ライフサイエンスコーパス: talc

1 by volume of the magnesium silicate mineral, talc.

2 CI, 50 to 199; p = 0.004) were greater after talc.

3 duced more systemic inflammation than graded talc.

4 ant effusions received tetracycline or mixed talc.

5 86 +/- 191 versus 85 +/- 37 microm) than did talc.

6 when compared with intrapleural injection of talc.

7 after, whereas a control group received only talc.

8 nt Effusion Trial [TIME2]) comparing IPC and talc (1:1) for which 106 patients with malignant pleural

9 The higher pressure vapor-absent reaction talc = 10 angstrom phase + enstatite + coesite was also

10 inflammation (change in C-reactive protein, talc 198 SD 79.2 vs. tetracycline 74 SD 79.4 microg/L; d

11 abbits received an intrapleural injection of talc (400 mg/kg) and an intramuscular injection of triam

12 were given TGF-beta(2) (1.7 or 5.0 microg), talc (400 mg/kg), doxycycline (10 mg/kg), or buffer intr

13 g inflammation (change in isotope clearance, talc -9.26, SD 14.3 vs. tetracycline 4.10, SD 13.8 minut

14 The mechanism whereby talc achieves this effect is unknown.

15 Conventional pleurodesing agents such as talc act by inducing pleural injury, which results in ac

16 Talc also enhanced intercellular adhesion molecule-1 (IC

17 In addition, talc and disordered biopyriboles were found replacing en

18 enes), with particular diversity among viral TalC and Hsp20 sequences.

19 ight inducible protein (hli), transaldolase (talC) and ribonucleotide reductase (nrd)--are transcribe

20 y anti-TGF-beta antibody in the TGF-beta(2), talc, and control (buffer and medium) groups.

21 y decreases the inflammatory reaction to the talc, and essentially prevents a pleurodesis from develo

22 Second, 48 patients received mixed or graded talc, and gas exchange was assessed from changes in the

23 an detect binders and fillers such as chalk, talc, and starch not revealed by traditional chromatogra

24 Our results demonstrated that talc at a therapeutically achievable concentration (6 mi

25 s significant, as the frictional strength of talc at elevated temperatures is sufficiently low to mee

26 uids that migrate up the fault zone, and the talc commonly occurs in sheared serpentinite.

27 Talc did not induce apoptosis in PMC, and glass beads di

28 he present study was designed to evaluate if talc directly effects cell death of malignant mesothelio

29 Electrophoresis of DNA isolated from talc-exposed MMC demonstrated the typical ladder pattern

30 Three confluent MMC and PMC were exposed to talc for 24, 48, and 72 h.

31 We conclude that the routine use of graded talc for pleurodesis would reduce the morbidity of this

32 p were admitted for chest tube insertion and talc for slurry pleurodesis.

33 experienced adverse events vs 7 of 54 in the talc group (OR, 4.70; 95% CI, 1.75-12.60; P = .002).

34 e in VAS score between the IPC group and the talc group of -14.0 mm (95% CI, -25.2 to -2.8 mm; P = .0

35 Twelve patients (22%) in the talc group required further pleural procedures compared

36 The talc group were admitted for chest tube insertion and ta

37 0-1 day) and 4 days (IQR, 2-6 days) for the talc group, with a difference of -3.5 days (95% CI, -4.8

38 m) and 24.4 mm (95% CI, 19.4-29.4 mm) in the talc group, with a difference of 0.16 mm (95% CI, -6.82

39 The reaction talc + H(2)O = 10 angstrom phase was observed within 20

40 perature synthesis of 10 angstrom phase from talc + H(2)O to be observed in situ in a multianvil appa

41 Here we report the discovery of talc in cuttings of serpentinite collected from the prob

42 estradiol (high E2) before i.p. injection of talc in saline or saline alone.

43 When PMC were challenged with talc in vitro, interleukin-8 (IL-8) and monocyte chemota

44 such as endometriosis or mucosal exposure to talc increase the risk for several types of cancer.

45 Furthermore, E2 suppressed talc-induced expression of JE/MCP-1 mRNA in murine macro

46 Talc-induced maximum apoptosis in MMC (39.50 +/- 2.55%,

47 Patients with mesothelioma who have talc-induced pleurodesis have a lower morbidity than do

48 The present study has demonstrated that talc induces apoptosis in MMC without affecting normal m

49 tion of triamcinolone (0.8 mg/kg) 1 d before talc instillation and weekly thereafter, whereas a contr

50 Pleurodesis with talc is an accepted method for the treatment of symptoma

51 wide variety of sclerosing agents, of which talc is considered to be the most successful.

52 We infer that the talc is forming as a result of the reaction of serpentin

53 The possibility that talc may directly affect malignant cells was not conside

54 Talc may therefore provide the connection between serpen

55 The mechanisms whereby talc mediated these effects were considered to be second

56 c inflammation than tetracycline or "graded" talc (most particles < 10 microm were removed).

57 Calcic amphibole and talc occur in thin (less than 0.3 micrometer) crosscutti

58 c and ultramafic basement which precipitates talc on mixing with seawater.

59 At Day 28, all 10 rabbits that received talc only had a pleurodesis score of 3 or 4, whereas onl

60 At 4 and 24 h, TGF-beta(2), but not talc or doxycycline, induced a significant increase in V

61 at although TGF-beta was more effective than talc or doxycycline, it induced transient production of

62 of TGF-beta(2) than after administration of talc or doxycycline.

63 +/- 0.9 for TGF-beta2 versus 2.4 +/- 0.6 for talc) or at any other time points.

64 red with 3 days (2-5) for those who received talc pleurodesis (p<0.0001).

65 ersus ten (14%) of 73 patients who completed talc pleurodesis (p=0.019), as were respiratory complica

66 s no significant difference between IPCs and talc pleurodesis at relieving patient-reported dyspnea.

67 randomly assigned (1:1) to either VAT-PP or talc pleurodesis by computer-generated random numbers, s

68 ) in the VAT-PP group and 57% (46-66) in the talc pleurodesis group (hazard ratio 1.04 [95% CI 0.76-1

69 of overall survival, and cost, of VAT-PP and talc pleurodesis in patients with malignant pleural meso

70 n due to malignant pleural mesothelioma, and talc pleurodesis might be preferable considering the few

71 Small-bore-catheter thoracostomy and talc pleurodesis was successful in treating malignant pl

72 We report two trials describing whether talc pleurodesis with a mean particle size of less than

73 ed 196 patients, of whom 175 (88 assigned to talc pleurodesis, 87 assigned to VAT-PP) had confirmed m

74 ficantly more common after VAT-PP than after talc pleurodesis, occurring in 24 (31%) of 78 patients w

75 derwent small-bore-catheter thoracostomy and talc pleurodesis.

76 article size of less than 15 microm ("mixed" talc) produces more lung and systemic inflammation than

77 shear at depth can become localized along a talc-rich principal-slip surface within serpentinite ent

78 dded), mottled deposits containing saponite, talc-saponite, Fe-rich mica (for example, glauconite-non

79 and given either TGF-beta(2) (1.7 microg) or talc slurry (400 mg/kg) via a chest tube.

80 pleurodesis in rabbits at a rate faster than talc slurry and all other pleurodesing agents investigat

81 TGF-beta2 may have advantages over talc slurry in the management of recurrent pleural effus

82 ing corticosteroids at 6 h through 4 d after talc slurry than in the other groups.

83 ucing excess inflammation when compared with talc slurry.

84 jection of 10 mg/kg doxycycline or 400 mg/kg talc slurry.

85 at the use of corticosteroids at the time of talc-slurry pleurodesis markedly decreases the inflammat

86 he concurrent use of steroids at the time of talc-slurry pleurodesis would influence the development

87 Talc-stimulated PMC culture supernatant showed chemotact

88 ive of this study was to investigate whether talc stimulates pleural mesothelial cells (PMC) to relea

89 The data demonstrate that talc stimulates PMC to release chemokines and express ad

90 bdominal wall tissue showed that five of six talc-treated animals given placebo expressed mRNA for th

91 Conversely, only one of five talc-treated animals that received E2 replacement expres

92 Talc-treated mice receiving low and high E2 replacement

93 65% decrease, respectively) as compared with talc-treated mice receiving placebo pellets.

94 experiments, glass beads similar in size to talc were included as control.

95 Mixed talc worsened gas exchange (oxygen gradient change, mixe