tail domain, indicating that sequence and/or structural

148 Lysine acetylation within the core histone tail domains inhibits self-association, an effect likely

149 yosin A (MyoA) and its light chain, myosin A tail domain interacting protein (MTIP), is an essential

150 tes of Plasmodium falciparum CDPK1: myosin A tail domain-interacting protein (MTIP) and glideosome-as

151 ity and includes the MyoA light chain myosin tail domain-interacting protein (MTIP) and several glide

152 ns, including the MyoA light chain, myosin A tail domain-interacting protein (MTIP).

153 Va is in a folded conformation such that the tail domain interacts with and inhibits myosin Va motor

154 found that the non-motor microtubule-binding tail domain interacts with the microtubule's E-hook tail

155 lar motors that possess a motor domain and a tail domain involved in cargo binding.

156 .0007 s-1), and the IQ motif adjacent to the tail domain (IQ3) has the fastest dissociation rate (0.5

157 e head domain of vinculin and F-actin to its tail domain is a potential mechanism for this function,

158 gth of the first coiled-coil (coil-1) of the tail domain is critical for GTD-dependent regulation of

159 The myosin V carboxyl-terminal globular tail domain is essential for the attachment of myosin V

160 The Cox2 C-tail domain is exported post-translationally by the high

161 ate asymmetric motility, suggesting that the tail domain is not required for the counterclockwise tur

162 Our data suggest that the C-tail domain is recognized posttranslationally by a speci

163 e isoform of myosin VI with no insert in the tail domain is required for the polarized transport of t

164 ail domain in the larval gut showed that the tail domain is sufficient for localization of Myo1B to t

165 This inhibition of ADP release by tail domains is formally analogous to the action of nucl

166 Physical linkage of the head and tail domains is required for maximal force responses.

167 Inhibition of release of ADP by tail domains is reversed by Unc-76 (FEZ1) which is a pot

168 the motor domain, but not the actin-binding tail domain, is required for stereocilia tip localizatio

169 e show that EB1 and the KIF17 autoinhibitory tail domain (KIF17-Tail) interacted competitively with t

170 d interarray interactions mediated by the H4 tail domain, known to play a predominant role in the for

171 omposed of histones lacking their N-terminal tail domains less efficiently than wild-type H3/H4 tetra

172 We found that mutating or deleting the beta3 tail domain loop has no effect on ligand binding by eith

173 lation of all four histone H4 NH(2)-terminal tail domain lysine residues is increased following DSB f

174 Interestingly, the tail domain markedly inhibits the actin-activated ATPase

175 domains works remains unclear, but kinesin-5 tail domains may be involved.

176 As acetylation of specific tail domains may encode distinct functions, we investiga

177 at the last 11 amino acids of the C-terminal tail domain mediate crosslinking by divalent ions.

178 The core histone tail domains mediate inter-nucleosomal interactions that

179 ormation of bundlelike configurations, while tail domain-mediated binding events act to stabilize the

180 contribute to furrow localization: a central tail domain mediating cortical furrow binding to heterol

181 utant, followed by those rescued with a Hec1 tail domain mutant.

182 A tail domain mutation (Val459Ile) showed milder effects o

183 characterized by a 68-residue insert in the tail domain (MVt) and correlates with hereditary idiopat

184 Metavinculin tail domain (MVT) binds actin filaments in a similar ori

185 The myosin V globular tail domain (MyoV-GTD) interacts directly with an evolut

186 The N-terminal tail domains (NTDs) of histones play important roles in

187 ey lack intrinsic structure, the N-terminal "tail" domains (NTDs) of the core histones and the C-term

188 tion in the Aspergillus nidulans heavy chain tail domain, nudA(F208V), which causes obvious defects i

189 93) and binds via its DUF593 to the globular tail domain of a tobacco pollen tube myosin XI.

190 These findings indicate that the cytoplasmic tail domain of BHA is important for efficient incorporat

191 Furthermore, C1q, MBL, and the tail domain of C1q were all chemoattractants for E. hist

192 we have examined the role of the C-terminal tail domain of Cin8 in regulating directionality.

193 mined that GEF-H1 interaction with the rod + tail domain of cingulin was required for inactivation of

194 that shows that the C-terminal intracellular tail domain of Cx46 is essential to induce degradation o

195 -binding sites (VBS) found in the C-terminal tail domain of IpaA.

196 Furthermore, the C-terminal tail domain of keratin 8 is shown to be essential for th

197 Here we identify an essential role of the tail domain of Kip3 in mediating both its destabilizing

198 MT rescue within the bud requires the tail domain of Kip3, whereas the motor domain mediates c

199 The tail domain of lamin A directly binds 21 known partners,

200 l change also occurs in the H1' helix of the tail domain of metavinculin (MVt) upon actin binding, a

201 rms is a 68-residue insert in the C-terminal tail domain of MV (MVt).

202 strin homology domain abolish binding of the tail domain of Myo1b to PIP(2) and PIP(3) in vitro.

203 The cargo-binding tail domain of Myo1c interacted with G-actin, and the mo

204 ed proteins to demonstrate that the globular tail domain of myosin Va binds directly to an intrinsica

205 proline-directed Ser/Thr residues within the tail domain of NF proteins by inhibiting the dephosphory

206 sites have been identified on the C-terminal tail domain of NF-H, with greater abundance of phosphory

207 cule motor and the cargo (i.e., the extended tail domain of the molecule) must be able to absorb the

208 The coiled-coil tail domain of the myosin II heavy chain mediates filame

209 The extended tail domain of these myosins consists of mechanically st

210 c domain of separase binds to the C-terminal tail domain of three homologs of the centromeric protein

211 filaments can interact directly through the tail domain of vimentin and that these inter-filament in

212 The tail domain of vinculin (Vt) binds to acidic phospholipi

213 The tail domain of vinculin (Vt) contains determinants neces

214 The tail domain of vinculin (Vt) forms tight autoinhibitory

215 ote binding of the intracellular cytoplasmic tail domains of cadherin receptors with beta-catenin, a

216 ants carrying mutations in the head, rod, or tail domains of desmin (S46F, E245D, and T453I).

217 We found that the ectopic expression of the tail domains of each of the class VIII, but not the clas

218 e structure and interactions of the head and tail domains of epidermal keratins 1 and 10, based on al

219 Acetylation mimics within the tail domains of H2B and H4 caused the largest inhibition

220 These data suggest that the CH and tail domains of Hec1 generate essential contacts between

221 cations that lie outside of the unstructured tail domains of histones.

222 examined how the properties of the motor and tail domains of human class III myosins impact their abi

223 ned the head domain of II-A with the rod and tail domains of II-B.

224 ll cases result from mutations affecting the tail domains of keratin-10 or keratin-1, and Suzuki et a

225 that lacks the transmembrane and cytoplasmic tail domains of M2 (M2 knockout [M2KO]) is attenuated in

226 The overexpression of the rod + tail domains of paracingulin perturbs the development of

227 pared the elastic properties of the extended tail domains of processive (mouse myosin Va) and nonproc

228 Mutations in the head and tail domains of the motor protein myosin VIIA (MYO7A) ca

229 Only the tail domains of the two invertebrate CCTs were competent

230 rane binding sites within the regulatory and tail domains of this myosin.

231 ooperative dissociation between the head and tail domains of vinculin with increasing temperature in

232 in vitro by disulfide derivatization of the "tail" domain of A2.

233 itical target of Aurora B is the N-terminal "tail" domain of Hec1, which is a component of the NDC80

234 The carboxyl terminal "tail" domains of the heavy and middle molecular weight m

235 -terminal RNA-binding core and a 125-residue tail domain, of which only the last 75 residues are cons

236 Tail domains only weakly inhibit the initial slow releas

237 es two dynein motor domains but not dynein's tail domain or any associated subunits.

238 followed by a transmembrane and cytoplasmic tail domains or by a glycosylphosphatidylinositol linker

239 eceptor family members, including a head and tail domain organization, multimerization that may regul

240 Previously, we demonstrated that the H3 tail domain participates in internucleosome interactions

241 Collectively these results indicate that H3 tail domain performs multiple functions during chromatin

242 The core histone tail domains play a central role in chromatin structure

243 of specific lysines within the core histone tail domains plays a critical role in regulating chromat

244 esults indicate that acetylation of specific tail domains plays distinct roles in the regulation of c

245 ults show that the Rh1 rhodopsin cytoplasmic tail domain, positioned to interact with cytoplasmic str

246 cid substitutions, residing in both head and tail domains, predicted perturbation of protein structur

247 erines localized in the variable "head" and "tail" domain regions.

248 d serine/threonine residues of neurofilament tail-domain repeats are exclusively phosphorylated in ax

249 association of farnesylated Delta50 lamin A tail domains requires calcium.

250 We show that PTEN tail-domain residues 394-403 permit PTEN to associate wi

251 However, whether the H4 tail domains stabilize array folding via inter-nucleosom

252 In 4RL isoform, amino acids in tail domain stay mostly apart from the MT surface.

253 Surprisingly, the kinesin tail domain stimulates microtubule assembly and stabilit

254 Sequence analysis of the proximal tail domain suggests that further calmodulin binding sit

255 formation seen with mutations in the 1A and tail domains suggests that dysfunction of seemingly inta

256 Previous mutations in the beta(2)-tail domain support the importance of extension, rather

257 uction of Med15 levels, a MED subunit in the tail domain, suppressed the Nodal signaling pathway but

258 he quaternary structure of GabR is a head-to-tail domain-swap homodimer.

259 The N-terminal tail domain targets Dyn1/HC to cortical Num1 receptor si

260 We show that SEPT9 interacts with the KIF17 tail domain that associates with mLin-10/Mint1, a cargo

261 an N-terminal 'head' domain and a C-terminal tail domain that contains several predicted coiled-coils

262 ding to yBre1, whereas the C-terminal acidic tail domain that is not required for a stable yBre1-yRad

263 ntramolecular interactions with the vinculin tail domain that normally clamp vinculin in an inactive

264 kinesin motor domain and a series of kinesin tail domains that can attach to their native vesicles; w

265 inesin-5, including some associated with the tail domain, that provide clues as to how spindles are a

266 in-specific insert is part of the C-terminal tail domain, the actin-binding site of both isoforms.

267 ddition to the previously suggested flexible tail domain, there is a compliant region between the mot

268 ned processivity of Kif18A, conferred by its tail domain, thus promotes concentration of Kif18A at K-

269 ide pocket is restricted upon binding of the tail domain to kinesin-1 heads.

270 gly, lysine-to-glutamine mutations in the H3 tail domain to mimic acetylation resulted in little or n

271 of the Tha4 amphipathic helix and C-terminal tail domains to form Tha4 oligomers.

272 Although this potentially allows a dimer of tail domains to interact symmetrically with a dimer of h

273 Binding of the tail domains to the heads inhibits net microtubule-stimu

274 region that links the distal calf-2 and beta-tail domains to their respective transmembrane (TM) doma

275 positioning upon removal of the core histone tail domains under physiological conditions, indicating

276 ational complexity of linker DNA and histone tail domains upon compact folding of the fiber.

277 As expected, deletion of the VCL tail domain (VCL(1-880)), which binds actin, does not no

278 rm the CDK8 submodule binds the Mediator leg/tail domain via the Med13 subunit, and this submodule-Me

279 Vinculin tail domain (VT) both binds and bundles actin filaments.

280 n is simulated either with only its vinculin tail domain (Vt), with all residues in its closed confor

281 ad domain (Vh) and to actin filaments at its tail domain (Vt).

282 Its tail domain, Vt, is crucial for vinculin activation and

283 nterface leads to the formation of a tail-to-tail domain wall.

284 viability of cenh3-1, but CENH3's lacking a tail domain were nonfunctional.

285 Various truncation mutants of the myosin IXb tail domain were produced, and it was revealed that the

286 e (SSP) and G2 transmembrane and cytoplasmic tail domains were essential for correct GPC maturation a

287 v1 proteins is mediated by their cytosolic C tail domain, where we identified seven cholesterol recog

288 gers the unfolding of the protein's proximal tail domain which could drive the needed lever-arm exten

289 Diffusion is promoted by the tail domain, which also contains a second MT-binding sit

290 multiple KSP repeats in the carboxy-terminal tail domain, which are phosphorylation sites of proline-

291 at K-MT plus ends depends on its C-terminal tail domain, while the ability of Kif18A to suppress MT

292 omain 1 prevents interaction of the vinculin tail domain with actin by steric hindrance.

293 s from MYO3B in that it contains an extended tail domain with an additional actin-binding motif.

294 Calcium binds to the tail domain with an affinity KD approximately 250 muM wh

295 rane-adjacent CRAC4 and the long cytosolic C tail domain with several other CRAC motifs, which are no

296 hese residues binds directly to the globular tail domain with the same affinity as melanophilin.

297 replacing the transmembrane and cytoplasmic tail domains with a 6His tag.

298 affect the interactions of the core histone tail domains with nucleosomal DNA, redirecting the tails

299 g(2+) and Ca(2+) can replace the role of the tail domains with regard to stabilization of histone-DNA

300 mation through interaction of the C-terminal tail domains with the N-terminal motor (head) domains.

301 only three, Mediator subunits, all from its tail domain, work as activators when fused to LexA.