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1 ma-dienyl thiol esters provide for a one-pot tandem 1,4-addition-nucleophilic acyl substitution react
2 context of a gold catalyzed enantioselective tandem [3,3]-sigmatropic rearrangement-[2+2]-cyclization
3 ovel paradigm of atrial ECC that is based on tandem activation of the RyRs by cytosolic and luminal C
5 to the organelle RNA editosome, we performed tandem affinity purification of the plastidial CHLOROPLA
7 mechanistic understanding of the UHRF1/DNMT1 tandem and the development of assays for the identificat
8 interest towards high-band gap absorbers for tandem applications led us to reconsider this attractive
10 in CCCTC-binding factor (CTCF), containing a tandem array of 11 zinc fingers (ZFs), modulates the thr
11 we employ a recently developed concatenated tandem array of consensus TF response elements (catTFRE)
15 slocase RecBCD travels along DNA occupied by tandem arrays of high-affinity DNA binding proteins.
16 ors (PBAF) chromatin remodeler, contains six tandem BDs and is frequently mutated in clear cell renal
17 erestingly, dialkynyl substrates can undergo tandem benzannulations to give substituted aza[5]helicen
19 This recruitment requires binding of BRD2's tandem bromodomains to H4Ac, which is generated at DSBs
20 ore interestingly, in the presence of K2CO3, tandem C-C/C-N cyclization products were obtained for a
23 re performed, which are consistent with auto-tandem catalysis involving atom-transfer radical cycliza
24 ations such as power-generating decorations, tandem cells, power-saving wearable devices and energy-e
26 esses the importance of employing a parallel tandem configuration for achieving efficient light harve
27 oceeds in good to excellent yields through a tandem conjugate addition/Smiles rearrangement involving
28 emical data to identify two enzymes that, in tandem, convert strictosidine to akuammicine, the stable
29 ibution of small RNAs in live, single cells, tandem copies of FASTmiR122 were expressed in different
30 n-carbon bond-forming reaction involving the tandem coupling of benzyltriboronates, enoates, and alky
32 ecific transformations entailing allylation, tandem cross coupling, and application to the synthesis
34 nolide has been prepared through a series of tandem cyclopropanation-Cope and translactonization-Cope
38 rovskite-based solar cells, instead of using tandem devices or near infrared (NIR)-absorbing Sn-conta
41 y published model that erroneously harbors a tandem duplicate of the CAG repeat-containing exon, and
42 ched for transcriptional regulation, whereas tandem duplicates were overrepresented by environmental
45 the tyrosine kinase domain (TKD) or internal tandem duplication (ITD) mutation with either a high rat
46 mal karyotype, the presence of FLT3-internal tandem duplication (ITD), and a < 4-log reduction in PB-
49 ermined significant iHR activity in internal tandem duplication FLT3 (FLT3-ITD) and JAK2V617F-mutated
52 taurtinib and control: 74% had FLT3-internal tandem duplication mutations, 23% FLT3-tyrosine kinase d
56 enotype NPM1 wild-type/FLT3 without internal-tandem duplications (EFS, 18% +/- 5 vs 40% +/- 7; Cox P
57 ) and frequently co-occur with FLT3 internal tandem duplications (ITD) or, less commonly, NRAS or KRA
58 that this family expanded from segmental and tandem duplications following a tetraploidization event.
59 African and Norwegian families is caused by tandem duplications in a non-coding genomic region conta
63 dent formation incidences, are predominantly tandem duplications or complex gains, exhibit breakpoint
64 We identified 33 hotspots of large (>100 kb) tandem duplications, a mutational signature associated w
67 ite dimers (Kleisin interacting winged-helix tandem elements), interact with Smc-kleisin rings from b
70 [95% CI, 0.53-1.29]; effect size, 0.68), and tandem gait (mean [SD] time, 22.2 [8.3] vs 14.0 [3.7] se
72 that these genes are derived from an ancient tandem gene duplication that likely predates the radiati
73 ers of non-syntenic genes and a high rate of tandem gene duplications, the latter of which have given
75 loyment of various enzymes singularly and in tandem have resulted in designing a multistate transient
76 ting the potential of the system to catalyze tandem heterogeneous/homogeneous processes by choice of
78 udy the global kinome and phosphoproteome in tandem in a model photosynthetic organism, the alga Chla
80 emonstrated with the development of one-pot, tandem, iron-catalyzed dihalogenation processes allowing
81 he synthetic route features iodine-catalyzed tandem isomerization followed by C-O and C-C bond format
84 ovation in MegaSTAR is the construction of a tandem library, in which two reagents are randomly-displ
85 c acid (3% w/v) and measured migration using tandem liquid chromatography (LC)/mass spectrometry (MS)
86 ther establish that BONCAT can be coupled to tandem liquid chromatography-mass spectrometry to identi
89 peptide sequencing based on matched pairs of tandem mass spectra (MS/MS) obtained by collision induce
92 ge-tagged carbene was generated in situ in a tandem mass spectrometer by decarboxylation of oxo[4-(tr
93 s how CBS can be applied for the concomitant tandem mass spectrometric (MS/MS) analysis of nine pharm
95 d and validated, using liquid chromatography-tandem mass spectrometric detection, in order to accurat
96 cal trial were analyzed using flow injection tandem mass spectrometry (60 metabolites) and convention
97 zone electrophoresis-electrospray ionization-tandem mass spectrometry (CZE-ESI-MS/MS) has been recogn
98 his study, a data-dependent, high-resolution tandem mass spectrometry (ddHRMS/MS) method capable of d
99 UHT milk (ULF) and infant formula (IF) using tandem mass spectrometry (electron transfer dissociation
100 ed to a negative-ion electrospray ionization tandem mass spectrometry (ESI-MS/MS) method has been dev
103 e obtained olive oil: (i) gas chromatography-tandem mass spectrometry (GC-MS/MS) for GC-amenable pest
104 ydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) for polar pestici
105 liquid chromatography-diode array detection- tandem mass spectrometry (HPLC-DAD-MS/MS) identified 29
106 iquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) are commonly e
107 ped a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method with multip
108 iquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) methodology empl
113 etected sensitively by liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis of the tiss
114 -I) were quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and their total amou
115 ditions for liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for quantitative mea
117 HLA)-bound peptides by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is poised to provide
119 (SCX) and analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) using a high-resolut
120 traction (TF-SPME) and liquid chromatography tandem mass spectrometry (LC-MS/MS) was used for collect
122 ectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) were used to quantif
123 ity were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) within the hydrolysa
124 (13)C6-metabolites via liquid chromatography-tandem mass spectrometry (LC-MS/MS), (13)C6-metabolites
132 and mass analysis (MS) with fragmentation by tandem mass spectrometry (MS(2) ) and an orthogonal onli
135 lex lipids, such as glycerophospholipids, by tandem mass spectrometry (MS/MS) continues to present a
138 kflows depend on acquisition of thousands of tandem mass spectrometry (MS/MS) spectra with adequate s
139 chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (MS/MS) to quantify oxidized li
140 fication of the residues was performed using tandem mass spectrometry (MS/MS) with a triple quadrupol
141 Ion mobility-mass spectrometry (IM-MS), tandem mass spectrometry (MS/MS), and computational meth
142 w liquid chromatography nanospray ionization tandem mass spectrometry (nanoLC-NSI/MS/MS) under the hi
145 ; (iii) reversed-phase liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) for low to medium
146 ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) has been evaluate
147 performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) methodology, allow
149 eration and multimodal liquid chromatography-tandem mass spectrometry analysis of >330,000 synthetic
150 hy coupled to accurate-mass, high-resolution tandem mass spectrometry analysis of peptides fractionat
152 5(OH)D was measured by liquid chromatography-tandem mass spectrometry and categorized as deficient (<
153 proteomics, intact proteins are analyzed by tandem mass spectrometry and proteoforms, which are defi
154 ercially available liquid chromatography and tandem mass spectrometry assay; follicle-stimulating hor
156 ipids across a wide range of high resolution tandem mass spectrometry experiments, including imaging
157 performance liquid chromatography coupled to tandem mass spectrometry for the detection of blood-deri
158 tein precipitation and liquid chromatography-tandem mass spectrometry for the determination of common
160 nd hemp seeds based on liquid chromatography tandem mass spectrometry has been optimized and validate
162 PBDEs were measured using gas chromatography-tandem mass spectrometry in 80 children aged 15-71 month
163 erum metabolites using liquid chromatography-tandem mass spectrometry in a cross-sectional study of 4
166 its derivatives in kynurenine pathway using tandem mass spectrometry in various fermented food produ
167 solid-phase extraction-liquid chromatography-tandem mass spectrometry method was developed, allowing
170 ging (AACT) with stable isotopes followed by tandem mass spectrometry sequencing and AACT quantitatio
171 aring and balance, we analyzed IE samples by tandem mass spectrometry to generate an unbiased, shotgu
173 ess using liquid chromatography coupled with tandem mass spectrometry to quantify acrylamide in foods
174 ion was carried out by liquid chromatography-tandem mass spectrometry with electrospray ionization so
175 hy-electrospray ionization-triple quadrupole-tandem mass spectrometry with online turbulent flow chro
176 d by an off-site unambiguous detection using tandem mass spectrometry, in a postattack situation.
177 rophoresis followed by liquid chromatography-tandem mass spectrometry, in order to detect biomarkers
178 el electrophoresis and liquid chromatography tandem mass spectrometry, showed that they disturb eithe
179 phy coupled to high-resolution accurate mass tandem mass spectrometry, the resulting degradation prod
180 xpressing HCs, coupled with FACS sorting and tandem mass spectrometry, to define the most complete HC
181 e co-immunoprecipitation assays coupled with tandem mass spectrometry, we identified potential bindin
184 he accuracy of an OFFGEL electrophoresis and tandem mass spectrometry-based proteomic approach with a
203 sed by using highly sensitive chromatography-tandem mass spectrometry.The mean +/- SD 25(OH)D3 concen
204 using high performance liquid chromatography tandem mass spectroscopy (LC/MS-MS) on plasma, urine, an
205 ultrahigh performance liquid chromatography-tandem mass spectroscopy and gas chromatography-mass spe
207 and commercially available carbonyl-reactive tandem mass tags (aminoxyTMT) enable multiplexed quantif
208 roach can be multiplexed up to 10-plex using tandem mass tags (TMT) reagents, further increasing thro
209 amine isotopic labelling of substrates with tandem mass tags (TMT-TAILS) for relative quantification
210 nkyrase double knockout cells using isobaric tandem mass tags reveals targets of degradation, includi
214 sample throughput to flow injection analysis-tandem MS (FIA-MS/MS) but with greater selectivity as re
215 PLC-PDA, LC-high resolution MS (LC-HRMS), LC-tandem MS (LC-MS/MS) and nuclear magnetic resonance (NMR
216 he quality of top-down liquid chromatography-tandem MS (LC-MS/MS) data sets is rapidly increasing on
217 peptidome analysis and liquid chromatography-tandem MS (LC-MS/MS), we selected three high abundance p
218 R-HRPF, electron-transfer dissociation (ETD) tandem MS (MS/MS) acquisition, measurement of effective
221 lution of cold-ion spectroscopy coupled with tandem MS may render this the key technology to unravel
222 addition to target information obtained via tandem MS, retrospective studies of the same sample via
225 romatography-coupled electrospray ionization tandem-MS/MS and NMR to determine the structural complex
227 Several neurological disorders are linked to tandem nucleotide repeat expansion in the mutated gene.
228 tions have been identified in the MyTH4-FERM tandems of these myosins in patients suffering visual an
229 ars catechol and carboxyl functionalities in tandem, on to the surface of Fe3O4 nanoparticles has dev
231 e platform comprises two major components: a tandem optical sensor for combined oxygen and pH detecti
234 nprecedented selective pseudo-four-component tandem oxidative cyclization with fragmentation from a 1
236 rapeutics within the tissue, and ii) a novel tandem peptide cargo to localize payload to bacterial me
237 e with a toxic peptide cargo and discovers a tandem peptide that displays synergy between the two dom
239 ding candidates for high efficiency low cost tandem photovoltaics, in part because they have band gap
240 ere, we present the crystal structure of the tandem plant homeodomain finger domain of human DPF2 at
241 5 from Arabidopsis thaliana, revealing three tandem polypeptide transport-associated (POTRA) domains,
243 e derivatives via a one-pot copper catalyzed tandem reaction of 2-iodobenzamides with 2-iodobenzylcya
246 nctional group tolerance was observed in the tandem reaction, which proceeds in high yield in 1-3 h.
249 -4.90), and, repeat variants variable number tandem repeat (VNTR) 4 DRD4 (odds ratio: 1.66; confidenc
250 w that two PER3 mutations, a variable number tandem repeat (VNTR) allele and a single-nucleotide poly
251 ified in the AKT1 gene a new variable number tandem repeat (VNTR) marker associated with baseline str
252 fect of a newly characterized variant number tandem repeat (VNTR) polymorphism in AKT1 [major alleles
253 racting effects of APZ and a variable number tandem repeat (VNTR) polymorphism in DAT1/SLC6A3 (the ge
254 ic pedigree searches with Y-chromosome short tandem repeat (Y-STR) profiling in large-scale crime inv
255 In this study, we assess the impact of large tandem repeat arrays on the recombination rate landscape
256 he analysis of a model protein of a spectrin tandem repeat that exemplified an intuitive stability pr
259 ibotyping and multiple-locus variable-number tandem-repeat analysis (MLVA) of selected strains was pe
261 ns in mammalian cells, which have dimeric or tandem-repeated CRDs enabling multivalency for various f
265 genome-wide SNPs and the other with 13 short tandem repeats (STRs) used in forensic applications-we f
267 rther classified them into groups, including tandem repeats and Staphylococcus aureus repeat (STAR)-l
268 r than single-domain enzymes, they appear as tandem repeats in large polypeptides we refer to as CSRP
269 NGTGGV, required for germline expression and tandem repeats of the motif YAACYGY, which enhance DUO1
270 served open reading frame composed solely of tandem repeats, yet it is still unclear why cells utiliz
271 ion signature composed of short deletions in tandem repeats; in the specific case of ribonucleotide-i
272 s activated by cytosolic and luminal Ca(2+) (tandem RyR activation) via a novel 'fire-diffuse-uptake-
274 evealed that interaction with the Hck SH3 or tandem SH3-SH2 domains induces protection of the Nef alp
276 HCV) host factor, binds and recruits Ago2 to tandem sites (S1 and S2) near the 5 end of the HCV genom
278 d indeed perovskite-based single bandgap and tandem solar cell designs have yielded impressive perfor
279 e resultant monolithic perovskite-perovskite tandem solar cell shows a high V oc of 1.98 V (approachi
282 l X-ray/neutron diffraction are exploited in tandem to allow structural visualization of the activati
283 a simple lipid compression model are used in tandem to gain insight into lipid redistribution around
285 ble-strand breaks via the interaction of the tandem Tudor domain with dimethylated lysine 20 of histo
288 rn7 N-terminal domain near Pol I wall or the tandem winged helix domain of A49 at a partially overlap
289 ng sequestration and dispersion abilities in tandem with a 10:1 (oil: NCS; w/w) loading capacity.
290 A mobile phone user interface operating in tandem with a portable Bluetooth-enabled cartridge-proce
291 a bar-coded transposon insertion library in tandem with cell sorting to assess genome-wide impact of
292 trapped ion mobility spectrometry (TIMS) in tandem with Fourier transform ion cyclotron resonance ma
293 sing an equilibrium/nonequilibrium system in tandem with its inherent self-healing properties and tri
295 lectron chemistry of photoredox catalysis in tandem with low-valent cobalt catalysts, new methods by
298 ced with the adenoviral vector and loaded in tandem with the recombinant protein reduced parasite bur
299 ic and vibrational spectroscopic studies, in tandem with theoretical density functional theory calcul
300 nt product, 4-hydroxycumyl alcohol (HCA), in tandem with transformation of a synthetic, Mn(III)-rich
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