ライフサイエンスコーパス: tailbud

1 n the posteriormost embryonic structure, the tailbud.

2 tion of tissue from the primitive streak and tailbud.

3 esicle, a transient structure of the teleost tailbud.

4 and ultimately promotes cell death in chick tailbud.

5 ith FGF signalling decline in the late chick tailbud.

6 l stem cells and mesoderm progenitors in the tailbud.

7 and Wnt target genes in the mouse and chick tailbud.

8 required for somitic precursors to exit the tailbud.

9 n cell fate markers is apparent in the human tailbud.

10 cell migration and cell adhesion within the tailbud.

11 nical and non-canonical Wnt signaling in the tailbud.

12 perinotochordal expression in the posterior tailbud.

13 nteroposterior neuraxis, midline, and streak/tailbud.

14 posterior tailbud progenitors move into the tailbud.

15 vements and behavior in wild type and mutant tailbuds.

16 n of LS neural segments with and without the tailbud, after isolation of normally positioned LS segme

17 spt is mutated, embryos develop an enlarged tailbud and are only able to form roughly half of their

18 careful balance between cells that leave the tailbud and cells that are held back in order to give ri

19 sure the 3D cell flow field of the zebrafish tailbud and identify changes in tissue fluidity revealed

20 An early step during this process occurs at tailbud and involves dissolution of the basement membran

21 of development, Hoxb-13 is expressed in the tailbud and posterior domains in the spinal cord, digest

22 GF-dependent mesoderm identity in late stage tailbud and provide evidence that rising endogenous reti

23 cell population that is incorporated in the tailbud and required for axial elongation of the mouse e

24 ise in endogenous retinoid signalling in the tailbud and show that here FGF no longer opposes retinoi

25 expression persists in the notochord during tailbud and tadpole stages.

26 nt3a and wnt8 are expressed in the zebrafish tailbud and that simultaneous inhibition of both wnt3a a

27 To study the dynamics of cells in the tailbud and their role in somite formation, we have anal

28 The vertebrate tailbud and trunk form very similar tissues.

29 lly positioned LS segments from the stage 13 tailbud, and after axial displacement of posterior parax

30 vergence-extension of cells as they exit the tailbud, and finally by a late volumetric growth in the

31 ures such as the notochord, somites, muscle, tailbud, and fins.

32 esis, myogenesis, kidney development, in the tailbud, and in the migrating neural crest.

33 cts are due to non-autonomous effects on the tailbud, and present evidence that the tailbud defects a

34 ortional levels of activity in the zebrafish tailbud, and this balance is important for axis elongati

35 e autonomously and their dynamics within the tailbud are drastically different than WT MPCs.

36 ents and cell movements within the posterior tailbud are impaired.

37 mp inhibitors expressed just anterior to the tailbud are important to restrain Bmp signaling we produ

38 Data suggest that inductive signals from the tailbud are primarily responsible for the programming of

39 hat some cell movements and behaviors in the tailbud are similar to those seen during gastrulation, w

40 in altered DFC migration or cohesion in the tailbud at somite stages.

41 generated along with a detailed analysis of tailbud cell movements.

42 aises the possibility that FGF maintains key tailbud cell populations and that rising retinoid activi

43 sterior body is derived from discrete, basal tailbud cell populations.

44 opment include the bilateral distribution of tailbud cell progeny and the exhibition of different for

45 ranscription factor Her1, we recorded single tailbud cells in vitro.

46 Our data suggest that the tailbud contains multipotent cells that make very late g

47 LS neural tube formation (stages 12-14), the tailbud contains the remnants of Hensen's node and the p

48 n the tailbud, and present evidence that the tailbud defects are caused by alterations in Wnt signali

49 ow that BMP4, a paracrine factor secreted by tailbud-derived mesenchyme, is required for ureter morph

50 e derived from the intermediate mesoderm and tailbud-derived mesoderm, which is selectively associate

51 Removing the posterior tailbud domain prevents Xnr1 expression in the L LPM, co

52 ression resulting in the restriction of this tailbud domain to paraxial mesodermal fates.

53 ifferent forms of ingression within specific tailbud domains.

54 These double mutants also develop a large tailbud due to the accumulation of progenitor cells that

55 e left lateral plate mesoderm (L LPM) during tailbud/early somitogenesis stages is associated in all

56 te, but not to ventrolateral mesoderm of the tailbud embryo.

57 in the midline, over a substantial period of tailbud embryogenesis, and therefore lend further insigh

58 cular marker of pronephric specification, in tailbud embryos indicated that injected xWT1 mRNA inhibi

59 overexpressing Xnr1 placed into the R LPM of tailbud embryos induced the expression of the normally L

60 We find in chobi tailbud embryos that the notochord is often bent, with c

61 1 expression in different regions of neurula-tailbud embryos.

62 Progenitor cells reside in the tailbud for variable amounts of time before they exit an

63 n transgenic mouse embryos, is stimulated in tailbud fragments when cultured in presence of Gdf11, a

64 Fate mapping of chick tailbud further revealed that spread of neural gene expr

65 ing in specifying cell fate in the zebrafish tailbud has been well established.

66 itogenesis to constrain Bmp signaling in the tailbud in order to allow normal expression of Wnt inhib

67 mitogenesis results in severe defects in the tailbud, including altered morphogenesis and gene expres

68 promote epibolic migration of cells into the tailbud, increasing tail formation at the expense of hea

69 oxd11/lacZ expression in cultured transgenic tailbuds, indicating that Smad3 may play a similar role

70 The tailbud is a population of stem cells in the posterior e

71 e that germ layer induction in the zebrafish tailbud is not a simple continuation of gastrulation eve

72 The tailbud is the posterior leading edge of the growing ver

73 Specifically, we find that the zebrafish tailbud is viscoelastic (elastic below a few seconds and

74 ithelium that form late in embryogenesis, as tailbuds mature into larvae.

75 They also elucidate that chd;spt tailbud mesodermal progenitor cells (MPC) behave autonom

76 signals specify germ layer fate in two basal tailbud midline progenitor populations.

77 Interestingly, the tailbud of GCNF(-/-) embryos develops ectopically outsid

78 direct cell fate in the primitive streak and tailbud of the early embryo.

79 tiating embryonic stem (ES) cells and in the tailbud of the embryo.

80 all neighborhoods of cells in the developing tailbud of Xenopus laevis.

81 The tailbuds of these mutant embryos protrude outside the yo

82 The ingression of cells in the anterior tailbud only gives rise to paraxial mesoderm, at the exc

83 somitic precursors are not able to leave the tailbud or differentiate.

84 f cells into the PSM during gastrulation and tailbud outgrowth.

85 ession of Hoxd11/lacZ reporter in the embryo tailbud, posterior mesoderm and neurectoderm.

86 strate developmental equivalency between the tailbud progenitor cell populations.

87 onstrates that the ventral derived posterior tailbud progenitors move into the tailbud.

88 ior tailbud to promote cell migration during tailbud protrusion, and that defective migration of thes

89 that drives expression of a reporter in the tailbud, PSM and somites during somitogenesis.

90 erential posterior movement of cells in this tailbud region and to the general extension of the tail.

91 onset of transcription occurs at E9.0 in the tailbud region.

92 The fate map of the zebrafish tailbud shows that it contains tissue-restricted domains

93 ylinositol-specific phospholipase C to early tailbud stage axolotl embryos reveals that a specific su

94 Whole-mount in situ hybridisation on tailbud stage embryo reveals strong expression of the ge

95 each ectoderm cell of the late neurula/early tailbud stage embryo, a time point just before onset of

96 ically blocks tail formation when induced in tailbud stage embryos, comfirming the importance of Xhox

97 pecific expression pattern of xmdc11a at the tailbud stage in the cranial neural crest and in a subse

98 Until the tailbud stage of development, all ERK activation domains

99 d genetic inhibition of BMP signaling at the tailbud stage resulted in severe inhibition of endocardi

100 sufficiency of no tail expression as late as tailbud stage to drive medial precursor cells towards th

101 of the germ line did not occur until the mid-tailbud stage, days after the somatic germ layers are es

102 At tailbud stage, forerunner cells form the dorsal roof of

103 tion and axis formation, however, during the tailbud stage, MocuFH1 is also expressed in ventral cell

104 al crest cells from all axial levels, at the tailbud stage, Sox10 is downregulated in the cranial neu

105 reshadowed by different somite counts at the tailbud stage, thought to be a highly conserved (phyloty

106 defect in the mutant embryos until the early tailbud stage.

107 the developing retina beginning in the early tailbud stage.

108 on and disruption of somite formation at the tailbud stage.

109 een the midblastula transition and the early tailbud stage.

110 progress faster through epiboly, leading to tailbud-stage embryos that have a narrow axis and an enl

111 late mesoderm restricted to the left side of tailbud-stage embryos.

112 tead the archenteron cavity almost closes at tailbud stages before providing a nucleus for the defini

113 ay: inhibition with MEK or Fgfr inhibitor at tailbud stages in Ciona results in a larva which fails t

114 established as being between 60% epiboly and tailbud stages using the Fgf receptor inhibitor SU5402.

115 At gastrula, neurula, and tailbud stages, Axdazl RNA is widely distributed.

116 During tailbud stages, axial expression resolves to the neural

117 At the neurula and tailbud stages, dorsoanterior structures are affected: e

118 en restarts in a second phase at neurula and tailbud stages, firstly in two symmetric patches near th

119 When cultured until tailbud stages, Keller explants develop neural tissue wi

120 By the early tailbud stages, these cells lie at the horizontal myosep

121 ning of ventral explants between neurula and tailbud stages.

122 arly stages into the long, thin shape of the tailbud stages.

123 n the left lateral plate mesoderm at neurula/tailbud stages.

124 ly at mid-gastrula but continuing as late as tailbud stages.

125 rivatives and other dorsal structures during tailbud stages.

126 n stabilised by binding to cdk2, persists to tailbud stages.

127 as evidence for pluripotent cells within the tailbud, suggest that complex inductive mechanisms accom

128 dermal cells along the posterior wall of the tailbud that make a germ layer decision after gastrulati

129 these and adjacent regions indicate that, at tailbud, the oral ectoderm is not specifically required

130 At the posterior tip of the tailbud, this flow makes sharp bilateral turns facilitat

131 ignaling is activated in the ventroposterior tailbud to promote cell migration during tailbud protrus

132 during gastrulation, continues to act in the tailbud to specify hypochord from a notochord/hypochord

133 scription and protein phosphorylation in the tailbud, to distinguish early effects of signal perturba

134 dorsal tissues, we find that the neurula-to-tailbud transition depends in part on activities of vent

135 tense morphogenetic activity, the neurula-to-tailbud transition.

136 Cells of the posterior tailbud undergo subduction, a novel form of ingression r

137 We show that, in one region of the tailbud, very small groups of adjacent cells can contrib

138 n the zebrafish, a fate map of the zebrafish tailbud was generated along with a detailed analysis of

139 Rates of cell proliferation in the tailbud were examined and found to be relatively low at

140 a population of multipotent precursors, the tailbud, which will give rise to all of the posterior st

141 ll fates and gene expression patterns in the tailbud will help to determine the nature of this import

142 ryos that have a narrow axis and an enlarged tailbud with expanded bmp4 and shh expression.

143 domains for Cdx expression (primitive streak/tailbud), yet, overall, they contain elevated levels of