ライフサイエンスコーパス: tanycyte

1 ulated in specific neurons, but not in glia (tanycytes).

2 (+), tyrosine hydroxylase (TH)(+)] and glia (tanycytes).

3 a specialized glial/ependymal cell type, the tanycyte.

4 diate-, and 15 high-level POMC expression in tanycytes.

5 a subset of closely located beta and alpha2 tanycytes.

6 ed by specialized ependymal cells called the tanycytes.

7 he cell bodies of all DARPP-32-immunolabeled tanycytes.

8 tricle, transducing ependymal wall cells and tanycytes.

9 ssing cells were mainly AgRP-NPY neurons and tanycytes.

10 hypothalamic ependymal cell layer containing tanycytes.

11 pressed in hypothalamic progenitor cells and tanycytes.

12 indicate that they correspond to subtypes of tanycytes.

13 the vast majority of alpha2, beta, and gamma tanycytes.

14 T4-to-T3 conversion between thyrotrophs and tanycytes.

15 cidate the physiologic importance of POMC in tanycytes.

16 ormed by specialized ependymal cells, called tanycytes.

17 es DBI expression in hypothalamic glial-like tanycytes.

18 Hypothalamic tanycytes, a radial glial-like ependymal cell population

19 Furthermore tanycytes also respond to non-metabolisable analogues of

20 Earlier studies suggested that tanycytes, an ependymoglial cell type of the median emin

21 s show that Rax is required for hypothalamic tanycyte and ependymal cell differentiation.

22 third ventricular wall and reduction of both tanycyte and ependymal markers.

23 ta has shown a metabolic interaction between tanycytes and AN neurons through lactate that may also b

24 n could alter the metabolic coupling between tanycytes and AN neurons, altering feeding behavior.

25 rmone (TH) and retinoic acid (RA) within the tanycytes and ependymal cells of the hypothalamus have b

26 fferentiation and patterning of hypothalamic tanycytes and ependymal cells, as well as for maintenanc

27 and its receptors were localised within the tanycytes and ependymal cells, with higher expression un

28 s composed of two distinct cell populations: tanycytes and ependymal cells.

29 odinase enzymes (DIO2 and DIO3) expressed in tanycytes and is the key regulator of seasonal cycles of

30 ence that some dual-labeled glial cells were tanycytes and radial glia.

31 ility that these two proteins may coexist in tanycytes and that DARPP-32 may modulate type 2 deiodina

32 lk/caudal median eminence, termed here gamma tanycytes, and a subset of closely located beta and alph

33 ax) is selectively expressed in hypothalamic tanycytes, and showed a complementary pattern of express

34 Together, our results suggest that tanycytes are a characteristic feature of all CVOs and y

35 a provide further support for the notion the tanycytes are an important component of the mechanism by

36 Hypothalamic tanycytes are considered to function as sensors of perip

37 orate previous findings that third ventricle tanycytes are functionally heterogeneous.

38 Tanycytes are glucosensitive and are able to respond to

39 Tanycytes are highly specialized ependymal cells that fo

40 A subset of tanycytes are located close to, and send processes towar

41 (T2) conditional driver indicates that alpha-tanycytes are self-renewing cells that constitutively gi

42 At least some tanycytes are stem cells and, in the median eminence, ma

43 tnatal and adult life, and identify Fgf10(+) tanycytes as a source of parenchymal neurons with putati

44 Here, we identify alpha-tanycytes as key components of a hypothalamic niche in t

45 These in vitro results identify tanycytes as targets of TGFalpha action and demonstrate

46 g cells that constitutively give rise to new tanycytes, astrocytes and sparse numbers of neurons.

47 pithelial cells of the choroid plexus and in tanycytes at the third ventricle, both peaking near the

48 ility studies to investigate the presence of tanycyte barriers along the ventricular walls of other b

49 Oligodendrocytes and third ventricle tanycytes, both of which we have previously described as

50 y for the colocalization of these factors to tanycytes but not the pituitary gland, may explain the h

51 In vitro studies demonstrate that alpha-tanycytes, but not beta-tanycytes or parenchymal cells,

52 Selective stimulation by glucose of tanycyte cell bodies evokes robust ATP-mediated Ca2+ res

53 blast growth factor 10-expressing (Fgf10(+)) tanycytes constitute a population of progenitor cells in

54 Hypothalamic tanycytes contact the cerebral spinal fluid of the third

55 All tanycytes containing DARPP-32-IR also contained CREB-IR

56 to the CSF and can receive signals via this tanycyte-controlled pathway.

57 Despite near-complete loss of brain D2, tanycyte D2 was preserved in astro-D2 KO mice at levels

58 Two weeks after alloxan injection, 3v tanycyte destruction was reversed along with restoration

59 The quest is on to understand how tanycytes detect and respond to changes in energy balanc

60 We observed that tanycyte development was severely disrupted when Lhx2 fu

61 To test the function of Lhx2 in tanycyte development, we used an intersectional genetic

62 of Rax, an essential homeodomain factor for tanycyte development.

63 To determine whether Rax controls tanycyte differentiation and function, we generated Rax

64 ntifies Lhx2 as a key intrinsic regulator of tanycyte differentiation, sustaining Rax-dependent activ

65 that Rax is selectively required for alpha2 tanycyte differentiation.

66 ic the morphological plasticity displayed by tanycytes during the hours encompassing the preovulatory

67 ltrastructural analysis revealed that mutant tanycytes exhibited a hybrid identity, retaining radial

68 Distinct subpopulations of alpha-tanycytes exist, amongst which only GFAP-positive dorsal

69 The LoC-associated tanycytes express both p75 and trkA receptors.

70 Here we show that cultured tanycytes express erbB-1 and erbB-2, two of the four mem

71 Here, we show that Fgf10(+) tanycytes express markers of neural stem/progenitor cell

72 Our results suggest that alpha-tanycytes form the critical component of a hypothalamic

73 The NGF extracted by tanycytes from the CSF has physiological effects on LoC

74 fate mapping, we found that median eminence tanycytes generate newborn neurons.

75 Tanycytes, glial-like cells that line the third ventricl

76 Although tanycytes have been proposed as glucosensors, our study

77 egulate the specification and maintenance of tanycyte identity are unknown, but are critical for unde

78 The strong GLAST expression by the ventral tanycytes in the hypophysiotropic area suggests a role o

79 f neurons throughout the brain as well as in tanycytes in the mediobasal hypothalamus.

80 vels lead to enhanced proliferation of alpha-tanycytes in vivo.

81 Remarkably, these tanycyte-like cells display well-organized tight junctio

82 The results show that most tanycytes lining the ventral third ventricle and many as

83 d in a group of specialized ependymal cells, tanycytes, lining the wall and floor of the third ventri

84 Lhx2-deficient tanycytes lost expression of tanycyte-specific genes, su

85 the hypophysiotropic area suggests a role of tanycyte-mediated glutamate transport in neuroendocrine

86 irst direct demonstration of this hypothesis.Tanycytes must therefore now be considered as active sig

87 That tanycytes, not astrocytes, are the cells within the MBH

88 ttern whereby low and high POMC syntheses in tanycytes occur periodically in each brain, or marked in

89 SOD immunoreactivity, EC-SOD localization in tanycytes occurred in a region lacking a blood-brain bar

90 ation, we demonstrate GLAST mRNA labeling in tanycytes of the ventral floor and lateral walls in the

91 roid hormone deiodinases in ependymal cells (tanycytes) of the fetal hypothalamus, and hence neuroend

92 also enriched, with Na,K-ATPase, in certain tanycytes or ependymal cells of the ventricle wall.

93 monstrate that alpha-tanycytes, but not beta-tanycytes or parenchymal cells, are neurospherogenic.

94 Fbeta1 have dramatically opposite effects on tanycyte plasticity.

95 ese results indicate that MCT1 expression in tanycytes plays a role in feeding behavior regulation.

96 ct Arc-ME cell populations, including a rare tanycyte population at the Arc-ME diffusion barrier, a n

97 GLT-1 and GLAST protein are expressed in the tanycyte populations as well.

98 amate transporters GLT-1 and GLAST in unique tanycyte populations of the third ventricle in rat brain

99 ongst which only GFAP-positive dorsal alpha2-tanycytes possess stem-like neurospherogenic activity.

100 The neuronal descendants of Fgf10(+) tanycytes predominantly populate the arcuate nucleus, a

101 nase mRNA and DARPP-32-IR also extended into tanycyte processes that ramified in the arcuate nucleus

102 of the 3rd ventricle and in the processes of tanycytes projecting to the median eminence.

103 In addition, endothelial cells, tanycytes, radial glia, ependymal cells, microglia, and

104 d, unlike other known POMC-expressing cells, tanycytes rarely contained detectable levels of adrenoco

105 s were associated with the destruction of 3v tanycytes, reduced glial fibrillary acidic protein-immun

106 Tanycytes regulate many aspects of hypothalamic physiolo

107 Tanycytes release ATP in response to glucose.

108 Nevertheless the signalling properties of tanycytes remain largely unstudied.

109 The functional role of GLT-1 in dorsal wall tanycytes remains to be explored.

110 Furthermore, the GLT-1-expressing tanycytes represent a population of tanycytes that, to d

111 ithin ventral tanycyte subpopulations; alpha-tanycytes require fibroblast growth factor signalling to

112 axonal routes of NGF trafficking to LoC, the tanycyte route is significantly more effective.

113 uggest high levels of neuronal plasticity in tanycytes, SCN, and ICj.

114 This programming effect depends on tanycyte sensitivity to thyroid stimulating hormone (TSH

115 First, the radial glia-like, hypothalamic tanycytes show high DCL expression that partly colocaliz

116 We now demonstrate that tanycytes signal via waves of intracellular Ca2+; they r

117 trong GLT-1 mRNA labeling in a population of tanycytes situated in the dorsolateral walls of caudal t

118 tion, sustaining Rax-dependent activation of tanycyte-specific genes while also inhibiting expression

119 Lhx2-deficient tanycytes lost expression of tanycyte-specific genes, such as Rax, while also display

120 Lhx2 resulted only in loss of expression of tanycyte-specific genes.

121 18 are expressed specifically within ventral tanycyte subpopulations; alpha-tanycytes require fibrobl

122 hows that DII is localized in astrocytes and tanycytes, supporting the hypothesis that these cells pl

123 pressing tanycytes represent a population of tanycytes that, to date, has not been recognized as func

124 olecules into the parenchyma of the ME while tanycyte tight junctions control their diffusion into th

125 Prolonged (>12 hr) exposure of tanycytes to TGFalpha resulted in focal tanycytic retrac

126 aphy at the ultrastructural level shows that tanycytes transcytose and deliver NGF to LoC neurons via

127 Stage-specific lineage-tracing of Fgf10(+) tanycytes using Fgf10-creERT2 mice, reveals robust neuro

128 pression of tdTomato in AgRP-NPY neurons and tanycytes, were significantly decreased by food deprivat

129 er 1 (MCT1) is the main isoform expressed by tanycytes, which could facilitate lactate release to hyp

130 tein was largely confined to a population of tanycytes within the infundibular stalk/caudal median em